Explanipedia

Persistent Imbalance Open

Alaina K. Kipps, Audrey C. Marshall, Neha Bansal, Holly Bauser‐Heaton, Nadine Choueiter , et al. · 2025

Women hold fewer leadership positions across most subsections of pediatric cardiology programs, with more equitable distribution at centers led by women division chiefs. Women are more likely to share a leadership position with another car…

Routine Echocardiographic Assessments of Single Ventricle Patients Should Include Atrial Strain Open

Alan Wang, Pei‐Ni Jone · 2025

ICU Admission Prediction for Patients With Kawasaki Disease or MIS-C Using Machine Learning Open

JiWon Woo, Rebecca Mosier, R. Mukherjee, Ashraf S. Harahsheh, Supriya Jain , et al. · 2025

ML algorithms can effectively predict ICU admission for pediatric patients with MIS-C or KD. These models may prompt physicians to pre-emptively implement supportive measures, possibly mitigating the risk of clinical deterioration.

Diagnostic Accuracy Prior to Congenital Heart Defect Surgery Open

Shobha Natarajan, Kasey J. Chaszczewski, Chris Penney, Steve Ampah, Douglas Ryba , et al. · 2025

This work represents the feasibility and advantages of a multicenter approach to preoperative diagnostic errors. Variability existed in sedated protocols, number of echos needed, use of other modalities, and in other processes. Common anat…

Artificial Intelligence in Fetal and Pediatric Echocardiography Open

Alan Wang, Tam Doan, Charitha D. Reddy, Pei‐Ni Jone · 2024

Echocardiography is the main modality in diagnosing acquired and congenital heart disease (CHD) in fetal and pediatric patients. However, operator variability, complex image interpretation, and lack of experienced sonographers and cardiolo…

Size and Function of the Right Atrium in Healthy Children by Three‐Dimensional Echocardiography Open

Brendan Haughian, Pei‐Ni Jone, Lisa Le, Nee Scze Khoo, Timothy Colen , et al. · 2024

Purpose Right atrial volume (RAV) and function have proven prognostic value in the assessment of cardiac disease and may be more accurately assessed using three‐dimensional echocardiography (3DE). Normal 3DE reference values for the right …

Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design Open

Rachel S. Gross, Tanayott Thaweethai, Erika B. Rosenzweig, James Chan, Lori B. Chibnik , et al. · 2024

Importance The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae of SARS-CoV-2 [PASC] or “Long COVID”) in children and young adults remain unknown. Studies must address the urgent need to define PASC, its…

Mind the Gap! Working Toward Gender Equity in Pediatric and Congenital Heart Disease: Present and Future Open

Devyani Chowdhury, Neha Bansal, Annette Ansong, Carissa M. Baker‐Smith, Holly Bauser‐Heaton , et al. · 2024

Evidence from medicine and other fields has shown that gender diversity results in better decision making and outcomes. The incoming workforce of congenital heart specialists (especially in pediatric cardiology) appears to be more gender b…

Consensus‐Based Development of a Pediatric Echocardiography Complexity Score: Design, Rationale, and Results of a Quality Improvement Collaborative Open

Sowmya Balasubramanian, Sunkyung Yu, Sarina K. Behera, Aarti Bhat, Joseph Camarda , et al. · 2024

Background The complexity of congenital heart disease has been primarily stratified on the basis of surgical technical difficulty, specific diagnoses, and associated outcomes. We report on the refinement and validation of a pediatric echoc…

Obesity and Outcomes of Kawasaki Disease and COVID-19–Related Multisystem Inflammatory Syndrome in Children Open

Michael Khoury, Ashraf S. Harahsheh, Geetha Raghuveer, Nagib Dahdah, Simon Lee , et al. · 2023

Importance Obesity may affect the clinical course of Kawasaki disease (KD) in children and multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19. Objective To compare the prevalence of obesity and associations with…

Cardiac Biomarkers Aid in Differentiation of Kawasaki Disease from Multisystem Inflammatory Syndrome in Children Associated with COVID-19 Open

Mollie Walton, Geetha Raghuveer, Ashraf S. Harahsheh, Michael A. Portman, Simon Lee , et al. · 2023

Background: Kawasaki disease (KD) and Multisystem Inflammatory Syndrome in Children (MIS-C) associated with COVID-19 show clinical overlap and both lack definitive diagnostic testing, making differentiation challenging. We sought to determ…

Pulmonary Hypertension in Congenital Heart Disease: A Scientific Statement From the American Heart Association Open

Pei‐Ni Jone, D. Dunbar Ivy, Amanda Hauck, Tara Karamlou, Uyen Truong , et al. · 2023

Patients with pulmonary hypertension associated with congenital heart disease make up an increasing proportion of the total pulmonary hypertension population who bring with them added complexity because of underlying anatomical and hemodyn…

Kawasaki Disease in the Time of COVID-19 and MIS-C: The International Kawasaki Disease Registry Open

Ashraf S. Harahsheh, Samay Shah, Frédéric Dallaire, Cedric Manlhiot, Michael Khoury , et al. · 2023

The (Heart and) Soul of a Human Creation: Designing Echocardiography for the Big Data Age Open

Rima Arnaout, Rebecca T. Hahn, Judy Hung, Pei‐Ni Jone, Steven J. Lester , et al. · 2023

Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design Open

Rachel S. Gross, Tanayott Thaweethai, Erika B. Rosenzweig, James Chan, Lori B. Chibnik , et al. · 2023

Importance The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae of SARS-CoV-2 [PASC] or “Long COVID”) in children and young adults remain unknown. Studies must address the urgent need to define PASC, its…

Can Multisystem Inflammatory Syndrome in Children Be Managed in the Outpatient Setting? An EHR-Based Cohort Study From the RECOVER Program Open

Ravi Jhaveri, Ryan Webb, Hanieh Razzaghi, Julia Schuchard, Asunción Mejías , et al. · 2023

Using electronic health record data combined with primary chart review, we identified seven children across nine participant pediatric medical centers with a diagnosis of Multisystem Inflammatory Syndrome in Children (MIS-C) managed exclus…

Utility of Fetal Echocardiography with Acute Maternal Hyperoxygenation Testing in Assessment of Complex Congenital Heart Defects Open

Sheetal Patel, Nitin Madan, Pei‐Ni Jone, Mary T. Donofrio · 2023

Fetal echocardiography is an excellent tool for accurately assessing the anatomy and physiology of most congenital heart defects (CHDs). Knowledge gathered from a thorough initial fetal echocardiogram and serial assessment assists with app…

Examination of Adverse Reactions After COVID-19 Vaccination Among Patients With a History of Multisystem Inflammatory Syndrome in Children Open

Matthew D. Elias, Dongngan T. Truong, Matthew E. Oster, Felicia Trachtenberg, Xiangyu Mu , et al. · 2023

Importance Data are limited regarding adverse reactions after COVID-19 vaccination in patients with a history of multisystem inflammatory syndrome in children (MIS-C). The lack of vaccine safety data in this unique population may cause hes…

Use of adjunctive 3-dimensional echocardiogram for His bundle pacing in pediatric patients Open

Johannes C. von Alvensleben, D. Martin Runciman, Michael Schäffer, Dale A. Burkett, Pei‐Ni Jone , et al. · 2022

The right ventricle has been the traditional site of transvenous pacing, but targeting the His bundle has emerged as potentially more physiologic, with reductions in pacemaker-mediated cardiomyopathy being suggested. Although the use of Hi…

Artificial Intelligence in Congenital Heart Disease Open

Pei‐Ni Jone, Addison Gearhart, Howard Lei, Fuyong Xing, Jai Nahar , et al. · 2022

The current era of big data offers a wealth of new opportunities for clinicians to leverage artificial intelligence to optimize care for pediatric and adult patients with a congenital heart disease. At present, there is a significant under…

Changes in Treatment and Severity of Multisystem Inflammatory Syndrome in Children: An EHR-based cohort study from the RECOVER program Open

Julia Schuchard, Deepika Thacker, Ryan Webb, L. Charles Bailey, Tellen D. Bennett , et al. · 2022

Objectives The purpose of this study was to examine how the treatment and severity of multisystem inflammatory syndrome in children (MIS-C) has changed over more than two years of the COVID-19 pandemic in the United States. Methods Electro…

Multisystem Inflammatory Syndrome in Children Managed in the Outpatient Setting: An EHR-based cohort study from the RECOVER program Open

Ravi Jhaveri, Ryan Webb, Hanieh Razzaghi, Julia Schuchard, Asunción Mejías , et al. · 2022

Using electronic health record data combined with primary chart review, we identified 7 children across 8 pediatric medical centers with a diagnosis of Multisystem Inflammatory Syndrome in Children (MIS-C) who were managed as outpatients. …

Cardiac Troponin Testing as a Component of Return to Play Cardiac Screening in Young Competitive Athletes Following SARS‐CoV‐2 Infection Open

Nathaniel Moulson, Bradley J. Petek, Timothy W. Churchill, Jonathan A. Drezner, Kimberly G. Harmon , et al. · 2022

Background Initial protocols for return to play cardiac testing in young competitive athletes following SARS‐CoV‐2 infection recommended cardiac troponin (cTn) to screen for cardiac involvement. This study aimed to define the diagnostic yi…

Epidemiological and Clinical Features of Kawasaki Disease During the COVID-19 Pandemic in the United States Open

Jennifer Burney, Samantha C. Roberts, Laurel L. DeHaan, Chisato Shimizu, Emelia Bainto , et al. · 2022

In this study of epidemiological and clinical features of KD during the COVID-19 pandemic in the United States, KD cases fell and remained low during the period of masking and school closure. Mobility data indicated that differential inten…

Association of Acute Anti-inflammatory Treatment With Medium-term Outcomes for Coronary Artery Aneurysms in Kawasaki Disease Open

Kevin G. Friedman, Brian W. McCrindle, Kyle Runeckles, Nagib Dahdah, Ashraf S. Harahsheh , et al. · 2022

Persistence of CAA and MACE are more strongly associated with baseline severity CAA than with acute adjuvant anti-inflammatory therapy. Patients who received late adjunctive therapy are at higher risk for worse outcomes.

Repolarization Dispersion Is Associated With Diastolic Electromechanical Discoordination in Children With Pulmonary Arterial Hypertension Open

Michal Schäfer, Benjamin S. Frank, D. Dunbar Ivy, Max B. Mitchell, Kathryn K. Collins , et al. · 2022

Background Electromechanical dyssynchrony is a well described comorbidity in pulmonary arterial hypertension (PAH). ECG‐derived measurements reflective of diastolic dysfunction and electromechanical imaging markers are yet to be investigat…

Artificial intelligence in echocardiography to diagnose congenital heart disease and fetal echocardiography Open

Addison Gearhart, Nicholas Dwork, Pei‐Ni Jone · 2022

Echocardiography is the primary tool in pediatric cardiology for diagnosing and managing congenital heart disease (CHD). Accurate and reliable echocardiographic assessment is critical in clinical decision making. Artificial intelligence (A…

Temporal clustering of Kawasaki disease cases around the world Open

Jennifer Burney, Laurel L. DeHaan, Chisato Shimizu, Emelia Bainto, Jane W. Newburger , et al. · 2021

Infliximab versus second intravenous immunoglobulin for treatment of resistant Kawasaki disease in the USA (KIDCARE): a randomised, multicentre comparative effectiveness trial Open

Jane C. Burns, Samantha C. Roberts, Adriana H. Tremoulet, Feng He, Beth F. Printz , et al. · 2021

Angiostatic Peptide, Endostatin, Predicts Severity in Pediatric Congenital Heart Disease–Associated Pulmonary Hypertension Open

Caroline M. Daly, Megan Griffiths, Catherine E. Simpson, Jun Yang, Rachel L. Damico , et al. · 2021

Background Endostatin, an angiogenic inhibitor, is associated with worse pulmonary arterial hypertension (PAH) outcomes in adults and poor lung growth in children. This study sought to assess whether endostatin is associated with disease s…

Pei‐Ni Jone YOU? Author Swipe