Peining Xu
YOU?
Author Swipe
View article: Altered lipid homeostasis is associated with cerebellar neurodegeneration in SNX14 deficiency
Altered lipid homeostasis is associated with cerebellar neurodegeneration in SNX14 deficiency Open
Dysregulated lipid homeostasis is emerging as a potential cause of neurodegenerative disorders. However, evidence of errors in lipid homeostasis as a pathogenic mechanism of neurodegeneration remains limited. Here, we show that cerebellar …
View article: PAQR8 promotes breast cancer recurrence and confers resistance to multiple therapies
PAQR8 promotes breast cancer recurrence and confers resistance to multiple therapies Open
Background Breast cancer mortality is principally due to recurrent disease that becomes resistant to therapy. We recently identified copy number (CN) gain of the putative membrane progesterone receptor PAQR8 as one of four focal CN alterat…
View article: Altered lipid homeostasis underlies selective neurodegeneration in SNX14 deficiency
Altered lipid homeostasis underlies selective neurodegeneration in SNX14 deficiency Open
Dysregulated lipid homeostasis is emerging as a potential cause of neurodegenerative disorders. However, evidence of errors in lipid homeostasis as a pathogenic mechanism of neurodegeneration remains limited. Here, we show that the cerebel…
View article: Frataxin controls ketone body metabolism through regulation of OXCT1
Frataxin controls ketone body metabolism through regulation of OXCT1 Open
Friedreich’s ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by the deficiency of mitochondrial protein frataxin, which plays a crucial role in iron–sulphur cluster formation and ATP production. The cellular functi…
View article: Direct anabolic metabolism of three-carbon propionate to a six-carbon metabolite occurs in vivo across tissues and species
Direct anabolic metabolism of three-carbon propionate to a six-carbon metabolite occurs in vivo across tissues and species Open
Anabolic metabolism of carbon in mammals is mediated via the one- and two-carbon carriers S-adenosyl methionine and acetyl-coenzyme A. In contrast, anabolic metabolism of three-carbon units via propionate has not been shown to extensively …
View article: Cumulus cell acetyl-CoA metabolism from acetate is associated with maternal age but only partially with oocyte maturity
Cumulus cell acetyl-CoA metabolism from acetate is associated with maternal age but only partially with oocyte maturity Open
Cumulus cell (CC) clumps that associate with oocytes provide the oocytes with growth and signaling factors. Thus, the metabolism of the CCs may influence oocyte function, and CC metabolism may be predictive of oocyte competence for in vitr…
View article: Analytical Considerations for Reducing the Matrix Effect for the Sphingolipidome Quantification in Whole Blood
Analytical Considerations for Reducing the Matrix Effect for the Sphingolipidome Quantification in Whole Blood Open
Aim: Plasma and serum are widely used blood-derived biofluids for metabolomics and lipidomics assays, but analytes that are present in high concentrations in blood cells cannot be evaluated in those samples and isolating serum or plasma co…
View article: Sphingolipidome Quantification by Liquid Chromatography- High Resolution Mass Spectrometry: Whole Blood vs. Plasma
Sphingolipidome Quantification by Liquid Chromatography- High Resolution Mass Spectrometry: Whole Blood vs. Plasma Open
Plasma and serum are the most widely used blood-derived biofluids for metabolomics and lipidomics assays, but the isolation of these products from blood may introduce additional bias as indicated by the fact that many analytes that are pre…
View article: Extra-mitochondrial mouse frataxin and its implications for mouse models of Friedreich’s ataxia
Extra-mitochondrial mouse frataxin and its implications for mouse models of Friedreich’s ataxia Open
Mature frataxin is essential for the assembly of iron–sulfur cluster proteins including a number of mitochondrial enzymes. Reduced levels of mature frataxin (81-20) in human subjects caused by the genetic disease Friedreich’s ataxia result…
View article: Association Between Midpregnancy Polyunsaturated Fatty Acid Levels and Offspring Autism Spectrum Disorder in a California Population-Based Case-Control Study
Association Between Midpregnancy Polyunsaturated Fatty Acid Levels and Offspring Autism Spectrum Disorder in a California Population-Based Case-Control Study Open
Polyunsaturated fatty acids (PUFAs) are critical for brain development and have been linked with neurodevelopmental outcomes. We conducted a population-based case-control study in California to examine the association between PUFAs measure…
View article: Cumulus cell acetyl-CoA metabolism from acetate is associated with maternal age but inconclusively with oocyte maturity
Cumulus cell acetyl-CoA metabolism from acetate is associated with maternal age but inconclusively with oocyte maturity Open
Cumulus cell (CC) clumps that associate with oocytes provide the oocytes with growth and signaling factors. Thus, the metabolism of the CCs may influence oocyte function and CC metabolism may be predictive of oocyte competence for in vitro…
View article: Direct anabolic three carbon metabolism via propionate to a six carbon metabolite occurs in human heart and in vivo across mouse tissues
Direct anabolic three carbon metabolism via propionate to a six carbon metabolite occurs in human heart and in vivo across mouse tissues Open
Anabolic metabolism of carbon in mammals is mediated via the one and two carbon carriers S-adenosyl methionine and acetyl-coenzyme A (acetyl-CoA). In contrast, anabolic metabolism using three carbon units via propionate is not thought to o…
View article: Subcellular metabolic pathway kinetics are revealed by correcting for artifactual post harvest metabolism
Subcellular metabolic pathway kinetics are revealed by correcting for artifactual post harvest metabolism Open
OBJECTIVE The dynamic regulation of metabolic pathways can be monitored by stable isotope tracing. Yet, many metabolites are part of distinct processes within different subcellular compartments. Standard isotope tracing experiments relying…
View article: Preliminary results of identification and quantification of paclitaxel and its metabolites in human meconium from newborns with gestational chemotherapeutic exposure
Preliminary results of identification and quantification of paclitaxel and its metabolites in human meconium from newborns with gestational chemotherapeutic exposure Open
Intact paclitaxel, 3'-p-hydroxypaclitaxel, and 6α-hydroxypaclitaxel were detected in meconium, providing unambiguous confirmation of human fetal exposure. Variability in meconium levels between individuals may indicate a potential for redu…
View article: Simultaneous isotope dilution quantification and metabolic tracing of deoxyribonucleotides by liquid chromatography high resolution mass spectrometry
Simultaneous isotope dilution quantification and metabolic tracing of deoxyribonucleotides by liquid chromatography high resolution mass spectrometry Open
Quantification of cellular deoxyribonucleoside mono-(dNMP), di-(dNDP), triphosphates (dNTPs) and related nucleoside metabolites are difficult due to their physiochemical properties and widely varying abundance. Involvement of dNTP metaboli…
View article: Artefactual formation of pyruvate from in‐source conversion of lactate
Artefactual formation of pyruvate from in‐source conversion of lactate Open
Rationale Lactate and pyruvate are high‐abundance products of glucose metabolism. Analysis of both molecules as part of metabolomics studies in cellular metabolism and physiology have been aided by advances in liquid chromatography/mass sp…
View article: Identification and Quantification of Paclitaxel and its Metabolites in Human Meconium from Newborns with Gestational Chemotherapeutic Exposure
Identification and Quantification of Paclitaxel and its Metabolites in Human Meconium from Newborns with Gestational Chemotherapeutic Exposure Open
Objective Cancer diagnosis during pregnancy occurs in 1 out of 1000 pregnancies with common malignancies including breast and hematological cancers. Fetal exposure to currently utilized agents is poorly described. We directly assessed feta…
View article: Discovery and mechanism of action of a novel HIV-1 capsid inhibitor, CX06
Discovery and mechanism of action of a novel HIV-1 capsid inhibitor, CX06 Open
Human immunodeficiency virus type 1 (HIV-1) is the etiologic agent responsible for the acquired immunodeficiency syndrome (AIDS) pandemic worldwide. Current therapies for HIV-1 are strongly limited not only by the development of multidrug-…