Peiqing Liu
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View article: Identification of ATG7 as a protein ATG8ylation substrate
Identification of ATG7 as a protein ATG8ylation substrate Open
Protein ATG8ylation is a post-translational modification where ubiquitin-like protein LC3/ATG8 forms covalent conjugation with cellular proteins, a process reversed by ATG4. In contrast to the well-characterized ATG8 lipidation/membrane AT…
View article: Quantitative Contrast-Enhanced Ultrasound Assessment of Renal Microcirculation and Function in a Rat Model of Sepsis-Induced Acute Kidney Injury
Quantitative Contrast-Enhanced Ultrasound Assessment of Renal Microcirculation and Function in a Rat Model of Sepsis-Induced Acute Kidney Injury Open
View article: CORE-RAG: Lossless Compression for Retrieval-Augmented LLMs via Reinforcement Learning
CORE-RAG: Lossless Compression for Retrieval-Augmented LLMs via Reinforcement Learning Open
Retrieval-Augmented Generation (RAG) has emerged as a promising approach to enhance the timeliness of knowledge updates and the factual accuracy of responses in large language models. However, incorporating a large number of retrieved docu…
View article: α-Ketoglutarate Attenuates Oxidative Stress-Induced Neuronal Aging via Modulation of the mTOR Pathway
α-Ketoglutarate Attenuates Oxidative Stress-Induced Neuronal Aging via Modulation of the mTOR Pathway Open
Background/Objectives: Oxidative stress constitutes a principal pathophysiological mechanism driving neurodegeneration and brain aging. α-Ketoglutarate (AKG), a key intermediate of the tricarboxylic acid (TCA) cycle, has shown potential in…
View article: Phase separation of RXRγ drives tumor chemoresistance and represents a therapeutic target for small-cell lung cancer
Phase separation of RXRγ drives tumor chemoresistance and represents a therapeutic target for small-cell lung cancer Open
Small-cell lung cancer (SCLC) is the most lethal type of lung cancer, characterized by rapid evolution from chemosensitivity to chemoresistance and limited treatment options. However, the mechanisms underlying this evolution remain poorly …
View article: Integration of Family Medicine and the Characteristics of Traditional Chinese Medicine: Constructing a New Primary Healthcare Model
Integration of Family Medicine and the Characteristics of Traditional Chinese Medicine: Constructing a New Primary Healthcare Model Open
View article: Geranyl hydroquinone alleviates rheumatoid arthritis-associated pain by suppressing neutrophil accumulation, N1 polarization and ROS production in mice
Geranyl hydroquinone alleviates rheumatoid arthritis-associated pain by suppressing neutrophil accumulation, N1 polarization and ROS production in mice Open
View article: YAP K236 acetylation facilitates its nucleic export and deprived the protection against cardiac hypertrophy in mice
YAP K236 acetylation facilitates its nucleic export and deprived the protection against cardiac hypertrophy in mice Open
The subcellular localization of Yes-associated protein (YAP) is dynamically regulated by post-transcriptional modifications, critically influencing cardiac function. Despite its significance, the precise mechanism controlling YAP nuclear s…
View article: Tumor mitochondrial oxidative phosphorylation stimulated by the nuclear receptor RORγ represents an effective therapeutic opportunity in osteosarcoma
Tumor mitochondrial oxidative phosphorylation stimulated by the nuclear receptor RORγ represents an effective therapeutic opportunity in osteosarcoma Open
Osteosarcoma (OS) is the most common malignant bone tumor with a poor prognosis. Here, we show that the nuclear receptor RORγ may serve as a potential therapeutic target in OS. OS exhibits a hyperactivated oxidative phosphorylation (OXPHOS…
View article: RPL9 acts as an oncogene by shuttling miRNAs through exosomes in human hepatocellular carcinoma cells
RPL9 acts as an oncogene by shuttling miRNAs through exosomes in human hepatocellular carcinoma cells Open
The exosomal pathway is an essential mechanism that regulates the abnormal content of microRNAs (miRNAs) in hepatocellular carcinoma (HCC). The directional transport of miRNAs requires the assistance of RNA-binding proteins (RBPs). The pre…
View article: Long-term effects of chronic exposure to electronic cigarette aerosol on the cardiovascular and pulmonary system in mice: A comparative study to cigarette smoke
Long-term effects of chronic exposure to electronic cigarette aerosol on the cardiovascular and pulmonary system in mice: A comparative study to cigarette smoke Open
Electronic cigarettes (e-cigarettes) have rapidly gained popularity as alternatives to traditional combustible cigarettes. However, their long-term health impact remains uncertain. This study aimed to investigate the effects of chronic exp…
View article: Targeting RORγ inhibits the growth and metastasis of hepatocellular carcinoma
Targeting RORγ inhibits the growth and metastasis of hepatocellular carcinoma Open
View article: Targeting the smooth muscle cell Keap1-Nrf2-GSDMD-pyroptosis axis by cryptotanshinone prevents abdominal aortic aneurysm formation
Targeting the smooth muscle cell Keap1-Nrf2-GSDMD-pyroptosis axis by cryptotanshinone prevents abdominal aortic aneurysm formation Open
Rationale: Abdominal aortic aneurysm (AAA) is an inflammatory, fatal aortic disease that currently lacks any effective drugs. Cryptotanshinone (CTS) is a prominent and inexpensive bioactive substance derived from Salvia miltiorrh…
View article: The SIRT3-ATAD3A axis regulates MAM dynamics and mitochondrial calcium homeostasis in cardiac hypertrophy
The SIRT3-ATAD3A axis regulates MAM dynamics and mitochondrial calcium homeostasis in cardiac hypertrophy Open
Mitochondria are energy-producing organelles that are mobile and harbor dynamic network structures. Although mitochondria and endoplasmic reticulum (ER) play distinct cellular roles, they are physically connected to maintain functional hom…
View article: Exosomal miRNA-146a-5p Derived from Senescent Hepatocellular Carcinoma Cells Promotes Aging and Inhibits Aerobic Glycolysis in Liver Cells via Targeting IRF7
Exosomal miRNA-146a-5p Derived from Senescent Hepatocellular Carcinoma Cells Promotes Aging and Inhibits Aerobic Glycolysis in Liver Cells via Targeting IRF7 Open
Hepatocellular carcinoma (HCC) is a major global health challenge. Chemotherapy can cause HCC cells to become senescent. Senescent HCC cells play an important role in inhibiting or promoting cancer by producing extracellular vesicles with …
View article: UBE3C tunes autophagy via ATG4B ubiquitination
UBE3C tunes autophagy via ATG4B ubiquitination Open
ATG4B is a core protein and essential for cleaving precursor MAP1LC3/LC3 or deconjugating lipidated LC3-II to drive the formation of autophagosomes. The protein stability and activity of ATG4B regulated by post-translational modification (…
View article: Regulation of toll-like receptor (TLR) signaling pathways in atherosclerosis: from mechanisms to targeted therapeutics
Regulation of toll-like receptor (TLR) signaling pathways in atherosclerosis: from mechanisms to targeted therapeutics Open
View article: Noncanonical autophagy is a new strategy to inhibit HSV-1 through STING1 activation
Noncanonical autophagy is a new strategy to inhibit HSV-1 through STING1 activation Open
STING1 (stimulator of interferon response cGAMP interactor 1) plays an essential role in immune responses for virus inhibition via inducing the production of type I interferon, inflammatory factors and macroautophagy/autophagy. In this stu…
View article: RUNX1 is required in granulocyte–monocyte progenitors to attenuate inflammatory cytokine production by neutrophils
RUNX1 is required in granulocyte–monocyte progenitors to attenuate inflammatory cytokine production by neutrophils Open
The transcription factor RUNX1 is mutated in familial platelet disorder with associated myeloid malignancy (FPDMM) and in sporadic myelodysplastic syndrome and leukemia. RUNX1 was shown to regulate inflammation in multiple cell types. Here…
View article: JMJD6 protects against isoproterenol-induced cardiac hypertrophy via inhibition of NF-κB activation by demethylating R149 of the p65 subunit
JMJD6 protects against isoproterenol-induced cardiac hypertrophy via inhibition of NF-κB activation by demethylating R149 of the p65 subunit Open
View article: A Numerical Study on the Flap Side-Edge Noise Reduction Using Passive Blowing Air Concept
A Numerical Study on the Flap Side-Edge Noise Reduction Using Passive Blowing Air Concept Open
The flap side-edge is a vital contributor to airframe noise. In this study, we propose a novel flap side-edge noise reduction method based on the concept of active blowing air. A long slot is opened from the flap’s lower surface to the tip…
View article: Pharmacokinetics and tissue distribution of bleomycin-induced idiopathic pulmonary fibrosis rats treated with cryptotanshinone
Pharmacokinetics and tissue distribution of bleomycin-induced idiopathic pulmonary fibrosis rats treated with cryptotanshinone Open
Introduction: Cryptotanshinone(CTS), a compound derived from the root of Salvia miltiorrhiza , has been linked to various of diseases, particularly pulmonary fibrosis. In the current study, we investigated the benefit of CTS on Sprague-Daw…
View article: Cigarettes smoking and e-cigarettes using among university students: a cross-section survey in Guangzhou, China, 2021
Cigarettes smoking and e-cigarettes using among university students: a cross-section survey in Guangzhou, China, 2021 Open
Background There is an increase in the use of cigarettes and e-cigarettes worldwide, and the similar trends may be observed in young adults. Since 2014, e-cigarettes have become the most commonly used nicotine products among young adults (…
View article: SIRT3 improved peroxisomes-mitochondria interplay and prevented cardiac hypertrophy via preserving PEX5 expression
SIRT3 improved peroxisomes-mitochondria interplay and prevented cardiac hypertrophy via preserving PEX5 expression Open
View article: RUNX1 is required in granulocyte-monocyte progenitors to attenuate inflammatory cytokine production by neutrophils
RUNX1 is required in granulocyte-monocyte progenitors to attenuate inflammatory cytokine production by neutrophils Open
The transcription factor RUNX1 is mutated in familial platelet disorder with associated myeloid malignancies (FPDMM) and in sporadic myelodysplastic syndrome and leukemia. RUNX1 regulates inflammation in multiple cell types. Here we show t…
View article: Cryptotanshinone attenuates LPS-induced acute lung injury by regulating metabolic reprogramming of macrophage
Cryptotanshinone attenuates LPS-induced acute lung injury by regulating metabolic reprogramming of macrophage Open
Background Acute lung injury (ALI) is a life-threatening inflammatory disease without effective therapeutic regimen. Macrophage polarization plays a key role in the initiation and resolution of pulmonary inflammation. Therefore, modulating…
View article: Signal Suppression in LC-ESI-MS/MS from Concomitant Medications and Its Impact on Quantitative Studies: An Example Using Metformin and Glyburide
Signal Suppression in LC-ESI-MS/MS from Concomitant Medications and Its Impact on Quantitative Studies: An Example Using Metformin and Glyburide Open
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been widely used in the quantitative analysis of drugs. The ubiquitous concomitant drug scenario in the clinic has spawned a large number of co-analyses based on this technique.…
View article: Discovery and mechanism studies of a novel ATG4B inhibitor Ebselen by drug repurposing and its anti-colorectal cancer effects in mice
Discovery and mechanism studies of a novel ATG4B inhibitor Ebselen by drug repurposing and its anti-colorectal cancer effects in mice Open
Cysteine protease ATG4B, a key autophagy protein, is an attractive target for colorectal cancer therapy. However, ATG4B inhibitors with higher efficiency, safety, and clear mechanism are still limited. In this study, we discovered ATG4B in…
View article: SNX3 aggravates pathological cardiac hypertrophy via targeting ATG5-dependent autophagy
SNX3 aggravates pathological cardiac hypertrophy via targeting ATG5-dependent autophagy Open
Autophagy is an intracellular lysosomal degradation pathway that plays a critical role in maintaining cardiac homeostasis. Disordered autophagy is closely related to the pathological process of many heart diseases, including cardiac hypert…
View article: Discovery of an autophagy inducer J3 to lower mutant huntingtin and alleviate Huntington’s disease-related phenotype
Discovery of an autophagy inducer J3 to lower mutant huntingtin and alleviate Huntington’s disease-related phenotype Open