Peng Han
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View article: Extrachromosomal circular miRNA-gene amplifications contribute to the renal cancer phenotype
Extrachromosomal circular miRNA-gene amplifications contribute to the renal cancer phenotype Open
Megabase-sized extrachromosomal circular DNA with intact oncogenes (ecDNA) plays crucial roles in cancer. However, the impact of smaller (100 bp-1 Mb), more ubiquitous extrachromosomal circular DNA (eccDNA) on tumor pathology is unclear. W…
Rutaceae Zanthoxylum–Derived 7‐Demethylsuberosin Alleviates the Rheumatoid Arthritis Through Inhibiting the Maturation of Dendritic Cells via Targeting MAPK14 Functional Food‐Based 7‐Demethylsuberosin Open
Zanthoxylum ailanthoides , a medicinal and edible plant, was mostly used as medicinal materials or spices, in which 7‐demethylsuberosin (7‐Dem) was identified as active component, but its function and mechanism on dendritic cells (DCs) are…
The genotypic and family characteristics and clinical intervention of neurofibromatosis type 1 gene are associated with dystrophic scoliosis by whole-exome sequencing Open
Background To investigate the genotypic and family genetic characteristics of neurofibromatosis type 1 (NF-1) patients associated with dystrophic scoliosis and to further evaluate the clinical efficiency of surgical intervention to these p…
View article: Boron-Insertion-Induced Lattice Engineering of Rh Nanocrystals Toward Enhanced Electrocatalytic Conversion of Nitric Oxide to Ammonia
Boron-Insertion-Induced Lattice Engineering of Rh Nanocrystals Toward Enhanced Electrocatalytic Conversion of Nitric Oxide to Ammonia Open
Electrocatalytic nitric oxide (NO) reduction reaction (NORR) is a promising and sustainable process that can simultaneously realize green ammonia (NH 3 ) synthesis and hazardous NO removal. However, current NORR performances are far from p…
Noninvasive prediction of EGFR 19Del and 21L858R subtypes in lung adenocarcinoma: a comparative study of logistic regression and decision tree models Open
Objective Despite the increasing interest in radiogenomic prediction, few studies have directly compared the performance of logistic regression and decision tree models in distinguishing epidermal growth factor receptor (EGFR) mutation sub…
View article: Data from Spatial–Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution and the Tumor Immune Microenvironment
Data from Spatial–Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution and the Tumor Immune Microenvironment Open
Extrachromosomal DNA (ecDNA) presents a promising target for cancer therapy; however, its spatial–temporal diversity and influence on tumor evolution and the immune microenvironment remain largely unclear. We apply computational methods to…
View article: Supplementary Figures 1-12 from Spatial–Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution and the Tumor Immune Microenvironment
Supplementary Figures 1-12 from Spatial–Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution and the Tumor Immune Microenvironment Open
Supplementary Figure 1. Prevalence of ecDNA in human cancers. Supplementary Figure 2. Characteristics of ecDNA. Supplementary Figure 3. ecDNA drives massive oncogene expression in UC. Supplementary Figure 4. ecDNA can arise in flat urothel…
View article: Supplementary Tables 1-24 from Spatial–Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution and the Tumor Immune Microenvironment
Supplementary Tables 1-24 from Spatial–Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution and the Tumor Immune Microenvironment Open
Table_S1. Study cohort. Table_S2. The sample composition of each dataset. Table_S3. Patient information. Table_S4. Whole genome sequencing (WGS) datasets. 1,411 UC whole genomes. Table_S5. Whole exome sequencing (WES) datasets. Table_S6. R…
Low Geomagnetic Field Intensity in Southern China 6,000 Years Ago Open
The West Pacific Anomaly (WPA), a low geomagnetic field anomaly observed in the 16th to 18th centuries, represents a recently recognized and complex feature of Earth's magnetic field. However, the history of the WPA is still uncertain due …
Piceatannol Inhibits the Immunostimulatory Functions of Dendritic Cells and Alleviates Experimental Arthritis Open
Rheumatoid arthritis (RA) is a highly prevalent systemic autoimmune disease. Recently, natural small molecules have been explored as alternative therapeutic agents. Iris halophila Pall is the traditional herbal medicine, and it is rich in …
View article: Carbon‐Extraction‐Triggered Phase Engineering of Rhodium Nanomaterials for Efficient Electrocatalytic Nitrate Reduction Reaction
Carbon‐Extraction‐Triggered Phase Engineering of Rhodium Nanomaterials for Efficient Electrocatalytic Nitrate Reduction Reaction Open
Phase engineering plays a crucial role in tuning the physicochemical properties of noble metal nanomaterials. However, synthesis of high‐purity unconventional‐phase noble metal nanomaterials remains highly challenging via current wet‐chemi…
View article: Carbon‐Extraction‐Triggered Phase Engineering of Rhodium Nanomaterials for Efficient Electrocatalytic Nitrate Reduction Reaction
Carbon‐Extraction‐Triggered Phase Engineering of Rhodium Nanomaterials for Efficient Electrocatalytic Nitrate Reduction Reaction Open
Phase engineering plays a crucial role in tuning the physicochemical properties of noble metal nanomaterials. However, synthesis of high‐purity unconventional‐phase noble metal nanomaterials remains highly challenging via current wet‐chemi…
View article: Spatial–Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution and the Tumor Immune Microenvironment
Spatial–Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution and the Tumor Immune Microenvironment Open
Extrachromosomal DNA (ecDNA) presents a promising target for cancer therapy; however, its spatial–temporal diversity and influence on tumor evolution and the immune microenvironment remain largely unclear. We apply computational methods to…
<span>DDX5</span> Alleviates Temporomandibular Joint Osteoarthritis via <span>TNF</span> ‐Induced <span>NF</span> ‐ <span>κB</span> Signaling Pathway Open
Background Temporomandibular joint osteoarthritis (TMJOA) is a prevalent musculoskeletal condition characterized by pain, cartilage degeneration, and subchondral bone loss. Objective This study sought to identify specific targets for the t…
View article: Plasma cell-free extrachromosomal circular DNA is a molecular hallmark of preeclampsia
Plasma cell-free extrachromosomal circular DNA is a molecular hallmark of preeclampsia Open
Background: Extrachromosomal circular DNA (eccDNA) is emerging as a novel biomarker for multiple diseases, but its role in reproductive diseases remains underexplored. Preeclampsia (PE) is associated with increased maternal and perinatal m…
Recent progress of noble metal-based nanozymes: structural engineering and biomedical applications Open
This review highlights the recent progress in structural engineering of noble metal-based nanozymes and their enzyme-like properties in various enzyme-mimicking reactions and diverse biomedical applications.
Unveiling the mysteries of extrachromosomal circular DNA: from generation to clinical relevance in human cancers and health Open
Extrachromosomal circular DNAs (eccDNAs) are a type of circular DNAs originating from but independent of chromosomal DNAs. Nowadays, with the rapid development of sequencing and bioinformatics, the accuracy of eccDNAs detection has signifi…
Overview of mechanisms and novel therapies on rheumatoid arthritis from a cellular perspective Open
Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation of joints in response to autoimmune disorders. Once triggered, many factors were involved in the development of RA, including both cellular factors l…
View article: Plasma extrachromosomal circular DNA as a potential diagnostic biomarker for nodular thyroid disease
Plasma extrachromosomal circular DNA as a potential diagnostic biomarker for nodular thyroid disease Open
Dear Editor, The accurate diagnosis of cancerous nodules in nodular thyroid disease remains a significant challenge.1, 2 Extrachromosomal circular DNA (eccDNA), generated during apoptosis, shows tissue/plasma-specific patterns, and varying…
Covid lockdown and repaying the immunity debt in children Open
Non-pharmaceutical interventions (NPIs) implemented during the SARS-CoV-2 pandemic have been proven effective. While reducing SARS-CoV-2 transmission, NPIs also reduced children's exposure to other pathogens, leading to a decline in the in…
View article: Photochemical Formation and Electronic Structure of an Alkane σ-Complex from Time-Resolved Optical and X-ray Absorption Spectroscopy
Photochemical Formation and Electronic Structure of an Alkane σ-Complex from Time-Resolved Optical and X-ray Absorption Spectroscopy Open
C-H bond activation reactions with transition metals typically proceed via the formation of alkane σ-complexes, where an alkane C-H σ-bond binds to the metal. Due to the weak nature of metal-alkane bonds, σ-complexes are challenging to cha…
Generative Modelling of Oncogene-carrying Extrachromosomal Circular DNA Biogenesis and Dynamics in Cells Open
Extrachromosomal circular DNAs (ecDNA) are focal gene amplifications frequently associated with cancer development and often indicating a poor prognosis. To understand the early dynamics of oncogene-carrying ecDNAs, we previously developed…
Atlas of eccDNA in Mus musculus reveals intron and isoform gene-density dependent protection of transcription-induced eccDNA formation Open
EccDNA is a driver of many cancers and a potential intermediate in other age-related disorders. However, little is known about the mechanisms underlying eccDNA formation in healthy tissue and how age affects these processes. We generated a…