Peiwen Ding
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View article: Clinicopathological and prognostic value of epithelial cell adhesion molecule in solid tumours: a meta-analysis
Clinicopathological and prognostic value of epithelial cell adhesion molecule in solid tumours: a meta-analysis Open
Background Malignant tumors, mainly solid tumors, are a significant obstacle to the improvement of life expectancy at present. Epithelial cell adhesion molecule (EpCAM), a cancer stem cell biomarker, showed widespread expression in most no…
View article: Head-to-head comparison of 68Ga-FAPI-04 PET/CT and 18F-FDG PET/CT in the evaluation of primary digestive system cancer: a systematic review and meta-analysis
Head-to-head comparison of 68Ga-FAPI-04 PET/CT and 18F-FDG PET/CT in the evaluation of primary digestive system cancer: a systematic review and meta-analysis Open
Introduction Althoug 18 F-FDG positron emission tomography/computed tomography (PET/CT) is widely accepted as a diagnostic tool for detecting digestive cancers, 68 Ga-FAPI-04 PET/CT may perform better in detecting gastrointestinal malignan…
View article: Application and Progress of Cultured Models of Gallbladder Carcinoma
Application and Progress of Cultured Models of Gallbladder Carcinoma Open
Gallbladder carcinoma (GBC) is a malignant tumor of the biliary system that is aggressive, difficult to detect early, and has a low surgical resection rate and poor prognosis. Appropriate in vitro growth models are expected to focus on the…
View article: Environmental and economic effects of grassroots environmental protection agencies in China: An analysis based on the synthetic control method
Environmental and economic effects of grassroots environmental protection agencies in China: An analysis based on the synthetic control method Open
Grassroots environmental protection agencies are the “last kilometer” of environmental supervision in China, but the effects of these agencies have not received sufficient attention from the economic community. This paper adopts the synthe…
View article: Integrative cross-species analysis of GABAergic neuron cell types and their functions in Alzheimer’s disease
Integrative cross-species analysis of GABAergic neuron cell types and their functions in Alzheimer’s disease Open
Understanding the phenotypic and functional diversity of cerebral cortical GABAergic neurons requires a comprehensive analysis of key transcriptional signatures and neuronal subtype identity. However, the diversity and conservation of GABA…
View article: SPEED: Single-cell Pan-species atlas in the light of Ecology and Evolution for Development and Diseases
SPEED: Single-cell Pan-species atlas in the light of Ecology and Evolution for Development and Diseases Open
It is a challenge to efficiently integrate and present the tremendous amounts of single-cell data generated from multiple tissues of various species. Here, we create a new database named SPEED for single-cell pan-species atlas in the light…
View article: Screening of cell‐virus, cell‐cell, gene‐gene crosstalk among animal kingdom at single cell resolution
Screening of cell‐virus, cell‐cell, gene‐gene crosstalk among animal kingdom at single cell resolution Open
Background The exact animal origin of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) remains obscure and understanding its host range is vital for preventing interspecies transmission. Methods Herein, we applied single‐cell s…
View article: Joint profiling of gene expression and chromatin accessibility during amphioxus development at single-cell resolution
Joint profiling of gene expression and chromatin accessibility during amphioxus development at single-cell resolution Open
Vertebrate evolution was accompanied by two rounds of whole-genome duplication followed by functional divergence in terms of regulatory circuits and gene expression patterns. As a basal and slow-evolving chordate species, amphioxus is an i…
View article: Molecular mechanisms governing circulating immune cell heterogeneity across different species revealed by single‐cell sequencing
Molecular mechanisms governing circulating immune cell heterogeneity across different species revealed by single‐cell sequencing Open
Background Immune cells play important roles in mediating immune response and host defense against invading pathogens. However, insights into the molecular mechanisms governing circulating immune cell diversity among multiple species are l…
View article: Comparative analysis of single cell lung atlas of bat, cat, tiger and pangolin
Comparative analysis of single cell lung atlas of bat, cat, tiger and pangolin Open
Horseshoe bats ( Rhinolophus sinicus ) might help maintain coronaviruses severely affecting human health, such as SARS-CoV and SARS-CoV-2. It has long been suggested that bats may be more tolerant of viral infection than other mammals due …
View article: Molecular mechanisms governing circulating immune cell heterogeneity across different species revealed by single cell sequencing
Molecular mechanisms governing circulating immune cell heterogeneity across different species revealed by single cell sequencing Open
Background Immune cells play important roles in mediating immune response and host defense against invading pathogens. However, insights into the molecular mechanisms governing circulating immune cell diversity among multiple species are l…
View article: Single cell atlas for 11 non-model mammals, reptiles and birds
Single cell atlas for 11 non-model mammals, reptiles and birds Open
The availability of viral entry factors is a prerequisite for the cross-species transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Large-scale single-cell screening of animal cells could reveal the expression pat…
View article: VThunter: a database for single-cell screening of virus target cells in the animal kingdom
VThunter: a database for single-cell screening of virus target cells in the animal kingdom Open
Viral infectious diseases are a devastating and continuing threat to human and animal health. Receptor binding is the key step for viral entry into host cells. Therefore, recognizing viral receptors is fundamental for understanding the pot…
View article: Screening of cell-virus, cell-cell, gene-gene cross-talks among kingdoms of life at single cell resolution
Screening of cell-virus, cell-cell, gene-gene cross-talks among kingdoms of life at single cell resolution Open
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) issued a significant and urgent threat to global health. The exact animal origin of SARS-CoV-2 remains obscure and understanding its host range is vital for preve…
View article: Viral receptor profiles of masked palm civet revealed by single-cell transcriptomics
Viral receptor profiles of masked palm civet revealed by single-cell transcriptomics Open
Civets are small mammals belonging to the family Viverridae . The masked palm civets ( Paguma larvata ) served as an intermediate host in the bat-to-human transmission of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003 1 .…
View article: Joint profiling of gene expression and chromatin accessibility of amphioxus development at single cell resolution
Joint profiling of gene expression and chromatin accessibility of amphioxus development at single cell resolution Open
Vertebrate evolution was accompanied with two rounds of whole genome duplication followed by functional divergence in terms of regulatory circuits and gene expression patterns. As a basal and slow-evolving chordate species, amphioxus is an…
View article: Single-cell atlas of domestic pig cerebral cortex and hypothalamus
Single-cell atlas of domestic pig cerebral cortex and hypothalamus Open
The brain of the domestic pig (Sus scrofa domesticus) has drawn considerable attention due to its high similarities to that of humans. However, the cellular compositions of the pig brain (PB) remain elusive. Here we investigated the single…
View article: A single-cell atlas of mouse olfactory bulb chromatin accessibility
A single-cell atlas of mouse olfactory bulb chromatin accessibility Open
Olfaction, the sense of smell, is a fundamental trait crucial to many species. The olfactory bulb (OB) plays pivotal roles in processing and transmitting odor information from the environment to the brain. The cellular heterogeneity of the…
View article: The Trans-omics Landscape of COVID-19
The Trans-omics Landscape of COVID-19 Open
The outbreak of coronavirus disease 2019 (COVID-19) has been causing a global health emergency. Although previous studies investigated COVID-19 at different omics levels, the molecular hallmarks of COVID-19, especially in those patients wi…
View article: The Trans-omics Landscape of COVID-19
The Trans-omics Landscape of COVID-19 Open
Summary System-wide molecular characteristics of COVID-19, especially in those patients without comorbidities, have not been fully investigated. We compared extensive molecular profiles of blood samples from 231 COVID-19 patients, ranging …
View article: Single cell chromatin accessibility of the developmental cephalochordate
Single cell chromatin accessibility of the developmental cephalochordate Open
The phylum chordata are composed of three groups: vertebrata, tunicate and cephalochordata. Single cell developmental atlas for typical species in vertebrata (mouse, zebrafish, western frog, worm) and tunicate (sea squirts) has been constr…
View article: Single cell atlas of trisomy 21 cerebral cortex
Single cell atlas of trisomy 21 cerebral cortex Open
Down syndrome (DS) is one of the most common human birth defects caused by trisomy 21 (T21), leading to a variety of cognitive impairments. The cellular composition of human brain has been explored using single cell RNA sequencing in both …
View article: Single cell RNA-seq reveals cellular diversity and developmental characteristics of human infant retina
Single cell RNA-seq reveals cellular diversity and developmental characteristics of human infant retina Open
Retina, located in the innermost layer of the eye of human, holds the decisive role in visual perception. Dissecting the heterogeneity of retina is essential for understanding the mechanism of vision formation and even the development of c…