Peiyuan Xia
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Author Swipe
View article: A systematic analysis of the global, regional, and national burden of fungal skin diseases from 1990 to 2021
A systematic analysis of the global, regional, and national burden of fungal skin diseases from 1990 to 2021 Open
Purpose We aimed to assess the burden of Fungal Skin Diseases (FSD) in 2021 and explore the changing trends from 1990 to 2021 across different age groups and time periods. Methods This study extracted three key indicators of the burden of …
View article: Docetaxel-loaded pH/ROS dual-responsive nanoparticles with self-supplied ROS for inhibiting metastasis and enhancing immunotherapy of breast cancer
Docetaxel-loaded pH/ROS dual-responsive nanoparticles with self-supplied ROS for inhibiting metastasis and enhancing immunotherapy of breast cancer Open
Background Although stimuli-responsive nanoplatforms were developed to deliver immunogenic cell death (ICD) inducers to enhance cancer immunotherapy, the complete release of ICD inducers into the tumor microenvironment (TME) was limited by…
View article: Simultaneous quantitative analysis and in vitro anti-arthritic effects of five polyphenols from Terminalia chebula
Simultaneous quantitative analysis and in vitro anti-arthritic effects of five polyphenols from Terminalia chebula Open
Background: The fruit of Terminalia chebula has been widely used for a thousand years for treating diarrhea, ulcers, and arthritic diseases in Asian countries. However, the active components of this Traditional Chinese medicine and their m…
View article: Luteolin Inhibits the Biofilm Formation and Cytotoxicity of Methicillin-Resistant Staphylococcus aureus via Decreasing Bacterial Toxin Synthesis
Luteolin Inhibits the Biofilm Formation and Cytotoxicity of Methicillin-Resistant Staphylococcus aureus via Decreasing Bacterial Toxin Synthesis Open
Owing to the fact that luteolin has antibacterial activity against Staphylococcus aureus (S. aureus) and methicillin-resistant S. aureus (MRSA), its specific mechanism in MRSA is worthy of investigation, which is the focus of this study. I…
View article: Long-term antithrombotic therapy for patients with atrial fibrillation and stable coronary artery disease
Long-term antithrombotic therapy for patients with atrial fibrillation and stable coronary artery disease Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the efficacy and safety of different long‐term antithrombotic regimens for people with AF and stable CAD.
View article: Folic acid-modified ROS-responsive nanoparticles encapsulating luteolin for targeted breast cancer treatment
Folic acid-modified ROS-responsive nanoparticles encapsulating luteolin for targeted breast cancer treatment Open
Luteolin (Lut) is a natural flavonoid polyphenolic compound with multiple pharmacological activities, such as anti-oxidant, anti-inflammatory, and anti-tumor effects. However, the poor aqueous solubility and low bioactivity of Lut restrict…
View article: Drug-Induced Hospital-Acquired Acute Kidney Injury in China: A Multicenter Cross-Sectional Survey
Drug-Induced Hospital-Acquired Acute Kidney Injury in China: A Multicenter Cross-Sectional Survey Open
Introduction: Drug-induced acute kidney injury (D-AKI) is one of the important types of AKI. The incidence of D-AKI in China has rarely been studied. Objective: This study aims to explore the disease burden, rel…
View article: Comparison of cryptococcal meningitis in HIV-negative patients with and without lung infections
Comparison of cryptococcal meningitis in HIV-negative patients with and without lung infections Open
Objective To investigate the clinical features and outcomes of cryptococcal meningitis (CM) in HIV-negative patients with and without lung infections. Methods We retrospectively reviewed the medical records of HIV-negative patients with CM…
View article: A Novel Cryptococcal Meningitis Therapy: The Combination of Amphotericin B and Posaconazole Promotes the Distribution of Amphotericin B in the Brain Tissue
A Novel Cryptococcal Meningitis Therapy: The Combination of Amphotericin B and Posaconazole Promotes the Distribution of Amphotericin B in the Brain Tissue Open
The deficient brain tissue distribution of amphotericin B (AMPB) seriously restricts its treatment for the clinical efficacy of cryptococcus neoformans meningitis (CNM). We strive to develop a tactic to increase its concentration in brain …
View article: A metabolomic study of Baihe Zhimu decoction in a rat model of depression
A metabolomic study of Baihe Zhimu decoction in a rat model of depression Open
Objective To investigate the changes in endogenous metabolites in a rat model of depression and the modulatory effect of Baihe Zhimu decoction (BZD) on the abnormal metabolites through a metabolomic approach. Methods Forty rats were random…
View article: Changes in the resistance and epidemiological characteristics of Pseudomonas aeruginosa during a ten-year period
Changes in the resistance and epidemiological characteristics of Pseudomonas aeruginosa during a ten-year period Open
These results indicated that the antibiotic resistance of P. aeruginosa in our respiratory department decreased. The loss of oprD gene was the main mechanism of carbapenem resistance, and mexX overexpression was the major contributing fact…
View article: Comparisons of cryptococcal meningitis caused by Cryptococcus neoformans between HIV-negative patients with and without lung infection in two Chinese university hospitals
Comparisons of cryptococcal meningitis caused by Cryptococcus neoformans between HIV-negative patients with and without lung infection in two Chinese university hospitals Open
Background Lung infection may cause many symptoms, such as fever and headache, that may be confused with cryptococcal meningitis (CM) symptoms. This study aimed to investigate the discrepancy in clinical features and outcomes of CM between…
View article: Hyperoside inhibits biofilm formation of Pseudomonas aeruginosa
Hyperoside inhibits biofilm formation of Pseudomonas aeruginosa Open
Pseudomonas aeruginosa (P. aeruginosa) is a common pathogen in hospital-acquired infection and is readily able to form biofilms. Due to its high antibiotic resistance, traditional antibacterial treatments exert a limited effect on <…
View article: Synergistic antibiotic effect of looped antimicrobial peptide CLP-19 with bactericidal and bacteriostatic agents
Synergistic antibiotic effect of looped antimicrobial peptide CLP-19 with bactericidal and bacteriostatic agents Open
The treatment of drug-resistant infections is complicated and the alarming rise in infectious diseases poses a unique challenge for development of effective therapeutic strategies. Antibiotic-induced liberation of the bacterial endotoxin l…
View article: Dissemination of IMP-4-encoding pIMP-HZ1-related plasmids among Klebsiella pneumoniae and Pseudomonas aeruginosa in a Chinese teaching hospital
Dissemination of IMP-4-encoding pIMP-HZ1-related plasmids among Klebsiella pneumoniae and Pseudomonas aeruginosa in a Chinese teaching hospital Open
View article: Quantification of neomangiferin in rat plasma by liquid chromatography–tandem mass spectrometry and its application to bioavailability study
Quantification of neomangiferin in rat plasma by liquid chromatography–tandem mass spectrometry and its application to bioavailability study Open
View article: Epidemiology of CTX-M-type extended-spectrum beta-lactamase (ESBL)-producing nosocomial -Escherichia coli infection in China
Epidemiology of CTX-M-type extended-spectrum beta-lactamase (ESBL)-producing nosocomial -Escherichia coli infection in China Open