L. Pekka Malmberg
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View article: Early childhood lower-airway symptoms and airway hyperresponsiveness linked to school-age small-airway dysfunction
Early childhood lower-airway symptoms and airway hyperresponsiveness linked to school-age small-airway dysfunction Open
AHR in symptomatic young children associated with subsequent persistent small-airway dysfunction. Further studies with larger samples of symptomatic young children are warranted to determine whether this connection predicts the development…
View article: Inspiratory Profiles Through Easyhaler Dry Powder Inhaler During Acute Bronchoconstriction
Inspiratory Profiles Through Easyhaler Dry Powder Inhaler During Acute Bronchoconstriction Open
Background: Dry powder inhalers (DPIs) are passive devices, which rely on a patient's inspiratory effort for drug dispersion and delivery. The aim of this study was to assess how acute bronchoconstriction affects the ability to use Easyhal…
View article: Diagnosing new-onset asthma in a paediatric clinical trial setting in school-age children
Diagnosing new-onset asthma in a paediatric clinical trial setting in school-age children Open
Asthma is a common chronic disease in children. It is a dynamic condition—symptoms change over time, and the outcome of diagnostic tests can vary. Consequently, evaluating the onset of asthma at a single point in time, perhaps when patient…
View article: Effect of fluticasone propionate/formoterol and fluticasone furoate/vilanterol on adolescents with chronic bronchial obstruction
Effect of fluticasone propionate/formoterol and fluticasone furoate/vilanterol on adolescents with chronic bronchial obstruction Open
Both ICS/LABA combinations demonstrated significant improvements in FEV1z score. More than one-third of the asthmatic adolescents with prolonged bronchial obstruction achieved a normal prebronchodilator FEV1/FVC ratio.
View article: Pets, furry animal allergen components, and asthma in childhood
Pets, furry animal allergen components, and asthma in childhood Open
Background The use of component‐resolved allergy diagnostics has provided a clearer understanding of the species‐specific sensitization and severity of potential allergic reactions. This cross‐sectional study aimed to determine whether sen…
View article: The link between early childhood lower airway symptoms, airway hyperresponsiveness, and school-age lung function
The link between early childhood lower airway symptoms, airway hyperresponsiveness, and school-age lung function Open
In symptomatic young children, increased AHR was associated with subsequent obstructive lung function, which appeared reversible by bronchodilation, and blood eosinophilia, indicative of type 2 inflammation.
View article: Subtypes of Adult-Onset Asthma at the Time of Diagnosis: A Latent Class Analysis
Subtypes of Adult-Onset Asthma at the Time of Diagnosis: A Latent Class Analysis Open
Introduction: Only a few previous studies have investigated the subtypes of adult-onset asthma. No previous study has assessed whether these subtypes are different between men and women, or whether these subtypes have different risk factor…
View article: Bronchial hyperresponsiveness and asthma during oral immunotherapy for egg or peanut allergy in children
Bronchial hyperresponsiveness and asthma during oral immunotherapy for egg or peanut allergy in children Open
Background Bronchial hyperresponsiveness (BHR) and asthma are frequently present in children with food allergy. We assessed BHR in children receiving oral immunotherapy (OIT) for persistent egg or peanut allergy and examined whether OIT af…
View article: Intermittent Tiotropium Bromide for Episodic Wheezing: A Randomized Trial
Intermittent Tiotropium Bromide for Episodic Wheezing: A Randomized Trial Open
BACKGROUND AND OBJECTIVES Options to treat and prevent episodic wheezing in children are scarce. Our objective was to assess the efficacy of intermittent tiotropium bromide treatment in early childhood episodic wheezing. METHODS This 48-we…
View article: The birth and development of clinical physiology in Finland
The birth and development of clinical physiology in Finland Open
The specialty of clinical physiology was established in Finland about 20 years later than in Sweden. In the early 1960s, six physicians working mainly in preclinical departments of physiology were certified as specialists in clinical physi…
View article: The continuous laryngoscopy exercise test in severe or in difficult-to-treat asthma in adults: a systematic review
The continuous laryngoscopy exercise test in severe or in difficult-to-treat asthma in adults: a systematic review Open
This systematic review revealed that only a small proportion of patients with asthma had undergone the CLE test to assess exercise-induced dyspnea. None of the selected manuscripts reported severity of asthma. Whether CLE provides a valuab…
View article: Impulse oscillometry and free-running tests for diagnosing asthma and monitoring lung function in young children
Impulse oscillometry and free-running tests for diagnosing asthma and monitoring lung function in young children Open
Impulse oscillometry is a useful tool in diagnosing asthma and monitoring lung function in young children.
View article: Overweight and exercise‐induced bronchoconstriction – Is there a link?
Overweight and exercise‐induced bronchoconstriction – Is there a link? Open
Background The objective of this study was to evaluate the role of body mass index with regard to exercise performance, exercise‐induced bronchoconstriction (EIB), and respiratory symptoms in 7‐ to 16‐year‐old children. Methods A total of …
View article: Patients with asthma or chronic obstructive pulmonary disease (COPD) can generate sufficient inspiratory flows via Easyhaler® dry powder inhaler: a pooled analysis of two randomized controlled trials
Patients with asthma or chronic obstructive pulmonary disease (COPD) can generate sufficient inspiratory flows via Easyhaler® dry powder inhaler: a pooled analysis of two randomized controlled trials Open
Over 99% of patients with asthma and/or COPD were able to inhale through the EH with an adequate PIF rate, irrespective of age, or severity of airway obstruction. This confirms that patients with asthma and/or COPD can achieve inspiratory …
View article: Eucapnic voluntary hyperventilation test decreases exhaled nitric oxide level in children
Eucapnic voluntary hyperventilation test decreases exhaled nitric oxide level in children Open
Background Exhaled nitric oxide (FeNO) measurements and eucapnic voluntary hyperventilation (EVH) tests have been used as diagnostic tools for asthma. Data on the impact of hyperventilation on the level of FeNO are limited. Aim We aimed to…
View article: Expiratory variability index is associated with asthma risk, wheeze and lung function in infants with recurrent respiratory symptoms
Expiratory variability index is associated with asthma risk, wheeze and lung function in infants with recurrent respiratory symptoms Open
Impedance pneumography enables the measurement of the expiratory variability index (EVI) at home during a night's sleep in infants with recurrent respiratory symptoms. EVI is associated with asthma risk, symptoms and lung function. https:/…
View article: Expiratory variability index (EVI) is associated with asthma risk, wheeze and lung function in infants with recurrent respiratory symptoms
Expiratory variability index (EVI) is associated with asthma risk, wheeze and lung function in infants with recurrent respiratory symptoms Open
Recurrent respiratory symptoms are common in infants but the paucity of lung function tests suitable for routine use in infants is a widely acknowledged clinical problem. In this study we evaluated tidal breathing variability (expiratory v…
View article: Patient Inspiratory Maneuver Performance; Peak Lungpower, Acceleration and Volume
Patient Inspiratory Maneuver Performance; Peak Lungpower, Acceleration and Volume Open
Background: Use of drug delivery devices between nebulizers, dry powder inhalers (DPIs), or metered dose inhalers (MDIs), for treating patients with asthma and chronic obstructive pulmonary disease (COPD), is based on patients' capability …
View article: Predictive value of childhood airway hyper‐responsiveness to indirect stimuli: 10‐year longitudinal study
Predictive value of childhood airway hyper‐responsiveness to indirect stimuli: 10‐year longitudinal study Open
Background Airway hyper‐responsiveness (AHR) is a common feature in asthma. The use of AHR in predicting active asthma or the persistence of AHR in childhood is poorly understood. By analyzing longitudinal connections including different m…
View article: Measurement of bronchial hyperreactivity: comparison of three Nordic dosimetric methods
Measurement of bronchial hyperreactivity: comparison of three Nordic dosimetric methods Open
Clinical testing of bronchial hyperreactivity (BHR) provides valuable information in asthma diagnostics. Nevertheless, the test results depend to a great extent on the testing procedure: test substance, apparatus and protocol. In Nordic co…
View article: Early bronchial inflammation and remodeling and airway hyperresponsiveness at school age
Early bronchial inflammation and remodeling and airway hyperresponsiveness at school age Open
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View article: Measurement of bronchial hyperreactivity: comparison of three Nordic dosimetric methods
Measurement of bronchial hyperreactivity: comparison of three Nordic dosimetric methods Open
Clinical testing of bronchial hyperreactivity (BHR) provides valuable information in asthma diagnostics. Nevertheless, the test results depend to a great extent on the testing procedure: test substance, apparatus and protocol. In Nordic co…
View article: Serum chitinase‐like protein YKL‐40 is linked to small airway function in children with asthmatic symptoms
Serum chitinase‐like protein YKL‐40 is linked to small airway function in children with asthmatic symptoms Open
Background Lung function impairment among asthmatic children begins in early life, and biomarkers for identifying this impairment are needed. The chitinase‐like protein YKL‐40 has been associated with asthma and lung function in adults, bu…
View article: Converting <scp><i>F</i><sub>ENO</sub></scp> by different flows to standard flow <scp><i>F</i><sub>ENO</sub></scp>
Converting <span><i>F</i><sub>ENO</sub></span> by different flows to standard flow <span><i>F</i><sub>ENO</sub></span> Open
In clinical practice, assessment of expiratory nitric oxide ( F ENO ) may reveal eosinophilic airway inflammation in asthmatic and other pulmonary diseases. Currently, measuring of F ENO is standardized to exhaled flow level of 50 ml s −1 …
View article: Shedding light on the breathing difficulties of children
Shedding light on the breathing difficulties of children Open
Medical students learn the four classic manoeuvres for carrying out a physical examination on a patient: inspection, palpation, percussion and auscultation. Inspection comes from the Latin word inspectio, meaning the act of beholding, and …
View article: Smoking and lung function among adults with newly onset asthma
Smoking and lung function among adults with newly onset asthma Open
Introduction Smoking increases the risk of asthma and reduces lung function among subjects with and without asthma. We assessed the effects of smoking on lung function reflecting both central and small airways among adults with newly onset…