D. Pendicheva-Duhlenska
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View article: Polymorphic Variants in Acenocoumarol-Related Genes <i>CYP2C9</i> and <i>VKORC1</i> and Their Frequencies in Bulgarian Population
Polymorphic Variants in Acenocoumarol-Related Genes <i>CYP2C9</i> and <i>VKORC1</i> and Their Frequencies in Bulgarian Population Open
Introduction. Acenocoumarol is an indirect anticoagulant, a 4-hydroxycoumarin derivative, which is used in the treatment of various thromboembolic diseases. Polymorphic variants in the CYP2C9 and VKORC1 genes significantly contribute to th…
View article: Establishment of Acenocoumarol Pharmacogenetic Algorithm Including CYP2C9 and VKORC1 Genotypes in Bulgarian Patients Treated with Coumarin Anticoagulants
Establishment of Acenocoumarol Pharmacogenetic Algorithm Including CYP2C9 and VKORC1 Genotypes in Bulgarian Patients Treated with Coumarin Anticoagulants Open
Introduction Acenocoumarol, a 4-hydroxycoumarin derivative, is widely prescribed for the primary and secondary prevention of thromboembolic disorders. Maintenance dosing of acenocoumarol is significantly influenced by polymorphic variants …
Enhanced Detection of Mitochondrial Heteroplasmy and DNA Hypomethylation in Adipose-Derived Mesenchymal Stem Cells Using a Novel Adaptive Sampling Protocol Open
Objective: Mitochondria drive cellular energy production and regulate key biological processes. High levels of heteroplasmic in mitochondrial DNA (mtDNA) variants can cause mitochondrial dysfunction and clinical symptoms. Third-generation …
Association Study of Polymorphic Variants in 9P21 Locus and the Manifestation of Coronary Artery Disease in Bulgarians Open
Objective The variant 9p21 is correlated with coronary artery disease (CAD) in multiple studies in the European population, but we lack information for the Eastern Europeans (Caucasian). We aimed at investigating the potential association …
View article: Key features of hospitals antibiotic stewardship software solutions needed for successfully optimizing patient outcomes while fighting antibiotic resistance on a global scale – a shared experience
Key features of hospitals antibiotic stewardship software solutions needed for successfully optimizing patient outcomes while fighting antibiotic resistance on a global scale – a shared experience Open
Antimicrobial resistance threatens the very core of modern medicine and currently costs the EU more than 11.7 billion euro per year. In 2050 it is projected that 10 million people will die from infections with the so called “superbugs”. In…
Serum Erythropoietin in Patients with Chronic Renal Failure in the Predialysis Stage Open
Summary A prospective study was carried out of serum erythropoietin levels in patients with chronic renal failure/chronic kidney disease in the predialysis period. The study is part of scientific project № 2/2022, financed by Medical Unive…
Polymorphic Variant rs11206510 in PCSK9 and Risk of Coronary Artery Disease in Bulgarians Open
Objective The aim of this study was to investigate the potential association of rs11206510 in PCSK9 gene with coronary artery disease (CAD) and myocardial infarction (MI) in Bulgarians. Materials and Methods The current analysis included 2…
ADAPTED MEDITERRANEAN DIET IMPACT ON THE SYMPTOMS OF CHRONIC FATIGUE, SERUM LEVELS OF OMEGA-3 POLYUNSATURATED FATTY ACIDS (PUFAS) AND INTERLEUKIN 17 (IL-17) IN PATIENTS WITH RELAPSING-REMITTING MULTIPLE SCLEROSIS UNDERGOING DISEASE-MODIFYING THERAPY: A PILOT STUDY Open
Purpose: This pilot study was designed to investigate the impact of a moderate-calorie Mediterranean diet compared to a regular diet with omega-3 PUFAs (eicosapentaenoic and docosahexaenoic acids) supplementation on fatigue symptoms in pat…