Penella J. Woll
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View article: Genes associated with genetic and rare lung diseases and the risk of lung cancer
Genes associated with genetic and rare lung diseases and the risk of lung cancer Open
Background We investigated whether markers, genes or terms of the Human Phenotype Ontology associated with genetic or rare diseases (GARDs) that affect airway or lung function are associated with lung cancer. Methods Genes of interest were…
View article: Selumetinib in Combination with Anti Retroviral Therapy in HIV-associated Kaposi sarcoma (SCART): an open-label, multicentre, phase I/II trial
Selumetinib in Combination with Anti Retroviral Therapy in HIV-associated Kaposi sarcoma (SCART): an open-label, multicentre, phase I/II trial Open
View article: Identification of genetically predicted DNA methylation markers associated with non–small cell lung cancer risk among 34,964 cases and 448,579 controls
Identification of genetically predicted DNA methylation markers associated with non–small cell lung cancer risk among 34,964 cases and 448,579 controls Open
Background Although the associations between genetic variations and lung cancer risk have been explored, the epigenetic consequences of DNA methylation in lung cancer development are largely unknown. Here, the genetically predicted DNA met…
View article: Axitinib in patients with advanced/metastatic soft tissue sarcoma (Axi-STS): an open-label, multicentre, phase II trial in four histological strata
Axitinib in patients with advanced/metastatic soft tissue sarcoma (Axi-STS): an open-label, multicentre, phase II trial in four histological strata Open
View article: Candidate pathway analysis of surfactant proteins identifies<i>CTSH</i>and<i>SFTA2</i>that influences lung cancer risk
Candidate pathway analysis of surfactant proteins identifies<i>CTSH</i>and<i>SFTA2</i>that influences lung cancer risk Open
Pulmonary surfactant is a lipoprotein synthesized and secreted by alveolar type II cells in lung. We evaluated the associations between 200,139 single nucleotide polymorphisms (SNPs) of 40 surfactant-related genes and lung cancer risk usin…
View article: Supplementary Data from Ganetespib in Combination with Pemetrexed–Platinum Chemotherapy in Patients with Pleural Mesothelioma (MESO-02): A Phase Ib Trial
Supplementary Data from Ganetespib in Combination with Pemetrexed–Platinum Chemotherapy in Patients with Pleural Mesothelioma (MESO-02): A Phase Ib Trial Open
Supplementary Tables 1-5 and Supplementary Figures 1-7. Includes results on treatment compliance, dose-limiting toxicities, genomic variable analyses and Kaplan-Meier plots for time-to-event outcomes.
View article: Data from Ganetespib in Combination with Pemetrexed–Platinum Chemotherapy in Patients with Pleural Mesothelioma (MESO-02): A Phase Ib Trial
Data from Ganetespib in Combination with Pemetrexed–Platinum Chemotherapy in Patients with Pleural Mesothelioma (MESO-02): A Phase Ib Trial Open
Purpose:Ganetespib, a highly potent, small-molecule Heatshock protein 90 inhibitor, has potential efficacy in malignant pleural mesothelioma (MPM) via activity on critical survival pathways and known synergies with antifolates and platinum…
View article: Supplementary Data from Ganetespib in Combination with Pemetrexed–Platinum Chemotherapy in Patients with Pleural Mesothelioma (MESO-02): A Phase Ib Trial
Supplementary Data from Ganetespib in Combination with Pemetrexed–Platinum Chemotherapy in Patients with Pleural Mesothelioma (MESO-02): A Phase Ib Trial Open
Supplementary Tables 1-5 and Supplementary Figures 1-7. Includes results on treatment compliance, dose-limiting toxicities, genomic variable analyses and Kaplan-Meier plots for time-to-event outcomes.
View article: Data from Ganetespib in Combination with Pemetrexed–Platinum Chemotherapy in Patients with Pleural Mesothelioma (MESO-02): A Phase Ib Trial
Data from Ganetespib in Combination with Pemetrexed–Platinum Chemotherapy in Patients with Pleural Mesothelioma (MESO-02): A Phase Ib Trial Open
Purpose:Ganetespib, a highly potent, small-molecule Heatshock protein 90 inhibitor, has potential efficacy in malignant pleural mesothelioma (MPM) via activity on critical survival pathways and known synergies with antifolates and platinum…
View article: MESO-02 Trial Protocol from Ganetespib in Combination with Pemetrexed–Platinum Chemotherapy in Patients with Pleural Mesothelioma (MESO-02): A Phase Ib Trial
MESO-02 Trial Protocol from Ganetespib in Combination with Pemetrexed–Platinum Chemotherapy in Patients with Pleural Mesothelioma (MESO-02): A Phase Ib Trial Open
MESO-02 Trial Protocol (version 7.0)
View article: MESO-02 Trial Protocol from Ganetespib in Combination with Pemetrexed–Platinum Chemotherapy in Patients with Pleural Mesothelioma (MESO-02): A Phase Ib Trial
MESO-02 Trial Protocol from Ganetespib in Combination with Pemetrexed–Platinum Chemotherapy in Patients with Pleural Mesothelioma (MESO-02): A Phase Ib Trial Open
MESO-02 Trial Protocol (version 7.0)
View article: Olaparib as maintenance treatment in patients with chemosensitive small cell lung cancer (STOMP): A randomised, double-blind, placebo-controlled phase II trial
Olaparib as maintenance treatment in patients with chemosensitive small cell lung cancer (STOMP): A randomised, double-blind, placebo-controlled phase II trial Open
This trial does not provide sufficient evidence that either the BD or TDS regimen for maintenance olaparib monotherapy improves PFS or OS in an unselected SCLC population to warrant further research. Toxicity for olaparib was similar to ot…
View article: Gene–gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer
Gene–gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer Open
View article: Iam hiQ—a novel pair of accuracy indices for imputed genotypes
Iam hiQ—a novel pair of accuracy indices for imputed genotypes Open
View article: Olaparib as Maintenance Treatment in Patients with Chemosensitive Small Cell Lung Cancer (STOMP): A Randomised, Double-Blind, Placebo-Controlled Phase II Trial
Olaparib as Maintenance Treatment in Patients with Chemosensitive Small Cell Lung Cancer (STOMP): A Randomised, Double-Blind, Placebo-Controlled Phase II Trial Open
View article: Gene-gene Interaction of AhR with and within the Wnt Cascade Affects Susceptibility to Lung Cancer
Gene-gene Interaction of AhR with and within the Wnt Cascade Affects Susceptibility to Lung Cancer Open
Background Aberrant Wnt signalling, regulating cell development and stemness, influences the development of many cancer types. The Aryl hydrocarbon receptor ( AhR ) mediates tumorigenesis of environmental pollutants. Complex interaction pa…
View article: Gene-gene Interaction of AhR With and Within the Wnt Cascade Affects Susceptibility to Lung Cancer
Gene-gene Interaction of AhR With and Within the Wnt Cascade Affects Susceptibility to Lung Cancer Open
Introduction: Aberrant Wnt signalling, regulating cell development and stemness, is observed in many cancer entities. Aryl hydrocarbon receptor ( AhR ) mediates tumorigenesis of environmental pollutants. Complex interaction patterns of gen…
View article: I’am hiQ – A Novel Accuracy Index for Imputed Genotypes
I’am hiQ – A Novel Accuracy Index for Imputed Genotypes Open
Background : Imputation of untyped markers is a standard tool in genome-wide association studies to close the gap between directly genotyped and other known DNA variants. However, high accuracy with which genotypes are imputed is fundament…
View article: Integration of multiomic annotation data to prioritize and characterize inflammation and immune‐related risk variants in squamous cell lung cancer
Integration of multiomic annotation data to prioritize and characterize inflammation and immune‐related risk variants in squamous cell lung cancer Open
Clinical trial results have recently demonstrated that inhibiting inflammation by targeting the interleukin‐1β pathway can offer a significant reduction in lung cancer incidence and mortality, highlighting a pressing and unmet need to unde…
View article: Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma
Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma Open
View article: Ganetespib in Combination with Pemetrexed–Platinum Chemotherapy in Patients with Pleural Mesothelioma (MESO-02): A Phase Ib Trial
Ganetespib in Combination with Pemetrexed–Platinum Chemotherapy in Patients with Pleural Mesothelioma (MESO-02): A Phase Ib Trial Open
Purpose: Ganetespib, a highly potent, small-molecule Heatshock protein 90 inhibitor, has potential efficacy in malignant pleural mesothelioma (MPM) via activity on critical survival pathways and known synergies with antifolates and platinu…
View article: Protein-altering germline mutations implicate novel genes related to lung cancer development
Protein-altering germline mutations implicate novel genes related to lung cancer development Open
View article: Association Analysis of Driver Gene–Related Genetic Variants Identified Novel Lung Cancer Susceptibility Loci with 20,871 Lung Cancer Cases and 15,971 Controls
Association Analysis of Driver Gene–Related Genetic Variants Identified Novel Lung Cancer Susceptibility Loci with 20,871 Lung Cancer Cases and 15,971 Controls Open
Background: A substantial proportion of cancer driver genes (CDG) are also cancer predisposition genes. However, the associations between genetic variants in lung CDGs and the susceptibility to lung cancer have rarely been investigated. Me…
View article: Transcriptome‐wide association study reveals candidate causal genes for lung cancer
Transcriptome‐wide association study reveals candidate causal genes for lung cancer Open
We have recently completed the largest GWAS on lung cancer including 29,266 cases and 56,450 controls of European descent. The goal of our study has been to integrate the complete GWAS results with a large‐scale expression quantitative tra…
View article: Genome‐wide association study of INDELs identified four novel susceptibility loci associated with lung cancer risk
Genome‐wide association study of INDELs identified four novel susceptibility loci associated with lung cancer risk Open
Genome‐wide association studies (GWAS) have identified 45 susceptibility loci associated with lung cancer. Only less than SNPs, small insertions and deletions (INDELs) are the second most abundant genetic polymorphisms in the human genome.…
View article: The clinical role of VeriStrat testing in patients with advanced non–small cell lung cancer considered unfit for first-line platinum-based chemotherapy
The clinical role of VeriStrat testing in patients with advanced non–small cell lung cancer considered unfit for first-line platinum-based chemotherapy Open
View article: Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development
Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development Open
The development of cancer is driven by the accumulation of many oncogenesis-related genetic alterations and tumorigenesis is triggered by complex networks of involved genes rather than independent actions. To explore the epistasis existing…
View article: Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis
Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis Open
Background: Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung cancer remains un…
View article: MA12.05 Phase 1 Study of HSP90 Inhibitor Ganetespib with Pemetrexed and Cisplatin/Carboplatin Chemotherapy for Pleural Mesothelioma
MA12.05 Phase 1 Study of HSP90 Inhibitor Ganetespib with Pemetrexed and Cisplatin/Carboplatin Chemotherapy for Pleural Mesothelioma Open
View article: Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity
Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity Open