Explanipedia

Molecular insights into the binding of human serum albumin to charged dendritic nanomicelles: A synergistic experimental and in silico approach Open

Gabriele Cavalieri, Domenico Marson, Dinesh Dhumal, Ling Peng, Erik Laurini , et al. · 2025

Nanobody conjugated with dendrimer nanoparticles effectively neutralizes tick-borne encephalitis virus Open

Jana Jozefiaková, Amod Kulkarni, Dinesh Dhumal, Ádám Kevély, Eva Nováková , et al. · 2025

Tick-borne encephalitis virus (TBEV) is a neurotropic flavivirus causing severe meningitis, encephalitis, or meningoencephalitis. The blood-brain barrier (BBB) prevents therapeutic agents from reaching the brain; therefore, specific antivi…

Mendelian randomization analysis of immune cell traits and oral microbiota in nasopharyngeal carcinoma during radiotherapy Open

Jianlong Wu, Jian Zhang, Yongjie Xu, Jianda Sun, Xiaoyang Wang , et al. · 2025

There is a close relationship between oral mucosal injury during radiotherapy of NPC patients and oral microflora imbalance. In the future, we can prevent the occurrence of oral mucosal injury by regulating oral microbiota, so as to provid…

Ultrafast Active Control of All-Optical Plasmonic Logic Gates States Open

Meng Wang, Tong Li, Boyu Ji, Ling Peng, Yang Xu , et al. · 2025

Surface Plasmon Polariton (SPP) can confine electromagnetic fields at metal-dielectric interfaces, breaking the diffraction limit and enabling sub-wavelength light confinement. Ultra-high modulation speeds of plasmonic logic gate devices c…

Phase I Trial of Pegylated Liposomal Doxorubicin Combined with Ifosfamide for Advanced Soft Tissue Sarcoma Open

Ting Ye, Li Fan, Rubo Cao, Ling Peng, Jing Chen · 2025

This study successfully determined the MTD of PLD in combination with IFO and rhG-CSF for advanced STS, offering a potentially valuable treatment option with a tolerable safety profile.

Mechanisms of induced resistance to the antitumoral agent ZZW-115 in pancreas ductal adenocarcinoma Open

Patricia Santofimia‐Castaño, Wenjun Lan, Matías Estarás, Yi Xia, Emma Cosialls , et al. · 2025

Drug resistance remains a major obstacle in treating pancreatic ductal adenocarcinoma (PDAC). Nuclear protein 1 (NUPR1), a stress-responsive protein implicated in cancer progression and treatment resistance, represents a potential therapeu…

P-cadherin mechanoactivates tumor-mesothelium metabolic coupling to promote ovarian cancer metastasis Open

Jing Ma, Sally Kit Yan To, Katie Sze Wai Fung, Kun Wang, Jiangwen Zhang , et al. · 2025

Research progress of PYK2 in digestive system diseases Open

Yajuan Duan, Mingzhu Xie, Hui Wang, Sijing Chen, Jun Hu , et al. · 2025

Belonging to the focal adhesion kinase (FAK) family, proline-rich tyrosine kinase 2 (PYK2) is a non-receptor tyrosine kinase, has become a focal point in cancer research owing to its essential participation in the formation and disseminati…

Advances in immunotherapy and targeted therapy for advanced clear-cell renal cell carcinoma: current strategies and future directions Open

Bo Wang, Yuchu Xiang, Xudong Liu, Xiaoting Pan, Ling Peng , et al. · 2025

Renal cell carcinoma (RCC), particularly the clear-cell subtype (ccRCC), accounts for 75-85% of kidney cancers and exhibits distinct genetic and biological heterogeneity. While surgical resection remains the mainstay of treatment for local…

Self-assembling dendrimer nanodrug formulations for decreased hERG-related toxicity and enhanced therapeutic efficacy Open

Xi Liu, Dinesh Dhumal, Patricia Santofimia‐Castaño, Juan Liu, Marion Casanova , et al. · 2025

Cardiotoxicity, especially human ether-a-go-go–related gene (hERG)–related toxicity, is a leading cause of drug failure or market withdrawal. Reducing hERG binding to obviate potential cardiac toxicity is crucial. Nanotechnology has been a…

Amphiphilic dendrimer-assisted delivery of antisense nucleic acid mimics against E. coli Open

Mariana Gomes, Igor Resende, Yana Zamoshchak, Daniela Araújo, Joana Vieira de Castro , et al. · 2025

Mechanisms of induced resistance to the antitumoral agent ZZW-115 in pancreas ductal adenocarcinoma Open

Patricia Santofimia‐Castaño, Wenjun Lan, Matias Estares, Yi Xia, Emma Cosialls , et al. · 2025

Drug resistance remains a major obstacle in treating pancreatic ductal adenocarcinoma (PDAC). Nuclear protein 1 (NUPR1), a stress-responsive protein implicated in cancer progression and treatment resistance, represents a promising therapeu…

DNA Sensors for the Detection of Mercury Ions Open

Li Feng, Jinxin Lin, Éric Lichtfouse, Haifeng Qi, Ling Peng , et al. · 2025

Ecosystem pollution by mercury ions (Hg2+) is a major health concern, yet classical analytical methods for mercury analysis are limited. This paper reviews the advances in Hg2+ detection using DNA as recognition elements in the sensors. DN…

Dynamin 1-mediated endocytic recycling of glycosylated N-cadherin sustains the plastic mesenchymal state to promote ovarian cancer metastasis Open

Yuee Cai, Zhangyan Guan, Yin Tong, Weiyang Zhao, Jiangwen Zhang , et al. · 2025

STING‐Activating Polymers Boost Lymphatic Delivery of mRNA Vaccine to Potentiate Cancer Immunotherapy (Adv. Mater. 10/2025) Open

Miao Zhang, Yongling Wang, Benhao Li, Bowei Yang, Mengyao Zhao , et al. · 2025

Advanced delivery systems for gene editing: A comprehensive review from the GenE-HumDi COST Action Working Group Open

Alessia Cavazza, Francisco J. Molina-Estévez, Álvaro Plaza Reyes, Victor Ronco, Asma Naseem , et al. · 2025

Bola-Amphiphilic Dendrimer Enhances Imatinib to Target Metastatic Ovarian Cancer via β-Catenin-HRP2 Signaling Axis Open

Zeyu Shi, Margarita Artemenko, Weiyu Yu, Ming Zhang, Canhui Yi , et al. · 2025

Ovarian cancer is the leading cause of death among all gynecological malignancies, and drug resistance renders the current chemotherapy agents ineffective for patients with advanced metastatic tumors. We report an effective treatment strat…

Identification of Corporate Policy Responses and Analysis of Their Market Consequences: A Natural Language Processing and Large Language Model Approach Open

Guowen Li, Ling Peng, Ke Li, Yinghui Wang · 2025

STING‐Activating Polymers Boost Lymphatic Delivery of mRNA Vaccine to Potentiate Cancer Immunotherapy Open

Miao Zhang, Yongling Wang, Benhao Li, Bowei Yang, Mengyao Zhao , et al. · 2024

The unprecedented success of mRNA vaccines against COVID‐19 has inspired scientists to develop mRNA vaccines for cancer immunotherapy. However, using nucleoside modified mRNA as vaccine, though evading innate immune toxicity, diminishes it…

P-cadherin mechanoactivates tumor-mesothelium metabolic coupling to promote ovarian cancer metastasis Open

Jing Ma, Sally Kit Yan To, Katie Sze Wai Fung, Kun Wang, Jiangwen Zhang , et al. · 2024

Impact of inner hydrophobicity of dendrimer nanomicelles on biodistribution: a PET imaging study Open

Tom Roussel, Twiany Cruz-Dubois, Béatrice Louis, Erik Laurini, Ling Ding , et al. · 2024

This study reports the impact of increased hydrophobicity of the amphiphilic dendrimer on hydrophilic/hydrophobic balance and consequently on the self-assembly and subsequent biodistribution.

Development of an efficient NUPR1 inhibitor with anticancer activity Open

Xi Liu, Ana Jiménez-Alesanco, Z Li, Bruno Rizzuti, José L. Neira , et al. · 2024

Dendrimères supramoléculaires auto-assemblants pour la bio-imagerie Open

Marion Casanova, Ling Ding, Ling Peng · 2024

International audience

Epidemiological and typing features of HPV co-infections in MSM with mpox: A hospital-based prospective study Open

Tianyang Liu, Siwei Zhang, Liuqing Yang, Ling Peng, Shanshan Tang , et al. · 2024

In this study, most of the mpox patients were found to be infected with HPV, mostly with high-risk types and multiple infections. Therefore, it is strongly recommended that mpox-infected individuals intensify HPV-related screening, prevent…

Analysis of the epidemiological characteristics of HIV-1 infection in Shenzhen and Dongguan, Guangdong Province, China Open

Yong Feng, Jinhu Liang, Songmei He, Lü Long, Liuqing Yang , et al. · 2024

Targeting the phosphatidylglycerol lipid: An amphiphilic dendrimer as a promising antibacterial candidate Open

N Zhang, Dinesh Dhumal, Shanny Hsuan Kuo, Shi Qian Lew, Pankaj D. Patil , et al. · 2024

The rapid emergence and spread of multidrug-resistant bacterial pathogens require the development of antibacterial agents that are robustly effective while inducing no toxicity or resistance development. In this context, we designed and sy…

Reinvigorating antitumor immunity in brain tumors with short peptides and siRNA–nanocarriers targeting the tumor microenvironment Open

Bożena Kamińska, Aleksandra Ellert‐Miklaszewska, Katarzyna Poleszak, Ling Peng, Paulina Pilanc · 2024

Insight into the Internal Structure of High-Performance Multicore Magnetic Nanoparticles Used in Cancer Thermotherapy Open

Tom Roussel, Daniel Ferry, Artémis Kosta, Dalila Miele, Giuseppina Sandri , et al. · 2024

Multicore magnetic nanoparticles (MNPs), comprising iron oxide cores embedded in a sugar or starch matrix, are a class of nanomaterials with promising magnetic heating properties. Their internal structure, and particularly the strength of …

Comparison of the Immunogenicity of the LZ901 Vaccine and HZ/su Vaccine in a Mouse Model Open

Yaru Quan, Chunxia Liu, Lu Xu, Xi Kong, Shuai Yang , et al. · 2024

Herpes zoster (HZ) is an infectious disease caused by the reactivation of varicella zoster virus (VZV), with 68% of cases occurring in adults over 50 years of age. HZ/su (Shingrix®) was approved by the Food and Drug Administration in 2017 …

Repeated Omicron infection dampens immune imprinting from previous vaccination and induces broad neutralizing antibodies against Omicron sub-variants Open

Xiaohua Gong, Ling Peng, Fuxiang Wang, J. Liu, Yimin Tang , et al. · 2024

Our results demonstrate that repeated Omicron infection dampens immune imprinting from vaccination with WT SARS-CoV-2 and induces broad neutralizing profiles against Omicron sub-variants.

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