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View article: Reduced FEV3/FVC as an Early Indicator of COPD in Individuals with Normal Spirometry: A Prospective Analysis from the ECOPD Study
Reduced FEV3/FVC as an Early Indicator of COPD in Individuals with Normal Spirometry: A Prospective Analysis from the ECOPD Study Open
A reduced FEV3/FVC ratio was associated with an increased risk of accelerated lung function decline and progression to COPD in individuals with normal spirometry. As a readily accessible measure derived from routine spirometry, …
View article: Latent Class Analysis to Identify Novel Phenotypes in Exacerbations of COPD: A Retrospective, Multicenter Cohort Study
Latent Class Analysis to Identify Novel Phenotypes in Exacerbations of COPD: A Retrospective, Multicenter Cohort Study Open
This study aimed to identify novel phenotypes in patients with exacerbations of chronic obstructive pulmonary disease (ECOPD) to enable precise management, as current phenotypic classifications show limited utility in predicting patient pr…
View article: Prevalence, risk factors, and clinical implications of failed spirometry in adults: Results from NHANES 2007–2012
Prevalence, risk factors, and clinical implications of failed spirometry in adults: Results from NHANES 2007–2012 Open
Failed spirometry is common among adults and correlates with increased respiratory symptoms and higher all-cause mortality risk, indicating the need for targeted attention.
View article: Assessment of the clinical prognosis of patients with chronic obstructive pulmonary disease using combined blood and sputum eosinophil counts
Assessment of the clinical prognosis of patients with chronic obstructive pulmonary disease using combined blood and sputum eosinophil counts Open
Background High blood or sputum eosinophil counts are linked to poor clinical outcomes in chronic obstructive pulmonary disease (COPD), yet the value of combining both for the assessment of clinical prognosis remains unclear. In this study…
View article: Impaired Ventilatory Efficiency as a Novel Indicator of Pre-COPD
Impaired Ventilatory Efficiency as a Novel Indicator of Pre-COPD Open
View article: Glycopyrrolate/formoterol fumarate MDI in mild-to-moderate chronic obstructive pulmonary disease (PIONEER): a protocol for a randomised, double-blind, placebo-controlled trial
Glycopyrrolate/formoterol fumarate MDI in mild-to-moderate chronic obstructive pulmonary disease (PIONEER): a protocol for a randomised, double-blind, placebo-controlled trial Open
Introduction Patients with mild-to-moderate chronic obstructive pulmonary disease (COPD) often experience rapid declines in lung function but are rarely treated early. The Prospect of early InterventiON in the managEment of chronic obstruc…
View article: Long Noncoding RNA Interleukin 6 Antisense RNA 1 Promotes Inflammatory Effects in Lung Macrophages via Exosomes Through the S100A9/TLR4 Pathway in Chronic Obstructive Pulmonary Disease Progression
Long Noncoding RNA Interleukin 6 Antisense RNA 1 Promotes Inflammatory Effects in Lung Macrophages via Exosomes Through the S100A9/TLR4 Pathway in Chronic Obstructive Pulmonary Disease Progression Open
This study investigates the role of interleukin 6 antisense RNA 1 ( IL6‐AS1 ), a highly expressed long noncoding RNA (lncRNA), in chronic obstructive pulmonary disease (COPD). An adeno‐associated virus (AAV) was used to induce the expressi…
View article: Assessment of Preserved Ratio Impaired Spirometry (PRISm) Based on Different Definitions in the Early COPD Cohort
Assessment of Preserved Ratio Impaired Spirometry (PRISm) Based on Different Definitions in the Early COPD Cohort Open
Our findings highlight concerns about the comparability of studies and the interchangeability of various definitions and reference equations for PRISm.
View article: Lung function decline and incidence of chronic obstructive pulmonary disease in participants with spirometry-defined small airway dysfunction: a 15-year prospective cohort study in China
Lung function decline and incidence of chronic obstructive pulmonary disease in participants with spirometry-defined small airway dysfunction: a 15-year prospective cohort study in China Open
View article: An integrated machine learning model of transcriptomic genes in multi-center chronic obstructive pulmonary disease reveals the causal role of TIMP4 in airway epithelial cell
An integrated machine learning model of transcriptomic genes in multi-center chronic obstructive pulmonary disease reveals the causal role of TIMP4 in airway epithelial cell Open
We developed a 13-gene model for distinguishing COPD at the molecular level and identified TIMP4 as a potential hub pathogenic gene. This finding provides insights into shared disease mechanisms and positions TIMP4 as a promising therapeut…
View article: An integrated machine learning model of transcriptomic genes in multi-center chronic obstructive pulmonary disease reveals the causal role of TIMP4 in airway epithelial cell
An integrated machine learning model of transcriptomic genes in multi-center chronic obstructive pulmonary disease reveals the causal role of TIMP4 in airway epithelial cell Open
Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous syndrome, resulting in inconsistent findings across studies. Identifying a core set of genes consistently involved in COPD pathogenesis, independent of patient vari…
View article: Effects of attention on the asymmetric serial dependences between form and motion patterns and their computational processes
Effects of attention on the asymmetric serial dependences between form and motion patterns and their computational processes Open
Recent studies have revealed that serial dependences are asymmetric in the estimation of the focus of expansion (FoE) in the global static form and dynamic optic flow displays. In the current study, we conducted two experiments to examine …
View article: Establishment and biological characterization of radioresistant colorectal cancer cell lines
Establishment and biological characterization of radioresistant colorectal cancer cell lines Open
Radiotherapy resistance is a major cause of recurrence and metastasis in colorectal cancer (CRC). We established radiotherapy‐resistant cell lines to explore the molecular mechanisms of radiotherapy resistance in CRC. HT29 and HCT116 cells…
View article: Intermittent Fasting Reduces Intestinal Inflammation in Dextran Sulfate Sodium‐Induced Colitis of Mice
Intermittent Fasting Reduces Intestinal Inflammation in Dextran Sulfate Sodium‐Induced Colitis of Mice Open
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), is a chronic condition impacting both the gastrointestinal tract and the immune system. Intestinal inflammation and epithelial injury are the pa…
View article: Comparing spirometry, impulse oscillometry with computed tomography for assessing small airway dysfunction in subjects with and without chronic obstructive pulmonary disease
Comparing spirometry, impulse oscillometry with computed tomography for assessing small airway dysfunction in subjects with and without chronic obstructive pulmonary disease Open
View article: Is Tiotropium Necessary For All Patients with Mild-to-Moderate COPD To Prevent Disease Progression?
Is Tiotropium Necessary For All Patients with Mild-to-Moderate COPD To Prevent Disease Progression? Open
View article: Identifying Patients with Mild-to-Moderate COPD Who Require Intensified Initial Treatment to Control Clinically Important Deterioration
Identifying Patients with Mild-to-Moderate COPD Who Require Intensified Initial Treatment to Control Clinically Important Deterioration Open
View article: Risk of All-Cause Mortality in Mild Chronic Obstructive Pulmonary Disease: Evidence From the NHANES III and 2007–2012
Risk of All-Cause Mortality in Mild Chronic Obstructive Pulmonary Disease: Evidence From the NHANES III and 2007–2012 Open
Patients with mild COPD had a higher all-cause mortality risk than those with normal spirometry, especially males, those aged ≥50 years, and current smokers. These results suggest the need for appropriate management of different subgroups …
View article: Impact of Housing Characteristics and Indoor Environmental Factors on Chronic Obstructive Pulmonary Disease: Findings from the China Pulmonary Health (Cph) Study
Impact of Housing Characteristics and Indoor Environmental Factors on Chronic Obstructive Pulmonary Disease: Findings from the China Pulmonary Health (Cph) Study Open
View article: Associations of anxiety and depression with prognosis in chronic obstructive pulmonary disease: A systematic review and meta-analysis
Associations of anxiety and depression with prognosis in chronic obstructive pulmonary disease: A systematic review and meta-analysis Open
The associations between anxiety, depression, and the prognosis of COPD remain uncertain. The present study aims to investigate the associations of anxiety and depression with 30-day readmission rates and acute exacerbations of COPD (AECOP…
View article: Increased plasma interleukin-1β is associated with accelerated lung function decline in non-smokers
Increased plasma interleukin-1β is associated with accelerated lung function decline in non-smokers Open
Interleukin-1β is one of the major cytokines involved in the initiation and persistence of airway inflammation in chronic obstructive pulmonary disease (COPD). However, the association between plasma interleukin-1β and lung function declin…
View article: Effect of high-dose N-acetylcysteine on exacerbations and lung function in patients with mild-to-moderate COPD: a double-blind, parallel group, multicentre randomised clinical trial
Effect of high-dose N-acetylcysteine on exacerbations and lung function in patients with mild-to-moderate COPD: a double-blind, parallel group, multicentre randomised clinical trial Open
View article: Detection of chronic obstructive pulmonary disease with deep learning using inspiratory and expiratory chest computed tomography and clinical information
Detection of chronic obstructive pulmonary disease with deep learning using inspiratory and expiratory chest computed tomography and clinical information Open
The proposed CNN model using double-phase CT images and clinical information can automatically detect COPD with high accuracy.
View article: The effects of different lung parts, age, and batches on the lung microbiota of healthy rats
The effects of different lung parts, age, and batches on the lung microbiota of healthy rats Open
These data represented that the lung bacterial communities were dynamic and rapidly susceptible to environmental influence, clustered strongly by age or different feeding batches but similar in the different lung tissue parts. This study i…
View article: The Nonlinear Relationship Between High-Density Lipoprotein and Changes in Pulmonary Structure Function and Pulmonary Function in COPD Patients in China
The Nonlinear Relationship Between High-Density Lipoprotein and Changes in Pulmonary Structure Function and Pulmonary Function in COPD Patients in China Open
A non-linear correlation existed between HDL levels with lung function and CT imaging in COPD patients. Prior to reaching 66 mg/dL, an elevation in HDL was significantly associated with impaired lung function, more severe gas trapping and …
View article: Clinical features and associated factors of impaired ventilatory efficiency: findings from the ECOPD study in China
Clinical features and associated factors of impaired ventilatory efficiency: findings from the ECOPD study in China Open
Background Impaired ventilatory efficiency during exercise is a predictor of mortality in chronic obstructive pulmonary disease. However, little is known about the clinical features and associated factors of impaired ventilatory efficiency…
View article: A Risk Stratification Scheme for In-Hospital Cardiogenic Shock in Patients With Acute Myocardial Infarction
A Risk Stratification Scheme for In-Hospital Cardiogenic Shock in Patients With Acute Myocardial Infarction Open
Objective: Cardiogenic shock (CS) is the leading cause of death in patients with acute myocardial infarction (AMI) despite advances in care. This study aims to derive and validate a risk score for in-hospital development of CS in patients …
View article: Clinical features and 1-year outcomes of variable obstruction in participants with preserved spirometry: results from the ECOPD study in China
Clinical features and 1-year outcomes of variable obstruction in participants with preserved spirometry: results from the ECOPD study in China Open
Background There are limited data on the clinical features and longitudinal prognosis of variable obstruction, particularly among never smokers and different variable obstruction types. Therefore, we aimed to evaluate the clinical characte…
View article: Clinical characterization and outcomes of impulse oscillometry-defined bronchodilator response: an ECOPD cohort-based study
Clinical characterization and outcomes of impulse oscillometry-defined bronchodilator response: an ECOPD cohort-based study Open
Background The clinical significance of the impulse oscillometry-defined small airway bronchodilator response (IOS-BDR) is not well-known. Accordingly, this study investigated the clinical characteristics of IOS-BDR and explored the associ…
View article: Deciphering the Genetic Architecture of Chronic Obstructive Pulmonary Disease (COPD): Insights from the UK Biobank and Mendelian Randomization Analysis
Deciphering the Genetic Architecture of Chronic Obstructive Pulmonary Disease (COPD): Insights from the UK Biobank and Mendelian Randomization Analysis Open
Genetic susceptibility plays a crucial role in the development of Chronic Obstructive Pulmonary Disease (COPD), however, the research on genetic susceptibility genes for COPD is currently limited by incomplete understanding and insufficien…