Pengchao Guo
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View article: Unveiling the molecular architecture of <scp><i>Tc</i>JHAMT</scp>: structural basis for catalytic efficiency and targeted inhibitor screening in the red flour beetle, <i>Tribolium castaneum</i>
Unveiling the molecular architecture of <span><i>Tc</i>JHAMT</span>: structural basis for catalytic efficiency and targeted inhibitor screening in the red flour beetle, <i>Tribolium castaneum</i> Open
BACKGROUND The red flour beetle, Tribolium castaneum , is a holometabolous insect regulated by juvenile hormone (JH), and juvenile hormone acid methyltransferase (JHAMT) serves as a rate‐limiting enzyme involved in JH biosynthesis. JHAMT t…
View article: Mechanisms Behind the Formation of Ellipsoid Eggs in Silk-Worms (<em>Bombyx mori</em>): Insights from Transcriptomic Profiling
Mechanisms Behind the Formation of Ellipsoid Eggs in Silk-Worms (<em>Bombyx mori</em>): Insights from Transcriptomic Profiling Open
Background/Objectives: The elongated egg is a morphological mutant of silkworm (Bombyx mori) eggs, yet the biochemical processes and molecular mechanisms underlying this trait remain unclear. Methods: In this study, we performed transcript…
View article: Recent development of mitochondrial metabolism and dysfunction in osteoarthritis
Recent development of mitochondrial metabolism and dysfunction in osteoarthritis Open
Osteoarthritis is a degenerative joint disorder characterized by cartilage degradation, synovial inflammation, and altered subchondral bone structure. Recent insights have identified mitochondrial dysfunction as a pivotal factor in OA path…
View article: Investigating the Interplay of Circp4ha3/Mir-5001-5p/Thbs2 Axis in Chondrocyte Function and Osteoarthritis Pathogenesis
Investigating the Interplay of Circp4ha3/Mir-5001-5p/Thbs2 Axis in Chondrocyte Function and Osteoarthritis Pathogenesis Open
View article: ukbFGSEA: an R Package for Applying Fast Preranked Gene Set Enrichment Analysis to UK Biobank Exome Data
ukbFGSEA: an R Package for Applying Fast Preranked Gene Set Enrichment Analysis to UK Biobank Exome Data Open
The Genebass dataset, released by Karczewski et al. (2022), provides a comprehensive resource elucidating associations between genes and 4,529 phenotypes based on nearly 400,000 exomes from the UK Biobank. This extensive dataset enables th…
View article: Structural Characterization and Functional Analysis of Mevalonate Kinase from Tribolium castaneum (Red Flour Beetle)
Structural Characterization and Functional Analysis of Mevalonate Kinase from Tribolium castaneum (Red Flour Beetle) Open
Mevalonate kinase (MevK) is an important enzyme in the mevalonate pathway that catalyzes the phosphorylation of mevalonate into phosphomevalonate and is involved in juvenile hormone biosynthesis. Herein, we present a structure model of Mev…
View article: Serpin-1a and serpin-6 regulate the Toll pathway immune homeostasis by synergistically inhibiting the Spätzle-processing enzyme CLIP2 in silkworm, Bombyx mori
Serpin-1a and serpin-6 regulate the Toll pathway immune homeostasis by synergistically inhibiting the Spätzle-processing enzyme CLIP2 in silkworm, Bombyx mori Open
The Toll receptor signaling pathway is an important innate immune response of insects to pathogen infection; its extracellular signal transduction involves serine protease cascade activation. However, excessive or constitutive activation o…
View article: Structural Characterization and Functional Analysis of Mevalonate Kinase: An Important Enzyme in Juvenile Hormone Biosynthesis of Tribolium Castaneum (Red Flour Beetle)
Structural Characterization and Functional Analysis of Mevalonate Kinase: An Important Enzyme in Juvenile Hormone Biosynthesis of Tribolium Castaneum (Red Flour Beetle) Open
View article: [Weighted gene co-expression network analysis of methylated genes in burn scar tissue].
[Weighted gene co-expression network analysis of methylated genes in burn scar tissue]. Open
Objective: To investigate the methylated genes in burn scar tissue by weighted gene co-expression network analysis (WGCNA), and to discover molecular markers and therapeutic targets of scar formation. Methods: An observationa…
View article: Structural basis for juvenile hormone biosynthesis by the juvenile hormone acid methyltransferase
Structural basis for juvenile hormone biosynthesis by the juvenile hormone acid methyltransferase Open
View article: Successful Treatment of Necrotizing Fasciitis of the Upper Extremity Caused by Vibrio vulnificus: Two case reports and literature review
Successful Treatment of Necrotizing Fasciitis of the Upper Extremity Caused by Vibrio vulnificus: Two case reports and literature review Open
BackgroundHuman body infection with V. vulnificus, especially for patients with some chronic diseases, can cause severe wound infections, septic shock and necrotizing fasciitis of skin and muscle, which in turn can lead to multiple organ f…
View article: Five Silkworm 30K Proteins Are Involved in the Cellular Immunity against Fungi
Five Silkworm 30K Proteins Are Involved in the Cellular Immunity against Fungi Open
Background: 30K proteins are a major group of nutrient storage proteins in the silkworm hemolymph. Previous studies have shown that 30K proteins are involved in the anti-fungal immunity; however, the molecular mechanism involved in this im…
View article: Efficient Delivery of dsRNA and DNA in Cultured Silkworm Cells for Gene Function Analysis Using PAMAM Dendrimers System
Efficient Delivery of dsRNA and DNA in Cultured Silkworm Cells for Gene Function Analysis Using PAMAM Dendrimers System Open
Polyamidoamine (PAMAM) dendrimers are emerging as intriguing nanovectors for nucleic acid delivery because of their unique well-defined architecture and high binding capacity, which have been broadly applied in DNA- and RNA-based therapeut…
View article: Antibacterial Mechanism of Gloverin2 from Silkworm, Bombyx mori
Antibacterial Mechanism of Gloverin2 from Silkworm, Bombyx mori Open
Gloverin is one of the glycine-rich antimicrobial peptide exclusively found in Lepidoptera insects. It is generally activated through the innate immune system in insects. In this study, recombinant Gloverin2 from Bombyx mori (BmGlv2) was s…
View article: In Situ Synthesis of Silver Nanoparticles on the Polyelectrolyte-Coated Sericin/PVA Film for Enhanced Antibacterial Application
In Situ Synthesis of Silver Nanoparticles on the Polyelectrolyte-Coated Sericin/PVA Film for Enhanced Antibacterial Application Open
To develop silk sericin (SS) as a potential antibacterial biomaterial, a novel composite of polyelectrolyte multilayers (PEMs) coated sericin/poly(vinyl alcohol) (SS/PVA) film modified with silver nanoparticles (AgNPs) has been developed u…
View article: Biosynthesis and Characterization of AgNPs–Silk/PVA Film for Potential Packaging Application
Biosynthesis and Characterization of AgNPs–Silk/PVA Film for Potential Packaging Application Open
Bionanocomposite packaging materials have a bright future for a broad range of applications in the food and biomedical industries. Antimicrobial packaging is one of the bionanocomposite packaging materials. Silver nanoparticle (AgNP) is on…
View article: Analysis of proteome dynamics inside the silk gland lumen of Bombyx mori
Analysis of proteome dynamics inside the silk gland lumen of Bombyx mori Open
The silk gland is the only organ where silk proteins are synthesized and secreted in the silkworm, Bombyx mori . Silk proteins are stored in the lumen of the silk gland for around eight days during the fifth instar. Determining their dynam…
View article: Structural insights into the unique inhibitory mechanism of the silkworm protease inhibitor serpin18
Structural insights into the unique inhibitory mechanism of the silkworm protease inhibitor serpin18 Open
View article: Comparative Proteome Analysis of Multi-Layer Cocoon of the Silkworm, Bombyx mori
Comparative Proteome Analysis of Multi-Layer Cocoon of the Silkworm, Bombyx mori Open
Bombyx mori cocoon has a multi-layer structure that provides optimal protection for silkworm pupa. Research on the mechanical properties of the multi-layer structure revealed structure-property relationships of the cocoon. Here, we investi…