Peng Yi
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View article: Targeting circGDI2 disrupt HNRNPC-mediated mPORCN stabilization and enhance LGK-974 anti-tumor therapy in hepatocellular carcinoma
Targeting circGDI2 disrupt HNRNPC-mediated mPORCN stabilization and enhance LGK-974 anti-tumor therapy in hepatocellular carcinoma Open
Background The functions of circRNAs in hepatocellular carcinoma (HCC) till needs to be further elucidated. Methods We assessed the biological functions of circGDI2 in vitro and in vivo by gain or loss of function experiments. Then, fuores…
View article: Targeting Cystine Metabolism in the Lung Cancer Environment Enhances the Efficacy of Immune Checkpoint Inhibition
Targeting Cystine Metabolism in the Lung Cancer Environment Enhances the Efficacy of Immune Checkpoint Inhibition Open
Immunotherapy with Immune Checkpoint Inhibitors (ICIs) has shown promising therapeutic effects in the treatment of lung cancer, the overall efficacy of PD‐1/PD‐L1 inhibitors is only 20%‐30%. Thus, more effective combination therapies are n…
View article: Prognostic Value of <scp>TBC1D1</scp> and Its Relationship With the Tumor Microenvironment in Pancreatic Cancer: A Study Based on Single‐Cell Sequencing
Prognostic Value of <span>TBC1D1</span> and Its Relationship With the Tumor Microenvironment in Pancreatic Cancer: A Study Based on Single‐Cell Sequencing Open
TBC1 Domain Family Member 1 (TBC1D1) plays a crucial role in various cancers. However, its specific function in pancreatic cancer (PC) remains poorly understood. In this study, we aimed to evaluate the prognostic value of TBC1D1 and its co…
View article: Morc4 is a novel functional gene associated with lipid metabolism in BXD recombinant inbred population
Morc4 is a novel functional gene associated with lipid metabolism in BXD recombinant inbred population Open
Aim The dysregulation of hepatic lipid metabolism is closely associated with dyslipidemia. Previous research suggested that Hepatic Morc4 may play a role in regulating lipid metabolism. This research aims to elucidate the function of MORC4…
View article: One-carbon metabolic reprogramming and its relationship with tumor-infiltrating lymphocytes and Immune checkpoint in Pancreatic cancer
One-carbon metabolic reprogramming and its relationship with tumor-infiltrating lymphocytes and Immune checkpoint in Pancreatic cancer Open
BACKGROUND The role of oncogene-driven metabolic reprogramming in pancreatic cancer (PC) remains unclear. This study explored the interplay between one-carbon metabolism (OCM), driver genes, and the tumor microenvironment (TME) in PC. METH…
View article: 7449 A Genome-wide CRISPR Screen Identifies Drivers of Impaired Glucose Uptake in Human Insulin Resistance
7449 A Genome-wide CRISPR Screen Identifies Drivers of Impaired Glucose Uptake in Human Insulin Resistance Open
Disclosure: N. Haider: None. Y. Lee: None. P. Yi: None. C.R. Kahn: None. Insulin resistance is a major risk factor in the development of type 2 diabetes (T2D), and metabolic syndrome. Although 25% of people within the general non-diabetic …
View article: A CRISPR Screen Identifies the E3 Ubiquitin Ligase Rfwd2 as a Negative Regulator of Glucose Uptake in Brown Adipocytes
A CRISPR Screen Identifies the E3 Ubiquitin Ligase Rfwd2 as a Negative Regulator of Glucose Uptake in Brown Adipocytes Open
Brown adipose tissue activation increases energy expenditure and has been shown to improve glucose tolerance, making it a promising target for the treatment of obesity and type 2 diabetes. Brown adipocytes differentiate into cells with mul…
View article: Novel variants and phenotypic heterogeneity in a cohort of 11 Chinese children with Wiedemann-Steiner syndrome
Novel variants and phenotypic heterogeneity in a cohort of 11 Chinese children with Wiedemann-Steiner syndrome Open
Objective: Wiedemann-Steiner syndrome (WSS) is a rare autosomal dominant disorder caused by deleterious heterozygous variants of the KMT2A gene. This study aims to describe the phenotypic and genotypic features of Chinese WSS patients, and…
View article: Plasma Amino Acid Profile in Children with Autism Spectrum Disorder in Southern China: Analysis of 110 Cases
Plasma Amino Acid Profile in Children with Autism Spectrum Disorder in Southern China: Analysis of 110 Cases Open
View article: Positive expression of ZNF689 indicates poor prognosis of hepatocellular carcinoma
Positive expression of ZNF689 indicates poor prognosis of hepatocellular carcinoma Open
The objective of the present study was to investigate the association between zinc finger protein (ZNF) 689 expression and the clinicopathological features and prognosis of hepatocellular carcinoma (HCC). A total of 102 paired HCC and pair…
View article: High expression of miR‑21 is not a predictor of poor prognosis in all patients with hepatocellular carcinoma
High expression of miR‑21 is not a predictor of poor prognosis in all patients with hepatocellular carcinoma Open
MicroRNA (miR)-21 has been identified as a novel biomarker of hepatocellular carcinoma (HCC). However, the prognostic value of miR-21 expression in HCC remains controversial. The aim of the present study was to investigate the value of hig…
View article: Interleukin-10 gene transfer into insulin-producing β cells protects against diabetes in non-obese diabetic mice
Interleukin-10 gene transfer into insulin-producing β cells protects against diabetes in non-obese diabetic mice Open
Type 1 diabetes is an autoimmune disorder, which occurs due to β cell damage. Interleukin (IL)-10, a pleotropic cytokine, has been reported to have anti‑inflammatory, immunosuppressive and immunostimulatory properties. Administration of IL…