Pei Han
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View article: Spatial spillover effects of the digital economy on high-quality development and carbon emissions: evidence from prefecture-level cities in Guangdong, China
Spatial spillover effects of the digital economy on high-quality development and carbon emissions: evidence from prefecture-level cities in Guangdong, China Open
The digital economy, as a sustainable and innovative mechanism for economic change, has emerged as a crucial national strategic driver for China’s attainment of high-quality development and low-carbon transition. Assessing the digital econ…
View article: Development and external validation of a nomogram for predicting one-year survival in patients with non-traumatic subarachnoid hemorrhage
Development and external validation of a nomogram for predicting one-year survival in patients with non-traumatic subarachnoid hemorrhage Open
Background Subarachnoid hemorrhage (SAH), a critical cerebrovascular emergency characterized by acute bleeding into the subarachnoid space, is associated with permanent neurological deficits, substantial mortality rates, and unfavorable cl…
View article: A Comparative Study on Various Pretreatment Methods of Anaerobic Digestion Piggery Effluent for Microalgae Cultivation
A Comparative Study on Various Pretreatment Methods of Anaerobic Digestion Piggery Effluent for Microalgae Cultivation Open
Anaerobic digestion piggery effluent (ADPE), dark brown with high turbidity and ammonium, inhibits algal growth and requires pretreatment for cultivation. This study compared various physical/biological pretreatment methods for microalgae …
View article: Targeting Drp1 inhibits ESCC progression via the ROS-PGC1-α-Nrf1/2 pathway
Targeting Drp1 inhibits ESCC progression via the ROS-PGC1-α-Nrf1/2 pathway Open
Background Esophageal squamous cell carcinoma (ESCC) ranks among the most prevalent malignancies of the digestive tract. Due to the absence of obvious symptoms in patients with early-stage ESCC, most cases are diagnosed at advanced stages,…
View article: Machine learning-based prediction of 6-month functional recovery in hypertensive cerebral hemorrhage: insights from XGBoost and SHAP analysis
Machine learning-based prediction of 6-month functional recovery in hypertensive cerebral hemorrhage: insights from XGBoost and SHAP analysis Open
Background The poor prognosis of hypertensive cerebral hemorrhage (HICH) remains high. The period of 3–6 months after onset is the most rapid phase of neurological recovery in hemorrhagic stroke patients. Accurate early prediction of 6-mon…
View article: Gut microbiota-derived metabolites in inflammatory diseases based on targeted metabolomics
Gut microbiota-derived metabolites in inflammatory diseases based on targeted metabolomics Open
The gut microbiota plays an important role in inflammatory diseases. Metabolites in the three metabolic pathways of tryptophan (Trp), histidine (His), and phenylalanine (Phe) can affect various inflammatory conditions, such as obesity, dia…
View article: Biotransformation of Liquiritigenin into Characteristic Metabolites by the Gut Microbiota
Biotransformation of Liquiritigenin into Characteristic Metabolites by the Gut Microbiota Open
The bioavailability of flavonoids is generally low after oral administration. The metabolic transformation of flavonoids by the gut microbiota may be one of the main reasons for this, although these metabolites have potential pharmacologic…
View article: Esterases From Bifidobacteria Exhibit the Conversion of Albiflorin in Gut Microbiota
Esterases From Bifidobacteria Exhibit the Conversion of Albiflorin in Gut Microbiota Open
Bifidobacteria is an important microbe that inhabits the human gut. It is capable of metabolizing complex compounds in the human diet. Albiflorin, an antidepressant natural product from Radix Paeoniae Alba in China, is difficult to absorb …
View article: Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota
Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota Open
Morinda officinalis oligosaccharides (MOO) are an oral drug approved in China for the treatment of depression in China. However, MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated. Here, we show that ora…
View article: Biotransformation of Timosaponin BII into Seven Characteristic Metabolites by the Gut Microbiota
Biotransformation of Timosaponin BII into Seven Characteristic Metabolites by the Gut Microbiota Open
Timosaponin BII is one of the most abundant Anemarrhena saponins and is in a phase II clinical trial for the treatment of dementia. However, the pharmacological activity of timosaponin BII does not match its low bioavailability. In this st…
View article: The Association Between Intestinal Bacteria and Allergic Diseases—Cause or Consequence?
The Association Between Intestinal Bacteria and Allergic Diseases—Cause or Consequence? Open
The incidence of allergic disorders has been increasing over the past few decades, especially in industrialized countries. Allergies can affect people of any age. The pathogenesis of allergic diseases is complex and involves genetic, epige…
View article: Determination and Application of Nineteen Monoamines in the Gut Microbiota Targeting Phenylalanine, Tryptophan, and Glutamic Acid Metabolic Pathways
Determination and Application of Nineteen Monoamines in the Gut Microbiota Targeting Phenylalanine, Tryptophan, and Glutamic Acid Metabolic Pathways Open
It has been reported that monoamine neurotransmitters can be produced by gut microbiota, and that several related metabolites of amino acids in these pathways are associated with nervous system (NVS) diseases. Herein, we focused on three p…
View article: Transforming of Triptolide into Characteristic Metabolites by the Gut Microbiota
Transforming of Triptolide into Characteristic Metabolites by the Gut Microbiota Open
The importance of the gut microbiota in drug metabolism, especially in that of nonabsorbable drugs, has become known. The aim of this study was to explore the metabolites of triptolide by the gut microbiota. With high-performance liquid ch…
View article: A Review on the Use of Microalgae for Sustainable Aquaculture
A Review on the Use of Microalgae for Sustainable Aquaculture Open
Traditional aquaculture provides food for humans, but produces a large amount of wastewater, threatening global sustainability. The antibiotics abuse and the water replacement or treatment causes safety problems and increases the aquacultu…
View article: Silencing the lncRNA <i>Maclpil</i> in pro-inflammatory macrophages attenuates acute experimental ischemic stroke via LCP1 in mice
Silencing the lncRNA <i>Maclpil</i> in pro-inflammatory macrophages attenuates acute experimental ischemic stroke via LCP1 in mice Open
Long noncoding RNAs (lncRNA) expression profiles change in the ischemic brain after stroke, but their roles in specific cell types after stroke have not been studied. We tested the hypothesis that lncRNA modulates brain injury by altering …
View article: Gut Microbiota-Based Pharmacokinetics and the Antidepressant Mechanism of Paeoniflorin
Gut Microbiota-Based Pharmacokinetics and the Antidepressant Mechanism of Paeoniflorin Open
Paeoniflorin, the main component of Xiaoyao Wan, presents low oral bioavailability and unclear antidepressant mechanism. To elucidate the potential reasons for the low bioavailability of paeoniflorin and explore its antidepressant mechanis…
View article: Metabolic phenotyping in the mouse model of urinary tract infection shows that 3-hydroxybutyrate in plasma is associated with infection
Metabolic phenotyping in the mouse model of urinary tract infection shows that 3-hydroxybutyrate in plasma is associated with infection Open
Urinary tract infection is one of the most common bacterial infections worldwide. Current diagnosis of urinary tract infection chiefly relies on its clinical presentation, urine dipstick tests and urine culture. Small molecules found in bi…
View article: Pathological Ace2-to-Ace enzyme switch in the stressed heart is transcriptionally controlled by the endothelial Brg1–FoxM1 complex
Pathological Ace2-to-Ace enzyme switch in the stressed heart is transcriptionally controlled by the endothelial Brg1–FoxM1 complex Open
Significance Angiotensin-converting enzymes Ace and Ace2 counteract each other to control the metabolism of angiotensin peptides and heart function. When the heart is pathologically stressed, Ace is up-regulated whereas Ace2 is down-regula…
View article: Overexpression of NSUN2 by DNA hypomethylation is associated with metastatic progression in human breast cancer
Overexpression of NSUN2 by DNA hypomethylation is associated with metastatic progression in human breast cancer Open
NSUN2 is a RNA methyltransferase that has been shown to be implicated in development of human cancer. However, the functional role of NSUN2, mechanism of NSUN2 overexpression and its association with clinicopathologic features in breast ca…
View article: Chromatin Remodeling in Heart Failure
Chromatin Remodeling in Heart Failure Open
Chromatin provides a dynamic DNA scaffold that reacts to physiological and pathological signals to control the accessibility of DNA sequence and the genomic responses to environmental stimuli. Chromatin can be regulated by nucleosome remod…
View article: Long non-coding RNA and chromatin remodeling
Long non-coding RNA and chromatin remodeling Open
Long noncoding RNAs (lncRNAs) are pivotal regulators of genome structure and gene expression. LncRNAs can directly interact with chromatin-modifying enzymes and nucleosome-remodeling factors to control chromatin structure and accessibility…