Caixia Dong
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View article: A galactoarabinan-containing glycoprotein isolated from the fruits of Lycium barbarum reverses the tumor-associated macrophage phenotype
A galactoarabinan-containing glycoprotein isolated from the fruits of Lycium barbarum reverses the tumor-associated macrophage phenotype Open
Lycium barbarum fruits possess a well-established history of use in traditional Chinese medicine due to their potent immunomodulatory properties, extending to cancer immunity. In this study, a purified galactoarabinan-containing glycoprote…
View article: Proteome-Wide Genetic Study in East Asians and Europeans Identified Multiple Therapeutic Targets for Ischemic Stroke
Proteome-Wide Genetic Study in East Asians and Europeans Identified Multiple Therapeutic Targets for Ischemic Stroke Open
BACKGROUND: Analyses of genomic and proteomics data in prospective biobank studies in diverse populations may discover novel or repurposing drug targets for stroke. METHODS: We extracted individual cis -protein quantitative trait locus for…
View article: Dissecting the anti-obesity components of ginseng: How ginseng polysaccharides and ginsenosides target gut microbiota to suppress high-fat diet-induced obesity
Dissecting the anti-obesity components of ginseng: How ginseng polysaccharides and ginsenosides target gut microbiota to suppress high-fat diet-induced obesity Open
GP and GS, containing diverse glycosyl groups, selectively stimulate specific gut bacteria, triggering mechanisms involved in SCFA-GLP-1/PYY signaling and IGN activation to reduce adiposity in HFD-fed mice. The study enhances understanding…
View article: Association between health insurance cost-sharing and choice of hospital tier for cardiovascular diseases in China: a prospective cohort study
Association between health insurance cost-sharing and choice of hospital tier for cardiovascular diseases in China: a prospective cohort study Open
View article: <i>PCSK9</i> genetic variants and risk of vascular and non-vascular diseases in Chinese and UK populations
<i>PCSK9</i> genetic variants and risk of vascular and non-vascular diseases in Chinese and UK populations Open
Aims Lowering low-density lipoprotein cholesterol (LDL-C) through PCSK9 inhibition represents a new therapeutic approach to preventing and treating cardiovascular disease (CVD). Phenome-wide analyses of PCSK9 genetic variants in large biob…
View article: Plasma Proteomics to Identify Drug Targets for Ischemic Heart Disease
Plasma Proteomics to Identify Drug Targets for Ischemic Heart Disease Open
View article: Alcohol consumption and risks of more than 200 diseases in Chinese men
Alcohol consumption and risks of more than 200 diseases in Chinese men Open
Alcohol consumption accounts for ~3 million annual deaths worldwide, but uncertainty persists about its relationships with many diseases. We investigated the associations of alcohol consumption with 207 diseases in the 12-year China Kadoor…
View article: Impact of Sulfur Fumigation on the Chemistry of Dioscoreae Rhizoma (Chinese Yam)
Impact of Sulfur Fumigation on the Chemistry of Dioscoreae Rhizoma (Chinese Yam) Open
Dioscoreae Rhizoma (Chinese yam; derived from the rhizome of Dioscorea opposita Thunb.) (DR), commonly consumed as a food or supplement, is often sulfur-fumigated during post-harvest handling, but it remains largely unknown if and h…
View article: Tobacco smoking and risks of more than 470 diseases in China: a prospective cohort study
Tobacco smoking and risks of more than 470 diseases in China: a prospective cohort study Open
View article: Impact of Sulfur Fumigation on Ginger: Chemical and Biological Evidence
Impact of Sulfur Fumigation on Ginger: Chemical and Biological Evidence Open
We previously found that sulfur fumigation, a commonly used controversial method for the post-harvest handling of ginger, induces the generation of a compound in ginger, which was speculated to be a sulfur-containing derivative of 6-shogao…
View article: Lycium Genus Polysaccharide: An Overview of its Extraction, Structures, Pharmacological Activities and Biological Applications
Lycium Genus Polysaccharide: An Overview of its Extraction, Structures, Pharmacological Activities and Biological Applications Open
Polysaccharide is considered to be the main active ingredient of the genus Lycium L., which is taken from the dried fruit of the famous Chinese herbal medicine and precious tonic known as wolfberry. Traditional uses include nourishing the …
View article: Dairy consumption and risks of total and site-specific cancers in Chinese adults: an 11-year prospective study of 0.5 million people
Dairy consumption and risks of total and site-specific cancers in Chinese adults: an 11-year prospective study of 0.5 million people Open
Background Previous studies of primarily Western populations have reported contrasting associations of dairy consumption with certain cancers, including a positive association with prostate cancer and inverse associations with colorectal a…
View article: 25-hydroxyvitamin D levels are inversely related to metabolic syndrome risk profile in northern Chinese subjects without vitamin D supplementation
25-hydroxyvitamin D levels are inversely related to metabolic syndrome risk profile in northern Chinese subjects without vitamin D supplementation Open
View article: An investigation of vitamin D nutritional status in children after outbreak of coronavirus disease 2019.
An investigation of vitamin D nutritional status in children after outbreak of coronavirus disease 2019. Open
Strict prevention and control measures for the COVID-19 epidemic may lead to a significant reduction in vitamin D level in children, especially school-aged and adolescent children. It is recommended to timely monitor vitamin D level in chi…
View article: Galactofucoidans from Sargassum fusiforme and their antagonistic effects against the proliferation-inhibition of RAW264.7 macrophage induced by culture supernatants of melanoma cells
Galactofucoidans from Sargassum fusiforme and their antagonistic effects against the proliferation-inhibition of RAW264.7 macrophage induced by culture supernatants of melanoma cells Open
Two purified galactofucoidans, SFA1B-1 and SFA1C-2, with apparent molecular weights of 1.6 × 105 and 8.9 × 104, respectively, were isolated from Sargassum fusiforme via ion-exchange and gel-filtration column chromatography. SFA1B-1 and SFA…
View article: Structural Characterization of Water-Soluble Polysaccharides from Sophora flavescensAit. and Their Anti-Inflammatory Evaluation Based on NO Release
Structural Characterization of Water-Soluble Polysaccharides from Sophora flavescensAit. and Their Anti-Inflammatory Evaluation Based on NO Release Open
Background: The dried roots of Sophora flavescens Ait. are traditionally used as Sophora Flavescens (Kushen in Chinese) to treat inflammatory diseases. It is traditionally served as a decoction, and polysaccharides represent one the major …
View article: Solid fuels for cooking and tobacco use and risk of major chronic liver disease mortality: a prospective cohort study of 0.5 million Chinese adults
Solid fuels for cooking and tobacco use and risk of major chronic liver disease mortality: a prospective cohort study of 0.5 million Chinese adults Open
Background Harmful substances in solid fuel and tobacco smoke are believed to enter the bloodstream via inhalation and to be metabolized in the liver, leading to chronic liver damage. However, little is known about the independent and join…
View article: Conventional and genetic evidence on alcohol and vascular disease aetiology: a prospective study of 500 000 men and women in China
Conventional and genetic evidence on alcohol and vascular disease aetiology: a prospective study of 500 000 men and women in China Open
View article: Biosynthesis of dendroketose from different carbon sources using in vitro and in vivo metabolic engineering strategies
Biosynthesis of dendroketose from different carbon sources using in vitro and in vivo metabolic engineering strategies Open
View article: Associations of General and Central Adiposity With Incident Diabetes in Chinese Men and Women
Associations of General and Central Adiposity With Incident Diabetes in Chinese Men and Women Open
OBJECTIVE We assess associations of general and central adiposity in middle age and of young adulthood adiposity with incident diabetes in adult Chinese and estimate the associated population burden of diabetes. RESEARCH DESIGN AND METHODS…
View article: Risks and Population Burden of Cardiovascular Diseases Associated with Diabetes in China: A Prospective Study of 0.5 Million Adults
Risks and Population Burden of Cardiovascular Diseases Associated with Diabetes in China: A Prospective Study of 0.5 Million Adults Open
Among Chinese adults, diabetes is associated with significantly increased risks of major cardiovascular diseases. The increasing prevalence and younger age of onset of diabetes foreshadow greater diabetes-attributable disease burden in Chi…
View article: The High Prevalence of Low HDL-Cholesterol Levels and Dyslipidemia in Rural Populations in Northwestern China
The High Prevalence of Low HDL-Cholesterol Levels and Dyslipidemia in Rural Populations in Northwestern China Open
This study found that the prevalence of low HDL-cholesterol was 67.6% and 55.4% for males and females. Male gender, non-alcohol drinker, BMI and central obesity were important risk factors for low HDL-cholesterol in Chinese adults.