Ping Yu Xiong
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View article: Prevalence of survival without major morbidity and associated risk factors among very preterm infants: a systematic review and meta-analysis
Prevalence of survival without major morbidity and associated risk factors among very preterm infants: a systematic review and meta-analysis Open
Introduction Survival without major morbidity (SWMM) in very preterm infants represents a critical outcome measure in neonatal care. This systematic review evaluates both the prevalence of SWMM among infants born before 32 weeks' gestation…
View article: Prediction models for intraventricular hemorrhage in very preterm infants: a systematic review
Prediction models for intraventricular hemorrhage in very preterm infants: a systematic review Open
Objective To provide an overview and critical appraisal of prediction models for Intraventricular hemorrhage (IVH) in very preterm infants. Methods Our comprehensive literature search encompassed PubMed (MEDLINE), Embase, Web of Science, t…
View article: Prognostic Significance of Homocysteine Levels in Patients with ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: A Propensity Score Matching and Weighting Analysis
Prognostic Significance of Homocysteine Levels in Patients with ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: A Propensity Score Matching and Weighting Analysis Open
Background: Elevated homocysteine (Hcy) levels have been linked to poorer outcomes in acute coronary syndrome. This study aimed to assess the predictive value of elevated Hcy levels for major adverse cardiac events (MACE) in patients with …
View article: Early diaphragm dysfunction assessed by ultrasonography after cardiac surgery: a retrospective cohort study
Early diaphragm dysfunction assessed by ultrasonography after cardiac surgery: a retrospective cohort study Open
Objective Approximately 10%–70% of patients may develop diaphragmatic dysfunction after cardiac surgery, which may lead to delayed weaning from mechanical ventilation, increased ICU stays, postoperative hospitalization stays, and respirato…
View article: DISC1 as a prognostic biomarker correlated with immune infiltrates in gastric cancer
DISC1 as a prognostic biomarker correlated with immune infiltrates in gastric cancer Open
View article: An integrated proteomic and transcriptomic signature of the failing right ventricle in monocrotaline induced pulmonary arterial hypertension in male rats
An integrated proteomic and transcriptomic signature of the failing right ventricle in monocrotaline induced pulmonary arterial hypertension in male rats Open
Aim: Pulmonary arterial hypertension (PAH) is an obstructive pulmonary vasculopathy that results in death from right ventricular failure (RVF). There is limited understanding of the molecular mechanisms of RVF in PAH. Methods: In a PAH-RVF…
View article: Inhibiting pyruvate kinase muscle isoform 2 regresses group 2 pulmonary hypertension induced by supra‐coronary aortic banding
Inhibiting pyruvate kinase muscle isoform 2 regresses group 2 pulmonary hypertension induced by supra‐coronary aortic banding Open
Introduction Group 2 pulmonary hypertension (PH) has no approved PH‐targeted therapy. Metabolic remodelling, specifically a biventricular increase in pyruvate kinase muscle (PKM) isozyme 2 to 1 ratio, occurs in rats with group 2 PH induced…
View article: Using health administrative data to identify patients with pulmonary hypertension: A single center, proof of concept validation study in Ontario, Canada
Using health administrative data to identify patients with pulmonary hypertension: A single center, proof of concept validation study in Ontario, Canada Open
Real‐world identification of pulmonary hypertension (PH) is largely based on the use of administrative databases identified by ICD codes. This approach has not been validated. The aim of this study was to validate a diagnosis of PH and its…
View article: Supra‐coronary aortic banding improves right ventricular function in experimental pulmonary arterial hypertension in rats by increasing systolic right coronary artery perfusion
Supra‐coronary aortic banding improves right ventricular function in experimental pulmonary arterial hypertension in rats by increasing systolic right coronary artery perfusion Open
Aim Pulmonary arterial hypertension (PAH) results in right ventricular (RV) dysfunction owing, in part, to RV ischemia. The relative contribution of RV microvascular rarefaction vs reduced right coronary artery perfusion pressure (RCA‐PP) …
View article: Evaluation of the Impact of an Echocardiographic Diagnosis of Pulmonary Hypertension on Patient Outcomes
Evaluation of the Impact of an Echocardiographic Diagnosis of Pulmonary Hypertension on Patient Outcomes Open
Despite the finding that an elevated RVSP ≥ 30 mm Hg is common and predicts adverse outcomes, most patients with elevated RVSP are not reported as having PH or investigated. The significance of the elevated RVSP is underappreciated.
View article: Biventricular Increases in Mitochondrial Fission Mediator (MiD51) and Proglycolytic Pyruvate Kinase (PKM2) Isoform in Experimental Group 2 Pulmonary Hypertension-Novel Mitochondrial Abnormalities
Biventricular Increases in Mitochondrial Fission Mediator (MiD51) and Proglycolytic Pyruvate Kinase (PKM2) Isoform in Experimental Group 2 Pulmonary Hypertension-Novel Mitochondrial Abnormalities Open
Introduction: Group 2 pulmonary hypertension (PH), defined as a mean pulmonary arterial pressure ≥25 mmHg with elevated pulmonary capillary wedge pressure >15 mmHg, has no approved therapy and patients often die from right ventricul…
View article: Models and Molecular Mechanisms of World Health Organization Group 2 to 4 Pulmonary Hypertension
Models and Molecular Mechanisms of World Health Organization Group 2 to 4 Pulmonary Hypertension Open
View article: Mediastinal Parathyroid Adenoma Mimicking Cancer Metastatic to Bone
Mediastinal Parathyroid Adenoma Mimicking Cancer Metastatic to Bone Open
Objective: Mediastinal parathyroid adenomas are rare in clinical practice. We report a case that mimicked cancer metastatic to bone on initial workup to increase awareness of this differential diagnosis in the evaluation of patients presen…