Peng Yuan
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View article: Structural and functional brain alterations associated with pain in Parkinson’s disease
Structural and functional brain alterations associated with pain in Parkinson’s disease Open
Pain is a common non-motor symptom in Parkinson's disease (PD), but its neural basis remains unclear. This study included 65 PD patients with pain (PDP), 55 without pain (nPDP), and 35 healthy controls (HC), who underwent structural, funct…
View article: The feasibility of the radiomics models for tumor-infiltrating lymphocytes level prediction in breast cancer based on dynamic contrast-enhanced MRI
The feasibility of the radiomics models for tumor-infiltrating lymphocytes level prediction in breast cancer based on dynamic contrast-enhanced MRI Open
View article: Cross-sectional study on exercise capacity in obese patients with severe obstructive sleep apnea syndrome
Cross-sectional study on exercise capacity in obese patients with severe obstructive sleep apnea syndrome Open
Objective To explore the exercise capacity in obese patients with severe obstructive sleep apnea syndrome (OSAS) through cardiopulmonary exercise test (CPET). Methods In this cross-sectional study, patients with simple obesity (36 cases) a…
View article: Construction and Validation of a Nomogram Prediction Model for the Risk of Cefoperazone Sodium/Sulbactam Sodium-Related Coagulation Disorders
Construction and Validation of a Nomogram Prediction Model for the Risk of Cefoperazone Sodium/Sulbactam Sodium-Related Coagulation Disorders Open
The nomogram model effectively identifies high-risk patients, indicating that attention should be paid to the risk of coagulation disorders in patients with the above risk factors during CPZ/SAM treatment.
View article: The impact of maternal health and lifestyle on low birth weight: a prospective cohort study
The impact of maternal health and lifestyle on low birth weight: a prospective cohort study Open
Background To explore maternal pregestational and periconceptional factors associated with low birth weight in offspring and inform the development of targeted interventions. Methods A prospective birth cohort involving 34,104 pregnant wom…
View article: Disrupted Glucose Metabolism Covariance Network in Amyotrophic Lateral Sclerosis.
Disrupted Glucose Metabolism Covariance Network in Amyotrophic Lateral Sclerosis. Open
Our findings may provide valuable biomarkers for monitoring the progression of ALS and suggest potential mechanistic pathways for the development of innovative therapeutic strategies for this disorder.
View article: Progressive subcortical involvement as spinocerebellar ataxia type 3 advances
Progressive subcortical involvement as spinocerebellar ataxia type 3 advances Open
Background and objectives Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disease characterized by heterogeneous motor and nonmotor manifestations. The progressive pattern of subcortical shape abnormalities and thei…
View article: MNX1-AS1 suppresses chemosensitivity by activating the PI3K/AKT pathway in breast cancer
MNX1-AS1 suppresses chemosensitivity by activating the PI3K/AKT pathway in breast cancer Open
Long noncoding RNAs (lncRNAs) critically regulate tumorigenesis and chemosensitivity. Despite the pivotal role of lncRNAs in breast cancer (BC), their specific functions and underlying mechanism, particularly in the context of drug resista…
View article: The Identification of Novel Prognostic and Predictive Biomarkers in Breast Cancer via the Elucidation of Tumor Ecotypes Using Ecotyper
The Identification of Novel Prognostic and Predictive Biomarkers in Breast Cancer via the Elucidation of Tumor Ecotypes Using Ecotyper Open
Background Breast cancer is a highly heterogeneous disease, characterized by tumor and nontumor cells at various cell states. Ecotyper is an innovative machine learning framework that quantifies the tumor microenvironment and delineates th…
View article: Trastuzumab deruxtecan in advanced breast cancer patients with brain metastases or leptomeningeal metastases
Trastuzumab deruxtecan in advanced breast cancer patients with brain metastases or leptomeningeal metastases Open
View article: Potential prognostic value of HER2/CEP17 FISH ratio in HER2-positive non-metastatic breast cancer: a real-world study
Potential prognostic value of HER2/CEP17 FISH ratio in HER2-positive non-metastatic breast cancer: a real-world study Open
For non-metastatic HER2-positive BC with or without trastuzumab treatment, the HER2/CEP17 ratio did not predict DFS and OS. However, our study supported that HER2 ultra-positive group had a worse DFS than the normal-positive group among no…
View article: Novel insight of critical genes involved in breast cancer brain metastasis: evidence from a cross-tissue transcriptome association study and validation through external clinical cohorts
Novel insight of critical genes involved in breast cancer brain metastasis: evidence from a cross-tissue transcriptome association study and validation through external clinical cohorts Open
Our study identified key gene CASP8, which was associated with BCBM, providing new insights into the occurrence of BCBM.
View article: Genetic associations of plasma proteins and breast cancer identify potential therapeutic drug candidates
Genetic associations of plasma proteins and breast cancer identify potential therapeutic drug candidates Open
To address the pressing need to improve breast cancer outcomes, we identify 9 plasma proteins with significant associations to breast cancer, namely ULK3, CSK, ASIP, TLR1 in breast cancer, ADH5, SARS2, ULK3, UBE2N in Luminal A subtype, PEX…
View article: Human menopausal gonadotropin (HMG) combined different doses of letrozole for treating anovulatory infertility in patients with polycystic ovary syndrome: a randomized controlled trial
Human menopausal gonadotropin (HMG) combined different doses of letrozole for treating anovulatory infertility in patients with polycystic ovary syndrome: a randomized controlled trial Open
View article: Availability and Characteristics of Support Groups for People With Head and Neck Cancer in Australia
Availability and Characteristics of Support Groups for People With Head and Neck Cancer in Australia Open
Aim Support groups are an effective way to improve quality of life (QoL) in cancer patients. Targeted support groups for head and neck cancer (HNC) can also help patients address specific treatment and survivorship challenges. The aim of t…
View article: Hepatocyte-derived liver progenitor-like cells attenuate liver cirrhosis via induction of apoptosis in hepatic stellate cells
Hepatocyte-derived liver progenitor-like cells attenuate liver cirrhosis via induction of apoptosis in hepatic stellate cells Open
Background: Cell therapy demonstrates promising potential as a substitute therapeutic approach for liver cirrhosis. We have developed a strategy to effectively expand murine and human hepatocyte-derived liver progenitor-like cells (HepLPCs…
View article: Characteristics of cardiopulmonary exercise capacity in adults with different degrees of obesity
Characteristics of cardiopulmonary exercise capacity in adults with different degrees of obesity Open
Objective To explore the characteristics of cardiopulmonary exercise capacity in adults with different degrees of obesity through cardiopulmonary exercise test (CPET). Methods From September 2019 to January 2024, the data of patients under…
View article: The effects and predictive values of novel anthropometric parameters on uric acid levels and hyperuricemia in adults
The effects and predictive values of novel anthropometric parameters on uric acid levels and hyperuricemia in adults Open
Novel anthropometric indices are more closely related to metabolic abnormalities than traditional anthropometric indices. Fewer studies have been conducted based on the relationship between novel anthropometric indicators and hyperuricemia…
View article: Childhood exposure to per- and polyfluoroalkyl substances during eating activities: Occurrence, exposure, and developmental risk
Childhood exposure to per- and polyfluoroalkyl substances during eating activities: Occurrence, exposure, and developmental risk Open
View article: Risk factors for in-hospital heart failure in patients with acute myocardial infarction and construction of predictive models
Risk factors for in-hospital heart failure in patients with acute myocardial infarction and construction of predictive models Open
In-hospital heart failure in AMI patients is associated with older age, diabetes, elevated Gensini score, reduced LVEF, and increased NT-proBNP levels. The developed nomogram model effectively predicts the risk of heart failure in this pop…
View article: Combined pyrotinib and fulvestrant for hormone receptor‐positive and HER2‐positive metastatic breast cancer: A multicenter, single‐arm, phase II trial
Combined pyrotinib and fulvestrant for hormone receptor‐positive and HER2‐positive metastatic breast cancer: A multicenter, single‐arm, phase II trial Open
This multicenter, single‐arm, phase II clinical trial (NCT04034589) evaluated the efficacy and safety of pyrotinib combined with fulvestrant in patients with HR‐positive/HER2‐positive metastatic breast cancer who had experienced trastuzuma…
View article: Correction: Quantification of intratumoral heterogeneity using habitat-based MRI radiomics to identify HER2-positive, -low and -zero breast cancers: a multicenter study
Correction: Quantification of intratumoral heterogeneity using habitat-based MRI radiomics to identify HER2-positive, -low and -zero breast cancers: a multicenter study Open
View article: Quantification of intratumoral heterogeneity using habitat-based MRI radiomics to identify HER2-positive, -low and -zero breast cancers: a multicenter study
Quantification of intratumoral heterogeneity using habitat-based MRI radiomics to identify HER2-positive, -low and -zero breast cancers: a multicenter study Open
View article: Incoherence-to-coherence crossover observed in charge-density-wave material 1T-TiSe2
Incoherence-to-coherence crossover observed in charge-density-wave material 1T-TiSe2 Open
View article: Transient-resting culture after activation enhances the generation of CD8+ stem cell-like memory T cells from peripheral blood mononuclear cells
Transient-resting culture after activation enhances the generation of CD8+ stem cell-like memory T cells from peripheral blood mononuclear cells Open
Adoptive cell therapy (ACT) has revolutionized the treatment of patients with cancer. The success of ACT depends largely on transferred T cell status, particularly their less-differentiated state with stem cell-like properties, which enhan…
View article: Disulfidptosis: disulfide stress‐induced novel cell death pathway
Disulfidptosis: disulfide stress‐induced novel cell death pathway Open
The aberrant accumulation of intracellular disulfides in solute carrier family 7 member 11 (SLC7A11)high cells under glucose starvation induces disulfidptosis. Disulfidptosis has shown potential in tumor diagnosis and treatment.
View article: Effects of novel anthropometric parameters on uric acid levels and hyperuricemia in adults and their predictive value: a cross-sectional study in Su-Wuxi-Chang area, Jiangsu, China
Effects of novel anthropometric parameters on uric acid levels and hyperuricemia in adults and their predictive value: a cross-sectional study in Su-Wuxi-Chang area, Jiangsu, China Open
Novel anthropometric indices are more closely related to metabolic abnormalities than traditional anthropometric indices. Fewer studies have been conducted based on the relationship between novel anthropometric indicators and hyperuricemia…
View article: Prognostic factors and benefit populations of ovarian function suppression in premenopausal <scp>HR</scp>+/<scp>HER2</scp>+ early‐stage breast cancer patients who received trastuzumab: Evidence from a real‐world study with long‐term follow‐up
Prognostic factors and benefit populations of ovarian function suppression in premenopausal <span>HR</span>+/<span>HER2</span>+ early‐stage breast cancer patients who received trastuzumab: Evidence from a real‐world study with long‐term follow‐up Open
Background Hormone receptor‐positive (HR+)/human epidermal growth factor receptor 2‐positive (HER2+) breast cancer exhibits considerable heterogeneity, and it is of great interest whether patients with premenopausal HR+/HER2+ breast cancer…
View article: Theoretical Screening of Multifunctional Single-Atom Catalysts Supported by Vs2 Monolayer for the Electrocatalytic Hydrogen Evolution, Oxygen Evolution and Oxygen Reduction Reactions
Theoretical Screening of Multifunctional Single-Atom Catalysts Supported by Vs2 Monolayer for the Electrocatalytic Hydrogen Evolution, Oxygen Evolution and Oxygen Reduction Reactions Open
View article: 294P Prognostic significance and evolution of HER2 zero, HER2 low and HER2 positive in breast cancer after neoadjuvant treatment
294P Prognostic significance and evolution of HER2 zero, HER2 low and HER2 positive in breast cancer after neoadjuvant treatment Open