Penghua Fang
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View article: Scorpion-Centipede extracts mitigate ovariectomy-induced osteoporosis in mice through facilitating Cx3cr1 expression
Scorpion-Centipede extracts mitigate ovariectomy-induced osteoporosis in mice through facilitating Cx3cr1 expression Open
Objectives Scorpion and Centipede (SC) is an ancient formula of traditional Chinese medicine that is commonly utilized in a range of disorders, and it has been shown to have pharmacological effects on postmenopausal osteoporosis (PMOP). Ho…
View article: Crosstalk between perivascular adipose tissue and adipocyte-derived peptide in the pathogenesis of diabetic cardiomyopathy
Crosstalk between perivascular adipose tissue and adipocyte-derived peptide in the pathogenesis of diabetic cardiomyopathy Open
View article: Serum Isthmin-1 levels are positively correlated with macrovascular complications in type 2 diabetic patients
Serum Isthmin-1 levels are positively correlated with macrovascular complications in type 2 diabetic patients Open
Objective Isthmin-1 (ISM-1), a novel adipokine, has dual effects of increasing fat and glucose uptake while inhibiting hepatic fat synthesis. However, little literature has been found dealing with ISM-1 levels in type 2 diabetes patients w…
View article: Circulating prosaposin and ependymin-related protein 1 levels are correlated with insulin resistance in type 2 diabetic patients
Circulating prosaposin and ependymin-related protein 1 levels are correlated with insulin resistance in type 2 diabetic patients Open
Objective Skeletal muscle and adipose tissues secrete myokines and adipokines to regulate energy metabolism. Experimental evidence indicates that prosaposin (PSAP) and ependymin-related protein 1 (EPDR1) are involved in the regulation of t…
View article: Role of lactoferrin and its derived peptides in metabolic syndrome treatment
Role of lactoferrin and its derived peptides in metabolic syndrome treatment Open
The prevalence of metabolic syndrome is increasing globally year by year, which has prompted researchers to actively seek and develop natural biotherapeutics to address this challenge. Lactoferrin (LF), as a multifunctional iron-binding na…
View article: Novel hypothalamic pathways for metabolic effects of spexin
Novel hypothalamic pathways for metabolic effects of spexin Open
One of the main underlying etiologies of type 2 diabetes (T2DM) is insulin resistance, which is most frequently caused by obesity. Notably, the deregulation of adipokine secretion from visceral adiposity has been identified as a crucial ch…
View article: Rhein targets macrophage SIRT2 to promote adipose tissue thermogenesis in obesity in mice
Rhein targets macrophage SIRT2 to promote adipose tissue thermogenesis in obesity in mice Open
View article: Acetylation of p65Lys310 by p300 in macrophages mediates anti-inflammatory property of berberine
Acetylation of p65Lys310 by p300 in macrophages mediates anti-inflammatory property of berberine Open
View article: The Value of Combining Wu Ling San Plus and Minus with Repaglinide in the Treatment of Obese Type 2 Diabetes
The Value of Combining Wu Ling San Plus and Minus with Repaglinide in the Treatment of Obese Type 2 Diabetes Open
Objective: To investigate the clinical value and practical effects of the treatment of obese type 2 diabetes mellitus patients with Wu Ling San plus and minus combined with Repaglinide. Methods: Twenty-two obese type 2 diabetic patients at…
View article: Emerging roles of histone deacetylases in adaptive thermogenesis
Emerging roles of histone deacetylases in adaptive thermogenesis Open
Brown and beige adipose tissues regulate body energy expenditure through adaptive thermogenesis, which converts energy into heat by oxidative phosphorylation uncoupling. Although promoting adaptive thermogenesis has been demonstrated to be…
View article: Puffball spores improve wound healing in a diabetic rat model
Puffball spores improve wound healing in a diabetic rat model Open
Persistent chronic oxidative stress is a primary pathogenic characteristics of diabetic foot ulcers. Puffball spores are a traditional Chinese medicine used to treat diabetic foot ulcers infections and bedsores. However, their effects agai…
View article: Emerging Protective Actions of PGC‐1<i>α</i> in Diabetic Nephropathy
Emerging Protective Actions of PGC‐1<i>α</i> in Diabetic Nephropathy Open
Renal impairment is affected by various mechanisms of oxidative stress, mitochondrial dysfunction, and basement membrane thickening, which are the major causes of renal dysfunction in diabetes. Of note, hyperglycemia‐induced mitochondrial …
View article: Upregulation of adiponectin by Ginsenoside Rb1 contributes to amelioration of hepatic steatosis induced by high fat diet
Upregulation of adiponectin by Ginsenoside Rb1 contributes to amelioration of hepatic steatosis induced by high fat diet Open
View article: Loss of chemerin triggers bone remodeling in vivo and in vitro
Loss of chemerin triggers bone remodeling in vivo and in vitro Open
Taken together, these data suggest an inhibitive effect of chemerin on osteoblast differentiation and proliferation through inhibition of Wnt/β-catenin signaling, as well as a stimulative effect of chemerin on osteoclast differentiation an…
View article: Galanin expression is down-regulated in patients with gastric cancer
Galanin expression is down-regulated in patients with gastric cancer Open
Objective To investigate whether galanin and its three receptors (Gal-R1, Gal-R2, Gal-R3) contribute to development of gastric cancer. Methods Preoperative and postoperative fasting venous blood samples were collected from 34 patients with…
View article: Effect of Baicalein on GLUT4 Translocation in Adipocytes of Diet-Induced Obese Mice
Effect of Baicalein on GLUT4 Translocation in Adipocytes of Diet-Induced Obese Mice Open
Background/Aims: Although baicalein has been shown to increase insulin sensitivity in liver of mice, there is no literature available about the effect of baicalein on glucose transporter 4 (GLUT4) translocation from intracellular membrane …
View article: Akt2-Dependent Beneficial Effect of Galanin on Insulin-Induced Glucose Uptake in Adipocytes of Diabetic Rats
Akt2-Dependent Beneficial Effect of Galanin on Insulin-Induced Glucose Uptake in Adipocytes of Diabetic Rats Open
Background/Aims: Glucose uptake occurs via the activation of an insulin-signaling cascade, resulting in the translocation of glucose transporter 4 (GLUT4) to the plasma membrane of adipocytes and myocytes. Recent research found that galani…
View article: Central Administration of Galanin Receptor 1 Agonist Boosted Insulin Sensitivity in Adipose Cells of Diabetic Rats
Central Administration of Galanin Receptor 1 Agonist Boosted Insulin Sensitivity in Adipose Cells of Diabetic Rats Open
Our previous studies testified the beneficial effect of central galanin on insulin sensitivity of type 2 diabetic rats. The aim of the study was further to investigate whether central M617, a galanin receptor 1 agonist, can benefit insulin…
View article: Elevated Circulating hsa-miR-106b, hsa-miR-26a, and hsa-miR-29b in Type 2 Diabetes Mellitus with Diarrhea-Predominant Irritable Bowel Syndrome
Elevated Circulating hsa-miR-106b, hsa-miR-26a, and hsa-miR-29b in Type 2 Diabetes Mellitus with Diarrhea-Predominant Irritable Bowel Syndrome Open
Background and Aims . Although the differential expression of microRNA (miRNA) genes has been identified in many diseases, little information exists concerning the miRNA expression profile in type 2 diabetes mellitus (T2DM) with diarrhea-p…
View article: Melittin induces human gastric cancer cell apoptosis<i>via</i>activation of mitochondrial pathway
Melittin induces human gastric cancer cell apoptosis<i>via</i>activation of mitochondrial pathway Open
Melittin can induce apoptosis of human gastric cancer (GC) cells through the mitochondria pathways, and it may be a potent agent in the treatment of human GC.
View article: Intracerebroventricular Injection of Alarin Increased Glucose Uptake in Skeletal Muscle of Diabetic Rats
Intracerebroventricular Injection of Alarin Increased Glucose Uptake in Skeletal Muscle of Diabetic Rats Open
In order to investigate the central effect of alarin on glucose uptake, we administered alarin and/ or its inhibitor, ala6-25Cys into the cerebral ventricles of the type 2 diabetic rats. Then the relative parameters about glucose uptake in…