Penghui Yang
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View article: LongSpec: Long-Context Lossless Speculative Decoding with Efficient Drafting and Verification
LongSpec: Long-Context Lossless Speculative Decoding with Efficient Drafting and Verification Open
As Large Language Models (LLMs) can now process extremely long contexts, efficient inference over these extended inputs has become increasingly important, especially for emerging applications like LLM agents that highly depend on this capa…
View article: Effects of the Mediterranean Diet on metabolic indices and quality of life in cancer patients: A systematic review and meta-analysis of randomized controlled trials
Effects of the Mediterranean Diet on metabolic indices and quality of life in cancer patients: A systematic review and meta-analysis of randomized controlled trials Open
The Mediterranean diet (MD) had a protective effect on cancer prevention. However, there has not been a systematic evaluation of the diet's comprehensive effects on metabolic indices and quality of life in cancer patients. The present meta…
View article: ChatCell: Facilitating Single-Cell Analysis with Natural Language
ChatCell: Facilitating Single-Cell Analysis with Natural Language Open
As Large Language Models (LLMs) rapidly evolve, their influence in science is becoming increasingly prominent. The emerging capabilities of LLMs in task generalization and free-form dialogue can significantly advance fields like chemistry …
View article: A Single-Cell Landscape of Human Liver Transplantation Reveals a Pathogenic Immune Niche Associated with Early Allograft Dysfunction
A Single-Cell Landscape of Human Liver Transplantation Reveals a Pathogenic Immune Niche Associated with Early Allograft Dysfunction Open
Liver transplantation (LT) is the standard therapy for individuals afflicted with end-stage liver disease. Despite notable advancements in LT technology, the incidence of early allograft dysfunction (EAD) remains a critical concern, exacer…
View article: Retraction: Decreased long intergenic noncoding RNA P7 predicts unfavorable prognosis and promotes tumor proliferation via the modulation of the STAT1-MAPK pathway in hepatocellular carcinoma
Retraction: Decreased long intergenic noncoding RNA P7 predicts unfavorable prognosis and promotes tumor proliferation via the modulation of the STAT1-MAPK pathway in hepatocellular carcinoma Open
// Sijie Cheng 1 , Tieling Li 2 , Cheng Wang 2 , Keyu Wang 3 , Chengcai Lai 3 , Jin Yan 1 , Hongxia Fan 1 , Fang Sun 1 , Zhaohai Wang 1 , Peirui Zhang 1 , Linxiang Yu 1 , Zhixian Hong 1 , Guanglin Lei 1 , Baijun Sun 1 , Yuan Gao 1 , Zhaohu…
View article: Protective efficacy of a novel recombinant influenza virus carrying partial human metapneumovirus F protein epitopes
Protective efficacy of a novel recombinant influenza virus carrying partial human metapneumovirus F protein epitopes Open
Human metapneumovirus (HMPV) is a leading cause of acute respiratory tract infections in infants and children. Currently, no approved HMPV vaccine is available. We developed a novel recombinant influenza virus, which carried partial HMPV F…
View article: Upregulation of long noncoding RNA W42 promotes tumor development by binding with DBN1 in hepatocellular carcinoma
Upregulation of long noncoding RNA W42 promotes tumor development by binding with DBN1 in hepatocellular carcinoma Open
In vitro and in vivo results suggested that the novel lncRNA W42, which is upregulated in HCC, may serve as a potential candidate prognostic biomarker and therapeutic target in HCC patients.
View article: A method of fast quality control inspection of loop heat pipe
A method of fast quality control inspection of loop heat pipe Open
The dynamic behaviour of loop heat pipe (LHP) changes with heat load and physical properties of LHP such as fluid charging, wick material, and tolerance in manufacture. The start-up phenomena of a LHP can be classified into four modes, acc…
View article: Long non-coding ribonucleic acid W5 inhibits progression and predicts favorable prognosis in hepatocellular carcinoma
Long non-coding ribonucleic acid W5 inhibits progression and predicts favorable prognosis in hepatocellular carcinoma Open
These results showed that lncRNA W5 is down-regulated in HCC, and it may suppress HCC progression and predict poor clinical outcomes in patients with HCC. LncRNA W5 may serve as a potential HCC prognostic biomarker in addition to a therape…
View article: A Long Non-coding RNA IVRPIE Promotes Host Antiviral Immune Responses Through Regulating Interferon β1 and ISG Expression
A Long Non-coding RNA IVRPIE Promotes Host Antiviral Immune Responses Through Regulating Interferon β1 and ISG Expression Open
Accumulating studies have shown that long non-coding RNAs (lncRNAs) modulate multiple biological processes, including immune response. However, the underlying mechanisms of lncRNAs regulating host antiviral immune response are not well elu…
View article: Up-Regulated CCDC34 Contributes to the Proliferation and Metastasis of Hepatocellular Carcinoma
Up-Regulated CCDC34 Contributes to the Proliferation and Metastasis of Hepatocellular Carcinoma Open
Zhibin Lin,* Shibin Qu,* Wei Peng,* Peijun Yang, Ruohan Zhang, Pengcheng Zhang, Dongnan Guo, Jianbing Du, Wenlong Wu, Kaishan Tao, Jianlin Wang Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, X…
View article: Long noncoding RNA<i>AVAN</i>promotes antiviral innate immunity by interacting with TRIM25 and enhancing the transcription of FOXO3a
Long noncoding RNA<i>AVAN</i>promotes antiviral innate immunity by interacting with TRIM25 and enhancing the transcription of FOXO3a Open
Accumulating evidence has shown that long noncoding RNAs (lncRNAs) are involved in several biological processes, including immune responses. However, the role of lncRNAs in antiviral innate immune responses remains largely unexplored. Here…
View article: SET domain containing 1B gene is mutated in primary hepatic neuroendocrine tumors
SET domain containing 1B gene is mutated in primary hepatic neuroendocrine tumors Open
Primary hepatic neuroendocrine tumors (PHNETs) are extremely rare NETs originating from the liver. These tumors are associated with heterogeneous prognosis, and few treatment targets for PHNETs have been identified. Because the major genet…
View article: Expanded Expression Landscape and Prioritization of Circular RNAs in Mammals
Expanded Expression Landscape and Prioritization of Circular RNAs in Mammals Open
Circular RNAs (circRNAs) are emerging as essential regulators of various biological and disease processes. To comprehensively understand the diversity of circRNAs and prioritize their importance, we present a large-scale study of circRNA r…
View article: High‑level SETD1B gene expression is associated with unfavorable prognosis in hepatocellular carcinoma
High‑level SETD1B gene expression is associated with unfavorable prognosis in hepatocellular carcinoma Open
The SET domain‑containing 1B (SETD1B) gene is involved in multiple biological processes, including tumor development and progression. However, the role of SETD1B in hepatocellular carcinoma (HCC) is largely unexplored. The present study, e…
View article: Somatic mutation profiling of liver and biliary cancer by targeted next generation sequencing
Somatic mutation profiling of liver and biliary cancer by targeted next generation sequencing Open
Liver and biliary cancers are highly lethal cancer types lacking effective treatments. The somatic mutations, particularly those with low mutant allele frequencies, in Chinese patients with liver and biliary cancer have not been profiled, …
View article: Downregulation of BRAF‑activated non‑protein coding RNA in patients with hepatitis B virus‑associated hepatocellular carcinoma
Downregulation of BRAF‑activated non‑protein coding RNA in patients with hepatitis B virus‑associated hepatocellular carcinoma Open
Long non-coding RNAs (lncRNAs) have been investigated as a novel class of regulators of cellular processes, including cell growth, apoptosis and carcinogenesis. lncRNA BRAF-activated non-protein coding RNA (BANCR) has recently been reveale…
View article: Intradermal delivery of a fractional dose of influenza H7N9 split vaccine elicits protective immunity in mice and rats
Intradermal delivery of a fractional dose of influenza H7N9 split vaccine elicits protective immunity in mice and rats Open
Vaccination is the most effective method of preventing the spread of the influenza virus. However, the traditional intramuscular (IM) immunization causes fear, pain, and cross infection. In contrast, needle-free (NF) immunization is quick …
View article: Decreased long intergenic noncoding RNA P7 predicts unfavorable prognosis and promotes tumor proliferation via the modulation of the STAT1-MAPK pathway in hepatocellular carcinoma
Decreased long intergenic noncoding RNA P7 predicts unfavorable prognosis and promotes tumor proliferation via the modulation of the STAT1-MAPK pathway in hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) is the most common neoplasm and is a leading cause of cancer-related death. Despite advances in the diagnosis and management of HCC, its prognosis remain unfavorable. Accumulating evidence has shown that long…
View article: miR-194 Inhibits Innate Antiviral Immunity by Targeting FGF2 in Influenza H1N1 Virus Infection
miR-194 Inhibits Innate Antiviral Immunity by Targeting FGF2 in Influenza H1N1 Virus Infection Open
Fibroblast growth factor 2 (FGF2 or basic FGF) regulates a wide range of cell biological functions including proliferation, angiogenesis, migration, differentiation, and injury repair. However, the roles of FGF2 and the underlying mechanis…
View article: Basic fibroblast growth factor protects against influenza A virus-induced acute lung injury by recruiting neutrophils
Basic fibroblast growth factor protects against influenza A virus-induced acute lung injury by recruiting neutrophils Open
Influenza virus (IAV) infection is a major cause of severe respiratory illness that affects almost every country in the world. IAV infections result in respiratory illness and even acute lung injury and death, but the underlying mechanisms…
View article: C-C Motif Chemokine Ligand 2 (CCL2) Mediates Acute Lung Injury Induced by Lethal Influenza H7N9 Virus
C-C Motif Chemokine Ligand 2 (CCL2) Mediates Acute Lung Injury Induced by Lethal Influenza H7N9 Virus Open
An avian-origin influenza A (H7N9) virus was a cause for concern in China in the spring of 2013. Most H7N9 infections resulted in acute respiratory distress syndrome (ARDS), which is a severe form of acute lung injury (ALI) that contribute…
View article: Virus-like particle vaccine by intranasal vaccination elicits protective immunity against respiratory syncytial viral infection in mice
Virus-like particle vaccine by intranasal vaccination elicits protective immunity against respiratory syncytial viral infection in mice Open
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory infection in infants and children, but there is still no licensed vaccine available. In this report, we developed virus-like particle (VLP) vaccines based on the Bac…
View article: Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus
Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus Open
View article: Primer pairs used for real-time PCR.
Primer pairs used for real-time PCR. Open
Primer pairs of human FGFR1, FGFR2, FGFR3, FGFR4, influenza virus M1, and GAPDH were designed using Primer 5.0 and presented in Table 1.Primer pairs used for real-time PCR.
View article: Lentivirus-mediated FGFR1 overexpression in A549 cells significantly decreased influenza A virus replication.
Lentivirus-mediated FGFR1 overexpression in A549 cells significantly decreased influenza A virus replication. Open
A549 cells were infected with recombinant lentivirus expressing FGFR1, FGFR4, or GFP (as a control). After 48 h, A549 cells were infected with PR8 virus (MOI = 1). The supernatants and lysates of A549 cells were harvested after 24 h virus …
View article: Lentivirus-delivered FGFR1 overexpression affected influenza A virus internalization, but not binding, during virus entry.
Lentivirus-delivered FGFR1 overexpression affected influenza A virus internalization, but not binding, during virus entry. Open
A549 cells with FGFR1, FGFR4, or GFP overexpression were pretreated with or without sialidase, and then infected with influenza A/PR8 (A) or H5N1 (B). The procedures were described in detail in the Methods, virus binding and …
View article: A Functional Role of Fibroblast Growth Factor Receptor 1 (FGFR1) in the Suppression of Influenza A Virus Replication
A Functional Role of Fibroblast Growth Factor Receptor 1 (FGFR1) in the Suppression of Influenza A Virus Replication Open
Influenza A virus causes annual epidemics and occasional pandemics in humans. Here, we investigated four members of the fibroblast growth factor receptor (FGFR) family; FGFR1 to 4, and examined their expression patterns in human lung epith…
View article: Immunization with a Live Attenuated H7N9 Influenza Vaccine Protects Mice against Lethal Challenge
Immunization with a Live Attenuated H7N9 Influenza Vaccine Protects Mice against Lethal Challenge Open
The emergence of severe cases of human influenza A (H7N9) viral infection in China in the spring of 2003 resulted in a global effort to rapidly develop an effective candidate vaccine. In this study, a cold-adapted (ca), live attenuated mon…
View article: Protection conferred by virus-like particle vaccines against respiratory syncytial virus infection in mice by intranasal vaccination
Protection conferred by virus-like particle vaccines against respiratory syncytial virus infection in mice by intranasal vaccination Open
Respiratory syncytial virus (RSV) is a major pathogen in infants and the elderly, causing pneumonia and bronchiolitis. Despite decades of research, to date there is still no approved RSV vaccine available. In this study, we developed RSV v…