Pengli Yu
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View article: Analysis of methylation features associated with neoadjuvant efficacy in HER2-positive breast cancer
Analysis of methylation features associated with neoadjuvant efficacy in HER2-positive breast cancer Open
Background Response to trastuzumab-based neoadjuvant therapy in human epidermal growth factor receptor type 2 (HER2)-positive breast cancer is affected by multiple features of the tumor. Few studies have investigated epigenetic features in…
View article: Comprehensive characterization of PD-L1 expression and immunotherapy-related genomic biomarkers in early- versus advanced-stage non-small cell lung cancer
Comprehensive characterization of PD-L1 expression and immunotherapy-related genomic biomarkers in early- versus advanced-stage non-small cell lung cancer Open
Not applicable.
View article: The evolving landscape of genetic biomarkers for immunotherapy in primary and metastatic breast cancer
The evolving landscape of genetic biomarkers for immunotherapy in primary and metastatic breast cancer Open
Background Major advances have been achieved in the characterization of primary breast cancer genomic profiles. Limited information is available on the genomic profile of tumors originating from different metastatic locations in recurrent/…
View article: Molecular characterization of EBV-associated primary pulmonary lymphoepithelial carcinoma by multiomics analysis
Molecular characterization of EBV-associated primary pulmonary lymphoepithelial carcinoma by multiomics analysis Open
View article: Case report: Target and immunotherapy of a lung adenocarcinoma with enteric differentiation, EGFR mutation, and high microsatellite instability
Case report: Target and immunotherapy of a lung adenocarcinoma with enteric differentiation, EGFR mutation, and high microsatellite instability Open
Background Pulmonary enteric adenocarcinoma (PEAC) is a rare histological subtype of non-small-cell lung cancer (NSCLC) with a predominant (>50%) enteric differentiation component. The frequency of high microsatellite instability (MSI-H…
View article: Circulating tumor DNA analysis predicts recurrence and avoids unnecessary adjuvant chemotherapy in I–IV colorectal cancer
Circulating tumor DNA analysis predicts recurrence and avoids unnecessary adjuvant chemotherapy in I–IV colorectal cancer Open
Background: Circulating tumor DNA (ctDNA) has emerged as a biomarker that can define the risk of recurrence after curative-intent surgery for patients with colorectal cancer (CRC). However, beyond the predictive power of postoperative ctDN…
View article: Case report: Successful sequential therapy of crizotinb and entrectinib in ROS1-positive non-small-cell lung cancer with brain metastasis in later-settings
Case report: Successful sequential therapy of crizotinb and entrectinib in ROS1-positive non-small-cell lung cancer with brain metastasis in later-settings Open
Rationale: Crizotinib has been approved in many countries for the treatment of patients with advanced ROS1 -rearranged non-small cell lung cancers (NSCLC). Entrectinib is a ROS1 inhibitor that has been designed to effectively penetrate and…
View article: Novel PPFIA1-ALK, ALK-C2orf91(intergenic) double-fusion responded well to alectinib in an advanced lung adenocarcinoma patient: a case report
Novel PPFIA1-ALK, ALK-C2orf91(intergenic) double-fusion responded well to alectinib in an advanced lung adenocarcinoma patient: a case report Open
Non-small cell lung cancers (NSCLCs) with anaplastic lymphoma kinase (ALK)-rearrangement have favorable responses to ALK inhibitors. However, ALK fusion mutations harbored approximately 90 distinct fusion partners. Patients with different …
View article: Assessment of durable chemoimmunotherapy response via circulating tumor <scp>DNA</scp> in advanced esophageal squamous cell carcinoma
Assessment of durable chemoimmunotherapy response via circulating tumor <span>DNA</span> in advanced esophageal squamous cell carcinoma Open
Immune checkpoint inhibitor (ICI)‐based therapies have shown promising advances for the first‐line treatment of advanced or metastatic esophageal cancer (EC). However, few studies concerning the identification of patients who achieve durab…
View article: Correlation of KMT2 family mutations with molecular characteristics and prognosis in colorectal cancer
Correlation of KMT2 family mutations with molecular characteristics and prognosis in colorectal cancer Open
Background Lysine methyltransferase 2 (KMT2) family proteins methylate lysine 4 on histone H3 (H3K4) to promote genome accessibility and transcription. Dysregulation or mutation of KMT2 family have been observed frequently in various types…