Explanipedia

In vivo neutrophils hitchhiking for tumor targeting and microenvironment regulation boosts oncolytic virus therapy Open

Xu Zhao, Han-Wei Huang, Mingyang Liu, Pengliang Wang, Shuhui Song , et al. · 2025

Studies on Typical Stalls of Airfoil at Low Reynolds Number Using Lagrangian Coherent Structures Open

Jia‐Zhong Zhang, Yan Liu, Pengliang Wang, Ruidong Jia, Yongkang Wang , et al. · 2025

Development of genome-wide insertion/deletion markers and genetic diversity in Sipunculus nudus along the Beibu Gulf of China Open

Yu Ni, Chunli Han, Yating Liu, Manman Li, Weijie He , et al. · 2025

Sipunculus nudus , a marine species of substantial medicinal and commercial importance, requires genetic enhancement to boost its production yield. However, progress in genetic research and selective breeding has been constrained by two cr…

EGLN3 attenuates gastric cancer cell malignant characteristics by inhibiting JMJD8/NF-κB signalling activation independent of hydroxylase activity Open

Fenglin Cai, Xiuding Yang, Gang Ma, Pengliang Wang, Mengmeng Zhang , et al. · 2024

Palliative Gastrectomy Plus Chemotherapy versus Chemotherapy Alone for Incurable Advanced Gastric Cancer: A Meta-Analysis [Corrigendum] Open

Pei Wu, Pengliang Wang, Bin Ma, Songcheng Yin, Yuen Tan , et al. · 2024

[This corrects the article DOI: 10.2147/CMAR.S179368.].

Drug-tolerant persister cancer cells Open

Pengliang Wang, Bin Ke, Gang Ma · 2023

Hsa_circ_0020134 promotes liver metastasis of colorectal cancer through the miR-183-5p-PFN2-TGF-β/Smad axis Open

Jin-Hao Yu, Jianan Tan, Guangyu Zhong, Lin Zhong, Dong Hou , et al. · 2023

Circular RNAs (circRNAs) are a distinct class of non-coding RNAs that play regulatory roles in the initiation and progression of tumors. With advancements in transcriptome sequencing technology, numerous circRNAs that play significant role…

PUM1 Promotes Tumor Progression by Activating DEPTOR‐Meditated Glycolysis in Gastric Cancer Open

Songcheng Yin, Huifang Liu, Zhijun Zhou, Xiaoyu Xu, Pengliang Wang , et al. · 2023

RNA‐binding proteins (RBPs) play essential roles in tumorigenesis and progression, but their functions in gastric cancer (GC) remain largely elusive. Here, it is reported that Pumilio 1 (PUM1), an RBP, induces metabolic reprogramming throu…

SMYD3 drives the proliferation in gastric cancer cells via reducing EMP1 expression in an H4K20me3-dependent manner Open

Yi Zeng, Gang Ma, Fenglin Cai, Pengliang Wang, Han Liang , et al. · 2023

Protein lysine methyltransferase SET and MYND domain-containing 3 (SMYD3) is aberrantly expressed in various cancer settings. The mechanisms that SMYD3 activates the expression of critical pro-tumoral genes in an H3K4me3-dependent manner h…

[Clinical and genetic analyses of Joubert syndrome in children]. Open

Guangyu Zhang, Yunxia Zhao, Huiling Zhao, Guo-Hao Tang, Pengliang Wang , et al. · 2023

For children with developmental delay, especially those with abnormal eye movement and hypotonia, it is recommended to perform a head imaging examination to determine the presence or absence of "molar tooth sign" and "midline cleft syndrom…

E3 ubiquitin ligase RNF180 prevents excessive PCDH10 methylation to suppress the proliferation and metastasis of gastric cancer cells by promoting ubiquitination of DNMT1 Open

Nannan Zhang, Xiaoliang Gao, Qiangqiang Yuan, Xin Fu, Pengliang Wang , et al. · 2023

Background Downregulation of certain tumor-suppressor genes (TSGs) by aberrant methylation of CpG islands in the promoter region contributes a great deal to the oncogenesis and progression of several cancers, including gastric cancer (GC).…

Evaluation of the prognostic value of negative to positive lymph node ratio in gastric cancer: results from multi-institutional cohorts from western and eastern datasets – Cohort study Open

Xinyu Wang, Pengliang Wang, Wei Wang, Zhe Sun, Zhenning Wang , et al. · 2023

Introduction: Lymph node (LN) stage is important for prognosis evaluation of gastric cancer (GC) patients. This study aimed to evaluate the prognostic value of the ratio of negative to positive LNs (Rnp) in GC. Methods: The authors evaluat…

Review of RoCoF Estimation Techniques for Low-Inertia Power Systems Open

Xiaoyu Deng, Ruo Mo, Pengliang Wang, Junru Chen, Dongliang Nan , et al. · 2023

As the traditional generation is gradually replaced by inverter-based resources, a lack of rotational inertia is now a common issue of modern power systems, which leads to an increasingly larger rate of change of frequency (RoCoF) followin…

The malignancy suppression and ferroptosis facilitation of BCL6 in gastric cancer mediated by FZD7 repression are strengthened by RNF180/RhoC pathway Open

Shiwei Guo, Jingyu Deng, Pengliang Wang, Fan Kou, Zizhen Wu , et al. · 2023

Palliative Gastrectomy Plus Chemotherapy versus Chemotherapy Alone for Incurable Advanced Gastric Cancer: A Meta-Analysis [Expression of Concern] Open

Pei Wu, Pengliang Wang, Bin Ma, Songcheng Yin, Yuen Tan , et al. · 2023

Cancer Management and Research is an international, peer-reviewed open access journal focusing on cancer research and the optimal use of preventative and integrated treatment interventions to achieve improved outcomes, enhanced survival an…

Inactivation of ZSCAN18 by promoter hypermethylation drives the proliferation via attenuating TP53INP2-mediated autophagy in gastric cancer cells Open

Bin Li, Baoqing Ren, Gang Ma, Fenglin Cai, Pengliang Wang , et al. · 2023

Cloning and Expression of Sox2 and Sox9 in Embryonic and Gonadal Development of Lutraria sieboldii Open

Min Lu, Zenghou Xing, Yurui Zhou, Youhou Xu, Huijing Peng , et al. · 2022

The Sox family plays essential roles as transcription factors in vertebrates; however, little is known about the Sox family in Lutraria sieboldii. L. sieboldii are pleasant to eat with a short growth cycle and have become one of the best b…

The malignancy suppression and ferroptosis facilitation of BCL6 in gastric cancer mediated by FZD7 repression are strengthened by RNF180/RhoC pathway Open

Shiwei Guo, Pengliang Wang, Fan Kou, Zizhen Wu, Nannan Zhang , et al. · 2022

Background B-cell lymphoma 6 (BCL6) is a transcription repressor that plays a tumor suppressor or promoting role in various tumors. However, its function and molecular mechanism in gastric cancer (GC) remain unclear. Ferroptosis, a novel p…

FOXK2 promotes the proliferation of papillary thyroid cancer cell by down-regulating autophagy: Erratum Open

Songze Li, Pengliang Wang, Hao Ju, Tiantong Zhu, Jingwen Shi , et al. · 2022

[This corrects the article DOI: 10.7150/jca.60730.].

FOXK2 promotes the proliferation of papillary thyroid cancer cell by down-regulating autophagy Open

Songze Li, Pengliang Wang, Hao Ju, Tiantong Zhu, Jingwen Shi , et al. · 2022

Papillary thyroid cancer (PTC) is the most common endocrine system tumor. FOXK2 is involved in the development of different types of cancers, however, its function has not been investigated in papillary thyroid cancer. In the present study…

ZSCAN18 Promoter is Hypermethylated and Its Restored Expression Inhibits Proliferation in Gastric Cancer Open

Baoqing Ren, Bin Li, Gang Ma, Fenglin Cai, Pengliang Wang , et al. · 2021

Background: Zinc finger and scan domain containing 18 (ZSCAN18) belongs to the zinc finger transcription factor superfamily, which consists of hundreds of members that play critical roles in all steps of tumorigenesis. Although hypermethyl…

Risk of station 12a lymph node metastasis in patients with lower-third gastric cancer Open

Yinping Dong, Fenglin Cai, Zizhen Wu, Pengliang Wang, Yang Yang , et al. · 2021

Metastasis of station 12a lymph nodes could be considered an independent prognosis factor for patients with lower-third GC. The dissection of station 12a lymph nodes may not be ignored in D2 or D2+ lymphadenectomy due to difficulties in pr…

DNMT3A-mediated silence in ADAMTS9 expression is restored by RNF180 to inhibit viability and motility in gastric cancer cells Open

Weilin Sun, Gang Ma, Li Zhang, Pengliang Wang, Nannan Zhang , et al. · 2021

Comparison of three lymph node staging methods for predicting outcome in breast cancer patients with mastectomy Open

Mengshen Wang, Mozhi Wang, Zhenning Wang, Yongxi Song, Peng Gao , et al. · 2021

Compared with pN and LNR, LODDS showed higher homeostasis in LN evaluation, and showed marked efficacy in evaluating survival differences among patients with negative LN staging. We constructed a BC prognosis model by incorporating highly …

Establishment and verification of prognostic model for gastric cancer based on autophagy-related genes. Open

Liqiao Chen, Gang Ma, Pengliang Wang, Yinping Dong, Yong Liu , et al. · 2021

Autophagy played a significant role in the development of cancer. In this study, we explored the value of autophagy-associated genes in gastric cancer. RNA sequencing and clinical information containing 375 gastric cancer and 32 normal tis…

Nomogram for predicting axillary lymph node status after neoadjuvant chemotherapy in breast cancer Open

Mengshen Wang, Mozhi Wang, Zhenning Wang, Yongxi Song, Peng Gao , et al. · 2020

After NAC, some patients may benefit from SLNB. Our nomogram predicts ALN status after NAC and has great potential to assist in clinical decision-making.

RNF180 mediates STAT3 activity by regulating the expression of RhoC via the proteasomal pathway in gastric cancer cells Open

Zizhen Wu, Huifang Liu, Weilin Sun, Yingxin Du, Wenting He , et al. · 2020

The complete mitochondrial genome of <i>Xyrias revulsus</i>（Jordan & Snyder, 1901） Open

Fangmei Liang, Lili Liu, Yanmei Wang, Pengliang Wang, Peng Zhu , et al. · 2020

Xyrias revulsus is one of the species in the China-Vietnam Collective Fishery Zone, which has a few relevant studies. In this study, the mitochondrial genome of X. revulsus was determined for the first time using next-generat…

RNF180 Suppresses Methylation of ADAMTS9 DNA Promotor by Ubiquitinating DNMT3A Inhibiting Metastasis in Gastric Cancer Open

Weilin Sun, Jingyu Deng, Gang Ma, Li Zhang, Pengliang Wang , et al. · 2020

BACKGROUND: A disintegrin-like and metalloprotease with thrombospondin type 1 motif 9 (ADAMTS9) is hypermethylated and inhibits the proliferation of various cancers. In this study, we demonstrated that the expression of ADAMTS9 was associa…

RNF180 mediates STAT3 activity by regulating the expression of RhoC via the proteasomal pathway in gastric cancer cells Open

Zizhen Wu, Huifang Liu, Weilin Sun, Yingxin Du, Wenting He , et al. · 2020

Background Ring finger protein 180 (RNF180) is an important member of the E3 ubiquitin ligase family. As a tumor suppressor gene, RNF180 is significantly associated with the prognosis of patients with gastric cancer (GC) and can inhibit th…

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