Pengrong Ouyang
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View article: Energy-based multiphase CFD framework integrating DPM and CIEM for predicting dynamic cell adhesion in porous scaffolds
Energy-based multiphase CFD framework integrating DPM and CIEM for predicting dynamic cell adhesion in porous scaffolds Open
View article: Stability simulation analysis of targeted puncture in L4/5 intervertebral space for PELD surgery
Stability simulation analysis of targeted puncture in L4/5 intervertebral space for PELD surgery Open
Introduction: The application prospects of percutaneous endoscopic lumbar discectomy (PELD) as a minimally invasive spinal surgery method in the treatment of lumbar disc herniation are extensive. This study aims to find the optimal entry a…
View article: Computational comparison of anterior lumbar interbody fusion and oblique lumbar interbody fusion with various supplementary fixation systems: a finite element analysis
Computational comparison of anterior lumbar interbody fusion and oblique lumbar interbody fusion with various supplementary fixation systems: a finite element analysis Open
View article: Irregular pore size of degradable bioceramic Voronoi scaffolds prepared by stereolithography: Osteogenesis and computational fluid dynamics analysis
Irregular pore size of degradable bioceramic Voronoi scaffolds prepared by stereolithography: Osteogenesis and computational fluid dynamics analysis Open
A Voronoi method is a feasible approach for developing biomimetic trabecular scaffolds. This study used algorithms based on scaling factors to design Voronoi scaffolds (pore sizes 600–1200 μm). Scaffolds were prepared from β-tricalcium pho…
View article: New synthetic PEKK/bioceramic hybrids and their surface sulfonation counterparts have increased cellular osteogenic capacity and promoted osseointegration
New synthetic PEKK/bioceramic hybrids and their surface sulfonation counterparts have increased cellular osteogenic capacity and promoted osseointegration Open
PEKK has good biocompatibility as an implantable material, but its mechanical properties and osseointegration are not satisfied enough. Aluminum oxide (Al2O3) is highly wear-resistant, while hydroxyapatite (HA) is a biologically active. Ho…
View article: Neuroprotective effect of remote ischemic preconditioning in patients undergoing cardiac surgery: A randomized controlled trial
Neuroprotective effect of remote ischemic preconditioning in patients undergoing cardiac surgery: A randomized controlled trial Open
Background The neuroprotective effect of remote ischemic preconditioning (RIPC) in patients undergoing elective cardiopulmonary bypass (CPB)-assisted coronary artery bypass graft (CABG) or valvular cardiac surgery remains unclear. Methods …
View article: Cervical non-fusion using biomimetic artificial disc and vertebra complex: technical innovation and biomechanics analysis
Cervical non-fusion using biomimetic artificial disc and vertebra complex: technical innovation and biomechanics analysis Open
Background Changes in spinal mobility after vertebral fusion are important factors contributing to adjacent vertebral disease (ASD). As an implant for spinal non-fusion, the motion-preserving prosthesis is an effective method to reduce the…
View article: Dorsal raphe serotonergic neurons promote arousal from isoflurane anesthesia
Dorsal raphe serotonergic neurons promote arousal from isoflurane anesthesia Open
Aims General anesthesia has been widely applied in surgical or nonsurgical medical procedures, but the mechanism behind remains elusive. Because of shared neural circuits of sleep and anesthesia, whether serotonergic system, which is highl…
View article: Exosomes from microRNA‐126 overexpressing mesenchymal stem cells promote angiogenesis by targeting the PIK3R2‐mediated PI3K/Akt signalling pathway
Exosomes from microRNA‐126 overexpressing mesenchymal stem cells promote angiogenesis by targeting the PIK3R2‐mediated PI3K/Akt signalling pathway Open
microRNA‐126 (miR‐126), an endothelial‐specific miRNA, is associated with vascular homeostasis and angiogenesis. However, the efficiency of miR‐126‐based treatment is partially compromised due to the low efficiency of miRNA delivery in viv…
View article: Biomechanical Comparison of 1-Level Corpectomy and 2-Level Discectomy for Cervical Spondylotic Myelopathy: A Finite Element Analysis
Biomechanical Comparison of 1-Level Corpectomy and 2-Level Discectomy for Cervical Spondylotic Myelopathy: A Finite Element Analysis Open
BACKGROUND Anterior cervical discectomy and fusion (ACDF) and anterior cervical corpectomy and fusion (ACCF) are effective treatments for cervical spondylotic myelopathy (CSM), but it is unclear which is better. In this study, we compared …
View article: Transplantation of sh-miR-199a-5p-Modified Olfactory Ensheathing Cells Promotes the Functional Recovery in Rats with Contusive Spinal Cord Injury
Transplantation of sh-miR-199a-5p-Modified Olfactory Ensheathing Cells Promotes the Functional Recovery in Rats with Contusive Spinal Cord Injury Open
MicroRNAs (miRNAs) function as gene expression switches, and participate in diverse pathophysiological processes of spinal cord injury (SCI). Olfactory ensheathing cells (OECs) can alleviate pathological injury and facilitate functional re…
View article: Prognostic Factors and Treatment Options for Patients with High-Grade Chondrosarcoma
Prognostic Factors and Treatment Options for Patients with High-Grade Chondrosarcoma Open
BACKGROUND The goal of this study was to determine the prognostic factors exclusive for high-grade chondrosarcoma and whether adjuvant radiotherapy could achieve better overall survival (OS) or cancer-specific survival (CSS) for patients w…
View article: Hydromechanical mechanism behind the effect of pore size of porous titanium scaffolds on osteoblast response and bone ingrowth
Hydromechanical mechanism behind the effect of pore size of porous titanium scaffolds on osteoblast response and bone ingrowth Open
View article: Biomechanical Comparison of Integrated Fixation Cage Versus Anterior Cervical Plate and Cage in Anterior Cervical Corpectomy and Fusion (ACCF): A Finite Element Analysis
Biomechanical Comparison of Integrated Fixation Cage Versus Anterior Cervical Plate and Cage in Anterior Cervical Corpectomy and Fusion (ACCF): A Finite Element Analysis Open
BACKGROUND Anterior cervical plate and cage fixation system (ACPC) used in anterior cervical corpectomy and fusion (ACCF) is reported to incur excess complications. This study aimed to introduce integrated fixation cage (IFC) into ACCF to …