Explanipedia

Tripeptide DT-109 (Gly-Gly-Leu) attenuates atherosclerosis and vascular calcification in nonhuman primates Open

Linying Jia, Pengxiang Qu, Yang Zhao, Liang Bai, Honghao Ren , et al. · 2025

Advanced atherosclerotic lesions and vascular calcification substantially increase the risk of cardiovascular events. However, effective strategies for preventing or treating advanced atherosclerosis and calcification are currently lacking…

HOPE and AMPK activation reduce reperfusion injury and metabolic dysfunction in primate steatotic liver grafts Open

Tao Li, Pengkang Chang, Yimeng Wang, Yihong Song, Pengxiang Qu , et al. · 2025

Living liver transplantation has become a significant and evolving aspect of organ transplantation, with a notable proportion of cases involving pediatric patients. Metabolic-associated fatty liver disease (MAFLD) is the most prevalent chr…

Targeted Metabolomics in Pcos Mice Identifies Hippuric Acid as a Therapeutic Metabolite Open

Hui Y. Lan, Bing Meng, Chenjing Duan, Shuangqing Liu, Jianbo Li , et al. · 2025

Characterization of small RNAs in the spleen of MASH in a non-human primate model Open

Juan Zhao, Yuelei Zhao, Hongyu Qin, Yun Ye, Liwei Zhang , et al. · 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) and its advanced stage, metabolic dysfunction-associated steatohepatitis (MASH), are increasingly recognized as a global health issue. This study examines the role of small R…

Single-cell transcriptome atlas of testes from mice with high-fat diets Open

Wenbin Cao, Yulin Zhang, Jia Qi, Yanru Zhang, Ruike Ding , et al. · 2024

Obesity is accompanied by multiple known health risks and increased morbidity, and obese men display reduced reproductive health. However, the impact of obesity on the testes at the molecular levels remain inadequately explored. This is pa…

Impact of high-fat diet on ovarian epigenetics: Insights from altered intestinal butyric acid levels Open

Jia Qi, Congcong Xia, Yulin Zhang, Ruike Ding, Yanru Zhang , et al. · 2024

DT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates Open

Pengxiang Qu, Oren Rom, Ke Li, Linying Jia, Xiaojing Gao , et al. · 2023

Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development is the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures …

Effect of Dietetic Obesity on Testicular Transcriptome in Cynomolgus Monkeys Open

Yanru Zhang, Jia Qi, Juan Zhao, Miaojing Li, Yulin Zhang , et al. · 2023

Obesity is a metabolic disorder resulting from behavioral, environmental and heritable causes, and can have a negative impact on male reproduction. There have been few experiments in mice, rats, and rabbits on the effects of obesity on rep…

Loss of Renewal of Extracellular Vesicles: Harmful Effects on Embryo Development in vitro Open

Pengxiang Qu, Jinpeng Zhao, Huizhong Hu, Wenbin Cao, Yanru Zhang , et al. · 2022

Loss of renewal in the IVC system affected EVs' role in embryonic development by causing an imbalance in ROS, autophagy, abnormal H3K36me3 levels and apoptosis, while gain of renewal in the IVC system reduced these adverse effects and ensu…

Sperm-borne miR-202 targets <i>SEPT7</i> and regulates first cleavage of bovine embryos via cytoskeletal remodeling Open

Mengyun Wang, Yue Du, Song Gao, Zheng Wang, Pengxiang Qu , et al. · 2021

In mammals, sperm-borne regulators can be transferred to oocytes during fertilization and have different effects on the formation of pronuclei, the first cleavage of zygotes, the development of preimplantation embryos and even the metaboli…

Insights into the roles of sperm in animal cloning Open

Pengxiang Qu, Yongsheng Wang, Chengsheng Zhang, Enqi Liu · 2020

Somatic cell nuclear transfer (SCNT) has shown a wide application in the generation of transgenic animals, protection of endangered animals, and therapeutic cloning. However, the efficiency of SCNT remains very low due to some poorly chara…

Melatonin Protects Rabbit Somatic Cell Nuclear Transfer (SCNT) Embryos from Electrofusion Damage Open

Pengxiang Qu, Chong Shen, Yue Du, Hongyu Qin, Shiwei Luo , et al. · 2020

The study’s objectives were to examine the effects of electrofusion on rabbit somatic cell nuclear transfer (SCNT) embryos, and to test melatonin as a protective agent against electrofusion damage to SCNT embryos. The levels of reactive ox…

Extracellular vesicles and melatonin benefit embryonic develop by regulating reactive oxygen species and 5‐methylcytosine Open

Pengxiang Qu, Shiwei Luo, Yue Du, Yanru Zhang, Xiaojie Song , et al. · 2020

Embryo culture conditions are crucial as they can affect embryo quality and even offspring. Oviductal extracellular vesicles (EVs) long been considered a major factor influencing interactions between the oviduct and embryos, and thus its a…

Use of oocytes selected by brilliant cresyl blue staining enhances rabbit cloned embryo development <i>in vitro</i> Open

Linying Jia, Bo Ding, Chong Shen, Shiwei Luo, Yanru Zhang , et al. · 2019

Summary Rabbits play an important role in people’s lives due to their high nutritional value and high-quality hair that can be used as raw material for textiles. Furthermore, rabbits are an important animal model for human disease, as geno…

Extracellular vesicles derived from donor oviduct fluid improved birth rates after embryo transfer in mice Open

Pengxiang Qu, Yuelei Zhao, Rong Wang, Yali Zhang, Lu Li , et al. · 2018

Embryo transfer (ET) is an important procedure for assisted reproduction. However, the relatively lower success rate of ET hampers its application potential. In this study we aimed to elucidate the effects of extracellular vesicles derived…

Tauroursodeoxycholic acid (TUDCA) alleviates endoplasmic reticulum stress of nuclear donor cells under serum starvation Open

Ying Zhang, Pengxiang Qu, Xiaonan Ma, Fang Qiao, Yefei Ma , et al. · 2018

Serum starvation is a routine protocol for synchronizing nuclear donor cells to G0/G1 phase during somatic cell nuclear transfer (SCNT). However, abrupt serum deprivation can cause serious stress to the cells cultured in vitro, which might…

Sperm-borne miR-449b influences cleavage, epigenetic reprogramming and apoptosis of SCNT embryos in bovine Open

Mengyun Wang, Yang Gao, Pengxiang Qu, Suzhu Qing, Fang Qiao , et al. · 2017

MicroRNA-125b is a key epigenetic regulatory factor that promotes nuclear transfer reprogramming Open

Jingcheng Zhang, Pengxiang Qu, Chuan Zhou, Xin Liu, Xiaonan Ma , et al. · 2017

Somatic cell nuclear transfer (SCNT)-mediated reprogramming is a rapid, efficient, and sophisticated process that reprograms differentiated somatic cells to a pluripotent state. However, many factors in this elaborate reprogramming process…

Effects of embryo-derived exosomes on the development of bovine cloned embryos Open

Pengxiang Qu, Suzhu Qing, Ruiqi Liu, Hongyu Qin, Weiwei Wang , et al. · 2017

The developmental competence of in vitro cultured (IVC) embryos is markedly lower than that of their in vivo counterparts, suggesting the need for optimization of IVC protocols. Embryo culture medium is routinely replaced three days after …

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