Pengyu Li
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View article: Outcomes of Successful Versus Failed Stenting in Patients With Unilateral Atherosclerotic Renal Artery Occlusion
Outcomes of Successful Versus Failed Stenting in Patients With Unilateral Atherosclerotic Renal Artery Occlusion Open
Stenting for renal artery occlusion (RAO) remains a subject of considerable debate. We aim to observe whether stenting can improve the clinical outcomes of patients with RAO. Patients with atherosclerotic unilateral RAO and at least 12 mon…
View article: Optimized Blood Pressure Control and Medication Burden Reduction in Bilateral Renal Artery Stenosis Patients Without Pickering Syndrome: A Retrospective Study
Optimized Blood Pressure Control and Medication Burden Reduction in Bilateral Renal Artery Stenosis Patients Without Pickering Syndrome: A Retrospective Study Open
Bilateral renal artery stenosis is a major cause of secondary hypertension, yet the benefits of percutaneous transluminal renal angioplasty and stenting in patients without Pickering syndrome remain uncertain. This retrospective study eval…
View article: Optimizing genotype imputation pipeline for low-coverage whole genome sequencing data in spotted sea bass and its application in genomic prediction
Optimizing genotype imputation pipeline for low-coverage whole genome sequencing data in spotted sea bass and its application in genomic prediction Open
View article: Drug-coated balloon with bailout stenting versus drug-eluting stent plus drug-coated balloon in TransAtlantic Inter-Society Consensus C and D femoropopliteal lesions: a propensity score-matched analysis
Drug-coated balloon with bailout stenting versus drug-eluting stent plus drug-coated balloon in TransAtlantic Inter-Society Consensus C and D femoropopliteal lesions: a propensity score-matched analysis Open
The double-drug strategy and DCB bailout strategy yielded comparable 24-month patency and freedom from target lesion revascularization (TLR) in TASC C and D lesions.
View article: Genome-Wide Identification and Characterization of Igf/Igfr/Igfbp Gene Families in Spotted Sea Bass and Their Expression Profiles in Response to Environmental Stress
Genome-Wide Identification and Characterization of Igf/Igfr/Igfbp Gene Families in Spotted Sea Bass and Their Expression Profiles in Response to Environmental Stress Open
View article: Evaluation of neostriatum changes in Crohn’s disease: a multimodal brain magnetic resonance imaging study
Evaluation of neostriatum changes in Crohn’s disease: a multimodal brain magnetic resonance imaging study Open
Our study indicated that CD patients had increased GMV and abnormal FC related to the putamen. The structural and functional differences could reflect that neostriatum may be linked with alterations of aberrant patterns of the default mode…
View article: Intratumoral CXCL13<sup>+</sup> CD160<sup>+</sup> CD8<sup>+</sup> T cells promote the formation of tertiary lymphoid structures to enhance the efficacy of immunotherapy in advanced gastric cancer
Intratumoral CXCL13<sup>+</sup> CD160<sup>+</sup> CD8<sup>+</sup> T cells promote the formation of tertiary lymphoid structures to enhance the efficacy of immunotherapy in advanced gastric cancer Open
Background Stage IV gastric cancer is a highly heterogeneous and lethal tumor with few therapeutic strategies. The combination of programmed cell death protein 1 inhibitors and chemotherapy is currently the standard frontline treatment reg…
View article: EMDFNet: Efficient Multi-scale and Diverse Feature Network for Traffic Sign Detection
EMDFNet: Efficient Multi-scale and Diverse Feature Network for Traffic Sign Detection Open
The detection of small objects, particularly traffic signs, is a critical subtask within object detection and autonomous driving. Despite the notable achievements in previous research, two primary challenges persist. Firstly, the main issu…
View article: ASO Visual Abstract: Robotic Versus Laparoscopic Pancreaticoduodenectomy for Pancreatic Cancer—Evaluation and Analysis of Surgical Efficacy
ASO Visual Abstract: Robotic Versus Laparoscopic Pancreaticoduodenectomy for Pancreatic Cancer—Evaluation and Analysis of Surgical Efficacy Open
View article: Leptin‐mediated suppression of lipoprotein lipase cleavage enhances lipid uptake and facilitates lymph node metastasis in gastric cancer
Leptin‐mediated suppression of lipoprotein lipase cleavage enhances lipid uptake and facilitates lymph node metastasis in gastric cancer Open
Background Lymph node metastasis (LNM) is the primary mode of metastasis in gastric cancer (GC). However, the precise mechanisms underlying this process remain elusive. Tumor cells necessitate lipid metabolic reprogramming to facilitate me…
View article: Exploring Causal Relationships between Circulating Inflammatory Proteins and Thromboangiitis Obliterans: A Mendelian Randomization Study
Exploring Causal Relationships between Circulating Inflammatory Proteins and Thromboangiitis Obliterans: A Mendelian Randomization Study Open
Background Thromboangiitis obliterans (TAO) is a vascular condition characterized by poor prognosis and an unclear etiology. This study employs Mendelian randomization (MR) to investigate the causal impact of circulating inflammatory prote…
View article: Dietary vitamin A modifies the gut microbiota and intestinal tissue transcriptome, impacting intestinal permeability and the release of inflammatory factors, thereby influencing Aβ pathology
Dietary vitamin A modifies the gut microbiota and intestinal tissue transcriptome, impacting intestinal permeability and the release of inflammatory factors, thereby influencing Aβ pathology Open
Background Alzheimer’s disease (AD) is an age-related neurodegenerative disorder with no effective interventions for curing or modifying its progression. However, emerging research suggests that vitamin A in the diet may play a role in bot…
View article: Efficacy of Whole-Brain Radiotherapy Plus Simultaneous Integrated Boost (SIB-WBRT) for Lung Cancer Brain Metastases
Efficacy of Whole-Brain Radiotherapy Plus Simultaneous Integrated Boost (SIB-WBRT) for Lung Cancer Brain Metastases Open
Objective: To investigate the outcomes of SIB-WBRT in patients with brain metastases and analyze the impact of some factors on prognosis. Materials and Methods: This single-arm retrospective study analyzed patients with brain…
View article: Genome-Wide Association Study (Gwas)Of Alkalinity Tolerance Trait in Spotted Sea Bass (Lateolabrax Maculatus) Using Whole-Genome Resequencing
Genome-Wide Association Study (Gwas)Of Alkalinity Tolerance Trait in Spotted Sea Bass (Lateolabrax Maculatus) Using Whole-Genome Resequencing Open
View article: Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals
Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals Open
In adult mammals, spermatogenesis embodies the complex developmental process from spermatogonial stem cells (SSCs) to spermatozoa. At the top of this developmental hierarchy lie a series of SSC subpopulations. Their individual identities a…
View article: FBXO28 suppresses liver cancer invasion and metastasis by promoting PKA-dependent SNAI2 degradation
FBXO28 suppresses liver cancer invasion and metastasis by promoting PKA-dependent SNAI2 degradation Open
FBXO28 is a member of F-box proteins that are the substrate receptors of SCF (SKP1, CULLIN1, F-box protein) ubiquitin ligase complexes. Despite the implications of its role in cancer, the function of FBXO28 in epithelial-mesenchymal transi…
View article: Decoding the spermatogonial stem cell niche under physiological and recovery conditions in adult mice and humans
Decoding the spermatogonial stem cell niche under physiological and recovery conditions in adult mice and humans Open
The intricate interaction between spermatogonial stem cell (SSC) and testicular niche is essential for maintaining SSC homeostasis; however, this interaction remains largely uncharacterized. In this study, to characterize the underlying si…
View article: Author Response: Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals
Author Response: Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals Open
In adult mammals, spermatogenesis embodies the complex developmental process from spermatogonial stem cells (SSCs) to spermatozoa. At the top of this developmental hierarchy lie a series of SSC subpopulations. Their individual identities a…
View article: Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals
Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals Open
In adult mammals, spermatogenesis embodies the complex developmental process from spermatogonial stem cells (SSCs) to spermatozoa. At the top of this developmental hierarchy lie a series of SSC subpopulations. Their individual identities a…
View article: Reviewer #1 (Public Review): Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals
Reviewer #1 (Public Review): Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals Open
In adult mammals, spermatogenesis embodies the complex developmental process from spermatogonial stem cells (SSCs) to spermatozoa. At the top of this developmental hierarchy lie a series of SSC subpopulations. Their individual identities a…
View article: Focused ultrasound thalamotomy for tremor treatment impacts the cerebello-thalamo-cortical network
Focused ultrasound thalamotomy for tremor treatment impacts the cerebello-thalamo-cortical network Open
View article: Figure S2 from The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival
Figure S2 from The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival Open
RING1 binds to p53 in vivo and in vitro, and affects the ubiqutination level of p53
View article: Figure S5 from The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival
Figure S5 from The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival Open
Knockdown of RING1 suppresses cancer cell migration and inhibits tumor growth in vivo
View article: Data from The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival
Data from The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival Open
As a component of the transcriptional repression complex 1 (PRC1), the ring finger protein RING1 participates in the epigenetic regulation in cancer. However, the contributions of RING1 to cancer etiology or development are unknown. In thi…
View article: Figure S1 from The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival
Figure S1 from The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival Open
Efficiency of RING1 knockdown and its effect on the transcriptional activity of p21
View article: Figure S6 from The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival
Figure S6 from The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival Open
p53 exerts little effect on RING1 expression and the genetic alterations of p53 and RING1
View article: Figure S5 from The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival
Figure S5 from The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival Open
Knockdown of RING1 suppresses cancer cell migration and inhibits tumor growth in vivo
View article: Figure S1 from The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival
Figure S1 from The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival Open
Efficiency of RING1 knockdown and its effect on the transcriptional activity of p21
View article: Figure S4 from The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival
Figure S4 from The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival Open
RING1 deficiency results in partial G1 arrest and p21 induction in the cells harboring wild-type p53, and its growth inhibitory effect is partially rescued by p53 silencing
View article: Figure S2 from The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival
Figure S2 from The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival Open
RING1 binds to p53 in vivo and in vitro, and affects the ubiqutination level of p53