Per Åkesson
YOU?
Author Swipe
View article: Complement activation was not increased in patients with post-acute sequelae after mild SARS-CoV-2 infection: A prospective cohort study
Complement activation was not increased in patients with post-acute sequelae after mild SARS-CoV-2 infection: A prospective cohort study Open
Dysregulation of the complement system has been proposed as a pathophysiological mechanism for Post-acute sequelae of SARS-CoV-2 (PASC). We analyzed the complement activation markers C3bc, C3bBbP and TCC in 48 PASC patients, grouped into w…
View article: Aerosolized Dornase Alfa (DNase I) for the Treatment of Severe Respiratory Failure in COVID-19: A Randomized Controlled Trial
Aerosolized Dornase Alfa (DNase I) for the Treatment of Severe Respiratory Failure in COVID-19: A Randomized Controlled Trial Open
Background Lung injury in COVID-19 is characterized by neutrophil invasion and the release of neutrophil extracellular traps (NETs). An aberrant NET formation may induce local inflammation and increase sputum viscosity. Inhalation of DNase…
View article: Scores for sepsis detection and risk stratification – construction of a novel score using a statistical approach and validation of RETTS
Scores for sepsis detection and risk stratification – construction of a novel score using a statistical approach and validation of RETTS Open
Even with a statistical approach, we could not construct better risk stratification scores for sepsis than NEWS2. RETTS was inferior to NEWS2 for screening for sepsis.
View article: Additional file 1 of Repeated measures of Heparin-binding protein (HBP) and procalcitonin during septic shock: biomarker kinetics and association with cardiovascular organ dysfunction
Additional file 1 of Repeated measures of Heparin-binding protein (HBP) and procalcitonin during septic shock: biomarker kinetics and association with cardiovascular organ dysfunction Open
Additional file 1: Figure S1. Procalcitonin and NA doses for all 24 patients during the first 72 hours of ICU stay. NA values are truncated at 0.5 μg/kg/min. Deaths within 72 hours are marked with a “+” (n = 2). Patient id 12 only had one …
View article: Risk of bacteremia in patients presenting with shaking chills and vomiting - a prospective cohort study
Risk of bacteremia in patients presenting with shaking chills and vomiting - a prospective cohort study Open
Chills and vomiting have traditionally been associated with severe bacterial infections and bacteremia. However, few modern studies have in a prospective way evaluated the association of these signs with bacteremia, which is the aim of thi…
View article: A population-based study on the treatment and outcome of enterococcal prosthetic joint infections. A consecutive series of 55 cases
A population-based study on the treatment and outcome of enterococcal prosthetic joint infections. A consecutive series of 55 cases Open
AIM: Enterococci cause 2-11% of all prosthetic joint infections (PJI) and are generally considered difficult to treat. However, study-results are not consistent. In this study we present a population-based case series of 55 cases with ente…
View article: NEWS2 Is Superior to qSOFA in Detecting Sepsis with Organ Dysfunction in the Emergency Department
NEWS2 Is Superior to qSOFA in Detecting Sepsis with Organ Dysfunction in the Emergency Department Open
Early administration of antibiotics is associated with better survival in sepsis, thus screening and early detection for sepsis is of clinical importance. Current risk stratification scores used for bedside detection of sepsis, for example…
View article: Heparin-Binding Protein as a Prognostic Biomarker of Sepsis and Disease Severity at the Emergency Department
Heparin-Binding Protein as a Prognostic Biomarker of Sepsis and Disease Severity at the Emergency Department Open
Objective: Rapid and early detection of patients at risk to develop sepsis remains demanding. Heparin-binding protein (HBP) has previously demonstrated good prognostic properties in detecting organ dysfunction among patients with suspected…
View article: Eradication of methicillin-resistant Staphylococcus aureus (MRSA) throat carriage: a randomised trial comparing topical treatment with rifampicin-based systemic therapy
Eradication of methicillin-resistant Staphylococcus aureus (MRSA) throat carriage: a randomised trial comparing topical treatment with rifampicin-based systemic therapy Open
Eradication of methicillin-resistant Staphylococcus aureus (MRSA) colonisation may prevent transmission of strains between patients and reduces the risk of clinical infection. Colonisation of the throat is associated with prolonged carriag…
View article: Heparin-Binding Protein Measurement Improves the Prediction of Severe Infection With Organ Dysfunction in the Emergency Department
Heparin-Binding Protein Measurement Improves the Prediction of Severe Infection With Organ Dysfunction in the Emergency Department Open
In patients presenting at the emergency department, heparin-binding protein is an early indicator of infection-related organ dysfunction and a strong predictor of disease progression to severe sepsis within 72 hours.