Per Berglund
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View article: Accelerated Uptake of CO <sub>2</sub> Catalyzed by Immobilized Thermophilic Carbonic Anhydrase on Dispersed Aminated Mesoporous Silica
Accelerated Uptake of CO <sub>2</sub> Catalyzed by Immobilized Thermophilic Carbonic Anhydrase on Dispersed Aminated Mesoporous Silica Open
Efficient and durable biocatalysts are important for sustainable CO2 capture technologies, but enzyme stability often limits their use under harsh process conditions. Here, we evaluate carbonic anhydrases (CAs) adsorbed onto aminated mesop…
View article: Mutagenesis study for understanding the superabsorbent behavior of patatin-based protein materials
Mutagenesis study for understanding the superabsorbent behavior of patatin-based protein materials Open
Protein-based absorbent materials exhibit significant limitations in water retention compared to synthetic superabsorbent polymers (SAPs), widely used in agriculture, hygiene, and biomedical applications. Recent investigations have focused…
View article: Exploring the Stability and Substrate Profile of Transaminase from <i>Silicibacter pomeroyi</i> with Ancestral Sequence Reconstruction
Exploring the Stability and Substrate Profile of Transaminase from <i>Silicibacter pomeroyi</i> with Ancestral Sequence Reconstruction Open
Amine transaminases (ATAs), belonging to the class III transaminases within the superfamily of pyridoxal‐5′‐phosphate‐dependent enzymes, catalyze transamination reactions between amino donors and amino acceptors. These enzymes are particul…
View article: Generating Triangulations and Fibrations with Reinforcement Learning
Generating Triangulations and Fibrations with Reinforcement Learning Open
We apply reinforcement learning (RL) to generate fine regular star triangulations of reflexive polytopes, that give rise to smooth Calabi-Yau (CY) hypersurfaces. We demonstrate that, by simple modifications to the data encoding and reward …
View article: Biosynthesis of Furfurylamines in Batch and Continuous Flow by Immobilized Amine Transaminases
Biosynthesis of Furfurylamines in Batch and Continuous Flow by Immobilized Amine Transaminases Open
Building blocks with amine functionality are crucial in the chemical industry. Biocatalytic syntheses and chemicals derived from renewable resources are increasingly desired to achieve sustainable production of these amines. As a result, r…
View article: Biosynthesis of Furfurylamines in Batch and Continuous Flow by Immobilized Amine Transaminases
Biosynthesis of Furfurylamines in Batch and Continuous Flow by Immobilized Amine Transaminases Open
Building blocks with amine functionality are crucial in the chemical industry. Biocatalytic syntheses and chemicals derived from renewable resources are increasingly desired to achieve sustainable production of these amines. As a result, r…
View article: Biosynthesis of Furfurylamines in Batch and Continuous Flow by Immobilized Amine Transaminases
Biosynthesis of Furfurylamines in Batch and Continuous Flow by Immobilized Amine Transaminases Open
Building blocks with amine functionality are crucial in the chemical industry. Biocatalytic syntheses and chemicals derived from renewable resources are increasingly desired to achieve sustainable production of these amines. As a result, r…
View article: Cover Feature: The Role of Buffer, Pyridoxal 5’‐Phosphate and Light on the Stability of the <i>Silicibacter Pomeroyi</i> Transaminase (ChemCatChem 2/2023)
Cover Feature: The Role of Buffer, Pyridoxal 5’‐Phosphate and Light on the Stability of the <i>Silicibacter Pomeroyi</i> Transaminase (ChemCatChem 2/2023) Open
The Cover Feature shows Spartan soldiers illustrating the different influences on the stability of the Silicibacter pomeroyi transaminase (SpATA). In their Research Article, P. Berglund and co-workers investigate how and why buffer, cofact…
View article: The Role of Buffer, Pyridoxal 5'-Phosphate and Light on the Stability of the Silicibacter Pomeroyi Transaminase
The Role of Buffer, Pyridoxal 5'-Phosphate and Light on the Stability of the Silicibacter Pomeroyi Transaminase Open
Transaminases are pyridoxal 5’-phosphate (PLP)-dependent enzymes that transfer amino-functions. The transaminase from Silicibacter pomeroyi (SpATA) exhibits a broad substrate spectrum. In this work we examined the effect of different condi…
View article: The Role of Buffer, Pyridoxal 5'-Phosphate and Light on the Stability of the Silicibacter Pomeroyi Transaminase
The Role of Buffer, Pyridoxal 5'-Phosphate and Light on the Stability of the Silicibacter Pomeroyi Transaminase Open
Transaminases are pyridoxal 5’-phosphate (PLP)-dependent enzymes that transfer amino-functions. The transaminase from Silicibacter pomeroyi (SpATA) exhibits a broad substrate spectrum. In this work we examined the effect of different condi…
View article: The Role of Buffer, Pyridoxal 5’‐Phosphate and Light on the Stability of the <i>Silicibacter Pomeroyi</i> Transaminase
The Role of Buffer, Pyridoxal 5’‐Phosphate and Light on the Stability of the <i>Silicibacter Pomeroyi</i> Transaminase Open
Transaminases are pyridoxal 5’‐phosphate (PLP)‐dependent enzymes that transfer amino‐functions. The transaminase from Silicibacter pomeroyi (SpATA) exhibits a broad substrate spectrum. In this work we examined the effect of different condi…
View article: Gravitizing the quantum
Gravitizing the quantum Open
We discuss a new approach to the problem of quantum gravity in which the quantum mechanical structures that are traditionally fixed, such as the Fubini–Study metric in the Hilbert space of states, become dynamical and so implement the idea…
View article: Synthetic Mucin Gels with Self‐Healing Properties Augment Lubricity and Inhibit HIV‐1 and HSV‐2 Transmission
Synthetic Mucin Gels with Self‐Healing Properties Augment Lubricity and Inhibit HIV‐1 and HSV‐2 Transmission Open
Mucus is a self‐healing gel that lubricates the moist epithelium and provides protection against viruses by binding to viruses smaller than the gel's mesh size and removing them from the mucosal surface by active mucus turnover. As the pri…
View article: Leadership, support and organisation for academics’ participation in engineering education change for sustainable development
Leadership, support and organisation for academics’ participation in engineering education change for sustainable development Open
This work spotlights the experiences from ten years of implementing sustainable development in all educational programs at a technical university. With a focus on the critical issue of involving more academics in the work, experiences are …
View article: Enantioselective Synthesis of Pharmaceutically Relevant Bulky Arylbutylamines Using Engineered Transaminases
Enantioselective Synthesis of Pharmaceutically Relevant Bulky Arylbutylamines Using Engineered Transaminases Open
ATAs engineered for having an enlarged small binding pocket were applied for the synthesis of enantiomerically pure ( R )‐benzo[1,3]dioxol‐5‐yl‐butylamine, a chiral component of human leukocyte elastase inhibitor DMP 777 (L‐694,458). Kinet…
View article: Application of Transaminases in a Disperse System for the Bioamination of Hydrophobic Substrates
Application of Transaminases in a Disperse System for the Bioamination of Hydrophobic Substrates Open
The challenging bioamination of hydrophobic substrates has been attained through the employment of a disperse system consisting of a combination of a low polarity solvent (e. g. isooctane or methyl‐ tert ‐butylether), a non‐ionic surfactan…
View article: Chemoenzymatic Synthesis of Sertraline
Chemoenzymatic Synthesis of Sertraline Open
A chemoenzymatic approach has been developed for the preparation of sertraline, an established anti‐depressant drug. Ketoreductases (KREDs) were employed to yield a key chiral precursor. The bioreduction of the racemic tetralone exhibited …
View article: Engineering the Active Site of an (<i>S</i>)‐Selective Amine Transaminase for Acceptance of Doubly Bulky Primary Amines
Engineering the Active Site of an (<i>S</i>)‐Selective Amine Transaminase for Acceptance of Doubly Bulky Primary Amines Open
A protein engineering approach for expanding the substrate scope of the ( S )‐selective Chromobacterium violaceum amine transaminase is presented. Amino acid residues in the small binding pocket of the active site were targeted in order to…
View article: Insight into the dimer dissociation process of the Chromobacterium violaceum (S)-selective amine transaminase
Insight into the dimer dissociation process of the Chromobacterium violaceum (S)-selective amine transaminase Open
One of the main factors hampering the implementation in industry of transaminase-based processes for the synthesis of enantiopure amines is their often low storage and operational stability. Our still limited understanding of the inactivat…
View article: Application of Amino Transaminases in a Disperse System for the Biotransformation of Hydrophobic Substrates
Application of Amino Transaminases in a Disperse System for the Biotransformation of Hydrophobic Substrates Open
The challenging bioamination of hydrophobic substrates has been attained through the employment of a disperse system consisting in a combination of a low polarity solvent (e.g. isooctane or MTBE), a non-ionic surfactant and a minimal amoun…
View article: Application of Amino Transaminases in a Disperse System for the Biotransformation of Hydrophobic Substrates
Application of Amino Transaminases in a Disperse System for the Biotransformation of Hydrophobic Substrates Open
The challenging bioamination of hydrophobic substrates has been attained through the employment of a disperse system consisting in a combination of a low polarity solvent (e.g. isooctane or MTBE), a non-ionic surfactant and a minimal amoun…
View article: Linking Education and Research: A Roadmap for Higher Education Institutions at the Dawn of the Knowledge Society
Linking Education and Research: A Roadmap for Higher Education Institutions at the Dawn of the Knowledge Society Open
In an era characterized by a move towards a “knowledge society”, universities are central in fostering “knowledgeability”, that is the reflexive understanding of knowledge in knowledge societies. The objective of &l…
View article: <i>B</i>‐factor Guided Proline Substitutions in <i>Chromobacterium violaceum</i> Amine Transaminase: Evaluation of the Proline Rule as a Method for Enzyme Stabilization
<i>B</i>‐factor Guided Proline Substitutions in <i>Chromobacterium violaceum</i> Amine Transaminase: Evaluation of the Proline Rule as a Method for Enzyme Stabilization Open
Biocatalysis is attracting interest in the chemical industry as a sustainable alternative in large‐scale chemical transformations. However, low operational stability of naturally evolved enzymes is a challenge and major efforts are require…
View article: Transaminase‐Catalyzed Racemization with Potential for Dynamic Kinetic Resolutions
Transaminase‐Catalyzed Racemization with Potential for Dynamic Kinetic Resolutions Open
Dynamic kinetic resolution (DKR) reactions in which a stereoselective enzyme and a racemization step are coupled in one pot would represent powerful tools for the production of enantiopure amines through enantioconvergence of racemates. Th…
View article: Characterization of the stability of Vibrio fluvialis JS17 amine transaminase
Characterization of the stability of Vibrio fluvialis JS17 amine transaminase Open
The amine transaminase from Vibrio fluvialis (Vf-ATA) is an attractive enzyme with applications within Biocatalysis for the preparation of chiral amines. Various catalytic properties of Vf-ATA have been investigated, but a biophysical char…
View article: Front Cover Picture: Chemoenzymatic Approaches to the Synthesis of the Calcimimetic Agent Cinacalcet Employing Transaminases and Ketoreductases (Adv. Synth. Catal. 11/2018)
Front Cover Picture: Chemoenzymatic Approaches to the Synthesis of the Calcimimetic Agent Cinacalcet Employing Transaminases and Ketoreductases (Adv. Synth. Catal. 11/2018) Open
The front cover picture, provided by Javier González-Sabín, Per Berglund and collaborators, illustrates several chemoenzymatic routes which have been explored for the preparation of the API cinacalcet. Transaminases (TAs) and ketoreductase…
View article: Chemoenzymatic Approaches to the Synthesis of the Calcimimetic Agent Cinacalcet Employing Transaminases and Ketoreductases
Chemoenzymatic Approaches to the Synthesis of the Calcimimetic Agent Cinacalcet Employing Transaminases and Ketoreductases Open
Several chemoenzymatic routes have been explored for the preparation of cinacalcet, a calcimimetic agent. Transaminases (TAs) and ketoreductases (KREDs) turned out to be useful biocatalysts for the preparation of key optically active precu…
View article: Transaminase biocatalysis: optimization and application
Transaminase biocatalysis: optimization and application Open
Transaminase biocatalysis shows immense potential in industrial applications, and optimizations of both proteins and processes are of great importance.