Per Nilsson
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View article: Routinely collected health data on 10-year genitourinary and gastrointestinal morbidity after ultra-hypofractionated versus conventionally fractionated radiotherapy for localised prostate cancer in the randomised, non-inferiority, phase 3 trial HYPO-RT-PC
Routinely collected health data on 10-year genitourinary and gastrointestinal morbidity after ultra-hypofractionated versus conventionally fractionated radiotherapy for localised prostate cancer in the randomised, non-inferiority, phase 3 trial HYPO-RT-PC Open
View article: Pathological response to pembrolizumab-based neoadjuvant therapy in ER-low vs. ER-zero breast cancer: a Swedish population-based cohort study
Pathological response to pembrolizumab-based neoadjuvant therapy in ER-low vs. ER-zero breast cancer: a Swedish population-based cohort study Open
View article: Chemoradiation therapy With Cisplatin Versus Cetuximab in Patients With Locoregionally Advanced Head and Neck Squamous Cell Cancer—Mature Results of the ARTSCAN III Trial
Chemoradiation therapy With Cisplatin Versus Cetuximab in Patients With Locoregionally Advanced Head and Neck Squamous Cell Cancer—Mature Results of the ARTSCAN III Trial Open
The study showed inferior treatment outcomes for cetuximab compared with cisplatin concurrent with RT. Cisplatin remains standard concomitant treatment for locoregionally advanced HNSCC.
View article: Preoperative Radiotherapy Does Not Increase the Risk for Early Complications Following Surgery for Oral Cancer: A Study on Data From the Randomized ARTSCAN 2 Trial
Preoperative Radiotherapy Does Not Increase the Risk for Early Complications Following Surgery for Oral Cancer: A Study on Data From the Randomized ARTSCAN 2 Trial Open
Importance The management of complications following oral cavity squamous cell carcinoma (OCSCC) surgery can be challenging. Previous studies show conflicting results on complication risks after preoperative radiotherapy (RT), necessitatin…
View article: Seat leak tests and commissioning of control valves in the cryogenic distribution system of the ESS superconducting linac
Seat leak tests and commissioning of control valves in the cryogenic distribution system of the ESS superconducting linac Open
The European Spallation Source (ESS) is a neutron-scattering facility which will use a pulsed 2.0 GeV proton beam generated in the linear accelerator (LINAC) for releasing high-energy neutrons in the ESS target station. The 2K superconduct…
View article: Design, implementation, and preliminary testing of the interlocks and safety functions for the CMDS (cryomodule and cryogenic distribution system) master system at the European Spallation Source ERIC
Design, implementation, and preliminary testing of the interlocks and safety functions for the CMDS (cryomodule and cryogenic distribution system) master system at the European Spallation Source ERIC Open
The current paper introduces the design and implementation of the Interlocks and Safety Functions implemented for operating the cryogenic system of the European Spallation Source (ESS) superconducting Linear Accelerator (LINAC), emphasizin…
View article: The Impact of Physical Activity on Abdominal Aortic Aneurysm: A Scoping Review
The Impact of Physical Activity on Abdominal Aortic Aneurysm: A Scoping Review Open
This review indicates that moderate PA is generally safe and may provide health benefits for individuals with small AAAs. However, significant knowledge gaps remain, especially regarding the optimal frequency, intensity, and duration of PA…
View article: Stereotactic body radiotherapy as metastasis-directed therapy in oligometastatic prostate cancer: a systematic review and meta-analysis of randomized controlled trials
Stereotactic body radiotherapy as metastasis-directed therapy in oligometastatic prostate cancer: a systematic review and meta-analysis of randomized controlled trials Open
Background The use of stereotactic body radiotherapy (SBRT) to definitively treat oligometastases in prostate cancer has drawn large clinical and research interests within radiation oncology. However, the evidence is considered in its earl…
View article: Design, development and commissioning of the control system for the cryogenic distribution system at ESS
Design, development and commissioning of the control system for the cryogenic distribution system at ESS Open
The cryogenic distribution system (CDS) at the European Spallation Source (ESS) connects the refrigeration plant with the linear accelerator, consisting in 13 spoke and 30 elliptical cryomodules that are cooled at 2K via multi-transfer lin…
View article: Commissioning of the cryogenic distribution system of the ESS superconducting linac
Commissioning of the cryogenic distribution system of the ESS superconducting linac Open
The European Spallation Source (ESS) is a neutron-scattering facility being built with extensive international collaboration in Lund, Sweden. An essential part of the project is the linear 2.0 GeV proton accelerator. Its superconducting pa…
View article: Ultrahypofractionated Radiation Therapy for Prostate Cancer Including Seminal Vesicles in the Target Volume: A Treatment-planning Study Based on the HYPO-RT-PC Fractionation Schedule
Ultrahypofractionated Radiation Therapy for Prostate Cancer Including Seminal Vesicles in the Target Volume: A Treatment-planning Study Based on the HYPO-RT-PC Fractionation Schedule Open
View article: Dose-volume relationships of planned versus estimated delivered radiation doses to pelvic organs at risk and side effects in patients treated with salvage radiotherapy for recurrent prostate cancer
Dose-volume relationships of planned versus estimated delivered radiation doses to pelvic organs at risk and side effects in patients treated with salvage radiotherapy for recurrent prostate cancer Open
View article: Causal discovery in a complex industrial system: A time series benchmark
Causal discovery in a complex industrial system: A time series benchmark Open
Causal discovery outputs a causal structure, represented by a graph, from observed data. For time series data, there is a variety of methods, however, it is difficult to evaluate these on real data as realistic use cases very rarely come w…
View article: Risk of prostate cancer death after radical radiotherapy with neoadjuvant and adjuvant therapy with bicalutamide or gonadotropin-releasing hormone agonists
Risk of prostate cancer death after radical radiotherapy with neoadjuvant and adjuvant therapy with bicalutamide or gonadotropin-releasing hormone agonists Open
In this observational study, risk of Pca death between men receiving different combinations of AST varied according to RRT type. No difference was found in risk of Pca death for men treated with bicalutamide or GnRH as adjuvant therapy to …
View article: Importance of tumor volume, overall treatment time and fractionation sensitivity for p16-positive and p16-negative oropharyngeal tumors
Importance of tumor volume, overall treatment time and fractionation sensitivity for p16-positive and p16-negative oropharyngeal tumors Open
Primary tumor volume plays a crucial role in predicting local tumor response, particularly in p16-positive OPSCC. The estimated α/β-ratio for p16-positive oropharyngeal tumors aligns with previous HNSCC studies, whereas the impact of prolo…
View article: Cost-effectiveness analysis of (accelerated) pre-operative versus (conventional) post-operative radiotherapy for patients with oral cavity cancer in Sweden
Cost-effectiveness analysis of (accelerated) pre-operative versus (conventional) post-operative radiotherapy for patients with oral cavity cancer in Sweden Open
Background Treatment for resectable oral cavity cancer (OCC) often includes combinations of surgery and radiotherapy (RT), but there is no conclusive information on the preferred treatment order. The aim of this study was to assess the cos…
View article: MRI-only radiotherapy from an economic perspective: Can new techniques in prostate cancer treatment be cost saving?
MRI-only radiotherapy from an economic perspective: Can new techniques in prostate cancer treatment be cost saving? Open
View article: A prospective phase II study of prostate-specific antigen-guided salvage radiotherapy and 68Ga-PSMA-PET for biochemical relapse after radical prostatectomy – The PROPER 1 trial
A prospective phase II study of prostate-specific antigen-guided salvage radiotherapy and 68Ga-PSMA-PET for biochemical relapse after radical prostatectomy – The PROPER 1 trial Open
This new personalised treatment concept with intensified SRT based on PSA response demonstrated a high tumour control rate in both responders and non-responders. These results suggest a clinically significant effect with moderate side effe…
View article: Primary tumor volume and prognosis for patients with p16-positive and p16-negative oropharyngeal squamous cell carcinoma treated with radiation therapy
Primary tumor volume and prognosis for patients with p16-positive and p16-negative oropharyngeal squamous cell carcinoma treated with radiation therapy Open
View article: Cost-effectiveness Analysis of Pre- Versus Post-operative Radiotherapy for Patients With Oral Cancer
Cost-effectiveness Analysis of Pre- Versus Post-operative Radiotherapy for Patients With Oral Cancer Open
Background : Treatment for resectable oral cavity cancer (OCC) often includes combinations of surgery and radiotherapy (RT), but there is no conclusive information on by which order these measures are best administered. The aim of this stu…
View article: Results from a prospective, randomised study on (accelerated) preoperative versus (conventional) postoperative radiotherapy in treatment of patients with resectable squamous cell carcinoma of the oral cavity – The ARTSCAN 2 study
Results from a prospective, randomised study on (accelerated) preoperative versus (conventional) postoperative radiotherapy in treatment of patients with resectable squamous cell carcinoma of the oral cavity – The ARTSCAN 2 study Open
This study does not support that AF prior to surgery improves outcome in oral cavity cancer compared with postoperative CF.
View article: ESS Cryogenic Controls Design
ESS Cryogenic Controls Design Open
View article: Adaptive sequential plan-on-plan optimization during prostate-specific antigen response guided radiotherapy of recurrent prostate cancer
Adaptive sequential plan-on-plan optimization during prostate-specific antigen response guided radiotherapy of recurrent prostate cancer Open
View article: ARTSCAN III: A Randomized Phase III Study Comparing Chemoradiotherapy With Cisplatin Versus Cetuximab in Patients With Locoregionally Advanced Head and Neck Squamous Cell Cancer
ARTSCAN III: A Randomized Phase III Study Comparing Chemoradiotherapy With Cisplatin Versus Cetuximab in Patients With Locoregionally Advanced Head and Neck Squamous Cell Cancer Open
PURPOSE We performed an open-label randomized controlled phase III study comparing treatment outcome and toxicity between radiotherapy (RT) with concomitant cisplatin versus concomitant cetuximab in patients with locoregionally advanced he…
View article: Long-Term Risk of Hip Complications After Radiation Therapy for Prostate Cancer: A Dose-Response Study
Long-Term Risk of Hip Complications After Radiation Therapy for Prostate Cancer: A Dose-Response Study Open
View article: PSA decay during salvage radiotherapy for prostate cancer as a predictor of disease outcome – 5 year follow-up of a prospective observational study
PSA decay during salvage radiotherapy for prostate cancer as a predictor of disease outcome – 5 year follow-up of a prospective observational study Open
The addition of k to established clinical variables significantly improves the possibility to predict treatment outcome after SRT and could be used to personalize future therapies.
View article: Altered fractionation diminishes importance of tumor volume in oropharyngeal cancer: Subgroup analysis of ARTSCAN‐trial
Altered fractionation diminishes importance of tumor volume in oropharyngeal cancer: Subgroup analysis of ARTSCAN‐trial Open
Background A large tumor volume negatively impacts the outcome of radiation therapy (RT). Altered fractionation (AF) can improve local control (LC) compared with conventional fractionation (CF). The aim of the present study was to investig…
View article: Radical radiotherapy for prostate cancer: patterns of care in Sweden 1998–2016
Radical radiotherapy for prostate cancer: patterns of care in Sweden 1998–2016 Open
Introduction: Radiotherapy is an established treatment option for prostate cancer (PCa), both as primary treatment and secondary treatment after radical prostatectomy (RP). Since 1998, detailed data on radiotherapy delivered to Swedish men…
View article: Helium Management of ESS Cryoplants with Common Safety Relief Header and Recovery System
Helium Management of ESS Cryoplants with Common Safety Relief Header and Recovery System Open
The European Spallation Source (ESS) is a neutron-scattering facility being built with extensive international collaboration in Lund, Sweden. Three cryogenic plants with a vast cryogenic distribution system meet the cooling requirements of…
View article: Commissioning of the Warm Compressor System for the ESS Accelerator Cryoplant
Commissioning of the Warm Compressor System for the ESS Accelerator Cryoplant Open
The accelerator cryoplant (ACCP) providing the cooling for the cryomodules and the cryogenic distribution system for the cold part of the ESS proton linac is being built and commissioned at the European Spallation Source (ESS) in Lund, Swe…