Per‐Erik Olsson
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View article: Models and challenges for studying forever chemicals and their impact on human health
Models and challenges for studying forever chemicals and their impact on human health Open
Per- and polyfluoroalkyl substances (PFAS), also known as ‘forever chemicals’, are of high concern for human and ecosystem health. PFAS were first synthesised and developed in the late 1930s, and are now commonplace in many everyday object…
View article: Preservation of Aquatic Environmental <scp>DNA</scp> Using Cationic Detergents
Preservation of Aquatic Environmental <span>DNA</span> Using Cationic Detergents Open
Environmental DNA (eDNA) analysis is a powerful tool for quantifying and assessing the diversity of organisms in the environment. Unfortunately, isolating eDNA from aquatic environments is challenging due to the difficulties associated wit…
View article: Exploring the Sublethal Impacts of Cu and Zn on Daphnia magna: a transcriptomic perspective
Exploring the Sublethal Impacts of Cu and Zn on Daphnia magna: a transcriptomic perspective Open
Metal contamination of aquatic environments remains a major concern due to their persistence. The water flea Daphnia magna is an important model species for metal toxicity studies and water quality assessment. However, most research has fo…
View article: Temporal sex specific brain gene expression pattern during early rat embryonic development
Temporal sex specific brain gene expression pattern during early rat embryonic development Open
Background: The classical concept of brain sex differentiation suggests that steroid hormones released from the gonads program male and female brains differently. However, several studies indicate that steroid hormones are not the only det…
View article: Assessing organism differences in mixed metal sensitivity
Assessing organism differences in mixed metal sensitivity Open
Metal contamination of aquatic environments remains a major concern and has received significant attention in recent years. The present study aimed to evaluate the effects of metal mixtures of varying concentrations over time in a lake rec…
View article: Utilization of Computer Classification Methods for Exposure Prediction and Gene Selection in Daphnia magna Toxicogenomics
Utilization of Computer Classification Methods for Exposure Prediction and Gene Selection in Daphnia magna Toxicogenomics Open
Zinc (Zn) is an essential element that influences many cellular functions. Depending on bioavailability, Zn can cause both deficiency and toxicity. Zn bioavailability is influenced by water hardness. Therefore, water quality analysis for h…
View article: Per- and polyfluoroalkyl substances enhance Staphylococcus aureus pathogenicity and impair host immune response
Per- and polyfluoroalkyl substances enhance Staphylococcus aureus pathogenicity and impair host immune response Open
Per- and Poly-fluoroalkyl substances (PFAS) are major persistent environmental contaminants. Epidemiological studies have linked PFAS exposures to altered immunity and increased occurrence of infections in children. However, the mechanisms…
View article: Water Hardness Alters the Gene Expression Response and Copper Toxicity in Daphnia magna
Water Hardness Alters the Gene Expression Response and Copper Toxicity in Daphnia magna Open
The influence of water hardness on copper (Cu) toxicity in Daphnia magna was studied using gene expression analysis. Exposing D. magna to Cu in water with increasing levels of hardness decreased the acute toxicity. Hardness did not affect …
View article: Carbapenemase-producing <i>Aeromonas</i> species isolated from the urban-impacted Akaki river in Ethiopia
Carbapenemase-producing <i>Aeromonas</i> species isolated from the urban-impacted Akaki river in Ethiopia Open
Carbapenemase-producing Aeromonas species are an emerging health threat. This study aimed to determine carbapenemase-mediated resistance among Aeromonas isolates from the Akaki river, Ethiopia during the dry and wet seasons in 2019–2020. A…
View article: Antimicrobial resistance genes in microbiota associated with sediments and water from the Akaki river in Ethiopia
Antimicrobial resistance genes in microbiota associated with sediments and water from the Akaki river in Ethiopia Open
The spread of antimicrobial-resistant pathogens is a global health concern. Most studies report high levels of antimicrobial resistance genes (ARGs) in the aquatic environment; however, levels associated with sediments are limited. This st…
View article: Lysinibacillus sphaericus mediates stress responses and attenuates arsenic toxicity in Caenorhabditis elegans
Lysinibacillus sphaericus mediates stress responses and attenuates arsenic toxicity in Caenorhabditis elegans Open
Exposure to toxic metals alters host response and that leads to disease development. Studies have revealed the effects of metals on microbial physiology, however, the role of metal resistant bacteria on host response to metals is unclear. …
View article: Influence of water hardness on zinc toxicity in <scp><i>Daphnia magna</i></scp>
Influence of water hardness on zinc toxicity in <span><i>Daphnia magna</i></span> Open
Zinc is an essential trace metal required for the maintenance of multiple physiological functions. Due to this, organisms can experience both zinc deficiency and toxicity. Hardness is recognized as one of the main modifying physiochemical …
View article: Genes in the Azoospermia Factor A Region of the Y Chromosome Show Sexual Dimorphism in Rat Brain Prior to Gonadal Sex Differentiation
Genes in the Azoospermia Factor A Region of the Y Chromosome Show Sexual Dimorphism in Rat Brain Prior to Gonadal Sex Differentiation Open
BackgroundThe classical concept of brain sex differentiation suggests that steroid hormones released from the gonads program male and female brains differently. However, several studies indicate that steroid hormones are not the only deter…
View article: In silico and in vitro assessment of androgen receptor antagonists
In silico and in vitro assessment of androgen receptor antagonists Open
There is a growing concern for male reproductive health as studies suggest that there is a sharp increase in prostate cancer and other fertility related problems. Apart from lifestyle, pollutants are also known to negatively affect the rep…
View article: Sublethal effects of DBE-DBCH diastereomers on physiology, behavior, and gene expression of Daphnia magna
Sublethal effects of DBE-DBCH diastereomers on physiology, behavior, and gene expression of Daphnia magna Open
1,2-dibromo-4-(1,2-dibromoethyl)-cyclohexane (DBE-DBCH) is a brominated flame retardant used in commercial and industrial applications. The use of DBE-DBCH containing products has resulted in an increased release into the environment. Howe…
View article: Perfluorinated alkyl substances impede growth, reproduction, lipid metabolism and lifespan in Daphnia magna
Perfluorinated alkyl substances impede growth, reproduction, lipid metabolism and lifespan in Daphnia magna Open
Per- and polyfluorinated alkyl substances (PFASs) are synthetic organofluorine compounds with unique stability accompanied with hydrophobic and lipophobic properties. Perfluorooctane sulfonate (PFOS) and Perfluorooctanoic acid (PFOA) are o…
View article: Zebrafish cyp17a1 knockout reveals that androgen-mediated signaling is important for male brain sex differentiation
Zebrafish cyp17a1 knockout reveals that androgen-mediated signaling is important for male brain sex differentiation Open
Brain sex differentiation is a complex process, wherein genes and steroid hormones act to induce specific gender brain differentiation. Testosterone (T) derived from the gonads has been linked to neural circuit modeling in a sex-specific m…
View article: Species differences in ligand interaction and activation of estrogen receptors in fish and human
Species differences in ligand interaction and activation of estrogen receptors in fish and human Open
Estrogen receptor (ER) sequences vary between species and this suggests that there are differences in the ligand-specificity, leading to species-specific effects. This would indicate that it is not possible to generalize effects across spe…
View article: Androgen receptor modulation following combination exposure to brominated flame-retardants
Androgen receptor modulation following combination exposure to brominated flame-retardants Open
Endocrine disrupting compounds can interfere with androgen receptor (AR) signaling and disrupt steroidogenesis leading to reproductive failure. The brominated flame-retardant (BFR) 1, 2-dibromo-4-(1, 2-dibromoethyl) cyclohexane (TBECH), is…
View article: Heat shock factor 5 is conserved in vertebrates and essential for spermatogenesis in zebrafish
Heat shock factor 5 is conserved in vertebrates and essential for spermatogenesis in zebrafish Open
Heat shock factors (Hsfs) are transcription factors that regulate response to heat shock and to variety of other environmental and physiological stimuli. Four HSFs (HSF1-4) known in vertebrates till date, perform a wide variety of function…