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View article: Absence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesis
Absence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesis Open
Obesity poses a global health challenge, demanding a deeper understanding of adipose tissue (AT) and its mitochondria. This study describes the role of the mitochondrial protein Methylation-controlled J protein (MCJ/DnaJC15) in orchestrati…
View article: Proteomics sample preparation v1
Proteomics sample preparation v1 Open
Protocol for proteomic analysis and data acquisition used in: "Selective Deficiency of MitochondrialRespiratory Complex I Subunits Ndufs4/6 Causes Tumor Immunogenicity". The paper's abstract is as follows: Cancer cells frequently rewire th…
View article: Riboflavin Drives Nucleotide Biosynthesis and Iron-Sulfur Metabolism to Promote Acute Myeloid Leukemia
Riboflavin Drives Nucleotide Biosynthesis and Iron-Sulfur Metabolism to Promote Acute Myeloid Leukemia Open
Cofactors, many of which are vitamin-derived, are organic molecules with diverse biological functions. They are required for many metabolic pathways and enzymatic reactions, and thus can influence cell proliferation and differentiation. Th…
View article: A chaperone-assisted mechanism of outer mitochondrial membrane TOM70 insertion protective against diet-induced obesity
A chaperone-assisted mechanism of outer mitochondrial membrane TOM70 insertion protective against diet-induced obesity Open
Outer mitochondrial membrane (OMM) proteins communicate with the cytosol and other organelles including the endoplasmic reticulum (ER)1,2. This communication is important in thermogenic adipocytes to increase energy expenditure that contro…
View article: Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread
Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread Open
The inherent ability of melanoma cells to alter the differentiation-associated transcriptional repertoire to evade treatment and facilitate metastatic spread is well accepted and has been termed phenotypic switching. However, how these fac…
View article: Abstract 2480 Adaptive Mechanisms of Mitochondrial Respiration
Abstract 2480 Adaptive Mechanisms of Mitochondrial Respiration Open
The appearance of oxygen in the atmosphere caused evolutionary processes to adapt cells to this new aerobic environment. Eukaryotic cells incorporated mitochondrial organelles and use oxygen in the respiratory chain as final electron accep…
View article: Cardiomyocyte PGC-1α enables physiological adaptations to endurance exercise through suppression of GDF15 and cardiac atrophy
Cardiomyocyte PGC-1α enables physiological adaptations to endurance exercise through suppression of GDF15 and cardiac atrophy Open
Summary Exercise training induces physiological cardiac hypertrophy, enhanced mitochondrial biogenesis and myocardial contractility. In skeletal muscle, the transcriptional coactivator PGC-1α is a key orchestrator of these responses. The h…
View article: Structural basis of respiratory complexes adaptation to cold temperatures
Structural basis of respiratory complexes adaptation to cold temperatures Open
In response to cold, mammals activate brown fat for respiratory-dependent thermogenesis reliant on the electron transport chain (1, 2). Yet, the structural basis of respiratory complex adaptation to cold remains elusive. Herein we combined…
View article: Selective Mitochondrial Respiratory Complex I Subunit Deficiency Causes Tumor Immunogenicity
Selective Mitochondrial Respiratory Complex I Subunit Deficiency Causes Tumor Immunogenicity Open
Targeting of specific metabolic pathways in tumor cells has the potential to sensitize them to immune-mediated attack. Here we provide evidence for a specific means of mitochondrial respiratory Complex I (CI) inhibition that improves tumor…
View article: Epigenetic suppression of PGC1α (PPARGC1A) causes collateral sensitivity to HMGCR-inhibitors within BRAF-treatment resistant melanomas
Epigenetic suppression of PGC1α (PPARGC1A) causes collateral sensitivity to HMGCR-inhibitors within BRAF-treatment resistant melanomas Open
While targeted treatment against BRAF(V600E) improve survival for melanoma patients, many will see their cancer recur. Here we provide data indicating that epigenetic suppression of PGC1α defines an aggressive subset of chronic BRAF-inhibi…
View article: Figure S3 from Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency
Figure S3 from Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency Open
Metabolic and inflammatory parameters of the DEN-treatment mice
View article: Figure S4 from Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency
Figure S4 from Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency Open
Cyclin D1 dependency positively correlates with palbociclib sensitivity in liver cancer cells
View article: Data from Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency
Data from Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency Open
Type 2 diabetes, which is mainly linked to obesity, is associated with increased incidence of liver cancer. We have previously found that in various models of obesity/diabetes, hyperinsulinemia maintains heightened hepatic expression of cy…
View article: Supplementary Figure Legend from Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency
Supplementary Figure Legend from Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency Open
Supplementary figure legends
View article: Figure S1 from Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency
Figure S1 from Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency Open
Gene expression profiles of liver or HCC derived from lean and obese/diabetic mice.
View article: Figure S2 from Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency
Figure S2 from Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency Open
Deletion of Cyclin D1 in hepatocytes does not alter the mouse metabolic responses.
View article: Figure S2 from Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency
Figure S2 from Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency Open
Deletion of Cyclin D1 in hepatocytes does not alter the mouse metabolic responses.
View article: Figure S4 from Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency
Figure S4 from Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency Open
Cyclin D1 dependency positively correlates with palbociclib sensitivity in liver cancer cells
View article: Figure S1 from Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency
Figure S1 from Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency Open
Gene expression profiles of liver or HCC derived from lean and obese/diabetic mice.
View article: Data from Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency
Data from Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency Open
Type 2 diabetes, which is mainly linked to obesity, is associated with increased incidence of liver cancer. We have previously found that in various models of obesity/diabetes, hyperinsulinemia maintains heightened hepatic expression of cy…
View article: Supplementary Figure Legend from Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency
Supplementary Figure Legend from Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency Open
Supplementary figure legends