Peri Millman
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View article: A novel nutritional approach to infants and children with congenital diarrhea due to homozygous DGAT1 mutations
A novel nutritional approach to infants and children with congenital diarrhea due to homozygous DGAT1 mutations Open
Objectives Diacylglycerol acyltransferase (DGAT) catalyzes the final step in triglyceride synthesis. DGAT1 is expressed in human enterocytes and is essential for fat absorption. Homozygous DGAT1 deficiency often presents with severe diarrh…
View article: DOP64 Pathogenic RIPK1 Mutations Cause Infantile-onset IBD with Inflammatory and Fistulizing Features
DOP64 Pathogenic RIPK1 Mutations Cause Infantile-onset IBD with Inflammatory and Fistulizing Features Open
Background Genetics plays a key role in the pathogenesis of inflammatory bowel disease (IBD). With the expanding use of next-generation sequencing, >70 different monogenic disorders associated with IBD have been identified, and most of …
View article: Hijab Pin Ingestions
Hijab Pin Ingestions Open
OBJECTIVES: To characterize the clinical manifestations, outcomes, and complications of hijab pin ingestion in adolescents and to identify risk factors for a need for intervention. METHODS: A retrospective review of patients <25 years o…
View article: Exogenous interleukin-2 can rescue <i>in-vitro</i> T cell activation and proliferation in patients with a novel capping protein regulator and myosin 1 linker 2 mutation
Exogenous interleukin-2 can rescue <i>in-vitro</i> T cell activation and proliferation in patients with a novel capping protein regulator and myosin 1 linker 2 mutation Open
Summary Capping protein regulator and myosin 1 linker 2 (CARMIL2) deficiency is characterized by impaired T cell activation, which is attributed to defective CD28-mediated co-signaling. Herein, we aimed to analyze the effect of exogenous i…
View article: P689 The effect of nutritional therapy on bone mineral density and bone metabolism in paediatric Crohn’s disease
P689 The effect of nutritional therapy on bone mineral density and bone metabolism in paediatric Crohn’s disease Open
Childhood is a critical time for accrual of bone density, which peaks at age 18–20 years. Both the inflammatory burden of CD and corticosteroid therapy have a negative effect on bone density, hence exclusive enteral nutrition (EEN) is the …
View article: P346 Small bowel permeability improves with nutritional therapy in mild-to-moderate active paediatric Crohn’s disease
P346 Small bowel permeability improves with nutritional therapy in mild-to-moderate active paediatric Crohn’s disease Open
Intestinal permeability (IP) is increased in Crohn’s disease (CD) patients and their first degree relatives. The causes of barrier disruption remain unclear but likely relate to inflammation with possible effects of nutrients and microbes.…