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View article: The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals a new Arpp19/PP2A-B55 feedback loop
The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals a new Arpp19/PP2A-B55 feedback loop Open
Arpp19 is a potent inhibitor of PP2A-B55 that regulates this phosphatase to ensure the stable phosphorylation of mitotic/meiotic substrates. At G2-M, Arpp19 is phosphorylated by Greatwall on S67. This phosphorylated Arpp19 form displays a …
View article: Greatwall dephosphorylation and inactivation upon mitotic exit is triggered by PP1
Greatwall dephosphorylation and inactivation upon mitotic exit is triggered by PP1 Open
Entry into mitosis is induced by the activation of cyclin-B–Cdk1 and Greatwall (Gwl; also known as MASTL in mammals) kinases. Cyclin-B–Cdk1 phosphorylates mitotic substrates, whereas Gwl activation promotes the phosphorylation of the small…
View article: The master Greatwall kinase, a critical regulator of mitosis and meiosis
The master Greatwall kinase, a critical regulator of mitosis and meiosis Open
Entry into mitosis requires the coordinated activation of various protein kinases and phosphatases that together activate sequential signaling pathways allowing entry, progression and exit of mitosis. The limiting step is thought to be the…