Petar Markov
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Label-Free Optical Biopsy Reveals Biomolecular and Morphological Features of Diabetic Kidney Tissue in 2D and 3D Open
Kidney disease, the ninth leading cause of death in the United States, has one of the poorest diagnostic efficiencies of only 10% 1 . Conventional diagnostic methods often rely on light microscopy analysis of 2D fixed tissue sections with …
View article: Delayed reorganisation of F-actin cytoskeleton and reversible chromatin condensation in scleral fibroblasts under simulated pathological strain
Delayed reorganisation of F-actin cytoskeleton and reversible chromatin condensation in scleral fibroblasts under simulated pathological strain Open
Mechanical loading regulates the functional capabilities of the ocular system, particularly in the sclera ('white of the eye') - the principal load-bearing tissue of the ocular globe. Resident fibroblasts of the scleral eye wall are contin…
Rational Designed Hybrid Peptides Show up to a 6-Fold Increase in Antimicrobial Activity and Demonstrate Different Ultrastructural Changes as the Parental Peptides Measured by BioSAXS Open
Antimicrobial peptides (AMPs) are a promising class of compounds being developed against multi-drug resistant bacteria. Hybridization has been reported to increase antimicrobial activity. Here, two proline-rich peptides (consP1: VRKPPYLPRP…
Rational Designed Hybrid Peptides Show up to a 6-fold Increase in Antimicrobial Activity and Demonstrate Different Ultrastructural Changes as the Parental Peptides measured by BioSAXS Open
Antimicrobial peptides (AMPs) are a promising class of compounds being developed against multi-drug resistant bacteria. Hybridization has been reported to increase antimicrobial activity. Here, two proline-rich peptides (consP1: VRKPPYLPRP…
View article: <scp>3D</scp> immuno‐confocal image reconstruction of fibroblast cytoskeleton and nucleus architecture
<span>3D</span> immuno‐confocal image reconstruction of fibroblast cytoskeleton and nucleus architecture Open
Computational models of cellular structures generally rely on simplifying approximations and assumptions that limit biological accuracy. This study presents a comprehensive image processing pipeline for creating unified three‐dimensional (…
Analysis of X-ray scattering microstructure data for implementation in numerical simulations of ocular biomechanical behaviour Open
This study aimed to analyse microstructure data on the density and orientation of collagen fibrils in whole eye globes and to propose an effective method for the preparation of data for use in numerical simulations of the eye's biomechanic…
View article: Quantification of collagen fiber structure using second harmonic generation imaging and two‐dimensional discrete Fourier transform analysis: Application to the human optic nerve head
Quantification of collagen fiber structure using second harmonic generation imaging and two‐dimensional discrete Fourier transform analysis: Application to the human optic nerve head Open
Second harmonic generation (SHG) microscopy is widely used to image collagen fiber microarchitecture due to its high spatial resolution, optical sectioning capabilities and relatively nondestructive sample preparation. Quantification of SH…
Bulk changes in posterior scleral collagen microstructure in human high myopia. Open
Bulk alterations in the normal posterior scleral collagen microstructure occur in human eyes with high myopia. These changes could reflect remodeling of the posterior sclera during axial lengthening and/or a mechanical adaption to tissue s…
Automatic differential analysis of NMR experiments in complex samples Open
Liquid state nuclear magnetic resonance (NMR) is a powerful tool for the analysis of complex mixtures of unknown molecules. This capacity has been used in many analytical approaches: metabolomics, identification of active compounds in natu…