Petar Raykov
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View article: Hippocampal mismatch signals are based on episodic memories and not schematic knowledge
Hippocampal mismatch signals are based on episodic memories and not schematic knowledge Open
Prediction errors drive learning by signaling mismatches between expectations and reality, but the neural systems supporting these computations remain debated. The hippocampus is implicated in mismatch detection, yet it is not known whethe…
Complementary MR measures of white matter and their relation to cardiovascular health and cognition Open
The microstructural and macrostructural integrity of white matter (WM) underpins efficient brain function, and is known to decline with age and vascular burden. Key aspects of WM health include axonal fibre density, myelination, free-water…
The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) longitudinal study protocol: Phase 4 (“Enrichment”) and Phase 5 (“Rescan”) Open
Background The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) started in 2010 to study the effect of healthy adult ageing on cognition and the brain in a population-derived sample. The study design and protocol for Phases 1-3 of Ca…
Complementary MR measures of white matter and their relation to cardiovascular health and cognition Open
Magnetic Resonance Imaging (MRI) offers many ways to non-invasively estimate the properties of white matter (WM) in the brain. In addition to the various metrics derived from diffusion-weighted MRI, one can estimate total WM volume from T1…
View article: Hippocampus responds to mismatches with predictions based on episodic memories but not generalised knowledge
Hippocampus responds to mismatches with predictions based on episodic memories but not generalised knowledge Open
Prediction errors drive learning by signalling a mismatch between our expectations and reality. The hippocampus plays a key role in mismatch detection, but it is not known what information the hippocampus uses to form expectations. Here we…
No effect of apolipoprotein E polymorphism on MRI brain activity during movie watching Open
Apolipoprotein E ε4 is a major genetic risk factor for Alzheimer’s disease, and some apolipoprotein E ε4 carriers show Alzheimer’s disease–related neuropathology many years before cognitive changes are apparent. Therefore, studying healthy…
Does functional system segregation mediate the effects of lifestyle on cognition in older adults? Open
Healthy aging is typically accompanied by cognitive decline. Previous work has shown that engaging in multiple, non-work activities during midlife can have a protective effect on cognition several decades later, rendering it less dependent…
False memories for ending of events. Open
Memories are not perfect recordings of the past and can be subject to systematic biases. Memory distortions are often caused by our experience of what typically happens in a given situation. However, it is unclear whether memory for events…
Does functional system segregation mediate the effects of lifestyle on cognition in older adults? Open
Healthy aging is typically accompanied by cognitive decline. Previous work has shown that engaging in multiple, non-work activities during midlife can have a protective effect on cognition several decades later, rendering it less dependent…
Unveiling coding of prediction and sharpening of perceptual features through multivariate pattern analysis Open
A recent study by Blank, Alink and Büchel, uses multivariate neuroimaging to investigate how the human brain processes the strength of face-related expectations and explores whether these expectations are represented in the same regions th…
Elevated representational similarity of voluntary action and inhibition in Tourette syndrome Open
Many people with Tourette syndrome are able to volitionally suppress tics, under certain circumstances. To understand better the neural mechanisms that underlie this ability, we used functional magnetic resonance neuroimaging to track regi…
Elevated representational similarity of voluntary action and inhibition in Tourette syndrome Open
Many people with Tourette syndrome (TS) are able to volitionally suppress tics, under certain circumstances. To better understand the neural mechanisms that underlie this ability, we used functional magnetic resonance neuroimaging (fMRI) t…
The Importance of Semantic Network Brain Regions in Integrating Prior Knowledge with an Ongoing Dialogue Open
To understand a dialogue, we need to know the topics that are being discussed. This enables us to integrate our knowledge of what was said previously to interpret the current dialogue. This study involved a large-scale behavioral experimen…
The Neural Representation of Events Is Dominated by Elements that Are Most Reliably Present Open
An episodic memory is specific to an event that occurred at a particular time and place. However, the elements that constitute the event—the location, the people present, and their actions and goals—might be shared with numerous other simi…
Activation of Person Knowledge in Medial Prefrontal Cortex during the Encoding of New Lifelike Events Open
Our knowledge about people can help us predict how they will behave in particular situations and interpret their actions. In this study, we investigated the cognitive and neural effects of person knowledge on the encoding and retrieval of …
Controlling for sparsity in sparse factor analysis models: adaptive latent feature sharing for piecewise linear dimensionality reduction Open
Ubiquitous linear Gaussian exploratory tools such as principle component analysis (PCA) and factor analysis (FA) remain widely used as tools for: exploratory analysis, pre-processing, data visualization and related tasks. However, due to t…
Latent feature sharing: an adaptive approach to linear decomposition models. Open
Ubiquitous linear Gaussian exploratory tools such as principle component analysis (PCA) and factor analysis (FA) remain widely used as tools for: exploratory analysis, pre-processing, data visualization and related tasks. However, due to t…
Neurobiology of specific and general prior knowledge Open
To understand the world around us we largely rely on our prior knowledge, which can help us structure newly incoming information. My research implemented naturalistic fMRI studies to investigate how previously acquired information affects …
The importance of semantic network brain regions in integrating prior knowledge with an ongoing dialogue Open
To understand a dialogue we need to know the specific topics that are being discussed. This enables us to integrate our knowledge of what was said previously, in order to interpret the current dialogue. Here, we selectively manipulated kno…