Explanipedia

A - 01 Association Between Co-occurring Depressive and Anxiety Symptoms and Post-Concussion Recovery Timelines Open

G Thomas, M Bradson, Peter A. Arnett · 2025

Purpose A growing body of evidence has highlighted the important role of affective symptoms in concussion recovery timelines. While most research has focused on affective symptoms broadly—or on depression or anxiety in isolation—there is a…

A - 45 The Role of Avoidant Coping in Depression: Barriers to Training Due to the COVID-19 Pandemic Open

B Makarus, M Bradson, Garrett A Thomas, McKenna S Sakamoto, Celeste Santivasci , et al. · 2025

Purpose The COVID-19 pandemic led to significant disruptions in collegiate athletes’ routines, including exercise and team practices, essential for mental health and physical performance. This study explored how disruptions to training and…

Coping is a moderator of relationships between cognitive fatigue and cognitive variability in multiple sclerosis Open

Peter A. Arnett, Kaitlin E Riegler, Garrett A Thomas, Megan L Bradson, McKenna Sakamoto , et al. · 2025

Objective: Mean levels of cognitive functioning typically do not show an association with self-reported cognitive fatigue in persons with multiple sclerosis (PwMS), but some studies indicate that cognitive variability has an association wi…

Improving Early Detection of Cognitive Impairment in Older Adults in Primary Care Clinics: Recommendations From an Interdisciplinary Geriatrics Summit Open

Robin C. Hilsabeck, William Perry, Laura H. Lacritz, Peter A. Arnett, Raj C. Shah , et al. · 2024

As the population ages, the prevalence of cognitive impairment due to neurodegenerative diseases such as Alzheimer disease (AD) is expected to double in the United States to nearly 14 million over the next 40 years. AD and related dementia…

Association Between Co-occurring Anxiety and Depressive Symptoms at Baseline and Risk for Sports-Related Concussion in Collegiate Athletes Open

Garrett A Thomas, Megan L Bradson, Kaitlin E Riegler, McKenna S Sakamoto, Peter A. Arnett · 2024

Background: There is limited research examining whether mental health problems increase the risk for future concussions, even though these problems are highly prevalent in college-aged populations—including student-athletes. Purpose/Hypoth…

Network-Dependent Variability in Functional Connectivity after Mild Traumatic Brain Injury and Repetitive Head Impacts: A Systematic Review Open

Owen W. Griffith, Jon Kelly, Peter A. Arnett, Danielle Symons Downs, Frank G. Hillary , et al. · 2024

Mild traumatic brain injury and repetitive head impacts alter brain network functional connectivity. This review aimed to systematically analyze literature surrounding alterations in connectivity in functional networks after mild traumatic…

39 Co-Occurring Depression and Anxiety is Associated with Greater Cognitive Variability in Persons with Multiple Sclerosis Open

Garrett A Thomas, Kaitlin E Riegler, Megan L Bradson, Dede U. O’Shea, Peter A. Arnett · 2023

Objective: Research examining co-occurring anxiety and depression in persons with multiple sclerosis (PwMS) is scarce, though an estimated 20% of PwMS experience clinically significant anxiety and depression (Gascoyne et al., 2019). Recent…

40 Social Support Moderates the Relationship Between Pain and Sleep Quality in Multiple Sclerosis Open

Kaitlin E Riegler, Megan L Bradson, Garrett A Thomas, Peter A. Arnett · 2023

Objective: Lower levels of social support in persons with Multiple Sclerosis (PwMS) are associated with myriad poor outcomes including worse mental health, lower quality of life, and reduced motor function (Kever et al., 2021). Social supp…

41 High Stress and Negative Attributional Style is Associated with Depression Symptoms in Multiple Sclerosis Open

Megan L Bradson, Kaitlin E Riegler, Garrett A Thomas, Gray Vargas, Peter A. Arnett · 2023

Objective: Depression is highly prevalent in persons with multiple sclerosis (pwMS). A reformulated version of the learned helplessness theory posits that individuals who attribute the cause of negative events to personal factors (internal…

Integrating Lifestyle Factor Science into Neuropsychological Practice: A National Academy of Neuropsychology Education Paper Open

John J. Randolph, Laura H. Lacritz, Mary K. Colvin, Patricia Espe‐Pfeifer, Kirstine R Carter , et al. · 2023

Objective The primary aim of this paper is to review evidence and clinical implications related to lifestyle activities associated with promoting brain and cognitive health. Our review targets four key lifestyle factors: physical activity …

Internet-delivered cognitive behavioural therapy programme to reduce depressive symptoms in patients with multiple sclerosis: a multicentre, randomised, controlled, phase 3 trial Open

Stefan M. Gold, Tim Friede, Björn Meyer, Rona Moss‐Morris, Joanna Hudson , et al. · 2023

National Multiple Sclerosis Society (USA).

Length of Disease More than Therapy Impacts Anxiety and Depression in Multiple Sclerosis Open

Patricia J. McLaughlin, Laura Odom, Peter A. Arnett, Gary A. Thomas, Shannon Orehek , et al. · 2023

Persons with multiple sclerosis (PwMS) often report a reduced quality of life related to their anxiety and depression associated with the biological unknowns of MS. The COVID-19 pandemic increased the risk of anxiety due to the uncertainti…

Multiple Sclerosis and Depression: Translation and Adaptation of the Spanish Version of the Chicago Multiscale Depression Inventory and the Study of Factors Associated with Depressive Symptoms Open

Carla Sanchís-Segura, Álvaro Javier Cruz-Gómez, Sónia Félix Esbrí, Alba Sebastián Tirado, Peter A. Arnett , et al. · 2022

Objective Depressive disorder occurs in up to 50% of persons with Multiple Sclerosis (PwMS). Accurate assessment of depression in MS is essential in clinical settings because depressive symptomatology can affect the clinical course of the …

Low-dose naltrexone reduced anxiety in persons with multiple sclerosis during the COVID-19 pandemic Open

Patricia J. McLaughlin, Laura Odom, Peter A. Arnett, Shannon Orehek, Gary A. Thomas , et al. · 2022

A-12 Physical Activity Attenuates the Effect of Pain on Depression Symptoms in Multiple Sclerosis Open

Megan L Bradson, Kaitlin E Riegler, Garrett A Thomas, Peter A. Arnett · 2022

Objective: This study examined physical activity as a potential moderator of the relationship between pain and depression symptoms in persons with multiple sclerosis (PwMS). We hypothesized that pain would predict depression symptoms only …

A-9 Cognitive Associations to Accelerated Brain Aging in Multiple Sclerosis Open

Cristina A F Román, Dede O'Shea, Gray Vargas, John DeLuca, Peter A. Arnett · 2022

Objective: Accelerated brain aging (ABA) has been identified in neurological/psychological populations and associated with poorer outcomes. Though studies in multiple sclerosis (MS) are limited, ABA in MS has been linked to disease progres…

A-11 Cognitive Fatigue Predicts Subjective Report of Cognitive Functioning Over and Above Depression and Anxiety in Persons with Multiple Sclerosis Open

Garrett A Thomas, Kaitlin E Riegler, Megan L Bradson, Dede U. O’Shea, Peter A. Arnett · 2022

Objective: Self-and informant-reports may be used to evaluate perceived neurocognitive functioning, such as with the Multiple Sclerosis Neuropsychological Screening Questionnaire (MSNQ). However, these measures may be influenced by depress…

Avoidant Coping Is Associated with Quality of Life in Persons with Multiple Sclerosis with High Cognitive Reserve Open

Samantha Vervoordt, Megan L Bradson, Peter A. Arnett · 2022

Objective The goal of this study was to determine the impact of the relationship between cognitive reserve and coping strategy on quality of life (QoL) outcomes in persons with MS (PwMS) across multiple domains. Methods We examined the eff…

Prospective Implications of Insufficient Sleep for Athletes Open

Kaitlin E Riegler, Erin Guty, Garrett A Thomas, Megan L Bradson, Peter A. Arnett · 2022

Context Poor sleep is common in collegiate student-athletes and is associated with heterogeneous self-reported complaints at baseline. However, the long-term implications of poor sleep at baseline have been less well studied. Objective To …

Relationship between subjective report and objective assessment of neurocognitive functioning in persons with multiple sclerosis Open

Garrett A Thomas, Kaitlin E Riegler, Megan L Bradson, Dede U. O’Shea, Peter A. Arnett · 2022

Objective: Persons with multiple sclerosis (PwMS) are at increased risk for cognitive dysfunction. Considering the impact and potential ramifications of cognitive dysfunction, it is important that cognition is routinely assessed in PwMS. T…

Coping Style Moderates the Effect of Pain on Depression Symptoms in Multiple Sclerosis Open

Megan L Bradson, Margaret Cadden, Erin Guty, Kaitlin E Riegler, Garrett A Thomas , et al. · 2022

Objective The present study examined coping style as a possible moderator in the relationship between pain and depression in persons with multiple sclerosis (PwMS). Methods Fifty-four PwMS completed a comprehensive neuropsychological test …

A-180 Predictors of Performance on the ImPACT Validity Indices at Baseline Open

Liora S. Greenberg, Victoria C. Merritt, Peter A. Arnett · 2021

Objective To circumvent “sandbagging”, the ImPACT, a widely used computerized program in sports-related concussion evaluations, contains five embedded validity indices (VIs). This study aimed to identify variables associated with invalid p…

A-76 Coping Style Moderates the Effect of Pain on Depression in Multiple Sclerosis Open

Megan L Bradson, Margaret Cadden, Erin Guty, Kaitlin E Riegler, Garrett A Thomas , et al. · 2021

Objective The present study examined coping style as a possible moderator in the relationship between pain and depression in persons with multiple sclerosis (PwMS). Method Fifty-four PwMS (38 female) completed a comprehensive neuropsycholo…

A-165 Normative Data for the Rivermead Behavioral Memory Test (RBMT) in Collegiate Athletes Open

Garrett A Thomas, Erin Guty, Kaitlin E Riegler, Megan L Bradson, Peter A. Arnett · 2021

Objective The Rivermead Behavioral Memory Test (RBMT) Story subtest has four alternate forms. While the use of different forms allows for greater test–retest reliability, it is unclear whether these forms are comparable in terms of difficu…

A-115 Does Cognitive Reserve Moderate Functional Outcomes for Collegiate Athletes with Sports-Related Concussion? Open

Erin Guty, Margaret Cadden, Kaitlin E Riegler, Garrett A Thomas, Peter A. Arnett · 2021

Objective Studies are lacking that examine whether cognitive reserve (CR) plays a role in differential outcomes for individuals in sports-related concussion (SRC), particularly within the acute phase. This study explored the relationship b…

A-14 Mechanisms and Neuropsychological Correlates of Sleep Disruption in Concussed College Athletes Open

Kaitlin E Riegler, Erin Guty, Garrett A Thomas, Megan L Bradson, Peter A. Arnett · 2021

Objective First, to explore demographic/injury characteristics associated with increased sleep disruption post-concussion. Second, to examine the association between sleep disruption post-concussion and symptom reporting and cognitive vari…

A-93 Comorbidity or Concussion: Can we Tell the Difference? Open

Garrett A Thomas, Kaitlin E Riegler, Erin Guty, Megan L Bradson, Peter A. Arnett · 2021

Objective To evaluate athletes with comorbid mood disturbances at baseline (without recent concussion) compared to those without mood symptoms tested post-concussion. This study is predicated upon previous findings showing that athletes wi…

Sensory-Motor and Affective-Fatigue Factors are Associated with Symbol Digit Performance in Multiple Sclerosis Open

Peter A. Arnett, Margaret Cadden, Cristina A F Román, Erin Guty, Kaitlin E Riegler , et al. · 2021

Objectives: The oral Symbol Digit Modalities Test (SDMT) has become the standard for the brief screening of cognitive impairment in persons with multiple sclerosis (PwMS). It has been shown to be sensitive to sensory-motor factors involvin…

Perceived Fatigue Impact and Cognitive Variability in Multiple Sclerosis Open

Kaitlin E Riegler, Margaret Cadden, Erin Guty, Jared M. Bruce, Peter A. Arnett · 2021

Objective: People with Multiple Sclerosis (PwMS) and healthy controls (HCs) were evaluated on cognitive variability indices and we examined the relationship between fatigue and cognitive variability between these groups. Intraindividual va…

Effects of diminished positive mood and depressed mood upon verbal learning and memory among people with multiple sclerosis Open

Jordan Hoffmeister, Michael R. Basso, Bradley Reynolds, Douglas M. Whiteside, Ryan Mulligan , et al. · 2021

Objective: Cognitive impairment affects as many as 65% of people with multiple sclerosis (PWMS), and memory impairment confers greater severity of disability and functional impairment. Depression is also common among PWMS, and lifet…

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