Peter A. Bampton
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View article: Surveillance colonoscopy findings in asymptomatic participants over 75 years of age
Surveillance colonoscopy findings in asymptomatic participants over 75 years of age Open
Background and Aim Surveillance colonoscopy for colorectal cancer (CRC) is generally not recommended beyond 75 years of age. The study determined incidence and predictors of advanced adenoma and CRC in older individuals undergoing surveill…
View article: Improving Concordance Between Clinicians With Australian Guidelines for Bowel Cancer Prevention Using a Digital Application: Randomized Controlled Crossover Study
Improving Concordance Between Clinicians With Australian Guidelines for Bowel Cancer Prevention Using a Digital Application: Randomized Controlled Crossover Study Open
Background Australia’s bowel cancer prevention guidelines, following a recent revision, are among the most complex in the world. Detailed decision tables outline screening or surveillance recommendations for 230 case scenarios alongside ce…
View article: Depression influences fatigue in inflammatory bowel disease amongst other factors: a structural modelling approach
Depression influences fatigue in inflammatory bowel disease amongst other factors: a structural modelling approach Open
Objectives: Fatigue is common in people with inflammatory bowel disease (IBD) and is associated with IBD activity, sleep disturbance, anxiety and depression. The relative contribution of these factors to fatigue is unclear. This study aime…
View article: Insomnia is common in inflammatory bowel disease (IBD) and is associated with mental health conditions as well as IBD activity
Insomnia is common in inflammatory bowel disease (IBD) and is associated with mental health conditions as well as IBD activity Open
Background/Aims: Insomnia is common in people with chronic medical conditions, such as inflammatory bowel disease (IBD), and is readily treatable through cognitive behavioral therapy for insomnia. This study aimed to describe the associati…
View article: FIT for purpose: study protocol for a randomized controlled trial to personalize surveillance colonoscopy for individuals at elevated risk of colorectal cancer
FIT for purpose: study protocol for a randomized controlled trial to personalize surveillance colonoscopy for individuals at elevated risk of colorectal cancer Open
Purpose There is increasing demand for colorectal cancer (CRC) surveillance, but healthcare capacity is limited. The burden on colonoscopy resources could be reduced by personalizing surveillance frequency using the fecal immunochemical te…
View article: Comparing the resource implications of old and new colorectal adenoma surveillance guidelines in Australia
Comparing the resource implications of old and new colorectal adenoma surveillance guidelines in Australia Open
Background The latest update to the Australian adenoma surveillance guideline in 2018 introduced a novel risk stratification system with updated surveillance recommendations. The resource implications of adopting this new system are unclea…
View article: Simple Novel Screening Tool for Obstructive Sleep Apnea in Inflammatory Bowel Disease
Simple Novel Screening Tool for Obstructive Sleep Apnea in Inflammatory Bowel Disease Open
Background Inflammatory bowel disease (IBD) has been associated with an increased risk of obstructive sleep apnea (OSA). We aimed to examine the associations of obstructive sleep apnea, sleepiness, and IBD-related data and comorbidities, w…
View article: Examining the influence of inflammatory bowel disease medications on sleep quality
Examining the influence of inflammatory bowel disease medications on sleep quality Open
Background and Aim Inflammatory bowel disease (IBD) can disrupt sleep, leading to poor sleep quality. This may in part be due to the symptoms of IBD and the influence of pro‐inflammatory cytokines on sleep. This study aimed to investigate …
View article: Quality of colonoscopy performed by medical or surgical specialists and trainees in five Australian hospitals
Quality of colonoscopy performed by medical or surgical specialists and trainees in five Australian hospitals Open
Significant differences in the quality of colonoscopy in Australia exist, even when national benchmarks are achieved. The role of possible contributing factors, like procedural specialty and patient gender need further evaluation.
View article: Systematic review and meta‐analysis of sleep quality in inactive inflammatory bowel disease
Systematic review and meta‐analysis of sleep quality in inactive inflammatory bowel disease Open
Poor sleep in people with inflammatory bowel disease (IBD) has been demonstrated to be prevalent and has been associated with disease activity. This meta‐analysis aimed to assess the prevalence of poor sleep in inactive IBD and in controls…
View article: An Extremes of Phenotype Approach Confirms Significant Genetic Heterogeneity in Patients with Ulcerative Colitis
An Extremes of Phenotype Approach Confirms Significant Genetic Heterogeneity in Patients with Ulcerative Colitis Open
Background and Aims Ulcerative colitis [UC] is a major form of inflammatory bowel disease globally. Phenotypic heterogeneity is defined by several variables including age of onset and disease extent. The genetics of disease severity remain…
View article: Proactive Metabolite Testing in Patients on Thiopurine May Yield Long-Term Clinical Benefits in Inflammatory Bowel Disease
Proactive Metabolite Testing in Patients on Thiopurine May Yield Long-Term Clinical Benefits in Inflammatory Bowel Disease Open
Thiopurine TDM resulted in a change in management for the majority of patients. Post TDM significantly more patients were in remission. TDM allowed the identification of non-adherence and shunters who, without intervention, would not reach…
View article: A systematic review and meta-analysis of the prevalence of poor sleep in inflammatory bowel disease
A systematic review and meta-analysis of the prevalence of poor sleep in inflammatory bowel disease Open
Study Objectives Poor sleep-in people with inflammatory bowel disease (IBD) has been associated with worse quality of life, along with anxiety, depression, and fatigue. This meta-analysis aimed to determine the pooled prevalence of poor sl…
View article: Circulating Dipeptidyl Peptidase Activity Is a Potential Biomarker for Inflammatory Bowel Disease
Circulating Dipeptidyl Peptidase Activity Is a Potential Biomarker for Inflammatory Bowel Disease Open
INTRODUCTION: Dipeptidyl peptidase (DPP)-4 is part of a larger family of proteases referred to as DPPs. DPP4 has been suggested as a possible biomarker for inflammatory bowel disease (IBD). Circulating DPP4 (cDPP4) enzyme activity was inve…
View article: An extremes of phenotype approach confirms significant genetic heterogeneity in patients with ulcerative colitis
An extremes of phenotype approach confirms significant genetic heterogeneity in patients with ulcerative colitis Open
Ulcerative colitis (UC) is a major form of inflammatory bowel disease with increasing global incidence. There is significant phenotypic heterogeneity defined by a range of clinical variables including age of onset and disease extent. Clini…
View article: P008 A systematic review and meta-analysis of inflammatory bowel disease activity and sleep quality
P008 A systematic review and meta-analysis of inflammatory bowel disease activity and sleep quality Open
Background Poor sleep quality has been associated with active inflammatory bowel disease (IBD) in several studies. This review examines sleep quality in people with active IBD and in those in remission, with meta-analyses performed, consid…
View article: The influence of the surveillance time interval on the risk of advanced neoplasia after non‐advanced adenoma removal
The influence of the surveillance time interval on the risk of advanced neoplasia after non‐advanced adenoma removal Open
Increasing the surveillance colonoscopy interval beyond five years after removal of non-advanced adenoma increases the risk of detection of advanced neoplasia at follow-up colonoscopy.
View article: The impact of coronavirus disease 2019 on surveillance colonoscopies in South Australia
The impact of coronavirus disease 2019 on surveillance colonoscopies in South Australia Open
Background and Aim The coronavirus disease 2019 (COVID‐19) global pandemic has affected elective procedures, including colonoscopy, worldwide. Delayed colorectal cancer surveillance may increase cancer risk. This study aimed to determine t…
View article: Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford
Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford Open
VDZ was safe and effective with 60% of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome.
View article: Fecal Immunochemical Screening for Advanced Colorectal Neoplasia in Patients with CKD: Accurate or Not?
Fecal Immunochemical Screening for Advanced Colorectal Neoplasia in Patients with CKD: Accurate or Not? Open
We read with interest the report by Wong et al.1 of the Detecting Bowel Cancer in CKD (DETECT) study of colorectal cancer screening in 1706 patients with CKD. DETECT investigated the test performance characteristics of fecal immunochemical…
View article: Anti-TNF Therapy in Pregnant Women With Inflammatory Bowel Disease: Effects of Therapeutic Strategies on Disease Behavior and Birth Outcomes
Anti-TNF Therapy in Pregnant Women With Inflammatory Bowel Disease: Effects of Therapeutic Strategies on Disease Behavior and Birth Outcomes Open
Discontinuation of anti-TNF before gestational week 30 did not increase the risk of relapse in the third trimester. Relapse and continuation of anti-TNF throughout pregnancy were each independently associated with lower birth weight, a mar…
View article: Nonsynonymous Polymorphism in Guanine Monophosphate Synthetase Is a Risk Factor for Unfavorable Thiopurine Metabolite Ratios in Patients With Inflammatory Bowel Disease
Nonsynonymous Polymorphism in Guanine Monophosphate Synthetase Is a Risk Factor for Unfavorable Thiopurine Metabolite Ratios in Patients With Inflammatory Bowel Disease Open
The GMPS SNP rs61750370 may be a reliable risk factor for extreme 6MMP preferential metabolism.
View article: Randomised clinical trial: efficacy, safety and dosage of adjunctive allopurinol in azathioprine/mercaptopurine nonresponders ( <scp>AAA</scp> Study)
Randomised clinical trial: efficacy, safety and dosage of adjunctive allopurinol in azathioprine/mercaptopurine nonresponders ( <span>AAA</span> Study) Open
Summary Background Thiopurine hypermethylation towards 6‐methylmercaptopurine (6 MMP ) instead of 6‐thioguanine nucleotides (6 TGN ) is associated with inefficacy in patients with IBD. Allopurinol reverses such hypermethylation. Aims To pr…