Explanipedia

Post‐stroke circadian rhythm disruption and stroke prognosis: A systematic review Open

Noyonika Nath, Peter A. Cistulli, Yu Sun Bin · 2025

Circadian rhythm disruption has been frequently reported in stroke patients. However, its impact on prognosis remains unclear. This systematic review aimed to: (i) comprehensively characterize circadian rhythm disruption following stroke, …

Supine hyperinflation and expiratory flow limitation are associated with respiratory arousals and nocturnal hypoventilation in COPD Open

Meera Srinivasan, David Touma, Kaj E. C. Blokland, Kieran Patel, Katrina O. Tonga , et al. · 2025

Introduction Subjective sleep disturbance is common in chronic obstructive pulmonary disease (COPD) and is related to hyperinflation when supine and tidal expiratory flow limitation (EFL). We hypothesised that abnormalities in supine lung …

Dose–response relationship of sleep apnea therapy and healthcare use in patients with comorbidities Open

Atul Malhotra, Suyog More, Naomi Alpert, Jean‐Louis Pépin, Kate Cole , et al. · 2025

Study Objectives Obstructive sleep apnea (OSA) has complex interactive relationships with several other conditions. Previous research suggests that consistent adherence to positive airway pressure (PAP) therapy can reduce healthcare resour…

Assessing new treatments for central sleep Apnoea in heart failure: sample size considerations for reliable detection of safety signals Open

Holger Woehrle, Karl Wegscheider, Anita K. Simonds, Michael Arzt, Jean‐Louis Pépin , et al. · 2025

Future clinical trials investigating treatments for CSA/CSR in HFrEF patients must incorporate sufficient sample sizes and event counts to ensure reliable detection of safety signals, particularly concerning all-cause mortality. This appro…

Device-measured movement behaviours and cancer incidence in a population sample of UK adults: Dual 24-hour analyses of postural and intensity compositions Open

John J. Mitchell, Raaj Kishore Biswas, Nicholas A. Koemel, Matthew Ahmadi, Joanna M. Blodgett , et al. · 2025

IMPORTANCE Insufficient physical activity (PA) and excessive sedentary behaviour is associated with several cancers. Personalised approaches to increasing healthy movement behaviours and reducing unhealthy behaviours may be more effective …

Sleeping With the Enemy Open

Peter A. Cistulli, Atul Malhotra, Jean‐Louis Pépin · 2025

Mandibular Advancement Device versus CPAP in Severe Obstructive Sleep Apnea Open

Juliana Tereza Colpani, Y.-H. Ou, Anastasya Maria Kosasih, Frank Lee, S.-P. Chan , et al. · 2025

Severe obstructive sleep apnea (OSA) is linked to adverse cardiovascular outcomes. While continuous positive airway pressure (CPAP) is the standard treatment, mandibular advancement devices (MADs) offer an alternative. This substudy of a r…

Craniofacial photography for detection of positional obstructive sleep apnoea Open

Kate Sutherland, John R. Wheatley, Kristina Kairaitis, Brendon J. Yee, Gary Cohen , et al. · 2025

Supine-dependent OSA is a well-recognised OSA phenotype and may relate to craniofacial structure. Our aim was to assess whether craniofacial photos are able to identify positional OSA, specifically supine-isolated OSA, in comparison to non…

Device-Measured Sleep Characteristics, Daily Step Count, and Cardiometabolic Health Markers: Findings From the Prospective Physical Activity, Sitting, and Sleep (ProPASS) Consortium Open

Weihe Bian, Matthew Ahmadi, Raaj Kishore Biswas, Joanna M. Blodgett, Andrew J. Atkin , et al. · 2025

BACKGROUND: Sleep and physical activity (PA) are important lifestyle-related behaviors that impact cardiometabolic health. This study investigated the joint associations of daily step count and sleep patterns (regularity and duration) with…

Associations of Device-Measured Sleep Duration, Regularity, and Efficiency with Cardiometabolic Health in Adults: Findings from the ProPASS Consortium Open

Annemarie Koster, Raaj Kishore Biswas, Matthew Ahmadi, Joanna M. Blodgett, Nicholas A. Koemel , et al. · 2025

Background Sleep is critical for cardiometabolic health, yet evidence on the independent and combined associations of device-measured sleep parameters remains limited. The aim of this study is to examine the independent and joint associati…

The role of confidence, motivation, and social support in PAP usage in obstructive sleep apnea: A real-world data analysis Open

Leanne Kaye, Vy Vuong, Meredith Barrett, Adam Benjafield, Peter A. Cistulli , et al. · 2025

Study Objectives Despite the well-established benefits of positive airway pressure (PAP) therapy in obstructive sleep apnea (OSA), adoption and persistence rates vary widely. Self-efficacy, motivation and social support may be important be…

Adherence to Positive Airway Pressure Therapy and Healthcare Resource Utilization and Costs Among Patients with Obstructive Sleep Apnea and Obesity Open

Fatima H. Sert Kuniyoshi, Ann Cameron, Jean‐Louis Pépin, R Benjamin Dexter, Caleb Woodford , et al. · 2025

Objective: Obstructive sleep apnea (OSA) and obesity are highly prevalent comorbid conditions associated with major societal and healthcare burden. Positive airway pressure (PAP) therapy is the first-line treatment for OSA. This study eval…

Estimation of the global prevalence and burden of insomnia: a systematic literature review-based analysis Open

Adam Benjafield, Fatima H. Sert Kuniyoshi, Atul Malhotra, Jennifer Martin, Charles M. Morin , et al. · 2025

Insomnia is common, is associated with major adverse medical and mental health outcomes, has a negative impact on quality of life, and has significant economic consequences. However, little is known about the global insomnia burden. This s…

Is there good evidence of mortality benefits from positive airway pressure? – Authors' reply Open

Adam Benjafield, Jean‐Louis Pépin, Peter A. Cistulli, Atul Malhotra · 2025

Impact of long-term non-invasive ventilation on severe exacerbations and survival in COPD: a French nationwide cohort study using multistate models Open

Jean‐Louis Pépin, É. Herquelot, Hélène Denis, Anne Josseran, Florent Lavergne , et al. · 2025

Rationale Chronic obstructive pulmonary disease (COPD) is the most common indication for domiciliary non-invasive ventilation (NIV), but long-term outcomes data are limited. Objective This multistate model analysis estimated the impact of …

0674 Short-Term Reliability of Obstructive Sleep Apnea Symptom Subtypes Open

Nathan Nesbitt, Michael J. Koenig, Brendan T Keenan, Peter A. Cistulli, Glenn M. Stewart , et al. · 2025

Introduction Over 10 years ago, a seminal study using cluster analysis in the Icelandic Sleep Apnea Cohort (ISAC) identified subtypes of patients with obstructive sleep apnea (OSA) defined as excessively sleepy (presenting with multiple sl…

0952 Prevalence of Obstructive Sleep Apnea in the Elderly Across the United States Through 2050 Open

Elroy Boers, Meredith Barrett, Adam Benjafield, Leanne Kaye, Atul Malhotra , et al. · 2025

Introduction Chronic conditions such as cardiovascular disease, diabetes, and chronic obstructive pulmonary disease are associated with obstructive sleep apnea (OSA). These conditions are more prevalent in older adults, who may be at heigh…

0926 The Disproportionate Burden of OSA in Women in the United States: A Call for Improved Awareness and Diagnosis Open

Elroy Boers, Meredith Barrett, Adam Benjafield, Leanne Kaye, Peter A. Cistulli , et al. · 2025

Introduction While obstructive sleep apnea (OSA) is widely recognized as a condition that predominantly impacts men, the burden on women is significant, yet often under-appreciated. Given increased attention on understanding gender differe…

Minimum concurrent sleep, physical activity, and nutrition variations associated with lifeSPAN and healthSPAN improvements: a population cohort study Open

Nicholas A. Koemel, Raaj Kishore Biswas, Matthew Ahmadi, Armando Teixeria-Pinto, Mark Hamer , et al. · 2025

Background Sleep, physical activity, and nutrition (SPAN) are key determinants of both life expectancy (lifespan) and disease-free life expectancy (healthspan) yet are often studied and promoted in isolation. This study examined the joint …

Forecasting the Global Economic and Health Burden of COPD From 2025 Through 2050 Open

Elroy Boers, Meredith Barrett, Adam Benjafield, John E. Barnett, Laurel A. Ravelo , et al. · 2025

Patterns of physical activity in Obstructive Sleep Apnoea and their association with sleepiness Open

By Jack Callum, Yu Sun Bin, Kate Sutherland, Amanda J. Piper, Kristina Kairaitis , et al. · 2025

Objectives Excessive daytime sleepiness (EDS) is a key symptom of Obstructive Sleep Apnoea (OSA). Both EDS and OSA affect, and are affected by, physical activity (PA). This study explores physical activity patterns in OSA patients and the …

Minimum and optimal combined variations in sleep, physical activity, and nutrition in relation to all-cause mortality risk Open

Emmanuel Stamatakis, Nicholas A. Koemel, Raaj Kishore Biswas, Matthew Ahmadi, Margaret Allman‐Farinelli , et al. · 2025

Dose-response associations of device-measured sleep regularity and duration with incident dementia in 82391 UK adults Open

Weihe Bian, Raaj Kishore Biswas, Matthew Ahmadi, Yu Sun Bin, Svetlana Postnova , et al. · 2025

Obstructive sleep apnea treatment is associated with reduction in myocardial extracellular volume (ECV): A cardiovascular magnetic resonance (CMR) study Open

Nithin R. Iyer, Y.-H. Ou, Jennifer E. Bryant, Thu‐Thao Le, Juliana Tereza Colpani , et al. · 2025

Treatment of Osa Using Mandibular Advancement Versus Cpap in Improving Cardiovascular Health Open

Yi-Hui Ou, Juliana Tereza Colpani, Crystal Cheong, Weiqiang Loke, As Tar Thant , et al. · 2025

Sleep regularity and major adverse cardiovascular events: a device-based prospective study in 72 269 UK adults Open

Jean‐Philippe Chaput, Raaj Kishore Biswas, Matthew Ahmadi, Peter A. Cistulli, Shantha M. W. Rajaratnam , et al. · 2024

Background This study examines the associations between device-measured sleep regularity and the risk of major adverse cardiovascular events (MACE), and aims to determine whether sufficient sleep duration attenuates or eliminates the effec…

Treatment With Bilevel PAP Is Associated With a Reduction in Severe Exacerbations in COPD-OSA Overlap Open

D. Tellez, Ann Cameron, Fatima H. Sert Kuniyoshi, Peter A. Cistulli, Jean‐Louis Pépin , et al. · 2024

Background: There are no guidelines for OSA assessment in patients with COPD. Home noninvasive ventilation (NIV) studies have excluded patients with comorbid OSA. Thus, it is unclear whether home NIV is associated with reduced exacerbation…

Phenotypic Characterisation of Obstructive Sleep Apnoea in Acute Coronary Syndrome Open

B Tong, Seren Ucak, Hasthi U. Dissanayake, Sanjay Patel, Glenn M. Stewart , et al. · 2024

A high prevalence of OSA in a mostly non-sleepy population with ACS was identified, highlighting a gross underdiagnosis of OSA among cardiovascular patients. The limitations of OSA screening questionnaires highlight the need for new models…

Sleep Irregularity and the Incidence of Type 2 Diabetes: A Device-Based Prospective Study in Adults Open

Jean‐Philippe Chaput, Raaj Kishore Biswas, Matthew Ahmadi, Peter A. Cistulli, Angelo Sabag , et al. · 2024

Objective: To prospectively examine the association between device-measured sleep regularity and incidence of type 2 diabetes (T2D) in a population-based sample of adults. We also examined if meeting sleep duration recommendations attenuat…

Sleep Irregularity and the Incidence of Type 2 Diabetes: A Device-Based Prospective Study in Adults Open

Jean‐Philippe Chaput, Raaj Kishore Biswas, Matthew Ahmadi, Peter A. Cistulli, Angelo Sabag , et al. · 2024

Objective: To prospectively examine the association between device-measured sleep regularity and incidence of type 2 diabetes (T2D) in a population-based sample of adults. We also examined if meeting sleep duration recommendations attenuat…

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