Peter A. Knight
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View article: High prevalence of obstructive sleep apnea in a surgical aortic valve replacement cohort: an observational study
High prevalence of obstructive sleep apnea in a surgical aortic valve replacement cohort: an observational study Open
Study Objectives A high prevalence of sleep apnea has been reported among transcatheter aortic valve replacement (AVR) patients; however, the prevalence of sleep apnea in the younger and relatively healthier population of surgical AVR (SAV…
View article: Aortic annulus rupture after transcatheter aortic valve replacement: successful management of a dangerous complication
Aortic annulus rupture after transcatheter aortic valve replacement: successful management of a dangerous complication Open
Objective Aortic annulus rupture remains one of the most fatal complications of TAVR. While attempts have been made to describe and predict this complication, the data remains insufficient without evidence-based guidelines for management o…
View article: Correction to: Role of PDE10A in vascular smooth muscle cell hyperplasia and pathological vascular remodelling
Correction to: Role of PDE10A in vascular smooth muscle cell hyperplasia and pathological vascular remodelling Open
Cardiovascular Research, cvab304, https://doi.org/10.1093/cvr/cvab304 In the originally published version of this manuscript, co-author Yujun Cai was not included in the author list. This error has now been corrected online.
View article: Role of PDE10A in vascular smooth muscle cell hyperplasia and pathological vascular remodelling
Role of PDE10A in vascular smooth muscle cell hyperplasia and pathological vascular remodelling Open
Aims Intimal hyperplasia is a common feature of vascular remodelling disorders. Accumulation of synthetic smooth muscle cell (SMC)-like cells is the main underlying cause. Current therapeutic approaches including drug-eluting stents are no…
View article: Efficacy of Intraventricular Sponge Placement to Capture Debris in Aortic Valve Replacement
Efficacy of Intraventricular Sponge Placement to Capture Debris in Aortic Valve Replacement Open
Background: Surgical aortic valve replacement (SAVR) carries the known risk of shedding debris into the left ventricle during valve leaflet excision and annulus debridement. Embolization of this debris may have devastating effects for the …
View article: Improving Automated Sonar Video Analysis to Notify About Jellyfish Blooms
Improving Automated Sonar Video Analysis to Notify About Jellyfish Blooms Open
Human enterprise often suffers from direct negative effects caused by\njellyfish blooms. The investigation of a prior jellyfish monitoring system\nshowed that it was unable to reliably perform in a cross validation setting,\ni.e. in new un…
View article: Using linked electronic health records to report healthcare-associated infections
Using linked electronic health records to report healthcare-associated infections Open
Basic factual information, such as demographic data, is almost-certainly better automated, and many other data fields can potentially be populated successfully from linked-EHR. Manual data collection is time-consuming and inefficient; auto…
View article: Titanium Fastener Utilization during HeartMate 3 Left Ventricular Assist Device Implantation
Titanium Fastener Utilization during HeartMate 3 Left Ventricular Assist Device Implantation Open
Objective The objective of this study was to investigate the feasibility of using titanium fasteners for securement of the inflow sewing ring during HeartMate 3 implantation. The secondary objective was to compare cardiopulmonary bypass an…
View article: Interactive translational research model and cadaveric simulation: where minimally invasive cardiac surgery and industry meet
Interactive translational research model and cadaveric simulation: where minimally invasive cardiac surgery and industry meet Open
Focused research targeting an identified clinical problem may result in more rapid development of medical devices, technologies, and surgical techniques that directly impact patient care. These medical advances to improve patient care may …
View article: Beyond the legislation- investing in sustainable transformation
Beyond the legislation- investing in sustainable transformation Open
Introduction: From April 2015, landmark legislation in Scotland established 31 new integrated health and social care organisations[1]. The Public Bodies (Joint Working) (Scotland) Act (2014) required NHS Boards and Local Authorities to est…
View article: Video assisted right mini-thoracotomy for aortic root replacement
Video assisted right mini-thoracotomy for aortic root replacement Open
Aortic root replacement is typically performed through a median sternotomy. The right anterior mini-thoracotomy approach has been shown to decrease hospital length of stay in aortic valve surgery when compared to sternotomy. This approach …
View article: Video assisted right mini-thoracotomy for aortic valve replacement
Video assisted right mini-thoracotomy for aortic valve replacement Open
Aortic valve replacement through minimally invasive access is increasing. These procedures have several advantages over conventional sternotomy including decreased intensive care unit and hospital length of stay and decreased ventilation t…
View article: Heterologous expression of<i>Streptococcus mutans</i>Cnm in<i>Lactococcus lactis</i>promotes intracellular invasion, adhesion to human cardiac tissues and virulence
Heterologous expression of<i>Streptococcus mutans</i>Cnm in<i>Lactococcus lactis</i>promotes intracellular invasion, adhesion to human cardiac tissues and virulence Open
In S. mutans, the expression of the surface glycoprotein Cnm mediates binding to extracellular matrix proteins, endothelial cell invasion and virulence in the Galleria mellonella invertebrate model. To further characterize Cnm as a virulen…
View article: Are Patients Satisfied with their Total Joint Replacement Surgery? A Prospective Cross Sectional Survey
Are Patients Satisfied with their Total Joint Replacement Surgery? A Prospective Cross Sectional Survey Open
Objective: The number of patients requiring arthroplasty increases annually.Joint replacement surgery can improve a patient's (QOL) quality of life.The effectiveness of this care from a patient's own perspective assessed by patient reporte…
View article: Who Owns the Data? Open Data for Healthcare
Who Owns the Data? Open Data for Healthcare Open
Research on large shared medical datasets and data-driven research are gaining fast momentum and provide major opportunities for improving health systems as well as individual care. Such open data can shed light on the causes of disease an…