Peter A. Pinto
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View article: Long‐Term Follow‐Up of Neoadjuvant Enzalutamide Plus Androgen Deprivation Therapy in Localized Prostate Cancer: A Secondary Analysis of a Neoadjuvant Feasibility Trial
Long‐Term Follow‐Up of Neoadjuvant Enzalutamide Plus Androgen Deprivation Therapy in Localized Prostate Cancer: A Secondary Analysis of a Neoadjuvant Feasibility Trial Open
Introduction Neoadjuvant intense androgen deprivation therapy (ADT) with androgen receptor signaling inhibitors (ARSIs) has shown pathologic complete responses (pCR) in prostate cancer (PCa), but long‐term survival outcomes remain unclear.…
View article: Radiogenomic Profiling of Prostate Tumors prior to External Beam Radiotherapy Converges on a Transcriptomic Signature of TGF-β Activity Driving Tumor Recurrence
Radiogenomic Profiling of Prostate Tumors prior to External Beam Radiotherapy Converges on a Transcriptomic Signature of TGF-β Activity Driving Tumor Recurrence Open
Purpose: Clinical risk grouping based on PSA, tumor grade, and disease extent guides treatment intensity for localized prostate cancer. However, many patients with intermediate- or high-risk disease treated with external beam radiotherapy …
View article: Discovery and performance of DNA methylation panels for cancer detection and classification in blood
Discovery and performance of DNA methylation panels for cancer detection and classification in blood Open
Examining DNA in a liquid biopsy for non-invasive cancer detection relies on identifying dilute signal in a high background. This study aims to identify DNA methylation biomarkers for multi-cancer detection. Utilizing large tissue datasets…
View article: Localized high-risk prostate cancer harbors an androgen receptor activity–low subpopulation susceptible to HER2 inhibition
Localized high-risk prostate cancer harbors an androgen receptor activity–low subpopulation susceptible to HER2 inhibition Open
BACKGROUNDLocalized high-risk prostate cancer (PCa) often recurs despite neoadjuvant androgen deprivation therapy (ADT). We sought to identify baseline molecular programs that predict pathologic response and reveal targetable vulnerabiliti…
View article: Novel Biopsy Gun Impacts Biopsy Sample Quality and Quantity
Novel Biopsy Gun Impacts Biopsy Sample Quality and Quantity Open
View article: Preoperative MRI-Guided Freehand Ultrasound Volume Reconstruction
Preoperative MRI-Guided Freehand Ultrasound Volume Reconstruction Open
View article: Augmented reality assisted MRI/US fusion for non-rectal fully trans-perineal prostate biopsy
Augmented reality assisted MRI/US fusion for non-rectal fully trans-perineal prostate biopsy Open
View article: Programmed death-1 inhibition increases vaccine-induced T-cell infiltration in patients with prostate cancer
Programmed death-1 inhibition increases vaccine-induced T-cell infiltration in patients with prostate cancer Open
Background Prostate cancer (PC) is the most frequently diagnosed cancer in men worldwide, making up 21% of all cancer cases. Although generally slow-growing, 370,000 men die from PC yearly. Immune checkpoint inhibitors (ICIs) are currently…
View article: Research-based clinical deployment of artificial intelligence algorithm for prostate MRI
Research-based clinical deployment of artificial intelligence algorithm for prostate MRI Open
Purpose A critical limitation to deployment and utilization of Artificial Intelligence (AI) algorithms in radiology practice is the actual integration of algorithms directly into the clinical Picture Archiving and Communications Systems (P…
View article: OpenPros: A Large-Scale Dataset for Limited View Prostate Ultrasound Computed Tomography
OpenPros: A Large-Scale Dataset for Limited View Prostate Ultrasound Computed Tomography Open
Prostate cancer is one of the most common and lethal cancers among men, making its early detection critically important. Although ultrasound imaging offers greater accessibility and cost-effectiveness compared to MRI, traditional transrect…
View article: Assessing the Impact of Transition and Peripheral Zone PSA Densities Over Whole‐Gland PSA Density for Prostate Cancer Detection on Multiparametric MRI
Assessing the Impact of Transition and Peripheral Zone PSA Densities Over Whole‐Gland PSA Density for Prostate Cancer Detection on Multiparametric MRI Open
Background Whole‐gland (WG) prostate‐specific antigen (PSA) density (PSAD) has proven useful in diagnosing to be beneficial in localized prostate cancer (PCa). This study aimed to evaluate the predictive performance of WG and zonal (transi…
View article: Predicting ADC Map Quality from T2-Weighted MRI: A Deep Learning Approach for Early Quality Assessment to Assist Point-of-Care
Predicting ADC Map Quality from T2-Weighted MRI: A Deep Learning Approach for Early Quality Assessment to Assist Point-of-Care Open
Purpose Poor quality prostate MRI images, especially ADC maps, can lead to missed lesions and unnecessary repeat scans. To address this issue, we aimed to develop an automated method to predict ADC map quality from T2 images acquired earli…
View article: Investigating Radiation Heat Transfer from the Cone Calorimeter Heater: A New View Factor Model and Uncertainty Quantification
Investigating Radiation Heat Transfer from the Cone Calorimeter Heater: A New View Factor Model and Uncertainty Quantification Open
View article: Theoretical Analysis of Misalignment Effects on Radiative Heat Flux in Cone Calorimeter Experiments
Theoretical Analysis of Misalignment Effects on Radiative Heat Flux in Cone Calorimeter Experiments Open
View article: A Prostate Imaging‐Reporting and Data System version 2.1‐based predictive model for clinically significant prostate cancer diagnosis
A Prostate Imaging‐Reporting and Data System version 2.1‐based predictive model for clinically significant prostate cancer diagnosis Open
Objectives To develop and validate a Prostate Imaging‐Reporting and Data System (PI‐RADS) version 2.1 (v2.1)‐based predictive model for diagnosis of clinically significant prostate cancer (csPCa), integrating clinical and multiparametric m…
View article: External Validation of a Previously Developed Deep Learning–based Prostate Lesion Detection Algorithm on Paired External and In-House Biparametric MRI Scans
External Validation of a Previously Developed Deep Learning–based Prostate Lesion Detection Algorithm on Paired External and In-House Biparametric MRI Scans Open
Purpose To evaluate the performance of an artificial intelligence (AI) model in detecting overall and clinically significant prostate cancer (csPCa)-positive lesions on paired external and in-house biparametric MRI (bpMRI) scans and assess…
View article: Deep learning-based image quality assessment: impact on detection accuracy of prostate cancer extraprostatic extension on MRI
Deep learning-based image quality assessment: impact on detection accuracy of prostate cancer extraprostatic extension on MRI Open
Objective To assess impact of image quality on prostate cancer extraprostatic extension (EPE) detection on MRI using a deep learning-based AI algorithm. Materials and methods This retrospective, single institution study included patients w…
View article: Location-Based Radiology Report-Guided Semi-Supervised Learning for Prostate Cancer Detection
Location-Based Radiology Report-Guided Semi-Supervised Learning for Prostate Cancer Detection Open
Prostate cancer is one of the most prevalent malignancies in the world. While deep learning has potential to further improve computer-aided prostate cancer detection on MRI, its efficacy hinges on the exhaustive curation of manually annota…
View article: Evaluation of a Cascaded Deep Learning–based Algorithm for Prostate Lesion Detection at Biparametric MRI
Evaluation of a Cascaded Deep Learning–based Algorithm for Prostate Lesion Detection at Biparametric MRI Open
A deep learning–based algorithm automatically detected cancerous lesions on prostate biparametric MRI scans with reasonable performance and reliably predicted clinically significant prostate cancer at biopsy.
View article: PRECISE Version 2: Updated Recommendations for Reporting Prostate Magnetic Resonance Imaging in Patients on Active Surveillance for Prostate Cancer
PRECISE Version 2: Updated Recommendations for Reporting Prostate Magnetic Resonance Imaging in Patients on Active Surveillance for Prostate Cancer Open
The updated PRECISE recommendations reflect expert consensus opinion on minimal standards and reporting criteria for prostate MRI in AS.
View article: Realistic digital phantoms for prostate ultrasound and photoacoustic imaging
Realistic digital phantoms for prostate ultrasound and photoacoustic imaging Open
======= MOTIVATION ======= This repository contains 248 sets of 3D realistic digital phantoms for prostate ultrasound and photoacoustic imaging in the male pelvic region. Our model encompasses surrounding tissues or organs around the prost…
View article: Localized high-risk prostate cancer harbors an androgen receptor low subpopulation susceptible to HER2 inhibition
Localized high-risk prostate cancer harbors an androgen receptor low subpopulation susceptible to HER2 inhibition Open
Patients diagnosed with localized high-risk prostate cancer have higher rates of recurrence, and the introduction of neoadjuvant intensive hormonal therapies seeks to treat occult micrometastatic disease by their addition to definitive tre…
View article: Deep Learning-Based Detection and Classification of Bone Lesions on Staging Computed Tomography in Prostate Cancer: A Development Study
Deep Learning-Based Detection and Classification of Bone Lesions on Staging Computed Tomography in Prostate Cancer: A Development Study Open
View article: Systematic Review and Meta-Analysis of Salvage Ablation for Radiation-Recurrent Localized Prostate Cancer – A Focal Therapy Society Project
Systematic Review and Meta-Analysis of Salvage Ablation for Radiation-Recurrent Localized Prostate Cancer – A Focal Therapy Society Project Open
View article: Quality of T2-weighted MRI re-acquisition versus deep learning GAN image reconstruction: A multi-reader study
Quality of T2-weighted MRI re-acquisition versus deep learning GAN image reconstruction: A multi-reader study Open
View article: AI-powered radiomics: revolutionizing detection of urologic malignancies
AI-powered radiomics: revolutionizing detection of urologic malignancies Open
Purpose of review This review aims to highlight the integration of artificial intelligence-powered radiomics in urologic oncology, focusing on the diagnostic and prognostic advancements in the realm of managing prostate, kidney, and bladde…
View article: Table of Contents
Table of Contents Open
View article: 587 Nivolumab increased vaccine induced T-cell infiltration in Prostate cancer
587 Nivolumab increased vaccine induced T-cell infiltration in Prostate cancer Open
Background Prostate cancer is the most diagnosed cancer in men worldwide, making up 21% of all cancer cases.1 Although this disease is slow growing, 370,000 men die from prostate cancer every year. Prostate cancer is mostly a co…
View article: Comparison of MRI-Based Staging and Pathologic Staging for Predicting Biochemical Recurrence of Prostate Cancer After Radical Prostatectomy
Comparison of MRI-Based Staging and Pathologic Staging for Predicting Biochemical Recurrence of Prostate Cancer After Radical Prostatectomy Open
BACKGROUND. Currently most clinical models for predicting biochemical recurrence (BCR) of prostate cancer (PCa) after radical prostatectomy (RP) incorporate staging information from RP specimens, creating a gap in preoperative risk …
View article: Deep Learning‐Based <scp>T2</scp>‐Weighted <scp>MR</scp> Image Quality Assessment and Its Impact on Prostate Cancer Detection Rates
Deep Learning‐Based <span>T2</span>‐Weighted <span>MR</span> Image Quality Assessment and Its Impact on Prostate Cancer Detection Rates Open
Background Image quality evaluation of prostate MRI is important for successful implementation of MRI into localized prostate cancer diagnosis. Purpose To examine the impact of image quality on prostate cancer detection using an in‐house p…