Explanipedia

Equalization of Right- and Left-Sided Intracardiac Pressures Open

Patricia Campbell, Jane A. Leopold, Andrew P. Selwyn, Donato Sisto · 2011

Comparison of Effects of Rosuvastatin (10 mg) Versus Atorvastatin (40 mg) on Rho Kinase Activity in Caucasian Men With a Previous Atherosclerotic Event Open

Ron Rawlings, Anju Nohria, Ping‐Yen Liu, J.Elisabeth Donnelly, Mark A. Creager , et al. · 2008

Improved characterization of atherosclerotic plaques by gadolinium contrast during intravascular magnetic resonance imaging of human arteries Open

Éric Larose, Scott Kinlay, Andrew P. Selwyn, Yerem Yeghiazarians, E. Kent Yucel , et al. · 2007

Characterization of Human Atherosclerotic Plaques by Intravascular Magnetic Resonance Imaging Open

Éric Larose, Yerem Yeghiazarians, Peter Libby, E. Kent Yucel, Masanori Aikawa , et al. · 2005

Background— Development and validation of novel imaging modalities to assess the composition of human atherosclerotic plaques will improve the understanding of atheroma evolution and could facilitate evaluation of therapeutic strategies fo…

Circulating Autoantibodies to Oxidized LDL Correlate With Impaired Coronary Endothelial Function After Cardiac Transplantation Open

James C. Fang, Scott Kinlay, Dominik Behrendt, Hiroyuki Hikita, Joseph L. Witztum , et al. · 2002

Objective— The oxidative modification of low density lipoprotein (LDL) may play a role in the pathogenesis of transplant-associated arteriosclerosis. Oxidized LDL (OxLDL) is immunogenic as well as atherogenic, and the level of autoantibodi…

Coronary Flow Velocity and Disturbed Flow Predict Adverse Clinical Outcome After Coronary Angioplasty Open

Scott Kinlay, Jasmine Grewal, Deborah Manuelin, James C. Fang, Andrew P. Selwyn , et al. · 2002

Objective— Laminar flow becomes disturbed at high velocities, reducing shear stress and augmenting vascular inflammation and proliferation, processes that are pivotal in restenosis and atherogenesis. We hypothesized that disturbed blood fl…

Rescue percutaneous coronary intervention following coronary artery bypass graft—A descriptive analysis of the changing interface between interventional cardiologist and cardiac surgeon Open

Mark Adams, James L. Orford, Gavin J. Blake, Marco Vugman Wainstein, John G. Byrne , et al. · 2002

Background : Despite decreasing rates of acute and suba‐cute complications of percutaneous coronary intervention (PCI), these procedures are generally only performed in centers where it is possible for failed PCI to be treated by rescue co…

Lack of compensatory enlargement at sites of coronary vasospasm: Identification by ultrasound and successful treatment with stenting Open

Scott Kinlay, Andrew P. Selwyn, Peter Ganz, Patrick T. O’Gara · 2000

The case of a young man with spontaneous vasospasm at two sites in his left anterior descending coronary artery is described. Intravascular ultrasound demonstrated mild eccentric atherosclerosis with smaller total artery cross‐sectional ar…

Plasma α-Tocopherol and Coronary Endothelium-Dependent Vasodilator Function Open

Scott Kinlay, James C. Fang, Hiroyuki Hikita, Ivan Ho, Danielle Delagrange , et al. · 1999

Background —In the presence of atherosclerosis, the coronary endothelial vasomotor response to acetylcholine is frequently abnormal but is variable between patients. We tested the hypothesis that the plasma concentration of α-tocopherol is…

Hemostatic/Fibrinolytic Predictors of Allograft Coronary Artery Disease after Cardiac Transplantation Open

Clyde R. Meckel, Todd J. Anderson, Gilbert H. Mudge, Richard N. Mitchell, Alan C. Yeung , et al. · 1997

Allograft coronary artery disease (CAD) remains the leading cause of morbidity and mortality affecting the long-term survival of patients after cardiac transplantation. Because there is increasing evidence that imbalances in hemostatic and…

Accuracy of electronic digital calipers compared with quantitative angiography in measuring coronary arterial diameter. Open

Akimi Uehata, Takeyuki Matsuguchi, John A. Bittl, John Orav, Ian T. Meredith , et al. · 1993

BACKGROUND Quantitative angiography is the accepted method for measuring coronary luminal diameter. Electronic digital calipers have been used to assess arterial diameters in vasomotor function studies and after interventional procedures. …

Functional significance of intimal thickening as detected by intravascular ultrasound early and late after cardiac transplantation. Open

Todd J. Anderson, Ian T. Meredith, Akimi Uehata, Gilbert H. Mudge, Andrew P. Selwyn , et al. · 1993

BACKGROUND Detection of transplant coronary disease remains difficult. Both intravascular ultrasound (IVUS) imaging and functional coronary vasomotion studies have been used to evaluate this process. However, the time course of intimal thi…

Myocardial Revascularization Before Repair of an Aortic Aneurysm Open

Todd J. Anderson, Ian T. Meredith, Andrew P. Selwyn, Khether E. Raby · 1993

Loss of the coronary microvascular response to acetylcholine in cardiac transplant patients. Open

Charles B. Treasure, Joseph A. Vita, Peter Ganz, Thomas J. Ryan, Frederick J. Schoen , et al. · 1992

BACKGROUND The coronary arteries of transplanted hearts frequently develop accelerated diffuse arteriosclerosis. The effects of this disease on resistance vessel function are unknown. METHODS AND RESULTS To investigate the integrity of end…

Epicardial coronary artery responses to acetylcholine are impaired in hypertensive patients. Open

Charles B. Treasure, Steven V. Manoukian, J. Larry Klein, Joseph A. Vita, E G Nabel , et al. · 1992

Hypertension is a risk factor for coronary atherosclerosis possibly via an adverse effect on the vascular endothelium. Endothelium-mediated relaxation is impaired in animal models of hypertension. However, the effects of hypertension on hu…

Patients with evidence of coronary endothelial dysfunction as assessed by acetylcholine infusion demonstrate marked increase in sensitivity to constrictor effects of catecholamines. Open

Joseph A. Vita, Charles B. Treasure, Alan C. Yeung, Vladimir I. Vekshtein, Gina Fantasia , et al. · 1992

BACKGROUND Studies in patients undergoing cardiac catheterization have demonstrated that normal coronary arteries dilate and atherosclerotic arteries constrict in response to exercise and the cold pressor test, but the mechanisms are unkno…

The Effect of Atherosclerosis on the Vasomotor Response of Coronary Arteries to Mental Stress Open

Alan C. Yeung, Vladimir I. Vekshtein, David S. Krantz, Joseph A. Vita, Thomas J. Ryan , et al. · 1991

Atherosclerosis disturbs the normal vasomotor response (no change or dilation) of large coronary arteries to mental stress; in patients with atherosclerosis paradoxical constriction occurs during mental stress, particularly at points of st…

Loss of flow-mediated endothelium-dependent dilation occurs early in the development of atherosclerosis. Open

James M. McLenachan, J. Koudy Williams, R. David Fish, Peter Ganz, Andrew P. Selwyn · 1991

BACKGROUND Healthy arteries exhibit endothelium-dependent dilation in response to both local acetylcholine and increased blood flow. In humans, clinically overt coronary artery disease is characterized by loss of dilation to both acetylcho…

Effects of asymptomatic ischemia on long-term prognosis in chronic stable coronary disease. Open

Alan C. Yeung, Joan Barry, John Orav, E Bonassin, Khether E. Raby , et al. · 1991

BACKGROUND Ischemia on ambulatory electrocardiographic monitoring has been shown to adversely affect short-term prognoses in patients with unstable angina, after myocardial infarction, and with chronic stable angina. METHODS AND RESULTS In…

Relations between heart rate, ischemia, and drug therapy during daily life in patients with coronary artery disease. Open

James M. McLenachan, Franz Weidinger, Joan Barry, Alan C. Yeung, E G Nabel , et al. · 1991

BACKGROUND Previous studies have shown that little if any increase in heart rate occurs 1 minute before the onset of ischemia in ambulant patients with coronary artery disease. This study tested the hypothesis that there are characteristic…

Coronary atherosclerosis is associated with left ventricular dysfunction and dilatation in aortic stenosis. Open

Vladimir I. Vekshtein, R. Wayne Alexander, Alan C. Yeung, Theodore Plappert, Martin G. St. John Sutton , et al. · 1990

Patients with aortic stenosis develop widely variable patterns of left ventricular hypertrophy and dysfunction. We postulated that coronary atherosclerosis (CAD) may be associated with impaired left ventricular function and chamber dilatat…

Early evidence of endothelial vasodilator dysfunction at coronary branch points. Open

James M. McLenachan, Joseph A. Vita, D.R. Fish, Charles B. Treasure, David A. Cox , et al. · 1990

Intracoronary acetylcholine produces endothelium-dependent dilation of normal coronary arteries and paradoxical constriction of atherosclerotic vessels. Regional differences in endothelium-dependent vasomotion, however, have not been studi…

Paradoxical narrowing of atherosclerotic coronary arteries induced by increases in heart rate. Open

E G Nabel, Andrew P. Selwyn, Peter Ganz · 1990

Vasodilation in normal and vasoconstriction in atherosclerotic coronary arteries have been observed in response to complex stimuli such as exercise and the cold pressor test. To study a single parameter that changes during these activities…

Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Open

Joseph A. Vita, Charles B. Treasure, E G Nabel, James M. McLenachan, R. David Fish , et al. · 1990

In animals, acetylcholine dilates normal arteries and produces vasoconstriction in the presence of hypercholesterolemia, hypertension, or atherosclerosis, reflecting endothelial cell dysfunction. In patients with angiographically smooth co…

Reflex increase in blood pressure during the intracoronary administration of adenosine in man. Open

David A. Cox, Joseph A. Vita, Charles B. Treasure, R. David Fish, Andrew P. Selwyn , et al. · 1989

Infusion of adenosine (0.022-2.2 mg/min) into the left anterior descending (LAD) coronary artery of 26 patients produced a dose-dependent increase in blood pressure without a change in heart rate. At adenosine 2.2 mg/min, systolic pressure…

Atherosclerosis influences the vasomotor response of epicardial coronary arteries to exercise. Open

J. B. Gordon, Peter Ganz, E G Nabel, R. David Fish, Jose Zebede , et al. · 1989

We studied the vasomotion of epicardial coronary arteries during exercise and tested the hypotheses that abnormal vasoconstriction is related to the presence of atherosclerosis and may be related to endothelial dilator dysfunction. During …

Responses of coronary arteries of cardiac transplant patients to acetylcholine. Open

R. David Fish, E G Nabel, Andrew P. Selwyn, Paul L. Ludmer, Gilbert H. Mudge , et al. · 1988

Accelerated coronary atherosclerosis is a major cause of graft failure after heart transplantation. Graft atherosclerosis is typically diffuse and difficult to detect even with coronary arteriography. Recently, acetylcholine was shown to d…

Dilation of normal and constriction of atherosclerotic coronary arteries caused by the cold pressor test. Open

E G Nabel, Peter Ganz, J. B. Gordon, R. Wayne Alexander, Andrew P. Selwyn · 1988

Increased vascular constriction has been observed at the site of atherosclerotic lesions, suggesting an association between atherosclerosis and altered vascular tone. While atherosclerosis may increase sensitivity to exogenous vasoconstric…

Circadian variation of transient myocardial ischemia in patients with coronary artery disease. Open

Monica Rocco, Joan Barry, Stephen Campbell, E G Nabel, E. Francis Cook , et al. · 1987

To examine whether a significant circadian variation of transient myocardial ischemia exists and to better understand the character of such variation, 32 patients with chronic stable symptoms of coronary artery disease underwent one or mor…

Value of the intracoronary electrocardiogram to monitor myocardial ischemia during percutaneous transluminal coronary angioplasty. Open

Peter L. Friedman, Thomas Shook, James M. Kirshenbaum, Andrew P. Selwyn, Peter Ganz · 1986

To enhance detection of ischemia during percutaneous transluminal coronary angioplasty (PTCA), unipolar intracoronary electrocardiograms (ECGs) were recorded during PTCA in 25 patients from the tips of guidewires positioned distal to steno…

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