Peter Vadas
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View article: Efficacy and safety results from the primary analysis of the pivotal summit trial: Bezuclastinib in adults with non-advanced systemic mastocytosis
Efficacy and safety results from the primary analysis of the pivotal summit trial: Bezuclastinib in adults with non-advanced systemic mastocytosis Open
Background: Systemic mastocytosis (SM) comprises a spectrum of subtypes characterized by neoplastic mast cell (MC) infiltration of tissues and release of MC mediators. Non-advanced SM (NonAdvSM), including indolent SM (ISM), smoldering SM …
View article: Avapritinib achieves deep and durable symptom control with a well-tolerated safety profile in ism: Long-term outcomes from pioneer
Avapritinib achieves deep and durable symptom control with a well-tolerated safety profile in ism: Long-term outcomes from pioneer Open
Introduction: Indolent systemic mastocytosis (ISM) is a clonal mast cell disease driven by the KIT D816V mutation in ~95% of cases and is associated with symptoms of mast cell activation and tissue infiltration. It can cause chronic, debil…
View article: Use of the Rema Score to Distinguish Individuals with Systemic Mastocytosis From Those with Hereditary Alpha-tryptasemia
Use of the Rema Score to Distinguish Individuals with Systemic Mastocytosis From Those with Hereditary Alpha-tryptasemia Open
Background: Systemic mastocytosis (SM) and hereditary alpha-tryptasemia (HαT) may present with overlapping clinical manifestations of mast cell activation, making them difficult to distinguish on clinical grounds. Diagnosing SM requires a …
View article: Prevalence of Autoantibodies in Patients with Hereditary Alpha-Tryptasemia
Prevalence of Autoantibodies in Patients with Hereditary Alpha-Tryptasemia Open
Introduction: Hereditary alpha-tryptasemia (HαT) is associated with postural orthostatic tachycardia syndrome (POTS), hypermobile Ehlers-Danlos syndrome (hEDS), and mast cell activation syndrome (MCAS). While POTS, hEDS, and MCAS have all …
View article: Use of the REMA score to distinguish individuals with systemic mastocytosis from those with hereditary alpha-tryptasemia: a retrospective chart review
Use of the REMA score to distinguish individuals with systemic mastocytosis from those with hereditary alpha-tryptasemia: a retrospective chart review Open
BACKGROUND Systemic mastocytosis (SM) and hereditary alpha-tryptasemia (HαT) may present with overlapping clinical manifestations of mast cell activation and are difficult to distinguish on clinical grounds. Diagnosis of SM requires bone m…
View article: Avapritinib versus Placebo in Indolent Systemic Mastocytosis
Avapritinib versus Placebo in Indolent Systemic Mastocytosis Open
BACKGROUND: Indolent systemic mastocytosis (ISM) is a clonal mast-cell disease driven by the KIT D816V mutation. We assessed the efficacy and safety of avapritinib versus placebo, both with best supportive care, in patients with ISM. METHO…
View article: Effect of omalizumab for autoimmune progesterone dermatitis refractory to bilateral oophorectomy: a case report
Effect of omalizumab for autoimmune progesterone dermatitis refractory to bilateral oophorectomy: a case report Open
Background Autoimmune progesterone dermatitis (APD) is a rare skin condition caused by sensitivity to high levels of progesterone secreted during the luteal phase of the menstrual cycle. This may be due to various pathophysiological mechan…
View article: Effect of Omalizumab for Autoimmune Progesterone Dermatitis Refractory to Bilateral Oophorectomy: A Case Report
Effect of Omalizumab for Autoimmune Progesterone Dermatitis Refractory to Bilateral Oophorectomy: A Case Report Open
Background: Autoimmune progesterone dermatitis (APD) is a rare skin condition caused by sensitivity to high levels of progesterone secreted during the luteal phase of the menstrual cycle. This may be due to various pathophysiological mecha…
View article: Effect of Omalizumab for Autoimmune Progesterone Dermatitis Refractory to Bilateral Oophorectomy: a case report
Effect of Omalizumab for Autoimmune Progesterone Dermatitis Refractory to Bilateral Oophorectomy: a case report Open
Background Autoimmune progesterone dermatitis (APD) is a rare skin condition caused by sensitivity to high levels of progesterone secreted during the luteal phase of the menstrual cycle. This may be due to various pathophysiological mechan…
View article: Anaphylaxis to Oatmeal and Psocid Crisps
Anaphylaxis to Oatmeal and Psocid Crisps Open
Occasionally, a seemingly straightforward history of food-induced anaphylaxis may prove to be misleading. Both patients and their physicians have a tendency to attribute the cause of an allergic reaction to the most conspicuous ingredient …
View article: Efficacy of Omalizumab in Indolent Systemic Mastocytosis
Efficacy of Omalizumab in Indolent Systemic Mastocytosis Open
Background . Systemic mastocytosis (SM) comprises a heterogeneous group of disorders characterized by the proliferation of clonal mast cells in skin and various internal organs. Omalizumab is an established, labelled therapy for allergic a…
View article: Febuxostat Desensitization in a Patient with Previous Stevens-Johnson Syndrome and <i>HLA-B*58:01</i> Genotype
Febuxostat Desensitization in a Patient with Previous Stevens-Johnson Syndrome and <i>HLA-B*58:01</i> Genotype Open
To the Editor: We describe the first case, to our knowledge, of successful desensitization to febuxostat in a young high-risk patient of Filipino descent with HLA-B*58:01 positive genotype and previous drug-induced Stevens-Johnson Syndrome…
View article: Angioedema suppressed by a combination of anti-histamine and leukotriene modifier
Angioedema suppressed by a combination of anti-histamine and leukotriene modifier Open
Herein, we report a form of angioedema without urticaria, mediated by a combination of histamine and leukotrienes. Clinical, demographic and therapeutic characteristics differentiate this from other recognized causes of angioedema.