Explanipedia

Enhancement of Sleep Slow Wave Activity using Transcranial Electrical Stimulation with Temporal Interference Open

Erin L. Schaeffer, Ido Haber, Zhiwei Fan, Simone Bruno, Beril Mat , et al. · 2025

Slow waves mediate restorative functions of non-rapid eye movement (NREM) sleep. To enhance slow wave activity (SWA, 0.5-4 Hz) non-invasively, we employed a novel neuromodulatory tool, Transcranial Electrical Stimulation with Temporal Inte…

5G radio-frequency-electromagnetic-field effects on the human sleep electroencephalogram: A randomized controlled study in CACNA1C genotyped volunteers Open

Georgia Sousouri, Corinne Eicher, Robert DʼAngelo, Marie Billecocq, Thomas Fussinger , et al. · 2025

0468 Enhancement of Sleep Slow Waves Using Transcranial Electrical Stimulation with Temporal Interference (TES-TI) Open

Erin Schaeffer, Ido Haber, Zhiwei Fan, Beril Mat, Simone Bruno , et al. · 2025

Introduction Slow waves are a key feature of high-quality, restorative sleep that occur during non-rapid eye movement (NREM) sleep, which comprises 75–80% of total time spent in sleep. Left ventromedial prefrontal cortex (vmPFC) regions ha…

Deficient synaptic neurotransmission results in a persistent sleep-like cortical activity across vigilance states in mice Open

Mathilde C. C. Guillaumin, Christian D. Harding, Lukas B. Krone, Tomoko Yamagata, Martin C. Kahn , et al. · 2025

Growing evidence suggests that brain activity during sleep, as well as sleep regulation, are tightly linked with synaptic function and network excitability at the local and global levels. We previously reported that a mutation in synaptobr…

Recommendations for the Safe Application of Temporal Interference Stimulation in the Human Brain Part I: Principles of Electrical Neuromodulation and Adverse Effects Open

Antonino M. Cassarà, Taylor Newton, Katie Zhuang, Sabine J. Regel, Peter Achermann , et al. · 2025

Temporal interference stimulation (TIS) is a new form of transcranial electrical stimulation (tES) that has been proposed as a method for targeted, non‐invasive stimulation of deep brain structures. While TIS holds promise for a variety of…

Recommendations for the Safe Application of Temporal Interference Stimulation in the Human Brain Part II: Biophysics, Dosimetry, and Safety Recommendations Open

Antonino M. Cassarà, Taylor Newton, Katie Zhuang, Sabine J. Regel, Peter Achermann , et al. · 2025

Temporal interference stimulation (TIS) is a new form of transcranial electrical stimulation (tES) that has been proposed as a method for targeted, noninvasive stimulation of deep brain structures. While TIS holds promise for a variety of …

The Infraslow Fluctuation of Sigma Power During Sleep: Links to Markers of Arousal and Memory Reactivation Across Development Open

Maria E. Dimitriades, Alejandro Osorio-Forero, Sara Fattinger, Sebastian von Arx, Salomé Kurth , et al. · 2024

Sleep is both a state of disconnection from the environment and a critical period for restoration. But how does sleep balance responsiveness with the protection of key functions? The infraslow fluctuation of sigma power (ISFS)—the clusteri…

Genetic contribution to sleep homeostasis in early adolescence Open

Andjela Markovic, Thomas Rusterholz, Peter Achermann, Michael Kaess, Leila Tarokh · 2024

The sleep homeostatic process in adults is moderately stable over time and unique to an individual. Work in transgenic mice has suggested a role of genes in sleep homeostasis. The current study quantified the genetic contribution to sleep …

Electrophysiological (EEG) microstates during dream‐like bizarre experiences in a naturalistic scenario using immersive virtual reality Open

Simone Denzer, Sarah Diezig, Peter Achermann, Fred W. Mast, Thomas Koenig · 2024

Monitoring the reality status of conscious experience is essential for a human being to interact successfully with the external world. Despite its importance for everyday functioning, reality monitoring can systematically become erroneous,…

Oscillatory-Quality of sleep spindles links brain state with sleep regulation and function Open

Cristina Blanco‐Duque, Suraya A Bond, Lukas B. Krone, Jean-Philippe Dufour, Edward Gillen , et al. · 2024

Here, we characterized the dynamics of sleep spindles, focusing on their damping, which we estimated using a metric called oscillatory-Quality (o-Quality), derived by fitting an autoregressive model to electrophysiological signals, recorde…

Reduced subjective sleep quality in people rating themselves as electro-hypersensitive: An observational study Open

Corinne Eicher, Benjamin Marty, Peter Achermann, Reto Huber, Hans‐Peter Landolt · 2023

Swiss National Clinical Trials Portal (SNCTP000002285) and ClinicalTrials.gov (NCT03074617).

Oscillatory-Quality of sleep spindles: from properties to function Open

Cristina Blanco‐Duque, Suraya A Bond, Lukas B. Krone, Jean-Phillipe Dufour, Edward Gillen , et al. · 2023

Sleep spindles are traditionally defined as 10-15Hz thalamo-cortical oscillations typical of NREM sleep. While substantial heterogeneity in the appearance or spatio-temporal dynamics of spindle events is well recognised, the physiological …

Processing of semantic incongruency at the onset of sleep: An auditory N400 evoked potential study Open

Sarah Diezig, Melissa Spaar, Simone Denzer, Peter Achermann, Fred W. Mast , et al. · 2023

The ability to organize self-generated thought into coherent, meaningful semantic representations is a central aspect of human cognition and undergoes regular alterations throughout the day. To investigate whether changes in semantic proce…

Reduced Subjective Sleep Quality in People Rating Themselves as Electro-hypersensitive: An Observational Study Open

Corinne Eicher, Benjamin Marty, Peter Achermann, Reto Huber, Hans‐Peter Landolt · 2023

Processing of Semantic Incongruency at the Onset of Sleep: An Auditory N400 Evoked Potential Study Open

Sarah Diezig, Melissa Spaar, Simone Denzer, Peter Achermann, Fred W. Mast , et al. · 2023

Safety Recommendations for Temporal Interference Stimulation in the Brain Open

Antonino M. Cassarà, Taylor Newton, Katie Zhuang, Sabine J. Regel, Peter Achermann , et al. · 2022

Temporal interference stimulation (TIS) is a new form of transcranial electrical stimulation (tES) that has been proposed as a method for targeted, non-invasive stimulation of deep brain structures. While TIS holds promise for a variety of…

EEG Microstate Dynamics Associated with Dream-Like Experiences During the Transition to Sleep Open

Sarah Diezig, Simone Denzer, Peter Achermann, Fred W. Mast, Thomas Koenig · 2022

Consciousness always requires some representational content; that is, one can only be conscious about something. However, the presence of conscious experience (awareness) alone does not determine whether its content is in line with the ext…

EEG Microstate Dynamics Associated with Dream-like Experiences during the Transition to Sleep Open

Sarah Diezig, Simone Denzer, Peter Achermann, Fred W. Mast, Thomas Koenig · 2022

Consciousness always requires some representational content; that is, one can only be conscious about something. However, the presence of conscious experience (awareness) alone does not determine whether its content is in line with the ext…

BizarreVR: Dream-like bizarreness in immersive virtual reality induced changes in conscious experience of reality while leaving spatial presence intact Open

Simone Denzer, Sarah Diezig, Peter Achermann, Thomas Koenig, Fred W. Mast · 2022

Differences in conscious experience of reality occur between waking, dreaming, and psychotic states. Between these states, there are systematic differences in the judgment about the reality of the experience when being confronted with biza…

Validation of Fitbit Charge 2 Sleep and Heart Rate Estimates Against Polysomnographic Measures in Shift Workers: Naturalistic Study Open

Benjamin Stucky, Ian D. Clark, Yasmine Azza, Walter Karlen, Peter Achermann , et al. · 2021

Background Multisensor fitness trackers offer the ability to longitudinally estimate sleep quality in a home environment with the potential to outperform traditional actigraphy. To benefit from these new tools for objectively assessing sle…

Linear causal filtering: definition and theory Open

Roberto D. Pascual‐Marqui, R. Biscay, Jorge Bosch‐Bayard, Peter Achermann, Pascal L. Faber , et al. · 2021

1. Abstract This work provides a framework based on multivariate autoregressive modeling for linear causal filtering in the sense of Granger. In its bivariate form, the linear causal filter defined here takes as input signals A and B, and …

Homeostatic response to sleep restriction in adolescents Open

Jelena Skoručak, Nathan Weber, Mary A. Carskadon, Chelsea Reynolds, Scott Coussens , et al. · 2021

The high prevalence of chronic sleep restriction in adolescents underscores the importance of understanding how adolescent sleep is regulated under such conditions. One component of sleep regulation is a homeostatic process: if sleep is re…

Automatic Detection of Microsleep Episodes With Deep Learning Open

Alexander Malafeev, Anneke Hertig-Godeschalk, David R. Schreier, Jelena Skoručak, Johannes Mathis , et al. · 2021

Brief fragments of sleep shorter than 15 s are defined as microsleep episodes (MSEs), often subjectively perceived as sleepiness. Their main characteristic is a slowing in frequency in the electroencephalogram (EEG), similar to stage N1 sl…

Naps not as effective as a night of sleep at dissipating sleep pressure Open

Leila Tarokh, Eliza Van Reen, Peter Achermann, Mary A. Carskadon · 2021

Summary The two‐process model of sleep posits that two processes interact to regulate sleep and wake: a homeostatic (Process S) and a circadian process (Process C). Process S compensates for sleep loss by increasing sleep duration and inte…

Pervasive false brain connectivity from electrophysiological signals Open

Roberto D. Pascual‐Marqui, Peter Achermann, Pascal L. Faber, Toshihiko Kinoshita, Kieko Kochi , et al. · 2021

1. Abstract Signals of brain electric neuronal activity, either invasively measured or non-invasively estimated, are commonly used for connectivity inference. One popular methodology assumes that the neural dynamics follow a multivariate a…

Validation of Fitbit Charge 2 Sleep and Heart Rate Estimates Against Polysomnographic Measures in Shift Workers: Naturalistic Study (Preprint) Open

Benjamin Stucky, Ian D. Clark, Yasmine Azza, Walter Karlen, Peter Achermann , et al. · 2020

BACKGROUND Multisensor fitness trackers offer the ability to longitudinally estimate sleep quality in a home environment with the potential to outperform traditional actigraphy. To benefit from these new tools for objectively assessing sl…

Fundamentally altered global- and microstate EEG characteristics in Huntington’s disease Open

Pascal L. Faber, Patricia Milz, Eva Z. Reininghaus, Sabrina Mörkl, Anna K. Holl , et al. · 2020

Combining global- and microstate analyses can be useful for a better understanding of progressive brain deterioration in HD.

Sensory stimulation in the treatment of children with sleep-related rhythmic movement disorder: a feasibility and acceptability study Open

Rachel van Sluijs, Elisabeth Wilhelm, Quincy J. Rondei, Lukas Jäger, Markus Gall , et al. · 2020

Global sleep homeostasis reflects temporally and spatially integrated local cortical neuronal activity Open

Christopher W. Thomas, Mathilde C. C. Guillaumin, Laura E. McKillop, Peter Achermann, Vladyslav V. Vyazovskiy · 2020

Sleep homeostasis manifests as a relative constancy of its daily amount and intensity. Theoretical descriptions define ‘Process S’, a variable with dynamics dependent on global sleep-wake history, and reflected in electroencephalogram (EEG…

Brain-electric activity during eyes open Brahma Kumaris Rajayoga meditation. Open

Kanishka Sharma, Peter Achermann, Bhawna Panwar, Shrikant Sahoo, A. G. Ramakrishnan , et al. · 2020

Brahma Kumaris Rajayoga’s open eyed ‘seed stage meditation’ was studied in 52 meditators. Meditation stages: concentration on peace, realization of being a soul and communion with the Supreme Soul. Frequency domain brain electric source lo…

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