Andreas Herrmann
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View article: CpG-induced immune responses <i>via</i> DNA micelles, gold nanoparticles, and liposomes
CpG-induced immune responses <i>via</i> DNA micelles, gold nanoparticles, and liposomes Open
This study compares the immunostimulatory efficiency among three different CpG-loaded nanocarriers: DNA micelles, liposomes, and gold nanoparticles.
View article: Size‐Dependent Ultrasound Activation of Thrombin Catalytic Activity by Mechano‐Nanoswitches
Size‐Dependent Ultrasound Activation of Thrombin Catalytic Activity by Mechano‐Nanoswitches Open
Integrating nanostructures with mechanochemistry significantly boosts drug loading capabilities and sonomechanical drug activation, outperforming traditional polymer systems. Nevertheless, the influence of nanoparticles’ physicochemical pr…
View article: Modular Design of Hydrogel Adhesives for Enhanced Tissue Healing
Modular Design of Hydrogel Adhesives for Enhanced Tissue Healing Open
Hydrogel adhesives exhibit significant potential in various biomedical fields such as wound hemostasis and healing. However, there is a lack of general strategies for preparing hydrogel adhesives that can be adapted to a variety of complex…
View article: The Palaearctic <i>Dermestes undulatus</i> Brahm 1790 (Coleoptera: Dermestidae: Dermestinae) species complex: descriptions of neotype and three new species
The Palaearctic <i>Dermestes undulatus</i> Brahm 1790 (Coleoptera: Dermestidae: Dermestinae) species complex: descriptions of neotype and three new species Open
Many species of Dermestidae have not been adequately described to facilitate current taxonomic studies. According to the World Catalogue of Dermestidae, the whereabouts of the holotype of Dermestes undulatus is not known. In the current st…
View article: Remote Control of Eukaryotic Gene Expression by a Modular Ultrasound‐Responsive RNA Toolkit
Remote Control of Eukaryotic Gene Expression by a Modular Ultrasound‐Responsive RNA Toolkit Open
Achieving remote control of biological processes remains a significant challenge in genetics. Although ultrasound has been employed to remotely regulate biological functions by targeting mechanosensitive ion channels, existing systems are …
View article: Remote Control of Eukaryotic Gene Expression by a Modular Ultrasound‐Responsive RNA Toolkit
Remote Control of Eukaryotic Gene Expression by a Modular Ultrasound‐Responsive RNA Toolkit Open
Achieving remote control of biological processes remains a significant challenge in genetics. Although ultrasound has been employed to remotely regulate biological functions by targeting mechanosensitive ion channels, existing systems are …
View article: Pepticombisomes: Biomimetic Vesicles Crafted From Recombinant Supercharged Polypeptides with Uniformly Distributed Side‐Chains
Pepticombisomes: Biomimetic Vesicles Crafted From Recombinant Supercharged Polypeptides with Uniformly Distributed Side‐Chains Open
Cell membranes play a key role in bottom‐up synthetic biology, as they enable interaction control, transport, and other essential functions. These ultra‐thin, flexible, yet stable structures form through the self‐assembly of lipids and pro…
View article: Minimally Invasive DNA-Mediated Photostabilization for Extended Single-Molecule and Super-resolution Imaging
Minimally Invasive DNA-Mediated Photostabilization for Extended Single-Molecule and Super-resolution Imaging Open
Photobleaching of fluorescence labels poses a major limitation in single-molecule and super-resolution microscopy. Conventional photostabilization methods, such as oxygen removal and addition of high concentrations of photostabilization ad…
View article: Exceptional Uptake, Limited Protein Expression: Liver Macrophages Lost in Translation of Synthetic mRNA
Exceptional Uptake, Limited Protein Expression: Liver Macrophages Lost in Translation of Synthetic mRNA Open
Most gene therapies exert their actions via manipulation of hepatocytes (parenchymal cells) and the reasons behind the suboptimal performance of synthetic mRNA in non‐parenchymal cells (NPC) such as Kupffer cells (KC), and liver macrophage…
View article: Ultrasonic Control of Protein Splicing by Split Inteins
Ultrasonic Control of Protein Splicing by Split Inteins Open
Utilizing ultrasound as an external stimulus to remotely modulate the activity of proteins is an important aspect of sonopharmacology and establishes the basis for the emerging field of sonogenetics. Here, we describe an ultrasound-respons…
View article: DNA Dissipative System for Controlled Release of Immunostimulatory CpG Oligodeoxynucleotides
DNA Dissipative System for Controlled Release of Immunostimulatory CpG Oligodeoxynucleotides Open
Herein, a dissipative system tailored for the controlled loading and release of CpG oligodeoxynucleotides (CpG ODNs), known for their pharmacological immunostimulatory properties, is reported. The approach involves multiple cycles of deact…
View article: Accelerated Mechanophore Activation and Drug Release in Network Core‐Structured Star Polymers Using High‐Intensity Focused Ultrasound
Accelerated Mechanophore Activation and Drug Release in Network Core‐Structured Star Polymers Using High‐Intensity Focused Ultrasound Open
The ultrasound (US)‐induced activation of mechanophores embedded in linear polymers (LPs) is the most widely employed technique to realize chemical function by polymer mechanochemistry. However, the commonly used US frequency in this conte…
View article: The Genus Orphilus Erichson, 1846 (Coleoptera: Dermestidae) in Europe
The Genus Orphilus Erichson, 1846 (Coleoptera: Dermestidae) in Europe Open
Holloway, Graham J., Foster, Christopher W., Herrmann, Andreas (2024): The Genus Orphilus Erichson, 1846 (Coleoptera: Dermestidae) in Europe. The Coleopterists Bulletin 78 (2): 117-124, DOI: 10.1649/0010-065X-78.2.117, URL: http://dx.doi.o…
View article: In Vivo Polymer Mechanochemistry with Polynucleotides
In Vivo Polymer Mechanochemistry with Polynucleotides Open
Polymer mechanochemistry utilizes mechanical force to activate latent functionalities in macromolecules and widely relies on ultrasonication techniques. Fundamental constraints of frequency and power intensity have prohibited the applicati…
View article: In vivo polymer mechanochemistry with polynucleotides
In vivo polymer mechanochemistry with polynucleotides Open
Original data underpinning Figures, Schemes, Videos, and Tables of the manuscript and supplementary information.
View article: High-Intensity Focused Ultrasound-Induced Disulfide Mechanophore Activation in Polymeric Nanostructures for Molecule Release
High-Intensity Focused Ultrasound-Induced Disulfide Mechanophore Activation in Polymeric Nanostructures for Molecule Release Open
Open AccessCCS ChemistryRESEARCH ARTICLES30 Apr 2024High-Intensity Focused Ultrasound-Induced Disulfide Mechanophore Activation in Polymeric Nanostructures for Molecule Release Jilin Fan, Kuan Zhang, Mingjun Xuan, Xiang Gao, Rostislav Vino…
View article: Significant downregulation of Alzheimer's amyloid-β levels enabled by engineered DNA nanomaterials
Significant downregulation of Alzheimer's amyloid-β levels enabled by engineered DNA nanomaterials Open
Although there are no effective therapies to block or reverse Alzheimer's disease (AD) progression at present, a promising therapeutic strategy is to reduce levels of amyloid-β (Aβ) proteins, which drive the formation of amyloid plaque, a …
View article: Mechanochemical Activation of DNAzyme by Ultrasound
Mechanochemical Activation of DNAzyme by Ultrasound Open
Controlling the activity of DNAzymes by external triggers is an important task. Here a temporal control over DNAzyme activity through a mechanochemical pathway with the help of ultrasound (US) is demonstrated. The deactivation of the DNAzy…
View article: Sonogenetics for Monitoring and Modulating Biomolecular Function by Ultrasound
Sonogenetics for Monitoring and Modulating Biomolecular Function by Ultrasound Open
Ultrasound technology, synergistically harnessed with genetic engineering and chemistry concepts, has started to open the gateway to the remarkable realm of sonogenetics—a pioneering paradigm for remotely orchestrating cellular functions a…
View article: Sonogenetics for Monitoring and Modulating Biomolecular Function by Ultrasound
Sonogenetics for Monitoring and Modulating Biomolecular Function by Ultrasound Open
Ultrasound technology, synergistically harnessed with genetic engineering and chemistry concepts, has started to open the gateway to the remarkable realm of sonogenetics—a pioneering paradigm for remotely orchestrating cellular functions a…
View article: In vivo polymer mechanochemistry with polynucleotides
In vivo polymer mechanochemistry with polynucleotides Open
Original data underpinning Figures, Schemes, Videos, and Tables of the manuscript and supplementary information.
View article: In vivo polymer mechanochemistry with polynucleotides
In vivo polymer mechanochemistry with polynucleotides Open
Polymer mechanochemistry utilizes mechanical force to activate latent functionalities in macromolecules and widely relies on ultrasonication techniques. Although ultrasound is a clinically established modality, fundamental constraints of f…