Peter B. Rupert
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View article: Optimizing Siglec-8-Directed Immunotherapy for Eosinophilic and Mast Cell Disorders
Optimizing Siglec-8-Directed Immunotherapy for Eosinophilic and Mast Cell Disorders Open
Background/Objective: Current treatments for eosinophilic and mast cell disorders are often ineffective. One promising target to improve outcomes is sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8). As limitations, there are few…
View article: Actinium chelation and crystallization in a macromolecular scaffold
Actinium chelation and crystallization in a macromolecular scaffold Open
Targeted alpha therapy (TAT) pairs the specificity of antigen targeting with the lethality of alpha particles to eradicate cancerous cells. Actinium-225 [ 225 Ac; t 1/2 = 9.920(3) days] is an alpha-emitting radioisotope driving the next ge…
View article: Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics
Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics Open
Mesothelin is a glypiated, cell-surface glycoprotein expressed at low levels on normal mesothelium but overexpressed by many cancers. Implicated in cell adhesion and multiple signaling pathways, mesothelin’s precise biological function and…
View article: Effects of HLA single chain trimer design on peptide presentation and stability
Effects of HLA single chain trimer design on peptide presentation and stability Open
MHC class I “ single-chain trimer ” molecules, coupling MHC heavy chain, β 2 -microglobulin, and a specific peptide into a single polypeptide chain, are widely used in research. To more fully understand caveats associated with this design …
View article: Ex silico engineering of cystine-dense peptides yielding a potent bispecific T cell engager
Ex silico engineering of cystine-dense peptides yielding a potent bispecific T cell engager Open
Cystine-dense peptides (CDPs) are a miniprotein class that can drug difficult targets with high affinity and low immunogenicity. Tools for their design, however, are not as developed as those for small-molecule and antibody drugs. CDPs hav…
View article: Evaluation of cell-based and surrogate SARS-CoV-2 neutralization assays
Evaluation of cell-based and surrogate SARS-CoV-2 neutralization assays Open
Determinants of protective immunity against SARS-CoV-2 infection require the development of well-standardized, reproducible antibody assays. This need has led to the emergence of a variety of neutralization assays. Head-to-head evaluation …
View article: Evaluation of Cell-Based and Surrogate SARS-CoV-2 Neutralization Assays
Evaluation of Cell-Based and Surrogate SARS-CoV-2 Neutralization Assays Open
Determinants of protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection require the development of well-standardized, reproducible antibody assays. This need has led to the emergence of a variety …
View article: Evaluation of SARS-CoV-2 neutralization assays for antibody monitoring in natural infection and vaccine trials
Evaluation of SARS-CoV-2 neutralization assays for antibody monitoring in natural infection and vaccine trials Open
Determinants of protective immunity against SARS-CoV-2 infection require the development of well-standardized, reproducible antibody assays to be utilized in concert with clinical trials to establish correlates of risk and protection. This…
View article: Investigating complexation-induced chirality in Ln(III) and An(III)-3,4,3-LI(1,2-HOPO) small-molecule and siderocalin protein complexes
Investigating complexation-induced chirality in Ln(III) and An(III)-3,4,3-LI(1,2-HOPO) small-molecule and siderocalin protein complexes Open
The solid-state interactions between the octadenate siderophore analogue 3,4,3-LI(1,2-HOPO) and trivalent Ln(III) and An(III) cations were investigated via single-crystal and protein crystallography.The ability to directly compare single c…
View article: Engineered Recognition of Tetravalent Zirconium and Thorium by Chelator–Protein Systems: Toward Flexible Radiotherapy and Imaging Platforms
Engineered Recognition of Tetravalent Zirconium and Thorium by Chelator–Protein Systems: Toward Flexible Radiotherapy and Imaging Platforms Open
Targeted α therapy holds tremendous potential as a cancer treatment: it offers the possibility of delivering a highly cytotoxic dose to targeted cells while minimizing damage to surrounding healthy tissue. The metallic α-generating radiois…
View article: Top scoring 4E10 and b12 PhIP-Seq 36-mer peptides.
Top scoring 4E10 and b12 PhIP-Seq 36-mer peptides. Open
The top fifteen scoring 36-mer peptides from the b12 IgG PhIP-Seq analysis (above) and the seventeen top scoring 36-mer peptides from the 4E10 IgG analysis exceeding the threshold set by the highest-scoring b12 peptide (below) are shown, c…
View article: Siderocalin-mediated recognition, sensitization, and cellular uptake of actinides
Siderocalin-mediated recognition, sensitization, and cellular uptake of actinides Open
Significance The release of actinides in the environment, particularly after a nuclear power plant accident or the potential use of a radiological dispersal device, is a public health threat, as all actinides are radioactive and will trigg…