P. Brian Smith
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View article: Early-Life Factors and Body Mass Index Trajectories Among Children in the ECHO Cohort
Early-Life Factors and Body Mass Index Trajectories Among Children in the ECHO Cohort Open
Importance Identifying atypical body mass index (BMI) trajectories in children and understanding associated, modifiable early-life factors may help prevent childhood obesity. Objective To characterize multiphase BMI trajectories in childre…
View article: SARS-CoV-2 N protein and anti-spike serologies: insights into COVID-19 disease severity and mortality—a secondary analysis of the ACTIV-1 trial
SARS-CoV-2 N protein and anti-spike serologies: insights into COVID-19 disease severity and mortality—a secondary analysis of the ACTIV-1 trial Open
Background: Understanding factors that predict progression to severe COVID-19 is critical. Antibodies targeting SARS-CoV-2 spike protein confer protection, while the N protein of SARS-CoV-2 plays roles in viral replication and immune dysfu…
View article: SARS-CoV-2 N protein and anti-spike serologies: insights into COVID-19 disease severity and mortality—a secondary analysis of the ACTIV-1 trial
SARS-CoV-2 N protein and anti-spike serologies: insights into COVID-19 disease severity and mortality—a secondary analysis of the ACTIV-1 trial Open
Background: Understanding factors that predict progression to severe COVID-19 is critical. Antibodies targeting SARS-CoV-2 spike protein confer protection, while the N protein of SARS-CoV-2 plays roles in viral replication and immune dysfu…
View article: Abatacept, Cenicriviroc, or Infliximab for Treatment of Adults Hospitalized With COVID-19 Pneumonia
Abatacept, Cenicriviroc, or Infliximab for Treatment of Adults Hospitalized With COVID-19 Pneumonia Open
Importance: Immune dysregulation contributes to poorer outcomes in COVID-19. Objective: To investigate whether abatacept, cenicriviroc, or infliximab provides benefit when added to standard care for COVID-19 pneumonia. Design, Setting, and…
View article: Racial and ethnic differences in prenatal exposure to environmental phenols and parabens in the ECHO Cohort
Racial and ethnic differences in prenatal exposure to environmental phenols and parabens in the ECHO Cohort Open
Background Research suggests racial/ethnic disparities in prenatal exposure to endocrine disrupting environmental phenols (EPs) in limited populations. However, no studies have investigated racial/ethnic disparities in prenatal EP exposure…
View article: Neighborhood Food Access in Early Life and Trajectories of Child Body Mass Index and Obesity
Neighborhood Food Access in Early Life and Trajectories of Child Body Mass Index and Obesity Open
Importance Limited access to healthy foods, resulting from residence in neighborhoods with low food access, is a public health concern. The contribution of this exposure in early life to child obesity remains uncertain. Objective To examin…
View article: Longitudinal Changes in Youth Mental Health From Before to During the COVID-19 Pandemic
Longitudinal Changes in Youth Mental Health From Before to During the COVID-19 Pandemic Open
Importance Robust longitudinal studies of within-child changes in mental health associated with the COVID-19 pandemic are lacking, as are studies examining sources of heterogeneity in such changes. Objective To investigate within-child cha…
View article: Infant Feeding and Weight Trajectories in the Eat, Sleep, Console Trial
Infant Feeding and Weight Trajectories in the Eat, Sleep, Console Trial Open
Importance Infants with neonatal opioid withdrawal syndrome (NOWS) cared for with the Eat, Sleep, Console (ESC) care approach receive less pharmacologic treatment and have shorter hospital stays compared to usual care with the Finnegan Neo…
View article: Abatacept Pharmacokinetics and Exposure Response in Patients Hospitalized With COVID-19
Abatacept Pharmacokinetics and Exposure Response in Patients Hospitalized With COVID-19 Open
Importance The pharmacokinetics of abatacept and the association between abatacept exposure and outcomes in patients with severe COVID-19 are unknown. Objective To characterize abatacept pharmacokinetics, relate drug exposure with clinical…
View article: Influence of Eat, Sleep, and Console on Infants Pharmacologically Treated for Opioid Withdrawal
Influence of Eat, Sleep, and Console on Infants Pharmacologically Treated for Opioid Withdrawal Open
Importance The function-based eat, sleep, console (ESC) care approach substantially reduces the proportion of infants who receive pharmacologic treatment for neonatal opioid withdrawal syndrome (NOWS). This reduction has led to concerns fo…
View article: Green Space and Internalizing or Externalizing Symptoms Among Children
Green Space and Internalizing or Externalizing Symptoms Among Children Open
Importance Evidence suggests that living near green space supports mental health, but studies examining the association of green space with early mental health symptoms among children are rare. Objective To evaluate the association between…
View article: Direct-to-participant recruitment of mothers and infants: A strategic approach during challenging pandemic times
Direct-to-participant recruitment of mothers and infants: A strategic approach during challenging pandemic times Open
Under traditional circumstances, most clinical trials rely on in-person operations to identify, recruit, and enroll study participants and to complete study-related visits. During unusual circumstances, such as the COVID-19 pandemic, the t…
Prenatal Exposure to Nonpersistent Environmental Chemicals and Postpartum Depression Open
Importance Postpartum depression (PPD) affects up to 20% of childbearing individuals, and a significant limitation in reducing its morbidity is the difficulty in modifying established risk factors. Exposure to synthetic environmental chemi…
Evaluation of pediatric epigenetic clocks across multiple tissues Open
Background Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational and chronological age determination. Results Our study used data from seven tissue types …
Sociodemographic Differences in COVID-19 Pandemic Experiences Among Families in the United States Open
Importance Few population-based studies in the US collected individual-level data from families during the COVID-19 pandemic. Objective To examine differences in COVID-19 pandemic–related experiences in a large sociodemographically diverse…
Maternal stress and early childhood BMI among US children from the Environmental influences on Child Health Outcomes (ECHO) program Open
Although existing literature suggests relationships between parental stress and childhood BMI, we found no linear associations between maternal stress in the first year of life and childhood BMI at 2-4 years of age among participants in EC…