Peter W. Baas
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View article: Analyses of exon 4a structure reveal the properties of Big tau related to distribution, function and aggregation
Analyses of exon 4a structure reveal the properties of Big tau related to distribution, function and aggregation Open
Tau, a microtubule-associated protein that modulates the dynamic properties of microtubules, is best known for its involvement in tauopathies. Usually expressed as the low molecular (LMW) variants of 45–60 kDa, tau is also expressed as a h…
View article: Analyses of exon 4a structure reveal unique properties of Big tau
Analyses of exon 4a structure reveal unique properties of Big tau Open
Tau is a microtubule-associated protein that modulates the dynamic properties of microtubules and is involved in neurodegenerative diseases known as tauopathies. Tau is expressed as multiple low molecular weight (LMW) isoforms in most neur…
View article: Genotype–Phenotype Distinctions in Spastic Paraplegia 4 Reveal HDAC6 as a Therapeutic Target
Genotype–Phenotype Distinctions in Spastic Paraplegia 4 Reveal HDAC6 as a Therapeutic Target Open
Spastic Paraplegia 4 (SPG4) is the most prevalent form of Hereditary Spastic Paraplegia (HSP), a neurodegenerative disorder characterized by progressive lower limb spasticity and debilitating gait impairment, primarily driven by axonal deg…
View article: Tau and MAP6 establish labile and stable domains on microtubules
Tau and MAP6 establish labile and stable domains on microtubules Open
We previously documented that individual microtubules in the axons of cultured juvenile rodent neurons consist of a labile domain and a stable domain and that experimental depletion of tau results in selective shortening and partial stabil…
View article: Bi‐phasic Microtubule Defects in Tauopathy: Treatment Implications
Bi‐phasic Microtubule Defects in Tauopathy: Treatment Implications Open
Background In tauopathies, such as Frontotemporal Dementia (FTD), tau loses association with microtubules (MTs) and forms neurofibrillary tangles. Tau is an abundant MT‐associated protein in neurons, which essentially regulate MT propertie…
View article: Antagonistic roles of tau and MAP6 in regulating neuronal development
Antagonistic roles of tau and MAP6 in regulating neuronal development Open
Association of tau (encoded by Mapt) with microtubules causes them to be labile, whereas association of MAP6 with microtubules causes them to be stable. As axons differentiate and grow, tau and MAP6 segregate from one another on individual…
View article: Antagonistic Roles of Tau and MAP6 in Regulating Neuronal Development
Antagonistic Roles of Tau and MAP6 in Regulating Neuronal Development Open
Association of tau with microtubules causes them to be labile while association of MAP6 with microtubules causes them to be stable. As axons differentiate and grow long, tau and MAP6 segregate from one another on individual microtubules, r…
View article: Reevaluating tau reduction as a therapeutic approach for tauopathies: Insights and perspectives
Reevaluating tau reduction as a therapeutic approach for tauopathies: Insights and perspectives Open
Tau, one of the most abundant microtubule‐associated protein in neurons plays a role in regulating microtubule dynamics in axons, as well as shaping the overall morphology of the axon. Recent studies challenge the traditional view of tau a…
View article: Is Gulf War Illness a prolonged early phase tauopathy?
Is Gulf War Illness a prolonged early phase tauopathy? Open
The work of the Gulf War Illness (GWI) Consortium and that of basic and clinical researchers across the USA have resulted in a better understanding in recent years of the pathological basis of GWI, as well as of the mechanisms underlying t…
View article: A half‐century of tau
A half‐century of tau Open
From its original trademark as an esoteric factor that stimulates tubulin polymerization into microtubules (MTs; Weingarten et al., 1975), a nevertheless classic finding in the annals of cytoskeleton history, tau eventually gained notoriet…
View article: ASD mutation of Katnal2 impairs ependymal ciliary motion and causes hydrocephalus
ASD mutation of Katnal2 impairs ependymal ciliary motion and causes hydrocephalus Open
Katanin catalytic subunit A1 like 2 ( KATNAL2 ) is a high-risk gene associated with autism spectrum disorders (ASD), however its impact on brain development and disease remains unclear. The present study revealed an unexpected role of KATN…
View article: Veteran-derived cerebral organoids display multifaceted pathological defects in studies on Gulf War Illness
Veteran-derived cerebral organoids display multifaceted pathological defects in studies on Gulf War Illness Open
Approximately 30% of the veterans who fought in the 1991 Gulf War (GW) suffer from a disease called Gulf War Illness (GWI), which encompasses a constellation of symptoms including cognitive deficits. A coalescence of evidence indicates tha…
View article: Microtubule polarity flaws as a treatable driver of neurodegeneration
Microtubule polarity flaws as a treatable driver of neurodegeneration Open
Microtubule disruption is a common downstream mechanism leading to axonal degeneration in a number of neurological diseases. To date, most studies on this topic have focused on the loss of microtubule mass from the axon, as well as changes…
View article: Modeling gain-of-function and loss-of-function components of<i>SPAST</i>-based hereditary spastic paraplegia using transgenic mice
Modeling gain-of-function and loss-of-function components of<i>SPAST</i>-based hereditary spastic paraplegia using transgenic mice Open
Hereditary spastic paraplegia (HSP) is a disease in which dieback degeneration of corticospinal tracts, accompanied by axonal swellings, leads to gait deficiencies. SPG4-HSP, the most common form of the disease, results from mutations of h…
View article: Boston biorepository, recruitment and integrative network (BBRAIN): A resource for the Gulf War Illness scientific community
Boston biorepository, recruitment and integrative network (BBRAIN): A resource for the Gulf War Illness scientific community Open
The BBRAIN repository network serves as a much needed resource for GWI researchers to utilize for identification and validation of objective diagnostic and pathobiological markers of the illness.
View article: Therapeutic Strategies for Mutant SPAST-Based Hereditary Spastic Paraplegia
Therapeutic Strategies for Mutant SPAST-Based Hereditary Spastic Paraplegia Open
Mutations of the SPAST gene that encodes the microtubule-severing enzyme called spastin are the chief cause of Hereditary Spastic Paraplegia. Growing evidence indicates that pathogenic mutations functionally compromise the spastin protein …
View article: The Carbamate, Physostigmine does not Impair Axonal Transport in Rat Cortical Neurons
The Carbamate, Physostigmine does not Impair Axonal Transport in Rat Cortical Neurons Open
Among the various chemicals that are commonly used as pesticides, organophosphates (OPs), and to a lesser extent, carbamates, are most frequently associated with adverse long-term neurological consequences. OPs and the carbamate, pyridosti…
View article: Aero-elastic loads on a 10 MW turbine exposed to extreme eventsselected from a year-long Large-Eddy Simulation over the NorthSea
Aero-elastic loads on a 10 MW turbine exposed to extreme eventsselected from a year-long Large-Eddy Simulation over the NorthSea Open
In this article the aero-elastic loads on a 10 MW turbine in response to unconventional wind conditions selected from a year long Large Eddy Simulation on a site at the North Sea are evaluated. Thereto an assessment is made of the practica…
View article: Issue Information
Issue Information Open
Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have f…
View article: Issue Information
Issue Information Open
Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have f…
View article: Mitotic Motor KIFC1 Is an Organizer of Microtubules in the Axon
Mitotic Motor KIFC1 Is an Organizer of Microtubules in the Axon Open
KIFC1 (also called HSET or kinesin-14a) is best known as a multifunctional motor protein essential for mitosis. The present studies are the first to explore KIFC1 in terminally postmitotic neurons. Using RNA interference to partially deple…