Peter Bartenstein
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View article: 3D printing of radioactive wall-less PET phantoms improves threshold-based target delineation and quantification
3D printing of radioactive wall-less PET phantoms improves threshold-based target delineation and quantification Open
Background Validation of threshold-based PET segmentation and PET quantification is typically performed with fillable phantoms. Theoretical considerations show that the inactive walls of the phantom cavities introduce a contrast dependence…
View article: Upregulation of SSTR2 Expression and Radioligand Binding of [<sup>18</sup>F]SiTATE in Neuroendocrine Tumour Cells with Combined Inhibition of Class I HDACs and LSD1
Upregulation of SSTR2 Expression and Radioligand Binding of [<sup>18</sup>F]SiTATE in Neuroendocrine Tumour Cells with Combined Inhibition of Class I HDACs and LSD1 Open
Introduction: Peptide receptor radionuclide therapy (PRRT) is a highly effective, targeted treatment option in advanced neuroendocrine tumours (NETs). However, NET patients expressing low levels of Somatostatin receptor type (SSTR) 2 do no…
View article: A Machine Learning Approach for Predicting Biochemical Outcome After PSMA-PET–Guided Salvage Radiotherapy in Recurrent Prostate Cancer After Radical Prostatectomy: Retrospective Study
A Machine Learning Approach for Predicting Biochemical Outcome After PSMA-PET–Guided Salvage Radiotherapy in Recurrent Prostate Cancer After Radical Prostatectomy: Retrospective Study Open
Background Salvage radiation therapy (sRT) is often the sole curative option in patients with biochemical recurrence after radical prostatectomy. After sRT, we developed and validated a nomogram to predict freedom from biochemical failure.…
View article: Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer’s disease
Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer’s disease Open
Background Microglial activation is one hallmark of Alzheimer disease (AD) neuropathology but the impact of the regional interplay of microglia cells in the brain is poorly understood. We hypothesized that microglial activation is regional…
View article: Towards multicenter β-amyloid PET imaging in mouse models: A triple scanner head-to-head comparison
Towards multicenter β-amyloid PET imaging in mouse models: A triple scanner head-to-head comparison Open
Our comparison of standardized small animal Aβ-PET acquired by three different scanners substantiates the possibility of moving towards a multicentric approach in preclinical AD research. The alignment of image acquisition and analysis met…
View article: Quantitative assessment of cardiac 123iodo-metaiodobenzylguanidine SPECT/CT in patients with arrhythmogenic right ventricular cardiomyopathy: Novel insight in disease monitoring
Quantitative assessment of cardiac 123iodo-metaiodobenzylguanidine SPECT/CT in patients with arrhythmogenic right ventricular cardiomyopathy: Novel insight in disease monitoring Open
Quantitative 123I-MIBG SPECT in ARCV patients offers robust potential for clinical reporting and demonstrates a significant correlation with RV function. Segmental RV analysis needs to be evaluated in larger samples. In summary, cardiac 12…
View article: Validation of the standardization framework SSTR-RADS 1.0 for neuroendocrine tumors using the novel SSTR‑targeting peptide [18F]SiTATE
Validation of the standardization framework SSTR-RADS 1.0 for neuroendocrine tumors using the novel SSTR‑targeting peptide [18F]SiTATE Open
Objectives Somatostatin receptor positron emission tomography/computed tomography (SSTR-PET/CT) using [ 68 Ga]-labeled tracers is a widely used imaging modality for neuroendocrine tumors (NET). Recently, [ 18 F]SiTATE, a SiFAlin tagged [Ty…
View article: Assessment of [18F]PI-2620 Tau-PET Quantification via Non-Invasive Automatized Image Derived Input Function
Assessment of [18F]PI-2620 Tau-PET Quantification via Non-Invasive Automatized Image Derived Input Function Open
Purpose [ 18 F]PI-2620 positron emission tomography (PET) detects misfolded tau in progressive supranuclear palsy (PSP) and Alzheimer’s disease (AD). We questioned the feasibility and value of absolute [ 18 F]PI-2620 PET quantification for…
View article: Development and Preclinical Evaluation of a Copper-64-Labeled Antibody Targeting Glycine-Alanine Dipeptides for PET Imaging of C9orf72-Associated Amyotrophic Lateral Sclerosis/Frontotemporal Dementia
Development and Preclinical Evaluation of a Copper-64-Labeled Antibody Targeting Glycine-Alanine Dipeptides for PET Imaging of C9orf72-Associated Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Open
Aggregating poly(glycine-alanine) (poly-GA) is derived from the unconventional translation of the pathogenic intronic hexanucleotide repeat expansion in the C9orf72 gene, which is the most common genetic cause of frontotemporal dementia (F…
View article: Improved Tau PET SUVR Quantification in 4-Repeat Tau Phenotypes with [<sup>18</sup>F]PI-2620
Improved Tau PET SUVR Quantification in 4-Repeat Tau Phenotypes with [<sup>18</sup>F]PI-2620 Open
We used a new data-driven methodology to identify a set of reference regions that enhanced the quantification of the SUV ratio of the second-generation tau tracer 2-(2-([18F]fluoro)pyridin-4-yl)-9H-pyrrolo[2,3-b:4,5-c']dipyridine ([18F]PI-…
View article: Functional maturation and longitudinal imaging of intraportal neonatal porcine islet grafts in genetically diabetic pigs
Functional maturation and longitudinal imaging of intraportal neonatal porcine islet grafts in genetically diabetic pigs Open
Allogeneic intraportal islet transplantation (ITx) has become an established treatment for patients with poorly controlled type 1 diabetes. However, the loss of viable beta-cell mass after transplantation remains a major challenge. Therefo…
View article: The Traumatic Inoculation Process Affects TSPO Radioligand Uptake in Experimental Orthotopic Glioblastoma
The Traumatic Inoculation Process Affects TSPO Radioligand Uptake in Experimental Orthotopic Glioblastoma Open
Background: The translocator protein (TSPO) has been proven to have great potential as a target for the positron emission tomography (PET) imaging of glioblastoma. However, there is an ongoing debate about the potential various sources of …
View article: Validity and value of metabolic connectivity in mouse models of β-amyloid and tauopathy
Validity and value of metabolic connectivity in mouse models of β-amyloid and tauopathy Open
Among functional imaging methods, metabolic connectivity (MC) is increasingly used for investigation of regional network changes to examine the pathophysiology of neurodegenerative diseases such as Alzheimer's disease (AD) or movement diso…
View article: PET imaging of microglia in Alzheimer's disease using copper-64 labeled TREM2 antibodies
PET imaging of microglia in Alzheimer's disease using copper-64 labeled TREM2 antibodies Open
Triggering receptor expressed on myeloid cells 2 (TREM2) plays an essential role in microglia activation and is being investigated as a potential therapeutic target for modulation of microglia in several neurological diseases. In this stud…
View article: Association of Neurofilament Light Chain, [ <sup>18</sup> F]PI-2620 Tau-PET, TSPO-PET, and Clinical Progression in Patients With β-Amyloid–Negative CBS
Association of Neurofilament Light Chain, [ <sup>18</sup> F]PI-2620 Tau-PET, TSPO-PET, and Clinical Progression in Patients With β-Amyloid–Negative CBS Open
[18F]PI-2620 tau-PET, [18F]GE-180 TSPO-PET, and plasma-NfL show prognostic potential for clinical progression in patients with Aβ-negative CBS with probable 4-repeat tauopathy, which can be useful for clinical decision-making and stratifyi…
View article: Biomarker interplay between CSF p‐tau and <sup>18</sup>F‐PI‐2620 PET in Alzheimer’s disease and 4R‐tauopathy
Biomarker interplay between CSF p‐tau and <sup>18</sup>F‐PI‐2620 PET in Alzheimer’s disease and 4R‐tauopathy Open
Background Reliable biomarkers for detecting different abnormal tau protein isoforms between neurodegenerative diseases are currently missing. Phosphorylated tau (p‐tau) in the cerebrospinal fluid (CSF) is acknowledged as a 3/4R tau biomar…
View article: PSMA-Expression Is Highly Associated with Histological Subtypes of Renal Cell Carcinoma: Potential Implications for Theranostic Approaches
PSMA-Expression Is Highly Associated with Histological Subtypes of Renal Cell Carcinoma: Potential Implications for Theranostic Approaches Open
In renal cell carcinoma (RCC), accurate imaging methods are required for treatment planning and response assessment to therapy. In addition, there is an urgent need for new therapeutic options, especially in metastatic RCC. One way to comb…
View article: Associations between sex, body mass index and the individual microglial response in Alzheimer’s disease
Associations between sex, body mass index and the individual microglial response in Alzheimer’s disease Open
Background and Objectives: 18-kDa translocator protein position-emission-tomography (TSPO-PET) imaging emerged for in vivo assessment of neuroinflammation in Alzheimer’s disease (AD) research. Sex and obesity effects on TSPO-PET binding ha…
View article: Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution
Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution Open
Various cellular sources hamper interpretation of positron emission tomography (PET) biomarkers in the tumor microenvironment (TME). We developed an approach of immunomagnetic cell sorting after in vivo radiotracer injection (scRadiotracin…
View article: Lymphatic drainage of sinonasal malignancies and the role of sentinel node biopsies
Lymphatic drainage of sinonasal malignancies and the role of sentinel node biopsies Open
Background: Locoregional recurrence is a critical factor in the prognosis of sinonasal malignancies. Due to the rarity of these tumours, as well as the heterogeneity of histologies and anatomical subsites, there is little evidence regardin…
View article: Proliferation and apoptosis after whole-body irradiation: longitudinal PET study in a mouse model
Proliferation and apoptosis after whole-body irradiation: longitudinal PET study in a mouse model Open
Purpose A reliable method for regional in vivo imaging of radiation-induced cellular damage would be of great importance for the detection of therapy-induced injury to healthy tissue and the choice of adequate treatment of radiation emerge…
View article: Primary presentation and clinical course of pediatric and adolescent patients with differentiated thyroid carcinoma after radioiodine therapy
Primary presentation and clinical course of pediatric and adolescent patients with differentiated thyroid carcinoma after radioiodine therapy Open
Introduction Differentiated thyroid carcinoma (DTC) in childhood and during adolescence is extremely rare. Pediatric DTC commonly presents with advanced disease at diagnosis including a high prevalence of cervical lymph node metastases and…
View article: Diagnostic accuracy of SSR-PET/CT compared to histopathology in the identification of liver metastases from well-differentiated neuroendocrine tumors
Diagnostic accuracy of SSR-PET/CT compared to histopathology in the identification of liver metastases from well-differentiated neuroendocrine tumors Open
Background Histopathology is the reference standard for diagnosing liver metastases of neuroendocrine tumors (NETs). Somatostatin receptor-positron emission tomography / computed tomography (SSR-PET/CT) has emerged as a promising non-invas…