Dávid Barton
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View article: DNA methylation changes in a pharmaco-epigenomic EWAS in depression: comparing fixed and response-guided dosing paradigms for ketamine in the KADS trial
DNA methylation changes in a pharmaco-epigenomic EWAS in depression: comparing fixed and response-guided dosing paradigms for ketamine in the KADS trial Open
DNA methylation is a dynamic biomarker suited to investigate processes, e.g., treatment response. We investigate DNA methylation changes in different dosing paradigms for ketamine (s.c.) vs. midazolam (s.c.) in treatment resistant depresse…
View article: Effect of ketamine on anxiety: findings from the Ketamine for Adult Depression Study
Effect of ketamine on anxiety: findings from the Ketamine for Adult Depression Study Open
Background Anxiety disorders and treatment-resistant major depressive disorder (TRD) are often comorbid. Studies suggest ketamine has anxiolytic and antidepressant properties. Aims To investigate if subcutaneous racemic ketamine, delivered…
View article: Blarcamesine for the treatment of Early Alzheimer's Disease: Results from the ANAVEX2-73-AD-004 Phase IIB/III trial
Blarcamesine for the treatment of Early Alzheimer's Disease: Results from the ANAVEX2-73-AD-004 Phase IIB/III trial Open
Blarcamesine, demonstrating a safety profile with no associated neuroimaging adverse events, significantly slowed clinical progression by 36.3% at 48 weeks with blarcamesine group as well as the individual 30 mg (by 34.6%) and 50 mg (by 38…
View article: Deferiprone in Alzheimer Disease
Deferiprone in Alzheimer Disease Open
Importance Interventions that substantially slow neurodegeneration are needed to address the growing burden of Alzheimer disease (AD) to societies worldwide. Elevated brain iron observed in AD has been associated with accelerated cognitive…
View article: Extended-release ketamine tablets for treatment-resistant depression: a randomized placebo-controlled phase 2 trial
Extended-release ketamine tablets for treatment-resistant depression: a randomized placebo-controlled phase 2 trial Open
Ketamine has rapid-onset antidepressant activity in patients with treatment-resistant major depression (TRD). The safety and tolerability of racemic ketamine may be improved if given orally, as an extended-release tablet (R-107), compared …
View article: Disaster in relation to attachment, loss, grief and recovery: the Marysville experience.
Disaster in relation to attachment, loss, grief and recovery: the Marysville experience. Open
The thesis is a study of the post-2009 Black Saturday bushfire community of Marysville. The central research question asks: ‘How did survivors of the Marysville Black Saturday bushfire experience attachment, loss and grief in the post-fire…
View article: Non-custodial fathers' experiences of attachment, loss and grief
Non-custodial fathers' experiences of attachment, loss and grief Open
It was John Bowlby who first provided an understanding of the attachments that human beings form with one another from the very earliest years of life, and of what may occur if those attachments are broken and lost. Whilst Bowlby’s at time…
View article: Donanemab in Early Symptomatic Alzheimer Disease
Donanemab in Early Symptomatic Alzheimer Disease Open
Importance There are limited efficacious treatments for Alzheimer disease. Objective To assess efficacy and adverse events of donanemab, an antibody designed to clear brain amyloid plaque. Design, Setting, and Participants Multicenter (277…
View article: Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial
Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial Open
Background Prior trials suggest that intravenous racemic ketamine is a highly effective for treatment-resistant depression (TRD), but phase 3 trials of racemic ketamine are needed. Aims To assess the acute efficacy and safety of a 4-week c…
View article: Measurement of Noradrenaline and Serotonin Metabolites With Internal Jugular Vein Sampling: An Indicator of Brain Monoamine Turnover in Depressive Illness and Panic Disorder
Measurement of Noradrenaline and Serotonin Metabolites With Internal Jugular Vein Sampling: An Indicator of Brain Monoamine Turnover in Depressive Illness and Panic Disorder Open
In research spanning three decades we have estimated brain monoamine turnover (approximately equating with synthesis rate) with sampling from the internal jugular veins and measurement of trans-cerebral plasma monoamine metabolite concentr…
View article: List of contributors
List of contributors Open
Communication at the University of Leeds (UK) and is editor of Visual Communication.Her research and publications use and develop a social semiotic approach to understand sign-making practices in digital environments, in place and in face-…
View article: IPBES VA Chapter 3. Systematic PCIV (Principles, Criteria, Indicators, Verifiers) review on valuation methods
IPBES VA Chapter 3. Systematic PCIV (Principles, Criteria, Indicators, Verifiers) review on valuation methods Open
Title: Systematic PCIV (Principles, Criteria, Indicators, Verifiers) review on valuation methods Code: IPBES_VA_3.1 Versioning: 05 (22.04.2022) DOI: 10.5281/zenodo.4404678 Description: This review corresponds to the IPBES Values assessmen…
View article: Academics Writing: The Dynamics of Knowledge Creation
Academics Writing: The Dynamics of Knowledge Creation Open
"Academics Writing recounts how academic writing is changing in the contemporary university, transforming what it means to be an academic and how, as a society, we produce academic knowledge. Writing practices are changing as the academic …
View article: Negotiating tensions around new forms of academic writing
Negotiating tensions around new forms of academic writing Open
Almost every aspect of an academic’s role involves specialised forms of writing, and the range of digital platforms used to produce this has increased. Core genres such as the journal article and monograph remain central, but the ways they…
View article: Known unknowns: Examining the burden of neurocognitive impairment in the end‐stage renal failure population
Known unknowns: Examining the burden of neurocognitive impairment in the end‐stage renal failure population Open
The burden of neurocognitive impairment (NCI) in patients receiving maintenance dialysis represents a spectrum of deficits across multiple cognitive domains that are associated with hospitalization, reduced quality‐of‐life, mortality and f…
View article: Additional file 1: of PHENOS: a high-throughput and flexible tool for microorganism growth phenotyping on solid media
Additional file 1: of PHENOS: a high-throughput and flexible tool for microorganism growth phenotyping on solid media Open
Validation by cell counting (xlsx). Raw data and calculations. (XLSX 549Â kb)
View article: Additional file 3: of PHENOS: a high-throughput and flexible tool for microorganism growth phenotyping on solid media
Additional file 3: of PHENOS: a high-throughput and flexible tool for microorganism growth phenotyping on solid media Open
A Validation by paraquat QTLs (xlsx). Full list of QTL intervals and their details. B Validation by paraquat QTLs measurements (zip). Initial DAT and csv files. (XLSX 53Â kb)
View article: Additional file 2: of PHENOS: a high-throughput and flexible tool for microorganism growth phenotyping on solid media
Additional file 2: of PHENOS: a high-throughput and flexible tool for microorganism growth phenotyping on solid media Open
Testing with multiple materials (xlsx). Raw data and calculations. (XLSX 434Â kb)
View article: Additional file 4: of PHENOS: a high-throughput and flexible tool for microorganism growth phenotyping on solid media
Additional file 4: of PHENOS: a high-throughput and flexible tool for microorganism growth phenotyping on solid media Open
E coli results (xlsx). Raw data and calculations. (XLSX 286Â kb)
View article: Victoria’s dependence on overseas trained doctors in psychiatry
Victoria’s dependence on overseas trained doctors in psychiatry Open
This paper analyses Australia’s growing reliance on overseas trained psychiatrists (OTPs) for provision of public sector mental health services, particularly in rural and regional Victoria. A number of critical issues are highlighted, incl…
View article: Sociolinguistic perspectives on everyday digital practices
Sociolinguistic perspectives on everyday digital practices Open
The four papers in this panel are by linguists who share a common approach to the study of language combining discourse studies and ethnographic approaches to the analysis of people’s experiences of online life. The first paper is an exami…