Peter Bede
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View article: Machine‐Learning Applications in Frontotemporal Dementia: Challenges, Prospects and Viable Clinical Applications
Machine‐Learning Applications in Frontotemporal Dementia: Challenges, Prospects and Viable Clinical Applications Open
View article: SC10X/U: A high-density electrode system for standardised surface recording of neural activity of the cervical spinal cord
SC10X/U: A high-density electrode system for standardised surface recording of neural activity of the cervical spinal cord Open
The proposed system addresses the gap of non-standardized multi-channel recording of neural signals from the upper spinal cord, facilitating reliable and reproducible recordings.
View article: Case Report: Reactivation of Chagas disease in a patient with advanced HIV 15 Years after migration
Case Report: Reactivation of Chagas disease in a patient with advanced HIV 15 Years after migration Open
Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. Chagas disease reactivation is an opportunistic infection in HIV-positive patients that commonly presents as meningoencephalitis and/or cent…
View article: New developments in imaging in ALS
New developments in imaging in ALS Open
Neuroimaging in ALS has contributed considerable academic insights in recent years demonstrating genotype-specific topological changes decades before phenoconversion and characterising longitudinal propagation patterns in specific phenotyp…
View article: Progressive Thalamo‐Cortical Disconnection in Amyotrophic Lateral Sclerosis Genotypes: Structural Degeneration and Network Dysfunction of Thalamus‐Relayed Circuits
Progressive Thalamo‐Cortical Disconnection in Amyotrophic Lateral Sclerosis Genotypes: Structural Degeneration and Network Dysfunction of Thalamus‐Relayed Circuits Open
Background The thalamus is a key subcortical hub of numerous corticobasal and corticocortical circuits mediating a wealth of cognitive, behavioural, sensory and motor processes. While thalamic pathology is increasingly recognised in amyotr…
View article: Cerebellar dysfunction in frontotemporal dementia: intra-cerebellar pathology and cerebellar network degeneration
Cerebellar dysfunction in frontotemporal dementia: intra-cerebellar pathology and cerebellar network degeneration Open
View article: Pseudobulbar affect: clinical associations, social impact and quality of life implications - Lessons from PLS
Pseudobulbar affect: clinical associations, social impact and quality of life implications - Lessons from PLS Open
Background Pseudobulbar affect (PBA) is a well-recognised and troublesome clinical phenomenon in a range of neuroinflammatory, neoplastic, neurovascular and neurodegenerative conditions. It is often under-recognised in the community, frequ…
View article: Sensory Dysfunction in ALS and Other Motor Neuron Diseases: Clinical Relevance, Histopathology, Neurophysiology, and Insights from Neuroimaging
Sensory Dysfunction in ALS and Other Motor Neuron Diseases: Clinical Relevance, Histopathology, Neurophysiology, and Insights from Neuroimaging Open
Background: The clinical profiles of MNDs are dominated by inexorable motor decline, but subclinical proprioceptive, nociceptive and somatosensory deficits may also exacerbate mobility, dexterity, and bulbar function. While extra-motor pat…
View article: Quantitative and Computational Spinal Imaging in Neurodegenerative Conditions and Acquired Spinal Disorders: Academic Advances and Clinical Prospects
Quantitative and Computational Spinal Imaging in Neurodegenerative Conditions and Acquired Spinal Disorders: Academic Advances and Clinical Prospects Open
Introduction: Quantitative spinal cord imaging has facilitated the objective appraisal of spinal cord pathology in a range of neurological conditions both in the academic and clinical setting. Diverse methodological approaches have been im…
View article: SC10X/U: A High-density Electrode System for Non-Invasive Recording of Neural Activity of the Cervical Spinal Cord
SC10X/U: A High-density Electrode System for Non-Invasive Recording of Neural Activity of the Cervical Spinal Cord Open
Objective To design and develop a high-density (HD) electrode system that describes the position of surface electrodes for recording electrophysiological signals from the human cervical spinal cord. The system is intended to standardize ex…
View article: Distinct Longitudinal Changes in EEG Measures Reflecting Functional Network Disruption in ALS Cognitive Phenotypes
Distinct Longitudinal Changes in EEG Measures Reflecting Functional Network Disruption in ALS Cognitive Phenotypes Open
View article: Clinical, Cortical, Subcortical, and White Matter Features of Right Temporal Variant FTD
Clinical, Cortical, Subcortical, and White Matter Features of Right Temporal Variant FTD Open
The distinct clinical and radiological characteristics of right temporal variant FTD have only been recently recognized. Methods: Eight patients with right temporal variant FTD were prospectively recruited and underwent a standardised neur…
View article: Limbic Network and Papez Circuit Involvement in ALS: Imaging and Clinical Profiles in GGGGCC Hexanucleotide Carriers in C9orf72 and C9orf72-Negative Patients
Limbic Network and Papez Circuit Involvement in ALS: Imaging and Clinical Profiles in GGGGCC Hexanucleotide Carriers in C9orf72 and C9orf72-Negative Patients Open
Background: While frontotemporal involvement is increasingly recognized in Amyotrophic lateral sclerosis (ALS), the degeneration of limbic networks remains poorly characterized, despite growing evidence of amnestic deficits, impaired emoti…
View article: Progressive Cerebrocerebellar Uncoupling in Sporadic and Genetic Forms of Amyotrophic Lateral Sclerosis
Progressive Cerebrocerebellar Uncoupling in Sporadic and Genetic Forms of Amyotrophic Lateral Sclerosis Open
ALS is associated with accruing intracerebellar disease burden as well as progressive corticocerebellar uncoupling. Contrary to previous suggestions, we have not detected evidence of compensatory structural or functional changes in respons…
View article: A Magnetic Resonance Spectroscopy Study on Polarity Subphenotypes in Bipolar Disorder
A Magnetic Resonance Spectroscopy Study on Polarity Subphenotypes in Bipolar Disorder Open
Although magnetic resonance spectroscopy (MRS) has provided in vivo measurements of brain chemical profiles in bipolar disorder (BD), there are no data on clinically and therapeutically important onset polarity (OP) and predominant polarit…
View article: Harnessing Big Data in Amyotrophic Lateral Sclerosis: Machine Learning Applications for Clinical Practice and Pharmaceutical Trials
Harnessing Big Data in Amyotrophic Lateral Sclerosis: Machine Learning Applications for Clinical Practice and Pharmaceutical Trials Open
The arrival of genotype-specific therapies in amyotrophic lateral sclerosis (ALS) signals the dawn of precision medicine in motor neuron diseases (MNDs). After decades of academic studies in ALS, we are now witnessing tangible clinical adv…
View article: Supra- and infra-tentorial degeneration patterns in primary lateral sclerosis: a multimodal longitudinal neuroradiology study
Supra- and infra-tentorial degeneration patterns in primary lateral sclerosis: a multimodal longitudinal neuroradiology study Open
View article: Distinct sources of resting-state EEG microstates in amyotrophic lateral sclerosis
Distinct sources of resting-state EEG microstates in amyotrophic lateral sclerosis Open
Brain microstates are a well-established method for the dynamic analysis of resting-state electroencephalogram (EEG). We observed four quasi-stable, transient and reoccurring resting-state topographies in the high density EEG data (128 ele…
View article: <scp>Electroencephalographic</scp> β‐band oscillations in the sensorimotor network reflect motor symptom severity in amyotrophic lateral sclerosis
<span>Electroencephalographic</span> β‐band oscillations in the sensorimotor network reflect motor symptom severity in amyotrophic lateral sclerosis Open
Background and purpose Resting‐state electroencephalography (EEG) holds promise for assessing brain networks in amyotrophic lateral sclerosis (ALS). We investigated whether neural β‐band oscillations in the sensorimotor network could serve…
View article: Distinct longitudinal changes in EEG measures reflecting functional network disruption in ALS cognitive phenotypes
Distinct longitudinal changes in EEG measures reflecting functional network disruption in ALS cognitive phenotypes Open
Amyotrophic lateral sclerosis (ALS) is characterised primarily by motor system degeneration, with clinical evidence of cognitive and behavioural change in up to 50% of cases. We have shown previously that resting-state EEG captures the dys…
View article: Primary lateral sclerosis: more than just an upper motor neuron disease
Primary lateral sclerosis: more than just an upper motor neuron disease Open
Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, Ireland (Tan EL, Lope J, Bede P) Department of Neurology, St James's Hospital, Dublin, Ireland (Bede P) *Correspondence to: Peter Bede, MD, PhD, [email pro…
View article: Functional network dynamics revealed by <scp>EEG</scp> microstates reflect cognitive decline in amyotrophic lateral sclerosis
Functional network dynamics revealed by <span>EEG</span> microstates reflect cognitive decline in amyotrophic lateral sclerosis Open
Recent electroencephalography (EEG) studies have shown that patterns of brain activity can be used to differentiate amyotrophic lateral sclerosis (ALS) and control groups. These differences can be interrogated by examining EEG microstates,…
View article: The involvement of language‐associated networks, tracts, and cortical regions in frontotemporal dementia and amyotrophic lateral sclerosis: Structural and functional alterations
The involvement of language‐associated networks, tracts, and cortical regions in frontotemporal dementia and amyotrophic lateral sclerosis: Structural and functional alterations Open
Background Language deficits are cardinal manifestations of some frontotemporal dementia (FTD) phenotypes and also increasingly recognized in sporadic and familial amyotrophic lateral sclerosis (ALS). They have considerable social and qual…
View article: Radiological correlates of pseudobulbar affect: Corticobulbar and cerebellar components in primary lateral sclerosis
Radiological correlates of pseudobulbar affect: Corticobulbar and cerebellar components in primary lateral sclerosis Open
View article: PRECISION ALS—an integrated pan European patient data platform for ALS
PRECISION ALS—an integrated pan European patient data platform for ALS Open
Amyotrophic Lateral Sclerosis (ALS) is an incurable neurodegenerative condition. Despite significant advances in pre-clinical models that enhance understanding of disease pathobiology, translation of candidate drugs to effective human ther…
View article: Presymptomatic grey matter alterations in ALS kindreds: a computational neuroimaging study of asymptomatic C9orf72 and SOD1 mutation carriers
Presymptomatic grey matter alterations in ALS kindreds: a computational neuroimaging study of asymptomatic C9orf72 and SOD1 mutation carriers Open
Background The characterisation of presymptomatic disease-burden patterns in asymptomatic mutation carriers has a dual academic and clinical relevance. The understanding of disease propagation mechanisms is of considerable conceptual inter…
View article: Brainstem–cortex disconnection in amyotrophic lateral sclerosis: bulbar impairment, genotype associations, asymptomatic changes and biomarker opportunities
Brainstem–cortex disconnection in amyotrophic lateral sclerosis: bulbar impairment, genotype associations, asymptomatic changes and biomarker opportunities Open
View article: Hippocampal Metabolic Alterations in Amyotrophic Lateral Sclerosis: A Magnetic Resonance Spectroscopy Study
Hippocampal Metabolic Alterations in Amyotrophic Lateral Sclerosis: A Magnetic Resonance Spectroscopy Study Open
Background: Magnetic resonance spectroscopy (MRS) in amyotrophic lateral sclerosis (ALS) has been overwhelmingly applied to motor regions to date and our understanding of frontotemporal metabolic signatures is relatively limited. The assoc…
View article: Not a benign motor neuron disease: longitudinal imaging captures relentless motor connectome disintegration in primary lateral sclerosis
Not a benign motor neuron disease: longitudinal imaging captures relentless motor connectome disintegration in primary lateral sclerosis Open
Background and purpose Primary lateral sclerosis (PLS) is a progressive upper motor neuron disorder associated with considerable clinical disability. Symptoms are typically exclusively linked to primary motor cortex degeneration and the co…
View article: Thalamic pathology in frontotemporal dementia: Predilection for specific nuclei, phenotype‐specific signatures, clinical correlates, and practical relevance
Thalamic pathology in frontotemporal dementia: Predilection for specific nuclei, phenotype‐specific signatures, clinical correlates, and practical relevance Open
Background Frontotemporal dementia (FTD) phenotypes are classically associated with distinctive cortical atrophy patterns and regional hypometabolism. However, the spectrum of cognitive and behavioral manifestations in FTD arises from mult…