Peter Birner
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View article: Screening for oncogenic AF1q expression predicts disease recurrence in gastric cancer patients
Screening for oncogenic AF1q expression predicts disease recurrence in gastric cancer patients Open
AF1q associates with tumor progression and metastases upon WNT signaling. The downstream WNT target CD44 has demonstrated prognostic significance in gastric cancer (GC). This study evaluates the impact of AF1q on tumor stage and survival i…
View article: Supplementary Tables 1-4 from MAPKAP Kinase 2 Overexpression Influences Prognosis in Gastrointestinal Stromal Tumors and Associates with Copy Number Variations on Chromosome 1 and Expression of p38 MAP Kinase and ETV1
Supplementary Tables 1-4 from MAPKAP Kinase 2 Overexpression Influences Prognosis in Gastrointestinal Stromal Tumors and Associates with Copy Number Variations on Chromosome 1 and Expression of p38 MAP Kinase and ETV1 Open
PDF file - 93K
View article: Supplemental Tables from MicroRNA Profiles of Barrett's Esophagus and Esophageal Adenocarcinoma: Differences in Glandular Non-native Epithelium
Supplemental Tables from MicroRNA Profiles of Barrett's Esophagus and Esophageal Adenocarcinoma: Differences in Glandular Non-native Epithelium Open
Supplemental Table 1: Patient clinical and demographic characteristics. Supplemental Table 2: miRNAs differentially detected among esophageal adenocarcinoma and Barrett's esophagus. Supplemental Table 3: miRNAs differentially expressed amo…
View article: Supplementary Tables 1-4 from MAPKAP Kinase 2 Overexpression Influences Prognosis in Gastrointestinal Stromal Tumors and Associates with Copy Number Variations on Chromosome 1 and Expression of p38 MAP Kinase and ETV1
Supplementary Tables 1-4 from MAPKAP Kinase 2 Overexpression Influences Prognosis in Gastrointestinal Stromal Tumors and Associates with Copy Number Variations on Chromosome 1 and Expression of p38 MAP Kinase and ETV1 Open
PDF file - 93K
View article: Data from Novel Clinically Relevant Genes in Gastrointestinal Stromal Tumors Identified by Exome Sequencing
Data from Novel Clinically Relevant Genes in Gastrointestinal Stromal Tumors Identified by Exome Sequencing Open
Purpose: Chromosomal gains and losses resulting in altered gene dosage are known to be recurrent in gastrointestinal stromal tumors (GIST). The aim of our study was the identification of clinical relevant genes in these candidate re…
View article: Data from MicroRNA Profiles of Barrett's Esophagus and Esophageal Adenocarcinoma: Differences in Glandular Non-native Epithelium
Data from MicroRNA Profiles of Barrett's Esophagus and Esophageal Adenocarcinoma: Differences in Glandular Non-native Epithelium Open
Background: The tissue specificity and robustness of miRNAs may aid risk prediction in individuals diagnosed with Barrett's esophagus. As an initial step, we assessed whether miRNAs can positively distinguish esophageal adenocarcino…
View article: Supplementary Tables 3 and 4 from Novel Clinically Relevant Genes in Gastrointestinal Stromal Tumors Identified by Exome Sequencing
Supplementary Tables 3 and 4 from Novel Clinically Relevant Genes in Gastrointestinal Stromal Tumors Identified by Exome Sequencing Open
PDF file, 24K, Supplemental Table 3 Variants per sample Supplemental Table 4 Variants unique per normal/cancer pair.
View article: Supplementary Tables 3 and 4 from Novel Clinically Relevant Genes in Gastrointestinal Stromal Tumors Identified by Exome Sequencing
Supplementary Tables 3 and 4 from Novel Clinically Relevant Genes in Gastrointestinal Stromal Tumors Identified by Exome Sequencing Open
PDF file, 24K, Supplemental Table 3 Variants per sample Supplemental Table 4 Variants unique per normal/cancer pair.
View article: Data from MicroRNA Profiles of Barrett's Esophagus and Esophageal Adenocarcinoma: Differences in Glandular Non-native Epithelium
Data from MicroRNA Profiles of Barrett's Esophagus and Esophageal Adenocarcinoma: Differences in Glandular Non-native Epithelium Open
Background: The tissue specificity and robustness of miRNAs may aid risk prediction in individuals diagnosed with Barrett's esophagus. As an initial step, we assessed whether miRNAs can positively distinguish esophageal adenocarcino…
View article: Data from Novel Clinically Relevant Genes in Gastrointestinal Stromal Tumors Identified by Exome Sequencing
Data from Novel Clinically Relevant Genes in Gastrointestinal Stromal Tumors Identified by Exome Sequencing Open
Purpose: Chromosomal gains and losses resulting in altered gene dosage are known to be recurrent in gastrointestinal stromal tumors (GIST). The aim of our study was the identification of clinical relevant genes in these candidate re…
View article: Supplementary Tables 1 and 2 and 5 from Novel Clinically Relevant Genes in Gastrointestinal Stromal Tumors Identified by Exome Sequencing
Supplementary Tables 1 and 2 and 5 from Novel Clinically Relevant Genes in Gastrointestinal Stromal Tumors Identified by Exome Sequencing Open
PDF file, 95K, Supplemental Table 1: Comparision of copy number variation regions of interest by FISH (n=125) and microarray (n=29). Supplemental Table 2: Antibodies used for detection of genes in regions of recurrent losses or gains Suppl…
View article: Supplementary Tables 1 and 2 and 5 from Novel Clinically Relevant Genes in Gastrointestinal Stromal Tumors Identified by Exome Sequencing
Supplementary Tables 1 and 2 and 5 from Novel Clinically Relevant Genes in Gastrointestinal Stromal Tumors Identified by Exome Sequencing Open
PDF file, 95K, Supplemental Table 1: Comparision of copy number variation regions of interest by FISH (n=125) and microarray (n=29). Supplemental Table 2: Antibodies used for detection of genes in regions of recurrent losses or gains Suppl…
View article: Supplemental Tables from MicroRNA Profiles of Barrett's Esophagus and Esophageal Adenocarcinoma: Differences in Glandular Non-native Epithelium
Supplemental Tables from MicroRNA Profiles of Barrett's Esophagus and Esophageal Adenocarcinoma: Differences in Glandular Non-native Epithelium Open
Supplemental Table 1: Patient clinical and demographic characteristics. Supplemental Table 2: miRNAs differentially detected among esophageal adenocarcinoma and Barrett's esophagus. Supplemental Table 3: miRNAs differentially expressed amo…
View article: Data from MAPKAP Kinase 2 Overexpression Influences Prognosis in Gastrointestinal Stromal Tumors and Associates with Copy Number Variations on Chromosome 1 and Expression of p38 MAP Kinase and ETV1
Data from MAPKAP Kinase 2 Overexpression Influences Prognosis in Gastrointestinal Stromal Tumors and Associates with Copy Number Variations on Chromosome 1 and Expression of p38 MAP Kinase and ETV1 Open
Purpose: ETV1 has been proposed to be activated by KIT mutations in gastrointestinal stromal tumors (GIST). The aim of the study was to evaluate the clinical role of ETV1 and associated proteins in GIST.Experimental Design…
View article: Data from MAPKAP Kinase 2 Overexpression Influences Prognosis in Gastrointestinal Stromal Tumors and Associates with Copy Number Variations on Chromosome 1 and Expression of p38 MAP Kinase and ETV1
Data from MAPKAP Kinase 2 Overexpression Influences Prognosis in Gastrointestinal Stromal Tumors and Associates with Copy Number Variations on Chromosome 1 and Expression of p38 MAP Kinase and ETV1 Open
Purpose: ETV1 has been proposed to be activated by KIT mutations in gastrointestinal stromal tumors (GIST). The aim of the study was to evaluate the clinical role of ETV1 and associated proteins in GIST.Experimental Design…
View article: Erratum: Gruber, E.S.; et al. The Oncogene AF1Q is Associated with WNT and STAT Signaling and Offers a Novel Independent Prognostic Marker in Patients with Resectable Esophageal Cancer. Cells 2019, 8, 1357
Erratum: Gruber, E.S.; et al. The Oncogene AF1Q is Associated with WNT and STAT Signaling and Offers a Novel Independent Prognostic Marker in Patients with Resectable Esophageal Cancer. Cells 2019, 8, 1357 Open
The authors wish to make the following change to their paper [...]
View article: p53 Loss Mediates Hypersensitivity to ETS Transcription Factor Inhibition Based on PARylation-Mediated Cell Death Induction
p53 Loss Mediates Hypersensitivity to ETS Transcription Factor Inhibition Based on PARylation-Mediated Cell Death Induction Open
The small-molecule E26 transformation-specific (ETS) factor inhibitor YK-4-279 was developed for therapy of ETS/EWS fusion-driven Ewing’s sarcoma. Here we aimed to identify molecular factors underlying YK-4-279 responsiveness in ETS fusion…
View article: The Immune Phenotype of Isolated Lymphoid Structures in Non-Tumorous Colon Mucosa Encrypts the Information on Pathobiology of Metastatic Colorectal Cancer
The Immune Phenotype of Isolated Lymphoid Structures in Non-Tumorous Colon Mucosa Encrypts the Information on Pathobiology of Metastatic Colorectal Cancer Open
The gut-associated lymphoid tissue represents an integral part of the immune system. Among the powerful players of the mucosa-associated lymphoid tissue are isolated lymphoid structures (ILSs), which as information centers, drive the local…
View article: The Oncogene AF1Q is Associated with WNT and STAT Signaling and Offers a Novel Independent Prognostic Marker in Patients with Resectable Esophageal Cancer
The Oncogene AF1Q is Associated with WNT and STAT Signaling and Offers a Novel Independent Prognostic Marker in Patients with Resectable Esophageal Cancer Open
AF1q impairs survival in hematologic and solid malignancies. AF1q expression is associated with tumor progression, migration and chemoresistance and acts as a transcriptional co-activator in WNT and STAT signaling. This study evaluates the…
View article: Quantitative evidence for early metastatic seeding in colorectal cancer
Quantitative evidence for early metastatic seeding in colorectal cancer Open
View article: Interrelations of Sphingolipid and Lysophosphatidate Signaling with Immune System in Ovarian Cancer
Interrelations of Sphingolipid and Lysophosphatidate Signaling with Immune System in Ovarian Cancer Open
The sphingolipid and lysophosphatidate regulatory networks impact diverse mechanisms attributed to cancer cells and the tumor immune microenvironment. Deciphering the complexity demands implementation of a holistic approach combined with h…
View article: High-risk Mucosal Human Papillomavirus Infection in Squamous Cell Carcinoma and Bowen's Disease of the Hand
High-risk Mucosal Human Papillomavirus Infection in Squamous Cell Carcinoma and Bowen's Disease of the Hand Open
View article: High correlation of temporal muscle thickness with lumbar skeletal muscle cross-sectional area in patients with brain metastases
High correlation of temporal muscle thickness with lumbar skeletal muscle cross-sectional area in patients with brain metastases Open
OBJECTIVES: This study aimed to assess the correlation of temporal muscle thickness (TMT), measured on routine cranial magnetic resonance (MR) images, with lumbar skeletal muscles obtained on computed tomography (CT) images in brain metast…
View article: Mutational profile of colorectal cancer lung metastases and paired primary tumors by targeted next generation sequencing: implications on clinical outcome after surgery
Mutational profile of colorectal cancer lung metastases and paired primary tumors by targeted next generation sequencing: implications on clinical outcome after surgery Open
Our findings suggest that CRC PM harbor a variety of conserved and de novo mutations. We could identify a mutational profile predicting clinical outcome after pulmonary metastasectomy. Moreover, our data provide a rationale for futu…
View article: Apigenin and Luteolin Attenuate the Breaching of MDA-MB231 Breast Cancer Spheroids Through the Lymph Endothelial Barrier in Vitro
Apigenin and Luteolin Attenuate the Breaching of MDA-MB231 Breast Cancer Spheroids Through the Lymph Endothelial Barrier in Vitro Open
Flavonoids, present in fruits, vegetables and traditional medicinal plants, show anticancer effects in experimental systems and are reportedly non-toxic. This is a favorable property for long term strategies for the attenuation of lymph no…
View article: Podoplanin expression in primary brain tumors induces platelet aggregation and increases risk of venous thromboembolism
Podoplanin expression in primary brain tumors induces platelet aggregation and increases risk of venous thromboembolism Open
Key Points Brain tumor patients have a very high risk of VTE. Podoplanin expression by primary brain tumors induces platelet aggregation and is associated with hypercoagulability and a high risk of VTE.
View article: Survival prediction using temporal muscle thickness measurements on cranial magnetic resonance images in patients with newly diagnosed brain metastases
Survival prediction using temporal muscle thickness measurements on cranial magnetic resonance images in patients with newly diagnosed brain metastases Open
OBJECTIVES: To evaluate the prognostic relevance of temporal muscle thickness (TMT) in brain metastasis patients. METHODS: We retrospectively analysed TMT on magnetic resonance (MR) images at diagnosis of brain metastasis in two independen…
View article: Combining standard clinical blood values for improving survival prediction in patients with newly diagnosed brain metastases—development and validation of the LabBM score
Combining standard clinical blood values for improving survival prediction in patients with newly diagnosed brain metastases—development and validation of the LabBM score Open
Standard clinical blood parameters, combined in the easy-to-calculate LabBM score, provide strong and independent prognostic information in patients with BM. The LabBM score is an objective, inexpensive, and reproducible tool to plan clini…
View article: Enhanced expression of the stemness-related factors OCT4, SOX15 and TWIST1 in ectopic endometrium of endometriosis patients
Enhanced expression of the stemness-related factors OCT4, SOX15 and TWIST1 in ectopic endometrium of endometriosis patients Open
View article: TMIC-18. ROLE OF MICROGLIA IN THE EARLY STEPS OF THE BRAIN METASTATIC CASCADE
TMIC-18. ROLE OF MICROGLIA IN THE EARLY STEPS OF THE BRAIN METASTATIC CASCADE Open
Gliomas are one of the cancers most at risk of causing life-threatening venous thromboemboli (VTE).Previously, we discovered that gliomas with mutations in isocitrate dehydrogenase (IDH1mut) are much less likely to contain intratumoral mic…