Peter Bitsch
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View article: A Recognition Tag of Human Origin for Bioorthogonal Generation of Antibody‐Drug Conjugates using Microbial Biotin Ligase
A Recognition Tag of Human Origin for Bioorthogonal Generation of Antibody‐Drug Conjugates using Microbial Biotin Ligase Open
The use of enzymes, such as microbial transglutaminase, lipoate protein ligase A, or sortase A, for the generation of antibody‐drug conjugates has proven to be a powerful tool for the site‐specific payload conjugation to tumor‐specific ant…
View article: Evaluation of Potency and Specificity of Cryptophycin‐Loaded Antibody‐Drug Conjugates
Evaluation of Potency and Specificity of Cryptophycin‐Loaded Antibody‐Drug Conjugates Open
An enhanced variant of the antimitotic toxin cryptophycin was conjugated to the anti‐Her2 monoclonal antibody (mAb) Trastuzumab upon Michael addition. Either antibodies with freed hinge‐region cysteines or THIOMAB formats with engineered c…
View article: Mimicking the immunosuppressive impact of fibroblasts in a 3D multicellular spheroid model
Mimicking the immunosuppressive impact of fibroblasts in a 3D multicellular spheroid model Open
Targeting the tumor microenvironment (TME) is an attractive strategy for cancer therapy, as tumor cells in vivo are surrounded by many different influential cell types, with complex interactions strongly affecting tumor progression and the…
View article: Penetration of Nanobody-Dextran Polymer Conjugates through Tumor Spheroids
Penetration of Nanobody-Dextran Polymer Conjugates through Tumor Spheroids Open
Here we report the generation of nanobody dextran polymer conjugates (dextraknobs) that are loaded with small molecules, i.e., fluorophores or photosensitizers, for potential applications in cancer diagnostics and therapy. To this end, the…